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Protein

NudC domain-containing protein 3

Gene

NUDCD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
NudC domain-containing protein 3
Gene namesi
Name:NUDCD3
Synonyms:KIAA1068
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22208. NUDCD3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi23386.
OpenTargetsiENSG00000015676.
PharmGKBiPA134989375.

Polymorphism and mutation databases

BioMutaiNUDCD3.
DMDMi145559509.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000579851 – 361NudC domain-containing protein 3Add BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei146PhosphoserineCombined sources1
Modified residuei340PhosphoserineCombined sources1
Modified residuei355PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IVD9.
MaxQBiQ8IVD9.
PaxDbiQ8IVD9.
PeptideAtlasiQ8IVD9.
PRIDEiQ8IVD9.

PTM databases

iPTMnetiQ8IVD9.
PhosphoSitePlusiQ8IVD9.

Expressioni

Gene expression databases

BgeeiENSG00000015676.
CleanExiHS_NUDCD3.
GenevisibleiQ8IVD9. HS.

Organism-specific databases

HPAiHPA019136.
HPA019528.
HPA019529.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CXorf57Q6NSI42EBI-744342,EBI-8634209
KLHDC10Q6PID82EBI-744342,EBI-3201175
KLHL23Q8NBE82EBI-744342,EBI-2512246
KLHL38Q2WGJ62EBI-744342,EBI-6426443
SF3B3Q153932EBI-744342,EBI-346977

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116962. 52 interactors.
DIPiDIP-53643N.
IntActiQ8IVD9. 125 interactors.
STRINGi9606.ENSP00000347626.

Structurei

Secondary structure

1361
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi179 – 185Combined sources7
Beta strandi191 – 195Combined sources5
Beta strandi198 – 204Combined sources7
Helixi212 – 214Combined sources3
Beta strandi215 – 219Combined sources5
Beta strandi221 – 229Combined sources9
Beta strandi231 – 244Combined sources14
Turni248 – 250Combined sources3
Beta strandi252 – 255Combined sources4
Beta strandi259 – 265Combined sources7
Beta strandi267 – 270Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WGVNMR-A176-286[»]
ProteinModelPortaliQ8IVD9.
SMRiQ8IVD9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IVD9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini185 – 277CSPROSITE-ProRule annotationAdd BLAST93

Sequence similaritiesi

Contains 1 CS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2265. Eukaryota.
ENOG410XQVU. LUCA.
GeneTreeiENSGT00530000063486.
HOGENOMiHOG000036072.
HOVERGENiHBG100537.
InParanoidiQ8IVD9.
OMAiRENYSWS.
OrthoDBiEOG091G0BZ5.
PhylomeDBiQ8IVD9.
TreeFamiTF300147.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR025934. NudC_N_dom.
IPR027761. NUDCD3.
[Graphical view]
PANTHERiPTHR12356:SF19. PTHR12356:SF19. 1 hit.
PfamiPF04969. CS. 1 hit.
PF14050. Nudc_N. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS51203. CS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IVD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METGAAELYD QALLGILQHV GNVQDFLRVL FGFLYRKTDF YRLLRHPSDR
60 70 80 90 100
MGFPPGAAQA LVLQVFKTFD HMARQDDEKR RQELEEKIRR KEEEEAKTVS
110 120 130 140 150
AAAAEKEPVP VPVQEIEIDS TTELDGHQEV EKVQPPGPVK EMAHGSQEAE
160 170 180 190 200
APGAVAGAAE VPREPPILPR IQEQFQKNPD SYNGAVRENY TWSQDYTDLE
210 220 230 240 250
VRVPVPKHVV KGKQVSVALS SSSIRVAMLE ENGERVLMEG KLTHKINTES
260 270 280 290 300
SLWSLEPGKC VLVNLSKVGE YWWNAILEGE EPIDIDKINK ERSMATVDEE
310 320 330 340 350
EQAVLDRLTF DYHQKLQGKP QSHELKVHEM LKKGWDAEGS PFRGQRFDPA
360
MFNISPGAVQ F
Length:361
Mass (Da):40,822
Last modified:April 17, 2007 - v3
Checksum:i06B54758C395818A
GO

