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Protein

Circadian clock protein PASD1

Gene

PASD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body (PubMed:25936801). Acts as a nuclear repressor of the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components (PubMed:25936801). Inhibits circadian clock function in cancer cells, when overexpressed (PubMed:25936801).1 Publication

GO - Molecular functioni

  • transcription coactivator binding Source: UniProtKB

GO - Biological processi

  • negative regulation of circadian rhythm Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • rhythmic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Biological rhythms

Names & Taxonomyi

Protein namesi
Recommended name:
Circadian clock protein PASD1Curated
Alternative name(s):
Cancer/testis antigen 631 Publication
Short name:
CT631 Publication
OX-TES-11 Publication
PAS domain-containing protein 11 PublicationImported
Gene namesi
Name:PASD1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:20686. PASD1.

Subcellular locationi

Isoform 1 :
Isoform 2 :

GO - Cellular componenti

  • Cry-Per complex Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi36V → E: Reduces inhibition of CLOCK-ARNTL/BMAL1 heterodimer activity; when associated with R-45. 1 Publication1
Mutagenesisi45M → R: Reduces inhibition of CLOCK-ARNTL/BMAL1 heterodimer activity; when associated with E-36. 1 Publication1

Organism-specific databases

DisGeNETi139135.
OpenTargetsiENSG00000166049.
PharmGKBiPA134909788.

Polymorphism and mutation databases

BioMutaiPASD1.
DMDMi74728046.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002994451 – 773Circadian clock protein PASD1Add BLAST773

Proteomic databases

PaxDbiQ8IV76.
PeptideAtlasiQ8IV76.
PRIDEiQ8IV76.

PTM databases

iPTMnetiQ8IV76.
PhosphoSitePlusiQ8IV76.

Expressioni

Tissue specificityi

Testis-specific (PubMed:25936801). Expressed in a broad range of cancer cells, including melanoma, lung cancer, and breast cancer (at protein level). Testis-specific (PubMed:15162151). Found in histologically normal tissues from patients with uterus, lung and small intestine cancers. Widespread expression seen in solid tumors and diffuse large B-cell lymphoma (DLBCL)-derived cell lines. Isoform 2 is expressed in all DLBCL-derived cell lines, while isoform 1 is preferentially expressed in cell lines derived from non-germinal center DLBCL (PubMed:15162151).2 Publications

Gene expression databases

BgeeiENSG00000166049.
CleanExiHS_PASD1.
GenevisibleiQ8IV76. HS.

Organism-specific databases

HPAiHPA011122.
HPA011152.

Interactioni

Subunit structurei

Interacts with the CLOCK-ARNTL/BMAL1 heterodimer; this interaction inhibits CLOCK-ARNTL/BMAL1 transcriptional activation and suppress circadian timekeeping (PubMed:25936801). Interacts with ARNTL/BMAL1 (PubMed:25936801).1 Publication

GO - Molecular functioni

  • transcription coactivator binding Source: UniProtKB

Protein-protein interaction databases

BioGridi126545. 1 interactor.
MINTiMINT-4719893.
STRINGi9606.ENSP00000359382.

Structurei

3D structure databases

ProteinModelPortaliQ8IV76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 102PASPROSITE-ProRule annotationAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni365 – 412Necessary for transcriptional repression1 PublicationAdd BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili365 – 412Sequence analysisAdd BLAST48
Coiled coili475 – 553Sequence analysisAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi229 – 236Poly-Ala8
Compositional biasi508 – 548Lys-richAdd BLAST41
Compositional biasi665 – 668Poly-Ser4

Domaini

C-terminus of isoform 1 and isoform 2 are sufficient to interact with and to repress the activity of CLOCK-ARNTL/BMAL1 (PubMed:25936801).1 Publication

Sequence similaritiesi

Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410JAH9. Eukaryota.
ENOG41117WC. LUCA.
GeneTreeiENSGT00530000064765.
HOGENOMiHOG000115455.
InParanoidiQ8IV76.
OMAiNVRDICN.
OrthoDBiEOG091G11CV.
PhylomeDBiQ8IV76.
TreeFamiTF324568.

