Q8IVA1 (PCP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Purkinje cell protein 2 homolog

Gene names

Name:

PCP2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	136 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May function as a cell-type specific modulator for G protein-mediated cell signaling By similarity.
Sequence similarities	Contains 2 GoLoco domains.

Ontologies

Keywords
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	signal transduction Inferred from electronic annotation. Source: InterPro
Molecular_function	guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 136	136	Purkinje cell protein 2 homolog		PRO_0000058260
Regions
	Domain	23 – 45	23	GoLoco 1
	Domain	63 – 85	23	GoLoco 2

Sequences

	Sequence		Length	Mass (Da)
	Q8IVA1 [UniParc]. Last modified September 19, 2006. Version 2. Checksum: 7BCD39A60924DC59	FASTA	136	14,547
	10 20 30 40 50 60 MMDQEEKTEE GSGPCAEAGS PDQEGFFNLL SHVQGDRMEG QRCSLQAGPG QTTKSQSDPT 70 80 90 100 110 120 PEMDSLMDML ASTQGRRMDD QRVTVSSLPG FQPVGSKDGA QKRAGTLSPQ PLLTPQDPTA 130 LGFRRNSSPQ PPTQAP

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC025387 mRNA. Translation: AAH25387.1. BC038715 mRNA. Translation: AAH38715.2.
IPI	IPI00182598.
RefSeq	NP_777555.1. NM_174895.2.
UniGene	Hs.591400.
3D structure databases
ProteinModelPortal	Q8IVA1.
SMR	Q8IVA1. Positions 22-49.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000310585.
PTM databases
PhosphoSite	Q8IVA1.
Polymorphism databases
DMDM	115311615.
Proteomic databases
PaxDb	Q8IVA1.
PeptideAtlas	Q8IVA1.
PRIDE	Q8IVA1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000311069; ENSP00000310585; ENSG00000174788.
GeneID	126006.
KEGG	hsa:126006.
UCSC	uc002mgz.3. human.
Organism-specific databases
CTD	126006.
GeneCards	GC19M007696.
HGNC	HGNC:30209. PCP2.
neXtProt	NX_Q8IVA1.
PharmGKB	PA134864901.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG276418.
HOGENOM	HOG000115787.
HOVERGEN	HBG008159.
InParanoid	Q8IVA1.
OMA	KDGVQKR.
OrthoDB	EOG437RG6.
Gene expression databases
Bgee	Q8IVA1.
CleanEx	HS_PCP2.
Genevestigator	Q8IVA1.
GermOnline	ENSG00000174788. Homo sapiens.
Family and domain databases
InterPro	IPR003109. GoLoco_motif. IPR024820. PCP2. [Graphical view]
PANTHER	PTHR10098:SF37. PTHR10098:SF37. 1 hit.
Pfam	PF02188. GoLoco. 2 hits. [Graphical view]
SMART	SM00390. GoLoco. 2 hits. [Graphical view]
PROSITE	PS50877. GOLOCO. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	126006.
NextBio	81627.

Entry information

Entry name

PCP2_HUMAN

Accession

Primary (citable) accession number: Q8IVA1
Secondary accession number(s): Q3KRG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	September 19, 2006
Last modified:	May 1, 2013
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.