Reviewed, UniProtKB/Swiss-Prot Q8IV38 (ANKY2_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin repeat and MYND domain-containing protein 2

Gene names

Name:

ANKMY2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	441 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Contains 3 ANK repeats. Contains 1 MYND-type zinc finger.

Ontologies

Keywords
Domain	ANK repeat Repeat Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 441	441	Ankyrin repeat and MYND domain-containing protein 2		PRO_0000247166
Regions
	Repeat	45 – 74	30	ANK 1
	Repeat	79 – 108	30	ANK 2
	Repeat	159 – 188	30	ANK 3
	Zinc finger	320 – 357	38	MYND-type

Sequences

	Sequence		Length	Mass (Da)
	Q8IV38-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: E9A5E1B9ABCBA4A6	FASTA	441	49,299
	10 20 30 40 50 60 MVHIKKGELT QEEKELLEVI GKGTVQEAGT LLSSKNVRVN CLDENGMTPL MHAAYKGKLD 70 80 90 100 110 120 MCKLLLRHGA DVNCHQHEHG YTALMFAALS GNKDITWVML EAGAETDVVN SVGRTAAQMA 130 140 150 160 170 180 AFVGQHDCVT IINNFFPRER LDYYTKPQGL DKEPKLPPKL AGPLHKIITT TNLHPVKIVM 190 200 210 220 230 240 LVNENPLLTE EAALNKCYRV MDLICEKCMK QRDMNEVLAM KMHYISCIFQ KCINFLKDGE 250 260 270 280 290 300 NKLDTLIKSL LKGRASDGFP VYQEKIIRES IRKFPYCEAT LLQQLVRSIA PVEIGSDPTA 310 320 330 340 350 360 FSVLTQAITG QVGFVDVEFC TTCGEKGASK RCSVCKMVIY CDQTCQKTHW FTHKKICKNL 370 380 390 400 410 420 KDIYEKQQLE AAKEKRQEEN HGKLDVNSNC VNEEQPEAEV GISQKDSNPE DSGEGKKESL 430 440 ESEAELEGLQ DAPAGPQVSE E

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon and Prostate.
[2]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC015453 mRNA. Translation: AAH15453.1. BC035353 mRNA. Translation: AAH35353.1.
IPI	IPI00216856.
RefSeq	NP_064715.1.
UniGene	Hs.157378
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q8IV38.
Genome annotation databases
Ensembl	ENST00000306999; ENSP00000303570; ENSG00000106524; Homo sapiens. [Genome view]
GeneID	57037.
KEGG	hsa:57037.
UCSC	uc003sti.1. human.
Organism-specific databases
CTD	57037.
GeneCards	GC07M016606.
HGNC	HGNC:25370. ANKMY2.
PharmGKB	PA134893861.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8IV38.
OMA	MLINENP
OrthoDB	EOG94BDN7
Gene expression databases
ArrayExpress	Q8IV38.
Bgee	Q8IV38.
CleanEx	HS_ANKMY2.
Genevestigator	Q8IV38.
GermOnline	ENSG00000106524. Homo sapiens.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR002893. Znf_MYND. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00023. Ank. 2 hits. PF01753. zf-MYND. 1 hit. [Graphical view]
SMART	SM00248. ANK. 3 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. PS01360. ZF_MYND_1. 1 hit. PS50865. ZF_MYND_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	62789.

Entry information

Entry name

ANKY2_HUMAN

Accession

Primary (citable) accession number: Q8IV38
Secondary accession number(s): Q96BL3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	March 1, 2003
Last modified:	November 24, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.