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Protein

Proline-rich protein 15

Gene

PRR15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May have a role in proliferation and/or differentiation.By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich protein 15
Gene namesi
Name:PRR15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000176532.3.
HGNCiHGNC:22310. PRR15.

Pathology & Biotechi

Organism-specific databases

DisGeNETi222171.
OpenTargetsiENSG00000176532.
PharmGKBiPA162400154.

Polymorphism and mutation databases

BioMutaiPRR15.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002711091 – 129Proline-rich protein 15Add BLAST129

Proteomic databases

EPDiQ8IV56.
MaxQBiQ8IV56.
PaxDbiQ8IV56.
PeptideAtlasiQ8IV56.
PRIDEiQ8IV56.

PTM databases

iPTMnetiQ8IV56.
PhosphoSitePlusiQ8IV56.

Expressioni

Gene expression databases

BgeeiENSG00000176532.
CleanExiHS_PRR15.
ExpressionAtlasiQ8IV56. baseline and differential.
GenevisibleiQ8IV56. HS.

Organism-specific databases

HPAiHPA040996.
HPA048121.

Interactioni

Protein-protein interaction databases

BioGridi128786. 2 interactors.
IntActiQ8IV56. 1 interactor.
STRINGi9606.ENSP00000317836.

Structurei

3D structure databases

ProteinModelPortaliQ8IV56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 50Pro-richAdd BLAST19

Sequence similaritiesi

Belongs to the PRR15 family.Curated

Phylogenomic databases

eggNOGiENOG410J434. Eukaryota.
ENOG410Y7UI. LUCA.
GeneTreeiENSGT00390000001407.
HOGENOMiHOG000234890.
HOVERGENiHBG079566.
InParanoidiQ8IV56.
OMAiPGDPHDD.
OrthoDBiEOG091G10R2.
PhylomeDBiQ8IV56.
TreeFamiTF333189.

Family and domain databases

InterProiView protein in InterPro
IPR028237. PRR15.
PANTHERiPTHR14581. PTHR14581. 1 hit.
PfamiView protein in Pfam
PF15321. ATAD4. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IV56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSGDAGSS GPWWKSLTNS RKKSKEAAVG VPPPAQPAPG EPTPPAPPSP
60 70 80 90 100
DWTSSSRENQ HPNLLGGAGE PPKPDKLYGD KSGSSRRNLK ISRSGRFKEK
110 120
RKVRATLLPE AGRSPEEAGF PGDPHEDKQ
Length:129
Mass (Da):13,715
Last modified:March 1, 2003 - v1
Checksum:i0B100677D003D64A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059710115P → S. Corresponds to variant dbSNP:rs10271996Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029131 mRNA. Translation: AAH29131.1.
CCDSiCCDS5421.1.
RefSeqiNP_001316925.1. NM_001329996.1.
NP_001316926.1. NM_001329997.1.
NP_787083.1. NM_175887.2.
XP_011513500.1. XM_011515198.1.
XP_011513501.1. XM_011515199.1.
UniGeneiHs.91109.

Genome annotation databases

EnsembliENST00000319694; ENSP00000317836; ENSG00000176532.
GeneIDi222171.
KEGGihsa:222171.
UCSCiuc003tac.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPRR15_HUMAN
AccessioniPrimary (citable) accession number: Q8IV56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2003
Last modified: November 22, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families