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Q8IV63

- VRK3_HUMAN

UniProt

Q8IV63 - VRK3_HUMAN

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Protein
Inactive serine/threonine-protein kinase VRK3
Gene
VRK3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus By similarity.2 Publications

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. protein kinase activity Source: InterPro

GO - Biological processi

  1. negative regulation of ERK1 and ERK2 cascade Source: Ensembl
  2. positive regulation of phosphoprotein phosphatase activity Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ8IV63.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive serine/threonine-protein kinase VRK3
Alternative name(s):
Serine/threonine-protein pseudokinase VRK3
Vaccinia-related kinase 3
Gene namesi
Name:VRK3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:18996. VRK3.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134923990.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Inactive serine/threonine-protein kinase VRK3
PRO_0000086808Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei55 – 551Phosphoserine1 Publication
Modified residuei59 – 591Phosphoserine1 Publication
Modified residuei82 – 821Phosphoserine3 Publications
Modified residuei83 – 831Phosphoserine3 Publications
Modified residuei90 – 901Phosphoserine1 Publication
Modified residuei115 – 1151Phosphoserine1 Publication
Modified residuei122 – 1221Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IV63.
PaxDbiQ8IV63.
PRIDEiQ8IV63.

PTM databases

PhosphoSiteiQ8IV63.

Expressioni

Gene expression databases

ArrayExpressiQ8IV63.
BgeeiQ8IV63.
CleanExiHS_VRK3.
GenevestigatoriQ8IV63.

Organism-specific databases

HPAiHPA016040.

Interactioni

Subunit structurei

Interacts with DUSP3 By similarity. Interacts with RAN.1 Publication

Protein-protein interaction databases

BioGridi119394. 5 interactions.
IntActiQ8IV63. 5 interactions.
MINTiMINT-8247443.
STRINGi9606.ENSP00000324636.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi157 – 1593
Beta strandi165 – 17511
Beta strandi178 – 1858
Beta strandi200 – 2067
Helixi211 – 22111
Helixi224 – 23310
Beta strandi246 – 2505
Turni251 – 2533
Beta strandi254 – 2607
Helixi266 – 2727
Helixi274 – 2763
Helixi280 – 29920
Beta strandi311 – 3155
Beta strandi318 – 3247
Helixi327 – 3293
Helixi335 – 3373
Turni354 – 3563
Helixi359 – 3624
Helixi369 – 38517
Helixi391 – 3933
Helixi397 – 40913
Helixi426 – 43611
Helixi446 – 45914

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2JIIX-ray2.00A/B146-474[»]
ProteinModelPortaliQ8IV63.
SMRiQ8IV63. Positions 145-472.

Miscellaneous databases

EvolutionaryTraceiQ8IV63.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini166 – 457292Protein kinase
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi49 – 6416Nuclear localization signal1 Publication
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG298316.
HOGENOMiHOG000293191.
HOVERGENiHBG047756.
InParanoidiQ8IV63.
KOiK08816.
OMAiYEEKPPY.
OrthoDBiEOG7KSX83.
PhylomeDBiQ8IV63.
TreeFamiTF106473.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR026870. Zinc_ribbon_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF13240. zinc_ribbon_2. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IV63-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MISFCPDCGK SIQAAFKFCP YCGNSLPVEE HVGSQTFVNP HVSSFQGSKR    50
GLNSSFETSP KKVKWSSTVT SPRLSLFSDG DSSESEDTLS SSERSKGSGS 100
RPPTPKSSPQ KTRKSPQVTR GSPQKTSCSP QKTRQSPQTL KRSRVTTSLE 150
ALPTGTVLTD KSGRQWKLKS FQTRDNQGIL YEAAPTSTLT CDSGPQKQKF 200
SLKLDAKDGR LFNEQNFFQR AAKPLQVNKW KKLYSTPLLA IPTCMGFGVH 250
QDKYRFLVLP SLGRSLQSAL DVSPKHVLSE RSVLQVACRL LDALEFLHEN 300
EYVHGNVTAE NIFVDPEDQS QVTLAGYGFA FRYCPSGKHV AYVEGSRSPH 350
EGDLEFISMD LHKGCGPSRR SDLQSLGYCM LKWLYGFLPW TNCLPNTEDI 400
MKQKQKFVDK PGPFVGPCGH WIRPSETLQK YLKVVMALTY EEKPPYAMLR 450
NNLEALLQDL RVSPYDPIGL PMVP 474
Length:474
Mass (Da):52,881
Last modified:October 10, 2003 - v2
Checksum:i86B9B91050A7F0CC
GO
Isoform 2 (identifier: Q8IV63-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     407-412: FVDKPG → LPWDSF
     413-474: Missing.

