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Protein

UNC5C-like protein

Gene

UNC5CL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets.1 Publication

GO - Molecular functioni

  • peptidase activity Source: MGI

GO - Biological processi

  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  • positive regulation of JNK cascade Source: MGI
  • signal transduction Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
UNC5C-like protein
Alternative name(s):
Protein unc-5 homolog C-like
ZU5 and death domain-containing protein
Gene namesi
Name:UNC5CL
Synonyms:ZUD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21203. UNC5CL.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10ExtracellularSequence analysis10
Transmembranei11 – 31Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini32 – 518CytoplasmicSequence analysisAdd BLAST487

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000124602.
PharmGKBiPA134906657.

Polymorphism and mutation databases

BioMutaiUNC5CL.
DMDMi160358941.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003095671 – 518UNC5C-like proteinAdd BLAST518

Proteomic databases

PaxDbiQ8IV45.
PeptideAtlasiQ8IV45.
PRIDEiQ8IV45.

PTM databases

iPTMnetiQ8IV45.
PhosphoSitePlusiQ8IV45.

Expressioni

Tissue specificityi

Expressed in pancreas, liver and kidney.1 Publication

Gene expression databases

BgeeiENSG00000124602.
CleanExiHS_UNC5CL.
ExpressionAtlasiQ8IV45. baseline and differential.
GenevisibleiQ8IV45. HS.

Organism-specific databases

HPAiHPA015725.

Interactioni

Subunit structurei

Interacts with p65/RELA and NFKB1.1 Publication

Protein-protein interaction databases

BioGridi128808. 16 interactors.
IntActiQ8IV45. 2 interactors.
STRINGi9606.ENSP00000244565.

Structurei

3D structure databases

ProteinModelPortaliQ8IV45.
SMRiQ8IV45.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 207ZU5PROSITE-ProRule annotationAdd BLAST108
Domaini415 – 494DeathPROSITE-ProRule annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni186 – 400Interaction with RELA and NFKB11 PublicationAdd BLAST215

Sequence similaritiesi

Belongs to the unc-5 family.Curated
Contains 1 death domain.PROSITE-ProRule annotation
Contains 1 ZU5 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1480. Eukaryota.
ENOG410XRS6. LUCA.
GeneTreeiENSGT00850000132260.
HOGENOMiHOG000154778.
HOVERGENiHBG108649.
InParanoidiQ8IV45.
OMAiLDCASAI.
OrthoDBiEOG091G04N6.
PhylomeDBiQ8IV45.
TreeFamiTF316767.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR033772. UPA.
IPR000906. ZU5_dom.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF17217. UPA. 1 hit.
PF00791. ZU5. 1 hit.
[Graphical view]
SMARTiSM00005. DEATH. 1 hit.
SM00218. ZU5. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS51145. ZU5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IV45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPQESSFQP SQFLLLVGVP VASVLLLAQC LRWHCPRRLL GACWTLNGQE
60 70 80 90 100
EPVSQPTPQL ENEVSRQHLP ATLPEMVAFY QELHTPTQGQ TMVRQLMHKL
110 120 130 140 150
LVFSAREVDH RGGCLMLQDT GISLLIPPGA VAVGRQERVS LILVWDLSDA
160 170 180 190 200
PSLSQAQGLV SPVVACGPHG ASFLKPCTLT FKHCAEQPSH ARTYSSNTTL
210 220 230 240 250
LDAKVWRPLG RPGAHASRDE CRIHLSHFSL YTCVLEAPVG REARKWLQLA
260 270 280 290 300
VFCSPLVPGQ SHLQLRIYFL NNTPCALQWA LTNEQPHGGR LRGPCQLFDF
310 320 330 340 350
NGARGDQCLK LTYISEGWEN VDDSSCQLVP HLHIWHGKCP FRSFCFRRKA
360 370 380 390 400
ADENEDCSAL TNEIIVTMHT FQDGLETKYM EILRFQASEE ESWAAPPPVS
410 420 430 440 450
QPPPCNRLPP ELFEQLRMLL EPNSITGNDW RRLASHLGLC GMKIRFLSCQ
460 470 480 490 500
RSPAAAILEL FEEQNGSLQE LHYLMTVMER LDCASAIQNY LSGTHGGSPG
510
PERGGARDNQ GLELDEKL
Length:518
Mass (Da):57,818
Last modified:November 13, 2007 - v2
Checksum:iA90218B4453E0937
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036979432R → G.2 PublicationsCorresponds to variant rs742493dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY510109 mRNA. Translation: AAS80165.1.
AL031778 Genomic DNA. Translation: CAI20283.1.
CH471081 Genomic DNA. Translation: EAX04007.1.
BC035284 mRNA. Translation: AAH35284.1.
CCDSiCCDS4847.1.
RefSeqiNP_775832.2. NM_173561.2.
UniGeneiHs.158357.

Genome annotation databases

EnsembliENST00000244565; ENSP00000244565; ENSG00000124602.
ENST00000373164; ENSP00000362258; ENSG00000124602.
GeneIDi222643.
KEGGihsa:222643.
UCSCiuc003opi.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY510109 mRNA. Translation: AAS80165.1.
AL031778 Genomic DNA. Translation: CAI20283.1.
CH471081 Genomic DNA. Translation: EAX04007.1.
BC035284 mRNA. Translation: AAH35284.1.
CCDSiCCDS4847.1.
RefSeqiNP_775832.2. NM_173561.2.
UniGeneiHs.158357.

3D structure databases

ProteinModelPortaliQ8IV45.
SMRiQ8IV45.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128808. 16 interactors.
IntActiQ8IV45. 2 interactors.
STRINGi9606.ENSP00000244565.

PTM databases

iPTMnetiQ8IV45.
PhosphoSitePlusiQ8IV45.

Polymorphism and mutation databases

BioMutaiUNC5CL.
DMDMi160358941.

Proteomic databases

PaxDbiQ8IV45.
PeptideAtlasiQ8IV45.
PRIDEiQ8IV45.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244565; ENSP00000244565; ENSG00000124602.
ENST00000373164; ENSP00000362258; ENSG00000124602.
GeneIDi222643.
KEGGihsa:222643.
UCSCiuc003opi.4. human.

Organism-specific databases

CTDi222643.
GeneCardsiUNC5CL.
H-InvDBHIX0025210.
HIX0165028.
HGNCiHGNC:21203. UNC5CL.
HPAiHPA015725.
neXtProtiNX_Q8IV45.
OpenTargetsiENSG00000124602.
PharmGKBiPA134906657.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1480. Eukaryota.
ENOG410XRS6. LUCA.
GeneTreeiENSGT00850000132260.
HOGENOMiHOG000154778.
HOVERGENiHBG108649.
InParanoidiQ8IV45.
OMAiLDCASAI.
OrthoDBiEOG091G04N6.
PhylomeDBiQ8IV45.
TreeFamiTF316767.

Miscellaneous databases

ChiTaRSiUNC5CL. human.
GenomeRNAii222643.
PROiQ8IV45.

Gene expression databases

BgeeiENSG00000124602.
CleanExiHS_UNC5CL.
ExpressionAtlasiQ8IV45. baseline and differential.
GenevisibleiQ8IV45. HS.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR033772. UPA.
IPR000906. ZU5_dom.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF17217. UPA. 1 hit.
PF00791. ZU5. 1 hit.
[Graphical view]
SMARTiSM00005. DEATH. 1 hit.
SM00218. ZU5. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS51145. ZU5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUN5CL_HUMAN
AccessioniPrimary (citable) accession number: Q8IV45
Secondary accession number(s): Q5TGU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 30, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.