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Protein

PAS domain-containing protein 1

Gene

PASD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a transcription factor.1 Publication

GO - Molecular functioni

  1. signal transducer activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
PAS domain-containing protein 1
Alternative name(s):
Cancer/testis antigen 63
Short name:
CT63
OX-TES-1
Gene namesi
Name:PASD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:20686. PASD1.

Subcellular locationi

  1. Nucleus Curated

GO - Cellular componenti

  1. nucleoplasm Source: HPA
  2. nucleus Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134909788.

Polymorphism and mutation databases

BioMutaiPASD1.
DMDMi74728046.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 773773PAS domain-containing protein 1PRO_0000299445Add
BLAST

Proteomic databases

PaxDbiQ8IV76.
PRIDEiQ8IV76.

PTM databases

PhosphoSiteiQ8IV76.

Expressioni

Tissue specificityi

Testis-specific. Found in histologically normal tissues from patients with uterus, lung and small intestine cancers. Widespread expression seen in solid tumors and diffuse large B-cell lymphoma (DLBCL)-derived cell lines. Isoform 2 is expressed in all DLBCL-derived cell lines, while isoform 1 is preferentially expressed in cell lines derived from non-germinal center DLBCL.1 Publication

Gene expression databases

BgeeiQ8IV76.
CleanExiHS_PASD1.
GenevestigatoriQ8IV76.

Organism-specific databases

HPAiHPA011122.
HPA011152.

Interactioni

Protein-protein interaction databases

BioGridi126545. 2 interactions.
MINTiMINT-4719893.
STRINGi9606.ENSP00000359382.

Structurei

3D structure databases

ProteinModelPortaliQ8IV76.
SMRiQ8IV76. Positions 16-137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 10273PASPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili365 – 41248Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi229 – 2368Poly-Ala
Compositional biasi508 – 54841Lys-richAdd
BLAST
Compositional biasi665 – 6684Poly-Ser

Sequence similaritiesi

Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG147281.
GeneTreeiENSGT00530000064765.
HOGENOMiHOG000115455.
InParanoidiQ8IV76.
OMAiLETPQDY.
OrthoDBiEOG7BCNB5.
PhylomeDBiQ8IV76.
TreeFamiTF324568.

Family and domain databases

InterProiIPR000014. PAS.
[Graphical view]
SMARTiSM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF55785. SSF55785. 1 hit.
PROSITEiPS50112. PAS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IV76-1) [UniParc]FASTAAdd to basket

Also known as: PASD1_v2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMRGEKRRD KVNPKSSQRK LNWIPSFPTY DYFNQVTLQL LDGFMITLST
60 70 80 90 100
DGVIICVAEN ISSLLGHLPA EIVGKKLLSL LPDEEKDEVY QKIILKFPLL
110 120 130 140 150
NSETHIEFCC HLKRGNVEHG DSSAYENVKF IVNVRDICNE FPVVFSGLFS
160 170 180 190 200
SHLCADFAAC VPQEDRLYLV GNVCILRTQL LQQLYTSKAV SDEAVLTQDS
210 220 230 240 250
DEEPFVGELS SSQGQRGHTS MKAVYVEPAA AAAAAAISDD QIDIAEVEQY
260 270 280 290 300
GPQENVHMFV DSDSTYCSST VFLDTMPESP ALSLQDFRGE PEVNPLYRAD
310 320 330 340 350
PVDLEFSVDQ VDSVDQEGPM DQQDPENPVA PLDQAGLMDP VDPEDSVDLG
360 370 380 390 400
AAGASAQPLQ PSSPVAYDII SQELELMKKL KEQLEERTWL LHDAIQNQQN
410 420 430 440 450
ALELMMDHLQ KQPNTLRHVV IPDLQSSEAV PKKQQKQHAG QVKRPLPHPK
460 470 480 490 500
DVKCFCGLSL SNSLKNTGEL QEPCVAFNQQ QLVQQEQHLK EQQRQLREQL
510 520 530 540 550
QQLREQRKVQ KQKKMQEKKK LQEQKMQEKK KLQEQRRQKK KKLQERKKWQ
560 570 580 590 600
GQMLQKEPEE EQQKQQLQEQ PLKHNVIVGN ERVQICLQNP RDVSVPLCNH
610 620 630 640 650
PVRFLQAQPI VPVQRAAEQQ PSGFYQDENC GQQEDESQSF YPEAYQGPPV
660 670 680 690 700
NQLPLIDTSN SEAISSSSIP QFPITSDSTI STLETPQDYI RLWQELSDSL
710 720 730 740 750
GPVVQVNTWS CDEQGTLHGQ PTYHQVQVSE VGVEGPPDPQ AFQGPAAYQP
760 770
DQMRSAEQTR LMPAEQRDSN KPC
Length:773
Mass (Da):87,428
Last modified:March 1, 2003 - v1
Checksum:i04DF5C10980CEE6F
GO
Isoform 2 (identifier: Q8IV76-2) [UniParc]FASTAAdd to basket

Also known as: PASD1_v1

The sequence of this isoform differs from the canonical sequence as follows:
     639-639: S → R
     640-773: Missing.