Note: No experimental confirmation available.

Show »
Length:412
Mass (Da):45,904
Checksum:iB8EA8340E4FB9824
GO
Isoform 3 (identifier: Q8IV63-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-96: Missing.

Note: No experimental confirmation available.

Show »
Length:424
Mass (Da):47,501
Checksum:iD17A379F153ED44E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591S → F.1 Publication
Corresponds to variant rs2033262 [ dbSNP | Ensembl ].
VAR_041295
Natural varianti105 – 1051P → T.1 Publication
Corresponds to variant rs11547882 [ dbSNP | Ensembl ].
VAR_041296
Natural varianti170 – 1701S → P.
Corresponds to variant rs11547881 [ dbSNP | Ensembl ].
VAR_051682
Natural varianti171 – 1711F → L.1 Publication
Corresponds to variant rs11547883 [ dbSNP | Ensembl ].
VAR_041297
Natural varianti188 – 1881T → A.
Corresponds to variant rs11879620 [ dbSNP | Ensembl ].
VAR_051683
Natural varianti268 – 2681S → L.1 Publication
Corresponds to variant rs10410075 [ dbSNP | Ensembl ].
VAR_041298
Natural varianti288 – 2881C → Y.1 Publication
Corresponds to variant rs10409482 [ dbSNP | Ensembl ].
VAR_041299
Natural varianti304 – 3041H → L.
Corresponds to variant rs35261919 [ dbSNP | Ensembl ].
VAR_051684
Natural varianti370 – 3701R → C.1 Publication
Corresponds to variant rs35331034 [ dbSNP | Ensembl ].
VAR_041300
Natural varianti371 – 3711S → G.1 Publication
Corresponds to variant rs56407496 [ dbSNP | Ensembl ].
VAR_041301

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei47 – 9650Missing in isoform 3.
VSP_043409Add
BLAST
Alternative sequencei407 – 4126FVDKPG → LPWDSF in isoform 2.
VSP_008544
Alternative sequencei413 – 47462Missing in isoform 2.
VSP_008545Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti161 – 1611K → E in AAP47180. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB031052 mRNA. Translation: BAA90769.1.
AF514788 mRNA. Translation: AAP47180.1.
AK292918 mRNA. Translation: BAF85607.1.
AK303010 mRNA. Translation: BAG64141.1.
AC011452 Genomic DNA. No translation available.
BC023556 mRNA. Translation: AAH23556.1.
BC095449 mRNA. Translation: AAH95449.1.
CCDSiCCDS12791.1. [Q8IV63-1]
CCDS33076.1. [Q8IV63-3]
RefSeqiNP_001020949.1. NM_001025778.1. [Q8IV63-3]
NP_057524.3. NM_016440.3. [Q8IV63-1]
XP_005259028.1. XM_005258971.1. [Q8IV63-1]
XP_005259029.1. XM_005258972.1. [Q8IV63-3]
XP_005259031.1. XM_005258974.2. [Q8IV63-2]
XP_006723300.1. XM_006723237.1. [Q8IV63-1]
XP_006723301.1. XM_006723238.1. [Q8IV63-3]
UniGeneiHs.443330.

Genome annotation databases

EnsembliENST00000316763; ENSP00000324636; ENSG00000105053. [Q8IV63-1]
ENST00000377011; ENSP00000366210; ENSG00000105053. [Q8IV63-3]
ENST00000594092; ENSP00000472541; ENSG00000105053. [Q8IV63-2]
ENST00000594948; ENSP00000473171; ENSG00000105053. [Q8IV63-1]
ENST00000599538; ENSP00000469880; ENSG00000105053. [Q8IV63-1]
ENST00000601341; ENSP00000470156; ENSG00000105053. [Q8IV63-3]
GeneIDi51231.
KEGGihsa:51231.
UCSCiuc002prg.2. human. [Q8IV63-1]
uc002pri.1. human. [Q8IV63-3]
uc002prk.2. human. [Q8IV63-2]

Polymorphism databases

DMDMi45593724.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB031052 mRNA. Translation: BAA90769.1 .
AF514788 mRNA. Translation: AAP47180.1 .
AK292918 mRNA. Translation: BAF85607.1 .
AK303010 mRNA. Translation: BAG64141.1 .
AC011452 Genomic DNA. No translation available.
BC023556 mRNA. Translation: AAH23556.1 .
BC095449 mRNA. Translation: AAH95449.1 .
CCDSi CCDS12791.1. [Q8IV63-1 ]
CCDS33076.1. [Q8IV63-3 ]
RefSeqi NP_001020949.1. NM_001025778.1. [Q8IV63-3 ]
NP_057524.3. NM_016440.3. [Q8IV63-1 ]
XP_005259028.1. XM_005258971.1. [Q8IV63-1 ]
XP_005259029.1. XM_005258972.1. [Q8IV63-3 ]
XP_005259031.1. XM_005258974.2. [Q8IV63-2 ]
XP_006723300.1. XM_006723237.1. [Q8IV63-1 ]
XP_006723301.1. XM_006723238.1. [Q8IV63-3 ]
UniGenei Hs.443330.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2JII X-ray 2.00 A/B 146-474 [» ]
ProteinModelPortali Q8IV63.
SMRi Q8IV63. Positions 145-472.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119394. 5 interactions.
IntActi Q8IV63. 5 interactions.
MINTi MINT-8247443.
STRINGi 9606.ENSP00000324636.

PTM databases

PhosphoSitei Q8IV63.

Polymorphism databases

DMDMi 45593724.

Proteomic databases

MaxQBi Q8IV63.
PaxDbi Q8IV63.
PRIDEi Q8IV63.

Protocols and materials databases

DNASUi 51231.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316763 ; ENSP00000324636 ; ENSG00000105053 . [Q8IV63-1 ]
ENST00000377011 ; ENSP00000366210 ; ENSG00000105053 . [Q8IV63-3 ]
ENST00000594092 ; ENSP00000472541 ; ENSG00000105053 . [Q8IV63-2 ]
ENST00000594948 ; ENSP00000473171 ; ENSG00000105053 . [Q8IV63-1 ]
ENST00000599538 ; ENSP00000469880 ; ENSG00000105053 . [Q8IV63-1 ]
ENST00000601341 ; ENSP00000470156 ; ENSG00000105053 . [Q8IV63-3 ]
GeneIDi 51231.
KEGGi hsa:51231.
UCSCi uc002prg.2. human. [Q8IV63-1 ]
uc002pri.1. human. [Q8IV63-3 ]
uc002prk.2. human. [Q8IV63-2 ]

Organism-specific databases

CTDi 51231.
GeneCardsi GC19M050479.
HGNCi HGNC:18996. VRK3.
HPAi HPA016040.
neXtProti NX_Q8IV63.
PharmGKBi PA134923990.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG298316.
HOGENOMi HOG000293191.
HOVERGENi HBG047756.
InParanoidi Q8IV63.
KOi K08816.
OMAi YEEKPPY.
OrthoDBi EOG7KSX83.
PhylomeDBi Q8IV63.
TreeFami TF106473.

Enzyme and pathway databases

SignaLinki Q8IV63.

Miscellaneous databases

ChiTaRSi VRK3. human.
EvolutionaryTracei Q8IV63.
GenomeRNAii 51231.
NextBioi 54332.
PROi Q8IV63.

Gene expression databases

ArrayExpressi Q8IV63.
Bgeei Q8IV63.
CleanExi HS_VRK3.
Genevestigatori Q8IV63.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR026870. Zinc_ribbon_dom.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
PF13240. zinc_ribbon_2. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Vaccinia related kinase 3 (VRK3)."
    Nezu J.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver.
  2. "Cloning and characterization of a novel human VRK3 gene."
    Ni X., Xie Y., Mao Y.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Testis and Trachea.
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Skin.
  6. "Characterization of three paralogous members of the Mammalian vaccinia related kinase family."
    Nichols R.J., Traktman P.
    J. Biol. Chem. 279:7934-7946(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNAL.
  7. "Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities."
    Sanz-Garcia M., Lopez-Sanchez I., Lazo P.A.
    Mol. Cell. Proteomics 7:2199-2214(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RAN.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-55 AND SER-59, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82; SER-83 AND SER-90, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82 AND SER-83, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82; SER-83; SER-115 AND SER-122, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site."
    Scheeff E.D., Eswaran J., Bunkoczi G., Knapp S., Manning G.
    Structure 17:128-138(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 146-474, FUNCTION, LACK OF CATALYTIC ACTIVITY.
  13. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] PHE-59; THR-105; LEU-171; LEU-268; TYR-288; CYS-370 AND GLY-371.

Entry informationi

Entry nameiVRK3_HUMAN
AccessioniPrimary (citable) accession number: Q8IV63
Secondary accession number(s): A6NEG5
, A8KA53, Q502Y2, Q9P2V8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: July 9, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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