Family and domain databases

InterProiIPR000014. PAS.
[Graphical view]
SMARTiSM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF55785. SSF55785. 1 hit.
PROSITEiPS50112. PAS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IV76-1) [UniParc]FASTAAdd to basket
Also known as: PASD1_v2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMRGEKRRD KVNPKSSQRK LNWIPSFPTY DYFNQVTLQL LDGFMITLST
60 70 80 90 100
DGVIICVAEN ISSLLGHLPA EIVGKKLLSL LPDEEKDEVY QKIILKFPLL
110 120 130 140 150
NSETHIEFCC HLKRGNVEHG DSSAYENVKF IVNVRDICNE FPVVFSGLFS
160 170 180 190 200
SHLCADFAAC VPQEDRLYLV GNVCILRTQL LQQLYTSKAV SDEAVLTQDS
210 220 230 240 250
DEEPFVGELS SSQGQRGHTS MKAVYVEPAA AAAAAAISDD QIDIAEVEQY
260 270 280 290 300
GPQENVHMFV DSDSTYCSST VFLDTMPESP ALSLQDFRGE PEVNPLYRAD
310 320 330 340 350
PVDLEFSVDQ VDSVDQEGPM DQQDPENPVA PLDQAGLMDP VDPEDSVDLG
360 370 380 390 400
AAGASAQPLQ PSSPVAYDII SQELELMKKL KEQLEERTWL LHDAIQNQQN
410 420 430 440 450
ALELMMDHLQ KQPNTLRHVV IPDLQSSEAV PKKQQKQHAG QVKRPLPHPK
460 470 480 490 500
DVKCFCGLSL SNSLKNTGEL QEPCVAFNQQ QLVQQEQHLK EQQRQLREQL
510 520 530 540 550
QQLREQRKVQ KQKKMQEKKK LQEQKMQEKK KLQEQRRQKK KKLQERKKWQ
560 570 580 590 600
GQMLQKEPEE EQQKQQLQEQ PLKHNVIVGN ERVQICLQNP RDVSVPLCNH
610 620 630 640 650
PVRFLQAQPI VPVQRAAEQQ PSGFYQDENC GQQEDESQSF YPEAYQGPPV
660 670 680 690 700
NQLPLIDTSN SEAISSSSIP QFPITSDSTI STLETPQDYI RLWQELSDSL
710 720 730 740 750
GPVVQVNTWS CDEQGTLHGQ PTYHQVQVSE VGVEGPPDPQ AFQGPAAYQP
760 770
DQMRSAEQTR LMPAEQRDSN KPC
Length:773
Mass (Da):87,428
Last modified:March 1, 2003 - v1
Checksum:i04DF5C10980CEE6F
GO
Isoform 2 (identifier: Q8IV76-2) [UniParc]FASTAAdd to basket
Also known as: PASD1_v1

The sequence of this isoform differs from the canonical sequence as follows:
     639-639: S → R
     640-773: Missing.

Note: Due to intron retention.
Show »
Length:639
Mass (Da):72,738
Checksum:iC787023A7F894705
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti107E → K in BAC05097 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034819213Q → E.Corresponds to variant rs5924658dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027663639S → R in isoform 2. 1 Publication1
Alternative sequenceiVSP_027664640 – 773Missing in isoform 2. 1 PublicationAdd BLAST134

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY270020 mRNA. Translation: AAQ01136.1.
AK097552 mRNA. Translation: BAC05097.1.
BC040301 mRNA. Translation: AAH40301.1.
AY623425 mRNA. Translation: AAT49049.1.
CCDSiCCDS35431.1. [Q8IV76-1]
RefSeqiNP_775764.2. NM_173493.2. [Q8IV76-1]
UniGeneiHs.160594.

Genome annotation databases

EnsembliENST00000370357; ENSP00000359382; ENSG00000166049. [Q8IV76-1]
GeneIDi139135.
KEGGihsa:139135.
UCSCiuc004fev.5. human. [Q8IV76-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY270020 mRNA. Translation: AAQ01136.1.
AK097552 mRNA. Translation: BAC05097.1.
BC040301 mRNA. Translation: AAH40301.1.
AY623425 mRNA. Translation: AAT49049.1.
CCDSiCCDS35431.1. [Q8IV76-1]
RefSeqiNP_775764.2. NM_173493.2. [Q8IV76-1]
UniGeneiHs.160594.

3D structure databases

ProteinModelPortaliQ8IV76.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126545. 1 interactor.
MINTiMINT-4719893.
STRINGi9606.ENSP00000359382.

PTM databases

iPTMnetiQ8IV76.
PhosphoSitePlusiQ8IV76.

Polymorphism and mutation databases

BioMutaiPASD1.
DMDMi74728046.

Proteomic databases

PaxDbiQ8IV76.
PeptideAtlasiQ8IV76.
PRIDEiQ8IV76.

Protocols and materials databases

DNASUi139135.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370357; ENSP00000359382; ENSG00000166049. [Q8IV76-1]
GeneIDi139135.
KEGGihsa:139135.
UCSCiuc004fev.5. human. [Q8IV76-1]

Organism-specific databases

CTDi139135.
DisGeNETi139135.
GeneCardsiPASD1.
H-InvDBHIX0022029.
HGNCiHGNC:20686. PASD1.
HPAiHPA011122.
HPA011152.
neXtProtiNX_Q8IV76.
OpenTargetsiENSG00000166049.
PharmGKBiPA134909788.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JAH9. Eukaryota.
ENOG41117WC. LUCA.
GeneTreeiENSGT00530000064765.
HOGENOMiHOG000115455.
InParanoidiQ8IV76.
OMAiNVRDICN.
OrthoDBiEOG091G11CV.
PhylomeDBiQ8IV76.
TreeFamiTF324568.

Miscellaneous databases

GeneWikiiPASD1.
GenomeRNAii139135.
PROiQ8IV76.

Gene expression databases

BgeeiENSG00000166049.
CleanExiHS_PASD1.
GenevisibleiQ8IV76. HS.

Family and domain databases

InterProiIPR000014. PAS.
[Graphical view]
SMARTiSM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF55785. SSF55785. 1 hit.
PROSITEiPS50112. PAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPASD1_HUMAN
AccessioniPrimary (citable) accession number: Q8IV76
Secondary accession number(s): Q3MNE0, Q69HD7, Q8N7X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.