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Q8IV76

- PASD1_HUMAN

UniProt

Q8IV76 - PASD1_HUMAN

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Protein
PAS domain-containing protein 1
Gene
PASD1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May function as a transcription factor.1 Publication

GO - Molecular functioni

  1. signal transducer activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PAS domain-containing protein 1
    Alternative name(s):
    Cancer/testis antigen 63
    Short name:
    CT63
    OX-TES-1
    Gene namesi
    Name:PASD1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:20686. PASD1.

    Subcellular locationi

    Nucleus Inferred

    GO - Cellular componenti

    1. nucleus Source: LIFEdb
    Complete GO annotation...

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134909788.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 773773PAS domain-containing protein 1
    PRO_0000299445Add
    BLAST

    Proteomic databases

    PaxDbiQ8IV76.
    PRIDEiQ8IV76.

    PTM databases

    PhosphoSiteiQ8IV76.

    Expressioni

    Tissue specificityi

    Testis-specific. Found in histologically normal tissues from patients with uterus, lung and small intestine cancers. Widespread expression seen in solid tumors and diffuse large B-cell lymphoma (DLBCL)-derived cell lines. Isoform 2 is expressed in all DLBCL-derived cell lines, while isoform 1 is preferentially expressed in cell lines derived from non-germinal center DLBCL.1 Publication

    Gene expression databases

    BgeeiQ8IV76.
    CleanExiHS_PASD1.
    GenevestigatoriQ8IV76.

    Organism-specific databases

    HPAiHPA011122.
    HPA011152.

    Interactioni

    Protein-protein interaction databases

    BioGridi126545. 2 interactions.
    MINTiMINT-4719893.
    STRINGi9606.ENSP00000359382.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IV76.
    SMRiQ8IV76. Positions 16-137.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 10273PAS
    Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili365 – 41248 Reviewed prediction
    Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi229 – 2368Poly-Ala
    Compositional biasi508 – 54841Lys-rich
    Add
    BLAST
    Compositional biasi665 – 6684Poly-Ser

    Sequence similaritiesi

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG147281.
    HOGENOMiHOG000115455.
    InParanoidiQ8IV76.
    OMAiLETPQDY.
    OrthoDBiEOG7BCNB5.
    PhylomeDBiQ8IV76.
    TreeFamiTF324568.

    Family and domain databases

    InterProiIPR000014. PAS.
    [Graphical view]
    SMARTiSM00091. PAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF55785. SSF55785. 1 hit.
    PROSITEiPS50112. PAS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IV76-1) [UniParc]FASTAAdd to Basket

    Also known as: PASD1_v2

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKMRGEKRRD KVNPKSSQRK LNWIPSFPTY DYFNQVTLQL LDGFMITLST    50
    DGVIICVAEN ISSLLGHLPA EIVGKKLLSL LPDEEKDEVY QKIILKFPLL 100
    NSETHIEFCC HLKRGNVEHG DSSAYENVKF IVNVRDICNE FPVVFSGLFS 150
    SHLCADFAAC VPQEDRLYLV GNVCILRTQL LQQLYTSKAV SDEAVLTQDS 200
    DEEPFVGELS SSQGQRGHTS MKAVYVEPAA AAAAAAISDD QIDIAEVEQY 250
    GPQENVHMFV DSDSTYCSST VFLDTMPESP ALSLQDFRGE PEVNPLYRAD 300
    PVDLEFSVDQ VDSVDQEGPM DQQDPENPVA PLDQAGLMDP VDPEDSVDLG 350
    AAGASAQPLQ PSSPVAYDII SQELELMKKL KEQLEERTWL LHDAIQNQQN 400
    ALELMMDHLQ KQPNTLRHVV IPDLQSSEAV PKKQQKQHAG QVKRPLPHPK 450
    DVKCFCGLSL SNSLKNTGEL QEPCVAFNQQ QLVQQEQHLK EQQRQLREQL 500
    QQLREQRKVQ KQKKMQEKKK LQEQKMQEKK KLQEQRRQKK KKLQERKKWQ 550
    GQMLQKEPEE EQQKQQLQEQ PLKHNVIVGN ERVQICLQNP RDVSVPLCNH 600
    PVRFLQAQPI VPVQRAAEQQ PSGFYQDENC GQQEDESQSF YPEAYQGPPV 650
    NQLPLIDTSN SEAISSSSIP QFPITSDSTI STLETPQDYI RLWQELSDSL 700
    GPVVQVNTWS CDEQGTLHGQ PTYHQVQVSE VGVEGPPDPQ AFQGPAAYQP 750
    DQMRSAEQTR LMPAEQRDSN KPC 773
    Length:773
    Mass (Da):87,428
    Last modified:March 1, 2003 - v1
    Checksum:i04DF5C10980CEE6F
    GO
    Isoform 2 (identifier: Q8IV76-2) [UniParc]FASTAAdd to Basket

    Also known as: PASD1_v1

    The sequence of this isoform differs from the canonical sequence as follows:
         639-639: S → R
         640-773: Missing.

