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Protein

Purkinje cell protein 2 homolog

Gene

PCP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a cell-type specific modulator for G protein-mediated cell signaling.By similarity

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Purkinje cell protein 2 homolog
Gene namesi
Name:PCP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000174788.9
HGNCiHGNC:30209 PCP2
neXtProtiNX_Q8IVA1

Pathology & Biotechi

Organism-specific databases

DisGeNETi126006
OpenTargetsiENSG00000174788
PharmGKBiPA134864901

Polymorphism and mutation databases

DMDMi115311615

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000582601 – 136Purkinje cell protein 2 homologAdd BLAST136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei127PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8IVA1
PeptideAtlasiQ8IVA1
PRIDEiQ8IVA1
ProteomicsDBi70677

PTM databases

iPTMnetiQ8IVA1
PhosphoSitePlusiQ8IVA1

Expressioni

Gene expression databases

BgeeiENSG00000174788
CleanExiHS_PCP2
GenevisibleiQ8IVA1 HS

Organism-specific databases

HPAiHPA057428

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GNAI3P087544EBI-12250122,EBI-357563

Protein-protein interaction databases

BioGridi125946, 8 interactors
IntActiQ8IVA1, 4 interactors
STRINGi9606.ENSP00000310585

Structurei

3D structure databases

ProteinModelPortaliQ8IVA1
SMRiQ8IVA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 45GoLoco 1PROSITE-ProRule annotationAdd BLAST23
Domaini63 – 85GoLoco 2PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1130 Eukaryota
ENOG410XP6N LUCA
GeneTreeiENSGT00530000063126
HOGENOMiHOG000115787
HOVERGENiHBG008159
InParanoidiQ8IVA1
OMAiSHVQGDR
OrthoDBiEOG091G0TSN
PhylomeDBiQ8IVA1

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR003109 GoLoco_motif
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF02188 GoLoco, 2 hits
SMARTiView protein in SMART
SM00390 GoLoco, 2 hits
PROSITEiView protein in PROSITE
PS50877 GOLOCO, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IVA1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMDQEEKTEE GSGPCAEAGS PDQEGFFNLL SHVQGDRMEG QRCSLQAGPG
60 70 80 90 100
QTTKSQSDPT PEMDSLMDML ASTQGRRMDD QRVTVSSLPG FQPVGSKDGA
110 120 130
QKRAGTLSPQ PLLTPQDPTA LGFRRNSSPQ PPTQAP
Length:136
Mass (Da):14,547
Last modified:September 19, 2006 - v2
Checksum:i7BCD39A60924DC59
GO
Isoform 2 (identifier: Q8IVA1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MMDQEEKTEEGSGPCAE → M

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:120
Mass (Da):12,825
Checksum:i6AC64E8F7729638C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0556541 – 17MMDQE…GPCAE → M in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008763 Genomic DNA No translation available.
BC025387 mRNA Translation: AAH25387.1
BC038715 mRNA Translation: AAH38715.2
CCDSiCCDS32893.1 [Q8IVA1-1]
CCDS62521.1 [Q8IVA1-2]
RefSeqiNP_001258759.1, NM_001271830.1 [Q8IVA1-2]
NP_777555.1, NM_174895.2 [Q8IVA1-1]
XP_016881740.1, XM_017026251.1 [Q8IVA1-1]
UniGeneiHs.591400
Hs.673964

Genome annotation databases

EnsembliENST00000311069; ENSP00000310585; ENSG00000174788 [Q8IVA1-1]
ENST00000598935; ENSP00000472761; ENSG00000174788 [Q8IVA1-2]
GeneIDi126006
KEGGihsa:126006
UCSCiuc002mgz.4 human [Q8IVA1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPCP2_HUMAN
AccessioniPrimary (citable) accession number: Q8IVA1
Secondary accession number(s): M0R2R7, Q3KRG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: September 19, 2006
Last modified: June 20, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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