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Protein

Proline-rich protein 15

Gene

PRR15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May have a role in proliferation and/or differentiation.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich protein 15
Gene namesi
Name:PRR15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22310. PRR15.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400154.

Polymorphism and mutation databases

BioMutaiPRR15.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 129129Proline-rich protein 15PRO_0000271109Add
BLAST

Proteomic databases

MaxQBiQ8IV56.
PaxDbiQ8IV56.
PRIDEiQ8IV56.

PTM databases

PhosphoSiteiQ8IV56.

Expressioni

Gene expression databases

BgeeiQ8IV56.
CleanExiHS_PRR15.
ExpressionAtlasiQ8IV56. baseline and differential.
GenevisibleiQ8IV56. HS.

Organism-specific databases

HPAiHPA040996.
HPA048121.

Interactioni

Protein-protein interaction databases

BioGridi128786. 2 interactions.
IntActiQ8IV56. 1 interaction.
STRINGi9606.ENSP00000317836.

Structurei

3D structure databases

ProteinModelPortaliQ8IV56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi32 – 5019Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the PRR15 family.Curated

Phylogenomic databases

eggNOGiENOG410J434. Eukaryota.
ENOG410Y7UI. LUCA.
GeneTreeiENSGT00390000001407.
HOGENOMiHOG000234890.
HOVERGENiHBG079566.
InParanoidiQ8IV56.
OMAiPGDPHDD.
OrthoDBiEOG7VDXRG.
PhylomeDBiQ8IV56.
TreeFamiTF333189.

Family and domain databases

InterProiIPR028237. PRR15.
[Graphical view]
PfamiPF15321. ATAD4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IV56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSGDAGSS GPWWKSLTNS RKKSKEAAVG VPPPAQPAPG EPTPPAPPSP
60 70 80 90 100
DWTSSSRENQ HPNLLGGAGE PPKPDKLYGD KSGSSRRNLK ISRSGRFKEK
110 120
RKVRATLLPE AGRSPEEAGF PGDPHEDKQ
Length:129
Mass (Da):13,715
Last modified:March 1, 2003 - v1
Checksum:i0B100677D003D64A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti115 – 1151P → S.
Corresponds to variant rs10271996 [ dbSNP | Ensembl ].
VAR_059710

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029131 mRNA. Translation: AAH29131.1.
CCDSiCCDS5421.1.
RefSeqiNP_787083.1. NM_175887.2.
XP_005249710.1. XM_005249653.3.
XP_011513500.1. XM_011515198.1.
XP_011513501.1. XM_011515199.1.
UniGeneiHs.91109.

Genome annotation databases

EnsembliENST00000319694; ENSP00000317836; ENSG00000176532.
GeneIDi222171.
KEGGihsa:222171.
UCSCiuc003tac.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029131 mRNA. Translation: AAH29131.1.
CCDSiCCDS5421.1.
RefSeqiNP_787083.1. NM_175887.2.
XP_005249710.1. XM_005249653.3.
XP_011513500.1. XM_011515198.1.
XP_011513501.1. XM_011515199.1.
UniGeneiHs.91109.

3D structure databases

ProteinModelPortaliQ8IV56.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128786. 2 interactions.
IntActiQ8IV56. 1 interaction.
STRINGi9606.ENSP00000317836.

PTM databases

PhosphoSiteiQ8IV56.

Polymorphism and mutation databases

BioMutaiPRR15.

Proteomic databases

MaxQBiQ8IV56.
PaxDbiQ8IV56.
PRIDEiQ8IV56.

Protocols and materials databases

DNASUi222171.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319694; ENSP00000317836; ENSG00000176532.
GeneIDi222171.
KEGGihsa:222171.
UCSCiuc003tac.1. human.

Organism-specific databases

CTDi222171.
GeneCardsiPRR15.
HGNCiHGNC:22310. PRR15.
HPAiHPA040996.
HPA048121.
neXtProtiNX_Q8IV56.
PharmGKBiPA162400154.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J434. Eukaryota.
ENOG410Y7UI. LUCA.
GeneTreeiENSGT00390000001407.
HOGENOMiHOG000234890.
HOVERGENiHBG079566.
InParanoidiQ8IV56.
OMAiPGDPHDD.
OrthoDBiEOG7VDXRG.
PhylomeDBiQ8IV56.
TreeFamiTF333189.

Miscellaneous databases

ChiTaRSiPRR15. human.
GenomeRNAii222171.
NextBioi91560.
PROiQ8IV56.

Gene expression databases

BgeeiQ8IV56.
CleanExiHS_PRR15.
ExpressionAtlasiQ8IV56. baseline and differential.
GenevisibleiQ8IV56. HS.

Family and domain databases

InterProiIPR028237. PRR15.
[Graphical view]
PfamiPF15321. ATAD4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.

Entry informationi

Entry nameiPRR15_HUMAN
AccessioniPrimary (citable) accession number: Q8IV56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.