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Protein

Zinc finger protein 584

Gene

ZNF584

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri159 – 18123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri214 – 23623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri242 – 26423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 584
Gene namesi
Name:ZNF584
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:27318. ZNF584.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134968861.

Polymorphism and mutation databases

BioMutaiZNF584.
DMDMi55976735.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421Zinc finger protein 584PRO_0000047676Add
BLAST

Proteomic databases

MaxQBiQ8IVC4.
PaxDbiQ8IVC4.
PRIDEiQ8IVC4.

PTM databases

iPTMnetiQ8IVC4.
PhosphoSiteiQ8IVC4.

Expressioni

Gene expression databases

BgeeiQ8IVC4.
CleanExiHS_ZNF584.
ExpressionAtlasiQ8IVC4. baseline and differential.
GenevisibleiQ8IVC4. HS.

Organism-specific databases

HPAiHPA043408.
HPA048075.

Interactioni

Protein-protein interaction databases

BioGridi128391. 2 interactions.
STRINGi9606.ENSP00000306756.

Structurei

3D structure databases

ProteinModelPortaliQ8IVC4.
SMRiQ8IVC4. Positions 129-405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 8872KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri159 – 18123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri214 – 23623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri242 – 26423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8IVC4.
KOiK09228.
OMAiKFFKYNH.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8IVC4.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IVC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGEAEAQLD PSLQGLVMFE DVTVYFSREE WGLLNVTQKG LYRDVMLENF
60 70 80 90 100
ALVSSLGLAP SRSPVFTQLE DDEQSWVPSW VDVTPVSRAE ARRGFGLDGL
110 120 130 140 150
CRVEDERAHP EHLKSYRVIQ HQDTHSEGKP RRHTEHGAAF PPGSSCGQQQ
160 170 180 190 200
EVHVAEKLFK CSDCGKVFLK AFALLDHLIT HSEERPFRCP TGRSAFKKSA
210 220 230 240 250
HINPRKIHTG ETAHVCNECG KAFSYPSKLR KHQKVHTGIK PFKCSDCGKT
260 270 280 290 300
FNRKDALVLH QRIHTGERPY ECSKCGKTFS VLSTLIRHRK VHIGERPYEC
310 320 330 340 350
TECGKFFKYN NSFILHQRVH TGERPFECKQ CGKGYVTRSG LYQHWKVHTG
360 370 380 390 400
ERPYECSLCG KTFTTRSYRN RHQQFHTEER SYECTECGKA FKHSSTLLQH
410 420
KKVHTPERRQ EDRAHGKVVS C
Length:421
Mass (Da):48,272
Last modified:March 1, 2003 - v1
Checksum:i76E20EC71CEE8685
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti142 – 1421P → S.
Corresponds to variant rs11668789 [ dbSNP | Ensembl ].
VAR_033579
Natural varianti301 – 3011T → A.1 Publication
Corresponds to variant rs7257872 [ dbSNP | Ensembl ].
VAR_033580

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290068 mRNA. Translation: BAF82757.1.
BC033149 mRNA. Translation: AAH33149.1.
CCDSiCCDS12979.1.
RefSeqiNP_001304931.1. NM_001318002.1.
NP_775819.1. NM_173548.2.
UniGeneiHs.439551.

Genome annotation databases

EnsembliENST00000306910; ENSP00000306756; ENSG00000171574.
GeneIDi201514.
KEGGihsa:201514.
UCSCiuc002qsp.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290068 mRNA. Translation: BAF82757.1.
BC033149 mRNA. Translation: AAH33149.1.
CCDSiCCDS12979.1.
RefSeqiNP_001304931.1. NM_001318002.1.
NP_775819.1. NM_173548.2.
UniGeneiHs.439551.

3D structure databases

ProteinModelPortaliQ8IVC4.
SMRiQ8IVC4. Positions 129-405.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128391. 2 interactions.
STRINGi9606.ENSP00000306756.

PTM databases

iPTMnetiQ8IVC4.
PhosphoSiteiQ8IVC4.

Polymorphism and mutation databases

BioMutaiZNF584.
DMDMi55976735.

Proteomic databases

MaxQBiQ8IVC4.
PaxDbiQ8IVC4.
PRIDEiQ8IVC4.

Protocols and materials databases

DNASUi201514.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306910; ENSP00000306756; ENSG00000171574.
GeneIDi201514.
KEGGihsa:201514.
UCSCiuc002qsp.4. human.

Organism-specific databases

CTDi201514.
GeneCardsiZNF584.
HGNCiHGNC:27318. ZNF584.
HPAiHPA043408.
HPA048075.
neXtProtiNX_Q8IVC4.
PharmGKBiPA134968861.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8IVC4.
KOiK09228.
OMAiKFFKYNH.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8IVC4.
TreeFamiTF337055.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF584. human.
GenomeRNAii201514.
PROiQ8IVC4.

Gene expression databases

BgeeiQ8IVC4.
CleanExiHS_ZNF584.
ExpressionAtlasiQ8IVC4. baseline and differential.
GenevisibleiQ8IVC4. HS.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-301.
    Tissue: Substantia nigra.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiZN584_HUMAN
AccessioniPrimary (citable) accession number: Q8IVC4
Secondary accession number(s): A8K203
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.