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Protein

Ankyrin repeat and MYND domain-containing protein 2

Gene

ANKMY2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the trafficking of signaling proteins to the cilia.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri320 – 35738MYND-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and MYND domain-containing protein 2
Gene namesi
Name:ANKMY2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:25370. ANKMY2.

Subcellular locationi

GO - Cellular componenti

  • cilium Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134893861.

Polymorphism and mutation databases

BioMutaiANKMY2.
DMDMi74750650.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 441441Ankyrin repeat and MYND domain-containing protein 2PRO_0000247166Add
BLAST

Proteomic databases

EPDiQ8IV38.
MaxQBiQ8IV38.
PaxDbiQ8IV38.
PRIDEiQ8IV38.

PTM databases

iPTMnetiQ8IV38.
PhosphoSiteiQ8IV38.

Expressioni

Gene expression databases

BgeeiQ8IV38.
CleanExiHS_ANKMY2.
ExpressionAtlasiQ8IV38. baseline and differential.
GenevisibleiQ8IV38. HS.

Organism-specific databases

HPAiHPA044900.
HPA050447.

Interactioni

Subunit structurei

Interacts with the retinal-specific guanylyl cyclase GC1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
TINF2Q9BSI42EBI-9393876,EBI-717399

Protein-protein interaction databases

BioGridi121333. 38 interactions.
IntActiQ8IV38. 6 interactions.
MINTiMINT-4711857.
STRINGi9606.ENSP00000303570.

Structurei

3D structure databases

ProteinModelPortaliQ8IV38.
SMRiQ8IV38. Positions 9-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati45 – 7430ANK 1Add
BLAST
Repeati79 – 10830ANK 2Add
BLAST
Repeati159 – 18830ANK 3Add
BLAST

Sequence similaritiesi

Contains 3 ANK repeats.PROSITE-ProRule annotation
Contains 1 MYND-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri320 – 35738MYND-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1710. Eukaryota.
ENOG410XPNY. LUCA.
GeneTreeiENSGT00390000016820.
HOGENOMiHOG000252933.
HOVERGENiHBG060001.
InParanoidiQ8IV38.
OMAiHWFMHKK.
OrthoDBiEOG7SXW39.
PhylomeDBiQ8IV38.
TreeFamiTF351374.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IV38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHIKKGELT QEEKELLEVI GKGTVQEAGT LLSSKNVRVN CLDENGMTPL
60 70 80 90 100
MHAAYKGKLD MCKLLLRHGA DVNCHQHEHG YTALMFAALS GNKDITWVML
110 120 130 140 150
EAGAETDVVN SVGRTAAQMA AFVGQHDCVT IINNFFPRER LDYYTKPQGL
160 170 180 190 200
DKEPKLPPKL AGPLHKIITT TNLHPVKIVM LVNENPLLTE EAALNKCYRV
210 220 230 240 250
MDLICEKCMK QRDMNEVLAM KMHYISCIFQ KCINFLKDGE NKLDTLIKSL
260 270 280 290 300
LKGRASDGFP VYQEKIIRES IRKFPYCEAT LLQQLVRSIA PVEIGSDPTA
310 320 330 340 350
FSVLTQAITG QVGFVDVEFC TTCGEKGASK RCSVCKMVIY CDQTCQKTHW
360 370 380 390 400
FTHKKICKNL KDIYEKQQLE AAKEKRQEEN HGKLDVNSNC VNEEQPEAEV
410 420 430 440
GISQKDSNPE DSGEGKKESL ESEAELEGLQ DAPAGPQVSE E
Length:441
Mass (Da):49,299
Last modified:March 1, 2003 - v1
Checksum:iE9A5E1B9ABCBA4A6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti273 – 2731K → KISLLMAFQCIKKRSLEKVS EK in CAH56419 (PubMed:17974005).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL050390 mRNA. Translation: CAH56419.1.
CH236948 Genomic DNA. Translation: EAL24286.1.
CH471073 Genomic DNA. Translation: EAW93672.1.
BC015453 mRNA. Translation: AAH15453.1.
BC035353 mRNA. Translation: AAH35353.1.
CCDSiCCDS5361.1.
RefSeqiNP_064715.1. NM_020319.2.
UniGeneiHs.157378.

Genome annotation databases

EnsembliENST00000306999; ENSP00000303570; ENSG00000106524.
GeneIDi57037.
KEGGihsa:57037.
UCSCiuc003sti.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL050390 mRNA. Translation: CAH56419.1.
CH236948 Genomic DNA. Translation: EAL24286.1.
CH471073 Genomic DNA. Translation: EAW93672.1.
BC015453 mRNA. Translation: AAH15453.1.
BC035353 mRNA. Translation: AAH35353.1.
CCDSiCCDS5361.1.
RefSeqiNP_064715.1. NM_020319.2.
UniGeneiHs.157378.

3D structure databases

ProteinModelPortaliQ8IV38.
SMRiQ8IV38. Positions 9-161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121333. 38 interactions.
IntActiQ8IV38. 6 interactions.
MINTiMINT-4711857.
STRINGi9606.ENSP00000303570.

PTM databases

iPTMnetiQ8IV38.
PhosphoSiteiQ8IV38.

Polymorphism and mutation databases

BioMutaiANKMY2.
DMDMi74750650.

Proteomic databases

EPDiQ8IV38.
MaxQBiQ8IV38.
PaxDbiQ8IV38.
PRIDEiQ8IV38.

Protocols and materials databases

DNASUi57037.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306999; ENSP00000303570; ENSG00000106524.
GeneIDi57037.
KEGGihsa:57037.
UCSCiuc003sti.3. human.

Organism-specific databases

CTDi57037.
GeneCardsiANKMY2.
HGNCiHGNC:25370. ANKMY2.
HPAiHPA044900.
HPA050447.
neXtProtiNX_Q8IV38.
PharmGKBiPA134893861.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1710. Eukaryota.
ENOG410XPNY. LUCA.
GeneTreeiENSGT00390000016820.
HOGENOMiHOG000252933.
HOVERGENiHBG060001.
InParanoidiQ8IV38.
OMAiHWFMHKK.
OrthoDBiEOG7SXW39.
PhylomeDBiQ8IV38.
TreeFamiTF351374.

Miscellaneous databases

GenomeRNAii57037.
PROiQ8IV38.

Gene expression databases

BgeeiQ8IV38.
CleanExiHS_ANKMY2.
ExpressionAtlasiQ8IV38. baseline and differential.
GenevisibleiQ8IV38. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Prostate.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiANKY2_HUMAN
AccessioniPrimary (citable) accession number: Q8IV38
Secondary accession number(s): A4D124, Q659G1, Q96BL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.