Note: Due to intron retention.

Show »
Length:639
Mass (Da):72,738
Checksum:iC787023A7F894705
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti107 – 1071E → K in BAC05097 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti213 – 2131Q → E.
Corresponds to variant rs5924658 [ dbSNP | Ensembl ].
VAR_034819

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei639 – 6391S → R in isoform 2. 1 PublicationVSP_027663
Alternative sequencei640 – 773134Missing in isoform 2. 1 PublicationVSP_027664Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY270020 mRNA. Translation: AAQ01136.1.
AK097552 mRNA. Translation: BAC05097.1.
BC040301 mRNA. Translation: AAH40301.1.
AY623425 mRNA. Translation: AAT49049.1.
CCDSiCCDS35431.1. [Q8IV76-1]
RefSeqiNP_775764.2. NM_173493.2. [Q8IV76-1]
UniGeneiHs.160594.

Genome annotation databases

EnsembliENST00000370357; ENSP00000359382; ENSG00000166049. [Q8IV76-1]
GeneIDi139135.
KEGGihsa:139135.
UCSCiuc004fev.4. human. [Q8IV76-1]

Polymorphism and mutation databases

BioMutaiPASD1.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY270020 mRNA. Translation: AAQ01136.1.
AK097552 mRNA. Translation: BAC05097.1.
BC040301 mRNA. Translation: AAH40301.1.
AY623425 mRNA. Translation: AAT49049.1.
CCDSiCCDS35431.1. [Q8IV76-1]
RefSeqiNP_775764.2. NM_173493.2. [Q8IV76-1]
UniGeneiHs.160594.

3D structure databases

ProteinModelPortaliQ8IV76.
SMRiQ8IV76. Positions 16-137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126545. 2 interactions.
MINTiMINT-4719893.
STRINGi9606.ENSP00000359382.

PTM databases

PhosphoSiteiQ8IV76.

Polymorphism and mutation databases

BioMutaiPASD1.
DMDMi74728046.

Proteomic databases

PaxDbiQ8IV76.
PRIDEiQ8IV76.

Protocols and materials databases

DNASUi139135.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370357; ENSP00000359382; ENSG00000166049. [Q8IV76-1]
GeneIDi139135.
KEGGihsa:139135.
UCSCiuc004fev.4. human. [Q8IV76-1]

Organism-specific databases

CTDi139135.
GeneCardsiGC0XP150732.
H-InvDBHIX0022029.
HGNCiHGNC:20686. PASD1.
HPAiHPA011122.
HPA011152.
neXtProtiNX_Q8IV76.
PharmGKBiPA134909788.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG147281.
GeneTreeiENSGT00530000064765.
HOGENOMiHOG000115455.
InParanoidiQ8IV76.
OMAiLETPQDY.
OrthoDBiEOG7BCNB5.
PhylomeDBiQ8IV76.
TreeFamiTF324568.

Miscellaneous databases

GeneWikiiPASD1.
GenomeRNAii139135.
NextBioi83900.
PROiQ8IV76.

Gene expression databases

BgeeiQ8IV76.
CleanExiHS_PASD1.
GenevestigatoriQ8IV76.

Family and domain databases

InterProiIPR000014. PAS.
[Graphical view]
SMARTiSM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF55785. SSF55785. 1 hit.
PROSITEiPS50112. PAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel diffuse large B-cell lymphoma-associated cancer testis antigen encoding a PAS domain protein."
    Liggins A.P., Brown P.J., Asker K., Pulford K., Banham A.H.
    Br. J. Cancer 91:141-149(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  4. "Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia."
    Guinn B.-A., Bland E.A., Lodi U., Liggins A.P., Tobal K., Petters S., Wells J.W., Banham A.H., Mufti G.J.
    Biochem. Biophys. Res. Commun. 335:1293-1304(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 469-773 (ISOFORM 1).

Entry informationi

Entry nameiPASD1_HUMAN
AccessioniPrimary (citable) accession number: Q8IV76
Secondary accession number(s): Q3MNE0, Q69HD7, Q8N7X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: April 29, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.