    Note: Due to intron retention.

    Show »
    Length:639
    Mass (Da):72,738
    Checksum:iC787023A7F894705
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti213 – 2131Q → E.
    Corresponds to variant rs5924658 [ dbSNP | Ensembl ].
    VAR_034819

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei639 – 6391S → R in isoform 2.
    VSP_027663
    Alternative sequencei640 – 773134Missing in isoform 2.
    VSP_027664Add
    BLAST

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti107 – 1071E → K in BAC05097. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY270020 mRNA. Translation: AAQ01136.1.
    AK097552 mRNA. Translation: BAC05097.1.
    BC040301 mRNA. Translation: AAH40301.1.
    AY623425 mRNA. Translation: AAT49049.1.
    CCDSiCCDS35431.1. [Q8IV76-1]
    RefSeqiNP_775764.2. NM_173493.2. [Q8IV76-1]
    UniGeneiHs.160594.

    Genome annotation databases

    EnsembliENST00000370357; ENSP00000359382; ENSG00000166049. [Q8IV76-1]
    GeneIDi139135.
    KEGGihsa:139135.
    UCSCiuc004fev.4. human. [Q8IV76-1]

    Polymorphism databases

    DMDMi74728046.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY270020 mRNA. Translation: AAQ01136.1 .
    AK097552 mRNA. Translation: BAC05097.1 .
    BC040301 mRNA. Translation: AAH40301.1 .
    AY623425 mRNA. Translation: AAT49049.1 .
    CCDSi CCDS35431.1. [Q8IV76-1 ]
    RefSeqi NP_775764.2. NM_173493.2. [Q8IV76-1 ]
    UniGenei Hs.160594.

    3D structure databases

    ProteinModelPortali Q8IV76.
    SMRi Q8IV76. Positions 16-137.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 126545. 2 interactions.
    MINTi MINT-4719893.
    STRINGi 9606.ENSP00000359382.

    PTM databases

    PhosphoSitei Q8IV76.

    Polymorphism databases

    DMDMi 74728046.

    Proteomic databases

    PaxDbi Q8IV76.
    PRIDEi Q8IV76.

    Protocols and materials databases

    DNASUi 139135.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370357 ; ENSP00000359382 ; ENSG00000166049 . [Q8IV76-1 ]
    GeneIDi 139135.
    KEGGi hsa:139135.
    UCSCi uc004fev.4. human. [Q8IV76-1 ]

    Organism-specific databases

    CTDi 139135.
    GeneCardsi GC0XP150732.
    H-InvDBi HIX0022029.
    HGNCi HGNC:20686. PASD1.
    HPAi HPA011122.
    HPA011152.
    neXtProti NX_Q8IV76.
    PharmGKBi PA134909788.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG147281.
    HOGENOMi HOG000115455.
    InParanoidi Q8IV76.
    OMAi LETPQDY.
    OrthoDBi EOG7BCNB5.
    PhylomeDBi Q8IV76.
    TreeFami TF324568.

    Miscellaneous databases

    GeneWikii PASD1.
    GenomeRNAii 139135.
    NextBioi 83900.
    PROi Q8IV76.

    Gene expression databases

    Bgeei Q8IV76.
    CleanExi HS_PASD1.
    Genevestigatori Q8IV76.

    Family and domain databases

    InterProi IPR000014. PAS.
    [Graphical view ]
    SMARTi SM00091. PAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55785. SSF55785. 1 hit.
    PROSITEi PS50112. PAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "A novel diffuse large B-cell lymphoma-associated cancer testis antigen encoding a PAS domain protein."
      Liggins A.P., Brown P.J., Asker K., Pulford K., Banham A.H.
      Br. J. Cancer 91:141-149(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    4. "Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia."
      Guinn B.-A., Bland E.A., Lodi U., Liggins A.P., Tobal K., Petters S., Wells J.W., Banham A.H., Mufti G.J.
      Biochem. Biophys. Res. Commun. 335:1293-1304(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 469-773 (ISOFORM 1).

    Entry informationi

    Entry nameiPASD1_HUMAN
    AccessioniPrimary (citable) accession number: Q8IV76
    Secondary accession number(s): Q3MNE0, Q69HD7, Q8N7X9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: March 1, 2003
    Last modified: July 9, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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