ID   ZN584_HUMAN             Reviewed;         421 AA.
AC   Q8IVC4; A8K203;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 155.
DE   RecName: Full=Zinc finger protein 584;
GN   Name=ZNF584;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-301.
RC   TISSUE=Substantia nigra;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK290068; BAF82757.1; -; mRNA.
DR   EMBL; BC033149; AAH33149.1; -; mRNA.
DR   CCDS; CCDS12979.1; -.
DR   RefSeq; NP_001304931.1; NM_001318002.1.
DR   RefSeq; NP_775819.1; NM_173548.2.
DR   AlphaFoldDB; Q8IVC4; -.
DR   SMR; Q8IVC4; -.
DR   BioGRID; 128391; 11.
DR   IntAct; Q8IVC4; 2.
DR   STRING; 9606.ENSP00000306756; -.
DR   iPTMnet; Q8IVC4; -.
DR   PhosphoSitePlus; Q8IVC4; -.
DR   BioMuta; ZNF584; -.
DR   DMDM; 55976735; -.
DR   MassIVE; Q8IVC4; -.
DR   MaxQB; Q8IVC4; -.
DR   PaxDb; 9606-ENSP00000306756; -.
DR   PeptideAtlas; Q8IVC4; -.
DR   ProteomicsDB; 70680; -.
DR   Pumba; Q8IVC4; -.
DR   Antibodypedia; 21593; 44 antibodies from 15 providers.
DR   DNASU; 201514; -.
DR   Ensembl; ENST00000306910.9; ENSP00000306756.3; ENSG00000171574.19.
DR   GeneID; 201514; -.
DR   KEGG; hsa:201514; -.
DR   MANE-Select; ENST00000306910.9; ENSP00000306756.3; NM_173548.3; NP_775819.1.
DR   UCSC; uc002qsp.4; human.
DR   AGR; HGNC:27318; -.
DR   CTD; 201514; -.
DR   DisGeNET; 201514; -.
DR   GeneCards; ZNF584; -.
DR   HGNC; HGNC:27318; ZNF584.
DR   HPA; ENSG00000171574; Low tissue specificity.
DR   neXtProt; NX_Q8IVC4; -.
DR   OpenTargets; ENSG00000171574; -.
DR   PharmGKB; PA134968861; -.
DR   VEuPathDB; HostDB:ENSG00000171574; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000163291; -.
DR   HOGENOM; CLU_002678_0_9_1; -.
DR   InParanoid; Q8IVC4; -.
DR   OMA; FKYSHSF; -.
DR   OrthoDB; 5250099at2759; -.
DR   PhylomeDB; Q8IVC4; -.
DR   TreeFam; TF337055; -.
DR   PathwayCommons; Q8IVC4; -.
DR   Reactome; R-HSA-212436; Generic Transcription Pathway.
DR   SignaLink; Q8IVC4; -.
DR   BioGRID-ORCS; 201514; 17 hits in 1177 CRISPR screens.
DR   ChiTaRS; ZNF584; human.
DR   GenomeRNAi; 201514; -.
DR   Pharos; Q8IVC4; Tdark.
DR   PRO; PR:Q8IVC4; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q8IVC4; Protein.
DR   Bgee; ENSG00000171574; Expressed in oocyte and 137 other cell types or tissues.
DR   ExpressionAtlas; Q8IVC4; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   Gene3D; 6.10.140.140; -; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 8.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1.
DR   PANTHER; PTHR23232:SF131; KRAB DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 7.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 8.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 5.
DR   SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
DR   Genevisible; Q8IVC4; HS.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..421
FT                   /note="Zinc finger protein 584"
FT                   /id="PRO_0000047676"
FT   DOMAIN          17..88
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         159..181
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         214..236
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         242..264
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         270..292
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         298..320
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         326..348
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         354..376
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         382..404
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          120..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          402..421
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..136
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         142
FT                   /note="P -> S (in dbSNP:rs11668789)"
FT                   /id="VAR_033579"
FT   VARIANT         301
FT                   /note="T -> A (in dbSNP:rs7257872)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_033580"
SQ   SEQUENCE   421 AA;  48272 MW;  76E20EC71CEE8685 CRC64;
     MAGEAEAQLD PSLQGLVMFE DVTVYFSREE WGLLNVTQKG LYRDVMLENF ALVSSLGLAP
     SRSPVFTQLE DDEQSWVPSW VDVTPVSRAE ARRGFGLDGL CRVEDERAHP EHLKSYRVIQ
     HQDTHSEGKP RRHTEHGAAF PPGSSCGQQQ EVHVAEKLFK CSDCGKVFLK AFALLDHLIT
     HSEERPFRCP TGRSAFKKSA HINPRKIHTG ETAHVCNECG KAFSYPSKLR KHQKVHTGIK
     PFKCSDCGKT FNRKDALVLH QRIHTGERPY ECSKCGKTFS VLSTLIRHRK VHIGERPYEC
     TECGKFFKYN NSFILHQRVH TGERPFECKQ CGKGYVTRSG LYQHWKVHTG ERPYECSLCG
     KTFTTRSYRN RHQQFHTEER SYECTECGKA FKHSSTLLQH KKVHTPERRQ EDRAHGKVVS
     C
//