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Q8IVC4 (ZN584_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 584
Gene names
Name:ZNF584
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length421 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 8 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 421421Zinc finger protein 584
PRO_0000047676

Regions

Domain17 – 8872KRAB
Zinc finger159 – 18123C2H2-type 1
Zinc finger214 – 23623C2H2-type 2
Zinc finger242 – 26423C2H2-type 3
Zinc finger270 – 29223C2H2-type 4
Zinc finger298 – 32023C2H2-type 5
Zinc finger326 – 34823C2H2-type 6
Zinc finger354 – 37623C2H2-type 7
Zinc finger382 – 40423C2H2-type 8

Natural variations

Natural variant1421P → S.
Corresponds to variant rs11668789 [ dbSNP | Ensembl ].
VAR_033579
Natural variant3011T → A. Ref.1
Corresponds to variant rs7257872 [ dbSNP | Ensembl ].
VAR_033580

Sequences

Sequence LengthMass (Da)Tools
Q8IVC4 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 76E20EC71CEE8685

FASTA42148,272
        10         20         30         40         50         60 
MAGEAEAQLD PSLQGLVMFE DVTVYFSREE WGLLNVTQKG LYRDVMLENF ALVSSLGLAP 

        70         80         90        100        110        120 
SRSPVFTQLE DDEQSWVPSW VDVTPVSRAE ARRGFGLDGL CRVEDERAHP EHLKSYRVIQ 

       130        140        150        160        170        180 
HQDTHSEGKP RRHTEHGAAF PPGSSCGQQQ EVHVAEKLFK CSDCGKVFLK AFALLDHLIT 

       190        200        210        220        230        240 
HSEERPFRCP TGRSAFKKSA HINPRKIHTG ETAHVCNECG KAFSYPSKLR KHQKVHTGIK 

       250        260        270        280        290        300 
PFKCSDCGKT FNRKDALVLH QRIHTGERPY ECSKCGKTFS VLSTLIRHRK VHIGERPYEC 

       310        320        330        340        350        360 
TECGKFFKYN NSFILHQRVH TGERPFECKQ CGKGYVTRSG LYQHWKVHTG ERPYECSLCG 

       370        380        390        400        410        420 
KTFTTRSYRN RHQQFHTEER SYECTECGKA FKHSSTLLQH KKVHTPERRQ EDRAHGKVVS 


C 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-301.
Tissue: Substantia nigra.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK290068 mRNA. Translation: BAF82757.1.
BC033149 mRNA. Translation: AAH33149.1.
RefSeqNP_775819.1. NM_173548.1.
UniGeneHs.439551.

3D structure databases

ProteinModelPortalQ8IVC4.
SMRQ8IVC4. Positions 11-65, 117-405.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128391. 1 interaction.
STRING9606.ENSP00000337473.

PTM databases

PhosphoSiteQ8IVC4.

Polymorphism databases

DMDM55976735.

Proteomic databases

PaxDbQ8IVC4.
PRIDEQ8IVC4.

Protocols and materials databases

DNASU201514.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000306910; ENSP00000306756; ENSG00000171574.
GeneID201514.
KEGGhsa:201514.
UCSCuc002qsp.3. human.

Organism-specific databases

CTD201514.
GeneCardsGC19P059248.
HGNCHGNC:27318. ZNF584.
HPAHPA043408.
HPA048075.
neXtProtNX_Q8IVC4.
PharmGKBPA134968861.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ8IVC4.
KOK09228.
OMAKFFKYNH.
OrthoDBEOG7KSX7Q.
PhylomeDBQ8IVC4.
TreeFamTF337055.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ8IVC4.
BgeeQ8IVC4.
CleanExHS_ZNF584.
GenevestigatorQ8IVC4.

Family and domain databases

Gene3D3.30.160.60. 8 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi201514.
NextBio90156.
PROQ8IVC4.

Entry information

Entry nameZN584_HUMAN
AccessionPrimary (citable) accession number: Q8IVC4
Secondary accession number(s): A8K203
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM