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Protein

UNC5C-like protein

Gene

UNC5CL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets.1 Publication

GO - Molecular functioni

  • peptidase activity Source: MGI

GO - Biological processi

  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  • positive regulation of JNK cascade Source: MGI
  • signal transduction Source: InterPro

Names & Taxonomyi

Protein namesi
Recommended name:
UNC5C-like protein
Alternative name(s):
Protein unc-5 homolog C-like
ZU5 and death domain-containing protein
Gene namesi
Name:UNC5CL
Synonyms:ZUD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124602.9.
HGNCiHGNC:21203. UNC5CL.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10ExtracellularSequence analysis10
Transmembranei11 – 31Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini32 – 518CytoplasmicSequence analysisAdd BLAST487

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi222643.
OpenTargetsiENSG00000124602.
PharmGKBiPA134906657.

Polymorphism and mutation databases

BioMutaiUNC5CL.
DMDMi160358941.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003095671 – 518UNC5C-like proteinAdd BLAST518

Proteomic databases

PaxDbiQ8IV45.
PeptideAtlasiQ8IV45.
PRIDEiQ8IV45.

PTM databases

iPTMnetiQ8IV45.
PhosphoSitePlusiQ8IV45.

Expressioni

Tissue specificityi

Expressed in pancreas, liver and kidney.1 Publication

Gene expression databases

BgeeiENSG00000124602.
CleanExiHS_UNC5CL.
ExpressionAtlasiQ8IV45. baseline and differential.
GenevisibleiQ8IV45. HS.

Organism-specific databases

HPAiHPA015725.

Interactioni

Subunit structurei

Interacts with p65/RELA and NFKB1.1 Publication

Protein-protein interaction databases

BioGridi128808. 16 interactors.
IntActiQ8IV45. 5 interactors.
STRINGi9606.ENSP00000244565.

Structurei

3D structure databases

ProteinModelPortaliQ8IV45.
SMRiQ8IV45.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 237ZU5PROSITE-ProRule annotationAdd BLAST136
Domaini415 – 494DeathPROSITE-ProRule annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni186 – 400Interaction with RELA and NFKB11 PublicationAdd BLAST215

Sequence similaritiesi

Belongs to the unc-5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1480. Eukaryota.
ENOG410XRS6. LUCA.
GeneTreeiENSGT00900000140886.
HOGENOMiHOG000154778.
HOVERGENiHBG108649.
InParanoidiQ8IV45.
OMAiLDCASAI.
OrthoDBiEOG091G04N6.
PhylomeDBiQ8IV45.
TreeFamiTF316767.

Family and domain databases

InterProiView protein in InterPro
IPR011029. DEATH-like_dom_sf.
IPR000488. Death_domain.
IPR033772. UPA.
IPR000906. ZU5_dom.
PfamiView protein in Pfam
PF00531. Death. 1 hit.
PF17217. UPA. 1 hit.
PF00791. ZU5. 1 hit.
SMARTiView protein in SMART
SM00005. DEATH. 1 hit.
SM00218. ZU5. 1 hit.
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiView protein in PROSITE
PS50017. DEATH_DOMAIN. 1 hit.
PS51145. ZU5. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IV45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPQESSFQP SQFLLLVGVP VASVLLLAQC LRWHCPRRLL GACWTLNGQE
60 70 80 90 100
EPVSQPTPQL ENEVSRQHLP ATLPEMVAFY QELHTPTQGQ TMVRQLMHKL
110 120 130 140 150
LVFSAREVDH RGGCLMLQDT GISLLIPPGA VAVGRQERVS LILVWDLSDA
160 170 180 190 200
PSLSQAQGLV SPVVACGPHG ASFLKPCTLT FKHCAEQPSH ARTYSSNTTL
210 220 230 240 250
LDAKVWRPLG RPGAHASRDE CRIHLSHFSL YTCVLEAPVG REARKWLQLA
260 270 280 290 300
VFCSPLVPGQ SHLQLRIYFL NNTPCALQWA LTNEQPHGGR LRGPCQLFDF
310 320 330 340 350
NGARGDQCLK LTYISEGWEN VDDSSCQLVP HLHIWHGKCP FRSFCFRRKA
360 370 380 390 400
ADENEDCSAL TNEIIVTMHT FQDGLETKYM EILRFQASEE ESWAAPPPVS
410 420 430 440 450
QPPPCNRLPP ELFEQLRMLL EPNSITGNDW RRLASHLGLC GMKIRFLSCQ
460 470 480 490 500
RSPAAAILEL FEEQNGSLQE LHYLMTVMER LDCASAIQNY LSGTHGGSPG
510
PERGGARDNQ GLELDEKL
Length:518
Mass (Da):57,818
Last modified:November 13, 2007 - v2
Checksum:iA90218B4453E0937
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036979432R → G2 PublicationsCorresponds to variant dbSNP:rs742493Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY510109 mRNA. Translation: AAS80165.1.
AL031778 Genomic DNA. No translation available.
CH471081 Genomic DNA. Translation: EAX04007.1.
BC035284 mRNA. Translation: AAH35284.1.
CCDSiCCDS4847.1.
RefSeqiNP_775832.2. NM_173561.2.
UniGeneiHs.158357.

Genome annotation databases

EnsembliENST00000244565; ENSP00000244565; ENSG00000124602.
ENST00000373164; ENSP00000362258; ENSG00000124602.
GeneIDi222643.
KEGGihsa:222643.
UCSCiuc003opi.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiUN5CL_HUMAN
AccessioniPrimary (citable) accession number: Q8IV45
Secondary accession number(s): Q5TGU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 22, 2017
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families