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Protein

Purkinje cell protein 2 homolog

Gene

PCP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a cell-type specific modulator for G protein-mediated cell signaling.By similarity

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Purkinje cell protein 2 homolog
Gene namesi
Name:PCP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30209. PCP2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134864901.

Polymorphism and mutation databases

DMDMi115311615.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 136136Purkinje cell protein 2 homologPRO_0000058260Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei127 – 1271PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8IVA1.
PeptideAtlasiQ8IVA1.
PRIDEiQ8IVA1.

PTM databases

PhosphoSiteiQ8IVA1.

Expressioni

Gene expression databases

BgeeiQ8IVA1.
CleanExiHS_PCP2.
GenevisibleiQ8IVA1. HS.

Interactioni

Protein-protein interaction databases

BioGridi125946. 8 interactions.
STRINGi9606.ENSP00000310585.

Structurei

3D structure databases

ProteinModelPortaliQ8IVA1.
SMRiQ8IVA1. Positions 21-83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 4523GoLoco 1PROSITE-ProRule annotationAdd
BLAST
Domaini63 – 8523GoLoco 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 GoLoco domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1130. Eukaryota.
ENOG410XP6N. LUCA.
GeneTreeiENSGT00500000045061.
HOGENOMiHOG000115787.
HOVERGENiHBG008159.
InParanoidiQ8IVA1.
OMAiPIGPKDG.
OrthoDBiEOG789CD3.
PhylomeDBiQ8IVA1.

Family and domain databases

InterProiIPR003109. GoLoco_motif.
[Graphical view]
PfamiPF02188. GoLoco. 2 hits.
[Graphical view]
SMARTiSM00390. GoLoco. 2 hits.
[Graphical view]
PROSITEiPS50877. GOLOCO. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IVA1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMDQEEKTEE GSGPCAEAGS PDQEGFFNLL SHVQGDRMEG QRCSLQAGPG
60 70 80 90 100
QTTKSQSDPT PEMDSLMDML ASTQGRRMDD QRVTVSSLPG FQPVGSKDGA
110 120 130
QKRAGTLSPQ PLLTPQDPTA LGFRRNSSPQ PPTQAP
Length:136
Mass (Da):14,547
Last modified:September 19, 2006 - v2
Checksum:i7BCD39A60924DC59
GO
Isoform 2 (identifier: Q8IVA1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MMDQEEKTEEGSGPCAE → M

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:120
Mass (Da):12,825
Checksum:i6AC64E8F7729638C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1717MMDQE…GPCAE → M in isoform 2. 1 PublicationVSP_055654Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008763 Genomic DNA. No translation available.
BC025387 mRNA. Translation: AAH25387.1.
BC038715 mRNA. Translation: AAH38715.2.
CCDSiCCDS32893.1. [Q8IVA1-1]
CCDS62521.1. [Q8IVA1-2]
RefSeqiNP_001258759.1. NM_001271830.1. [Q8IVA1-2]
NP_777555.1. NM_174895.2. [Q8IVA1-1]
XP_011525978.1. XM_011527676.1. [Q8IVA1-1]
UniGeneiHs.591400.
Hs.673964.

Genome annotation databases

EnsembliENST00000311069; ENSP00000310585; ENSG00000174788. [Q8IVA1-1]
ENST00000598935; ENSP00000472761; ENSG00000174788. [Q8IVA1-2]
GeneIDi126006.
KEGGihsa:126006.
UCSCiuc002mgz.4. human. [Q8IVA1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008763 Genomic DNA. No translation available.
BC025387 mRNA. Translation: AAH25387.1.
BC038715 mRNA. Translation: AAH38715.2.
CCDSiCCDS32893.1. [Q8IVA1-1]
CCDS62521.1. [Q8IVA1-2]
RefSeqiNP_001258759.1. NM_001271830.1. [Q8IVA1-2]
NP_777555.1. NM_174895.2. [Q8IVA1-1]
XP_011525978.1. XM_011527676.1. [Q8IVA1-1]
UniGeneiHs.591400.
Hs.673964.

3D structure databases

ProteinModelPortaliQ8IVA1.
SMRiQ8IVA1. Positions 21-83.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125946. 8 interactions.
STRINGi9606.ENSP00000310585.

PTM databases

PhosphoSiteiQ8IVA1.

Polymorphism and mutation databases

DMDMi115311615.

Proteomic databases

PaxDbiQ8IVA1.
PeptideAtlasiQ8IVA1.
PRIDEiQ8IVA1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311069; ENSP00000310585; ENSG00000174788. [Q8IVA1-1]
ENST00000598935; ENSP00000472761; ENSG00000174788. [Q8IVA1-2]
GeneIDi126006.
KEGGihsa:126006.
UCSCiuc002mgz.4. human. [Q8IVA1-1]

Organism-specific databases

CTDi126006.
GeneCardsiPCP2.
HGNCiHGNC:30209. PCP2.
neXtProtiNX_Q8IVA1.
PharmGKBiPA134864901.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1130. Eukaryota.
ENOG410XP6N. LUCA.
GeneTreeiENSGT00500000045061.
HOGENOMiHOG000115787.
HOVERGENiHBG008159.
InParanoidiQ8IVA1.
OMAiPIGPKDG.
OrthoDBiEOG789CD3.
PhylomeDBiQ8IVA1.

Miscellaneous databases

GenomeRNAii126006.
NextBioi81627.
PROiQ8IVA1.

Gene expression databases

BgeeiQ8IVA1.
CleanExiHS_PCP2.
GenevisibleiQ8IVA1. HS.

Family and domain databases

InterProiIPR003109. GoLoco_motif.
[Graphical view]
PfamiPF02188. GoLoco. 2 hits.
[Graphical view]
SMARTiSM00390. GoLoco. 2 hits.
[Graphical view]
PROSITEiPS50877. GOLOCO. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.

Entry informationi

Entry nameiPCP2_HUMAN
AccessioniPrimary (citable) accession number: Q8IVA1
Secondary accession number(s): M0R2R7, Q3KRG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: September 19, 2006
Last modified: May 11, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.