Sequence cautioni

The sequence AAH03691 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ96892 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB14855 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti205V → L in AAH35014 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0540363T → P.1 PublicationCorresponds to variant rs307007dbSNPEnsembl.1
Natural variantiVAR_031709235R → C.1 PublicationCorresponds to variant rs11550029dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004453 Genomic DNA. Translation: AAQ96892.1. Sequence problems.
BC003691 mRNA. Translation: AAH03691.1. Different initiation.
BC011673 mRNA. Translation: AAH11673.2.
BC035014 mRNA. Translation: AAH35014.1.
AB028991 mRNA. Translation: BAA83020.1.
AK024226 mRNA. Translation: BAB14855.1. Different initiation.
CCDSiCCDS5490.2.
RefSeqiNP_056147.2. NM_015332.3.
UniGeneiHs.488171.

Genome annotation databases

EnsembliENST00000355451; ENSP00000347626; ENSG00000015676.
GeneIDi23386.
KEGGihsa:23386.
UCSCiuc003tkz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004453 Genomic DNA. Translation: AAQ96892.1. Sequence problems.
BC003691 mRNA. Translation: AAH03691.1. Different initiation.
BC011673 mRNA. Translation: AAH11673.2.
BC035014 mRNA. Translation: AAH35014.1.
AB028991 mRNA. Translation: BAA83020.1.
AK024226 mRNA. Translation: BAB14855.1. Different initiation.
CCDSiCCDS5490.2.
RefSeqiNP_056147.2. NM_015332.3.
UniGeneiHs.488171.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WGVNMR-A176-286[»]
ProteinModelPortaliQ8IVD9.
SMRiQ8IVD9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116962. 52 interactors.
DIPiDIP-53643N.
IntActiQ8IVD9. 125 interactors.
STRINGi9606.ENSP00000347626.

PTM databases

iPTMnetiQ8IVD9.
PhosphoSitePlusiQ8IVD9.

Polymorphism and mutation databases

BioMutaiNUDCD3.
DMDMi145559509.

Proteomic databases

EPDiQ8IVD9.
MaxQBiQ8IVD9.
PaxDbiQ8IVD9.
PeptideAtlasiQ8IVD9.
PRIDEiQ8IVD9.

Protocols and materials databases

DNASUi23386.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355451; ENSP00000347626; ENSG00000015676.
GeneIDi23386.
KEGGihsa:23386.
UCSCiuc003tkz.4. human.

Organism-specific databases

CTDi23386.
DisGeNETi23386.
GeneCardsiNUDCD3.
HGNCiHGNC:22208. NUDCD3.
HPAiHPA019136.
HPA019528.
HPA019529.
MIMi610296. gene.
neXtProtiNX_Q8IVD9.
OpenTargetsiENSG00000015676.
PharmGKBiPA134989375.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2265. Eukaryota.
ENOG410XQVU. LUCA.
GeneTreeiENSGT00530000063486.
HOGENOMiHOG000036072.
HOVERGENiHBG100537.
InParanoidiQ8IVD9.
OMAiRENYSWS.
OrthoDBiEOG091G0BZ5.
PhylomeDBiQ8IVD9.
TreeFamiTF300147.

Miscellaneous databases

ChiTaRSiNUDCD3. human.
EvolutionaryTraceiQ8IVD9.
GeneWikiiNUDCD3_(gene).
GenomeRNAii23386.
PROiQ8IVD9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000015676.
CleanExiHS_NUDCD3.
GenevisibleiQ8IVD9. HS.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR025934. NudC_N_dom.
IPR027761. NUDCD3.
[Graphical view]
PANTHERiPTHR12356:SF19. PTHR12356:SF19. 1 hit.
PfamiPF04969. CS. 1 hit.
PF14050. Nudc_N. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS51203. CS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUDC3_HUMAN
AccessioniPrimary (citable) accession number: Q8IVD9
Secondary accession number(s): Q9BTI3, Q9H7W9, Q9UPT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: April 17, 2007
Last modified: November 2, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.