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Protein

NudC domain-containing protein 3

Gene

NUDCD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
NudC domain-containing protein 3
Gene namesi
Name:NUDCD3
Synonyms:KIAA1068
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22208. NUDCD3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134989375.

Polymorphism and mutation databases

BioMutaiNUDCD3.
DMDMi145559509.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361NudC domain-containing protein 3PRO_0000057985Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei146 – 1461PhosphoserineCombined sources
Modified residuei355 – 3551PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IVD9.
MaxQBiQ8IVD9.
PaxDbiQ8IVD9.
PRIDEiQ8IVD9.

PTM databases

iPTMnetiQ8IVD9.
PhosphoSiteiQ8IVD9.

Expressioni

Gene expression databases

BgeeiQ8IVD9.
CleanExiHS_NUDCD3.
GenevisibleiQ8IVD9. HS.

Organism-specific databases

HPAiHPA019136.
HPA019528.
HPA019529.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CXorf57Q6NSI42EBI-744342,EBI-8634209
KLHDC10Q6PID82EBI-744342,EBI-3201175
KLHL23Q8NBE82EBI-744342,EBI-2512246
KLHL38Q2WGJ62EBI-744342,EBI-6426443
SF3B3Q153932EBI-744342,EBI-346977

Protein-protein interaction databases

BioGridi116962. 52 interactions.
DIPiDIP-53643N.
IntActiQ8IVD9. 125 interactions.
STRINGi9606.ENSP00000347626.

Structurei

Secondary structure

1
361
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi179 – 1857Combined sources
Beta strandi191 – 1955Combined sources
Beta strandi198 – 2047Combined sources
Helixi212 – 2143Combined sources
Beta strandi215 – 2195Combined sources
Beta strandi221 – 2299Combined sources
Beta strandi231 – 24414Combined sources
Turni248 – 2503Combined sources
Beta strandi252 – 2554Combined sources
Beta strandi259 – 2657Combined sources
Beta strandi267 – 2704Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WGVNMR-A176-286[»]
ProteinModelPortaliQ8IVD9.
SMRiQ8IVD9. Positions 176-286.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IVD9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini185 – 27793CSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2265. Eukaryota.
ENOG410XQVU. LUCA.
GeneTreeiENSGT00530000063486.
HOGENOMiHOG000036072.
HOVERGENiHBG100537.
InParanoidiQ8IVD9.
OMAiRENYSWS.
OrthoDBiEOG7HQN8G.
PhylomeDBiQ8IVD9.
TreeFamiTF300147.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR025934. NudC_N_dom.
IPR027761. NUDCD3.
[Graphical view]
PANTHERiPTHR12356:SF19. PTHR12356:SF19. 1 hit.
PfamiPF04969. CS. 1 hit.
PF14050. Nudc_N. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS51203. CS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IVD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METGAAELYD QALLGILQHV GNVQDFLRVL FGFLYRKTDF YRLLRHPSDR
60 70 80 90 100
MGFPPGAAQA LVLQVFKTFD HMARQDDEKR RQELEEKIRR KEEEEAKTVS
110 120 130 140 150
AAAAEKEPVP VPVQEIEIDS TTELDGHQEV EKVQPPGPVK EMAHGSQEAE
160 170 180 190 200
APGAVAGAAE VPREPPILPR IQEQFQKNPD SYNGAVRENY TWSQDYTDLE
210 220 230 240 250
VRVPVPKHVV KGKQVSVALS SSSIRVAMLE ENGERVLMEG KLTHKINTES
260 270 280 290 300
SLWSLEPGKC VLVNLSKVGE YWWNAILEGE EPIDIDKINK ERSMATVDEE
310 320 330 340 350
EQAVLDRLTF DYHQKLQGKP QSHELKVHEM LKKGWDAEGS PFRGQRFDPA
360
MFNISPGAVQ F
Length:361
Mass (Da):40,822
Last modified:April 17, 2007 - v3
Checksum:i06B54758C395818A
GO

