##gff-version 3 Q8IVB4 UniProtKB Chain 1 645 . . . ID=PRO_0000052367;Note=Sodium/hydrogen exchanger 9 Q8IVB4 UniProtKB Topological domain 1 20 . . . Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F7B113 Q8IVB4 UniProtKB Transmembrane 21 41 . . . Note=Helical%3B Name%3D1;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8IVB4 UniProtKB Topological domain 42 45 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F7B113 Q8IVB4 UniProtKB Transmembrane 46 66 . . . Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8IVB4 UniProtKB Topological domain 67 126 . . . Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F7B113 Q8IVB4 UniProtKB Transmembrane 127 147 . . . Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8IVB4 UniProtKB Topological domain 148 164 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F7B113 Q8IVB4 UniProtKB Transmembrane 165 185 . . . Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8IVB4 UniProtKB Topological domain 186 203 . . . Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F7B113 Q8IVB4 UniProtKB Transmembrane 204 224 . . . Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8IVB4 UniProtKB Topological domain 225 235 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F7B113 Q8IVB4 UniProtKB Transmembrane 236 256 . . . Note=Helical%3B Name%3D6;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8IVB4 UniProtKB Topological domain 257 277 . . . Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F7B113 Q8IVB4 UniProtKB Transmembrane 278 298 . . . Note=Helical%3B Name%3D7;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8IVB4 UniProtKB Topological domain 299 301 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F7B113 Q8IVB4 UniProtKB Transmembrane 302 322 . . . Note=Helical%3B Name%3D8;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8IVB4 UniProtKB Transmembrane 323 343 . . . Note=Helical%3B Name%3D9;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8IVB4 UniProtKB Topological domain 344 364 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F7B113 Q8IVB4 UniProtKB Transmembrane 365 385 . . . Note=Helical%3B Name%3D10;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8IVB4 UniProtKB Topological domain 386 386 . . . Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F7B113 Q8IVB4 UniProtKB Transmembrane 387 407 . . . Note=Helical%3B Name%3D11;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8IVB4 UniProtKB Topological domain 408 429 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F7B113 Q8IVB4 UniProtKB Transmembrane 430 450 . . . Note=Helical%3B Name%3D12;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8IVB4 UniProtKB Topological domain 451 465 . . . Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F7B113 Q8IVB4 UniProtKB Transmembrane 466 486 . . . Note=Helical%3B Name%3D13;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8IVB4 UniProtKB Topological domain 487 645 . . . Note=Cytoplasmic;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18057008;Dbxref=PMID:18057008 Q8IVB4 UniProtKB Region 594 622 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8IVB4 UniProtKB Glycosylation 96 96 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218 Q8IVB4 UniProtKB Natural variant 423 645 . . . ID=VAR_087549;Note=In AUTS16. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18621663;Dbxref=PMID:18621663 Q8IVB4 UniProtKB Natural variant 540 540 . . . ID=VAR_050232;Note=I->V;Dbxref=dbSNP:rs16853300 Q8IVB4 UniProtKB Natural variant 589 589 . . . ID=VAR_022114;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17974005;Dbxref=dbSNP:rs2289491,PMID:17974005 Q8IVB4 UniProtKB Mutagenesis 176 176 . . . Note=Normal protein expression. Does not affect endosomal localizatiion. Fails to alkalinizes endosomal lumen. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24065030;Dbxref=PMID:24065030 Q8IVB4 UniProtKB Mutagenesis 236 236 . . . Note=Normal protein expression. Fails to alkalinizes endosomal lumen. Does not affect endosomal localizatiion. L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24065030;Dbxref=PMID:24065030 Q8IVB4 UniProtKB Mutagenesis 438 438 . . . Note=Normal protein expression. Fails to alkalinizes endosomal lumen. Does not affect endosomal localizatiion. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24065030;Dbxref=PMID:24065030