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Q8IV92

- Q8IV92_HUMAN

UniProt

Q8IV92 - Q8IV92_HUMAN

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Protein
Submitted name:

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Gene

PLCB1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. phosphatidylinositol phospholipase C activity Source: InterPro

GO - Biological processi

  1. brain development Source: InterPro
  2. intracellular signal transduction Source: InterPro
  3. regulation of cell cycle Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1Imported
Gene namesi
Name:PLCB1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:15917. PLCB1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
  2. nucleus Source: InterPro
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ8IV92.

Expressioni

Gene expression databases

ExpressionAtlasiQ8IV92. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ8IV92.
SMRiQ8IV92. Positions 1-152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118936.
HOGENOMiHOG000202437.
OMAiINNTIAF.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR001192. PI-PLC_fam.
IPR028400. PLC-beta1.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF12. PTHR10336:SF12. 1 hit.
PfamiPF00168. C2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8IV92-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
IISGQFLSDK KVGTYVEVDM FGLPVDTRRK AFKTKTSQGN AVNPVWEEEP
60 70 80 90 100
IVFKKVVLPT LACLRIAVYE EGGKFIGHRI LPVQAIRPGY HYICLRNERN
110 120 130 140 150
QPLTLPAVFV YIEVKDYVPD TYADVIEALS NPIRYVNLME QRAKQLAALT
160 170 180 190
LEDEEEVKKE GGFLHDEIMR LTRNTLEKLM ALPLTHVVPI QSKMLS
Length:196
Mass (Da):22,328
Last modified:March 1, 2003 - v1
Checksum:iE76782BE3DD52E1A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021406 Genomic DNA. No translation available.
AL031655 Genomic DNA. No translation available.
AL031683 Genomic DNA. No translation available.
AL034551 Genomic DNA. No translation available.
AL049593 Genomic DNA. No translation available.
AL049632 Genomic DNA. No translation available.
AL050315 Genomic DNA. No translation available.
AL050319 Genomic DNA. No translation available.
AL050323 Genomic DNA. No translation available.
AL121589 Genomic DNA. No translation available.
AL365212 Genomic DNA. No translation available.
AL445567 Genomic DNA. No translation available.
KF456806 Genomic DNA. No translation available.
KF456807 Genomic DNA. No translation available.
KF456810 Genomic DNA. No translation available.
KF456814 Genomic DNA. No translation available.
KF456816 Genomic DNA. No translation available.
KF510482 Genomic DNA. No translation available.
KF511324 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000439627; ENSP00000391162; ENSG00000182621.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021406 Genomic DNA. No translation available.
AL031655 Genomic DNA. No translation available.
AL031683 Genomic DNA. No translation available.
AL034551 Genomic DNA. No translation available.
AL049593 Genomic DNA. No translation available.
AL049632 Genomic DNA. No translation available.
AL050315 Genomic DNA. No translation available.
AL050319 Genomic DNA. No translation available.
AL050323 Genomic DNA. No translation available.
AL121589 Genomic DNA. No translation available.
AL365212 Genomic DNA. No translation available.
AL445567 Genomic DNA. No translation available.
KF456806 Genomic DNA. No translation available.
KF456807 Genomic DNA. No translation available.
KF456810 Genomic DNA. No translation available.
KF456814 Genomic DNA. No translation available.
KF456816 Genomic DNA. No translation available.
KF510482 Genomic DNA. No translation available.
KF511324 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali Q8IV92.
SMRi Q8IV92. Positions 1-152.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q8IV92.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000439627 ; ENSP00000391162 ; ENSG00000182621 .

Organism-specific databases

HGNCi HGNC:15917. PLCB1.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000118936.
HOGENOMi HOG000202437.
OMAi INNTIAF.

Miscellaneous databases

ChiTaRSi PLCB1. human.

Gene expression databases

ExpressionAtlasi Q8IV92. baseline and differential.

Family and domain databases

Gene3Di 2.60.40.150. 1 hit.
InterProi IPR000008. C2_dom.
IPR001192. PI-PLC_fam.
IPR028400. PLC-beta1.
[Graphical view ]
PANTHERi PTHR10336. PTHR10336. 1 hit.
PTHR10336:SF12. PTHR10336:SF12. 1 hit.
Pfami PF00168. C2. 1 hit.
[Graphical view ]
SMARTi SM00239. C2. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
PROSITEi PS50004. C2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ8IV92_HUMAN
AccessioniPrimary (citable) accession number: Q8IV92
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3