Sequence cautioni

The sequence AAH03691.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAQ96892.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAB14855.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti205 – 2051V → L in AAH35014 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31T → P.1 Publication
Corresponds to variant rs307007 [ dbSNP | Ensembl ].
VAR_054036
Natural varianti235 – 2351R → C.1 Publication
Corresponds to variant rs11550029 [ dbSNP | Ensembl ].
VAR_031709

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004453 Genomic DNA. Translation: AAQ96892.1. Sequence problems.
BC003691 mRNA. Translation: AAH03691.1. Different initiation.
BC011673 mRNA. Translation: AAH11673.2.
BC035014 mRNA. Translation: AAH35014.1.
AB028991 mRNA. Translation: BAA83020.1.
AK024226 mRNA. Translation: BAB14855.1. Different initiation.
CCDSiCCDS5490.2.
RefSeqiNP_056147.2. NM_015332.3.
UniGeneiHs.488171.

Genome annotation databases

EnsembliENST00000355451; ENSP00000347626; ENSG00000015676.
GeneIDi23386.
KEGGihsa:23386.
UCSCiuc003tkz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004453 Genomic DNA. Translation: AAQ96892.1. Sequence problems.
BC003691 mRNA. Translation: AAH03691.1. Different initiation.
BC011673 mRNA. Translation: AAH11673.2.
BC035014 mRNA. Translation: AAH35014.1.
AB028991 mRNA. Translation: BAA83020.1.
AK024226 mRNA. Translation: BAB14855.1. Different initiation.
CCDSiCCDS5490.2.
RefSeqiNP_056147.2. NM_015332.3.
UniGeneiHs.488171.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WGVNMR-A176-286[»]
ProteinModelPortaliQ8IVD9.
SMRiQ8IVD9. Positions 176-286.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116962. 52 interactions.
DIPiDIP-53643N.
IntActiQ8IVD9. 125 interactions.
STRINGi9606.ENSP00000347626.

PTM databases

iPTMnetiQ8IVD9.
PhosphoSiteiQ8IVD9.

Polymorphism and mutation databases

BioMutaiNUDCD3.
DMDMi145559509.

Proteomic databases

EPDiQ8IVD9.
MaxQBiQ8IVD9.
PaxDbiQ8IVD9.
PRIDEiQ8IVD9.

Protocols and materials databases

DNASUi23386.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355451; ENSP00000347626; ENSG00000015676.
GeneIDi23386.
KEGGihsa:23386.
UCSCiuc003tkz.4. human.

Organism-specific databases

CTDi23386.
GeneCardsiNUDCD3.
HGNCiHGNC:22208. NUDCD3.
HPAiHPA019136.
HPA019528.
HPA019529.
MIMi610296. gene.
neXtProtiNX_Q8IVD9.
PharmGKBiPA134989375.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2265. Eukaryota.
ENOG410XQVU. LUCA.
GeneTreeiENSGT00530000063486.
HOGENOMiHOG000036072.
HOVERGENiHBG100537.
InParanoidiQ8IVD9.
OMAiRENYSWS.
OrthoDBiEOG7HQN8G.
PhylomeDBiQ8IVD9.
TreeFamiTF300147.

Miscellaneous databases

ChiTaRSiNUDCD3. human.
EvolutionaryTraceiQ8IVD9.
GeneWikiiNUDCD3_(gene).
GenomeRNAii23386.
PROiQ8IVD9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IVD9.
CleanExiHS_NUDCD3.
GenevisibleiQ8IVD9. HS.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR025934. NudC_N_dom.
IPR027761. NUDCD3.
[Graphical view]
PANTHERiPTHR12356:SF19. PTHR12356:SF19. 1 hit.
PfamiPF04969. CS. 1 hit.
PF14050. Nudc_N. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS51203. CS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PRO-3 AND CYS-235.
    Tissue: Brain, Pancreas and Placenta.
  3. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-361.
    Tissue: Brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-361.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-355, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-355, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Solution structure of the CS domain of human KIAA1068."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 176-286.

Entry informationi

Entry nameiNUDC3_HUMAN
AccessioniPrimary (citable) accession number: Q8IVD9
Secondary accession number(s): Q9BTI3, Q9H7W9, Q9UPT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: April 17, 2007
Last modified: June 8, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.