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Protein

Protein HID1

Gene

HID1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in the development of cancers in a broad range of tissues.1 Publication

GO - Biological processi

  • intracellular protein transport Source: UniProtKB
  • response to brefeldin A Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HID1
Alternative name(s):
Down-regulated in multiple cancers 1
HID1 domain-containing protein
Protein hid-1 homolog
Gene namesi
Name:HID1
Synonyms:C17orf28, DMC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:15736. HID1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytoplasmic microtubule Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extrinsic component of Golgi membrane Source: UniProtKB
  • Golgi apparatus Source: HPA
  • Golgi medial cisterna Source: UniProtKB
  • Golgi trans cisterna Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi283987.
OpenTargetsiENSG00000167861.
PharmGKBiPA25583.

Polymorphism and mutation databases

BioMutaiHID1.
DMDMi68565199.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000792962 – 788Protein HID1Add BLAST787

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei653PhosphoserineCombined sources1
Modified residuei670PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

MaxQBiQ8IV36.
PaxDbiQ8IV36.
PeptideAtlasiQ8IV36.
PRIDEiQ8IV36.

PTM databases

iPTMnetiQ8IV36.
PhosphoSitePlusiQ8IV36.

Expressioni

Tissue specificityi

Expressed in heart, skeletal muscle, colon, spleen, kidney, liver, small intestine and lung. Highest expression is seen in brain and placenta. Loss of expression is seen in some breast, cervical, hepatocellular, lung, thyroid, gastric and renal cell-cancer lines. Highly expressed in secretory cell lines.2 Publications

Gene expression databases

BgeeiENSG00000167861.
CleanExiHS_C17orf28.
HS_DMC1.
ExpressionAtlasiQ8IV36. baseline and differential.
GenevisibleiQ8IV36. HS.

Organism-specific databases

HPAiHPA023095.
HPA031406.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CSDE1O755343EBI-743438,EBI-719186
INPPL1O153572EBI-743438,EBI-1384248

Protein-protein interaction databases

BioGridi129720. 7 interactors.
IntActiQ8IV36. 9 interactors.
STRINGi9606.ENSP00000413520.

Structurei

3D structure databases

ProteinModelPortaliQ8IV36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hid-1 family.Curated

Phylogenomic databases

eggNOGiKOG2226. Eukaryota.
ENOG410XPB2. LUCA.
GeneTreeiENSGT00390000003070.
HOGENOMiHOG000231062.
HOVERGENiHBG061276.
InParanoidiQ8IV36.
OMAiITVFHKI.
OrthoDBiEOG091G02BK.
PhylomeDBiQ8IV36.
TreeFamiTF314291.

Family and domain databases

InterProiIPR026705. Hid-1/Ecm30.
[Graphical view]
PANTHERiPTHR21575. PTHR21575. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IV36-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSTDSKLNF RKAVIQLTTK TQPVEATDDA FWDQFWADTA TSVQDVFALV
60 70 80 90 100
PAAEIRAVRE ESPSNLATLC YKAVEKLVQG AESGCHSEKE KQIVLNCSRL
110 120 130 140 150
LTRVLPYIFE DPDWRGFFWS TVPGAGRGGQ GEEDDEHARP LAESLLLAIA
160 170 180 190 200
DLLFCPDFTV QSHRRSTVDS AEDVHSLDSC EYIWEAGVGF AHSPQPNYIH
210 220 230 240 250
DMNRMELLKL LLTCFSEAMY LPPAPESGST NPWVQFFCST ENRHALPLFT
260 270 280 290 300
SLLNTVCAYD PVGYGIPYNH LLFSDYREPL VEEAAQVLIV TLDHDSASSA
310 320 330 340 350
SPTVDGTTTG TAMDDADPPG PENLFVNYLS RIHREEDFQF ILKGIARLLS
360 370 380 390 400
NPLLQTYLPN STKKIQFHQE LLVLFWKLCD FNKKFLFFVL KSSDVLDILV
410 420 430 440 450
PILFFLNDAR ADQSRVGLMH IGVFILLLLS GERNFGVRLN KPYSIRVPMD
460 470 480 490 500
IPVFTGTHAD LLIVVFHKII TSGHQRLQPL FDCLLTIVVN VSPYLKSLSM
510 520 530 540 550
VTANKLLHLL EAFSTTWFLF SAAQNHHLVF FLLEVFNNII QYQFDGNSNL
560 570 580 590 600
VYAIIRKRSI FHQLANLPTD PPTIHKALQR RRRTPEPLSR TGSQEGTSME
610 620 630 640 650
GSRPAAPAEP GTLKTSLVAT PGIDKLTEKS QVSEDGTLRS LEPEPQQSLE
660 670 680 690 700
DGSPAKGEPS QAWREQRRPS TSSASGQWSP TPEWVLSWKS KLPLQTIMRL
710 720 730 740 750
LQVLVPQVEK ICIDKGLTDE SEILRFLQHG TLVGLLPVPH PILIRKYQAN
760 770 780
SGTAMWFRTY MWGVIYLRNV DPPVWYDTDV KLFEIQRV
Length:788
Mass (Da):88,745
Last modified:March 1, 2003 - v1
Checksum:i52BE7F0ACC9BE0E3
GO
Isoform 2 (identifier: Q8IV36-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-130: Missing.

Note: No experimental confirmation available.
Show »
Length:787
Mass (Da):88,616
Checksum:i90179F69FD5C7DAF
GO
Isoform 3 (identifier: Q8IV36-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-257: Missing.

Show »
Length:560
Mass (Da):63,245
Checksum:iA68AD1F3317D6DA2
GO

Sequence cautioni

The sequence BAB85070 differs from that shown. Reason: Frameshift at position 594.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti352P → L in CAB70810 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01447230 – 257Missing in isoform 3. 1 PublicationAdd BLAST228
Alternative sequenceiVSP_014473130Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074401 mRNA. Translation: BAB85070.1. Frameshift.
BC032219 mRNA. Translation: AAH32219.2.
BC035372 mRNA. Translation: AAH35372.1.
AL137556 mRNA. Translation: CAB70810.2.
CCDSiCCDS32726.1. [Q8IV36-1]
PIRiT46395.
RefSeqiNP_085133.1. NM_030630.2. [Q8IV36-1]
XP_005257283.1. XM_005257226.1. [Q8IV36-2]
UniGeneiHs.11067.

Genome annotation databases

EnsembliENST00000425042; ENSP00000413520; ENSG00000167861. [Q8IV36-1]
GeneIDi283987.
KEGGihsa:283987.
UCSCiuc002jmj.5. human. [Q8IV36-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074401 mRNA. Translation: BAB85070.1. Frameshift.
BC032219 mRNA. Translation: AAH32219.2.
BC035372 mRNA. Translation: AAH35372.1.
AL137556 mRNA. Translation: CAB70810.2.
CCDSiCCDS32726.1. [Q8IV36-1]
PIRiT46395.
RefSeqiNP_085133.1. NM_030630.2. [Q8IV36-1]
XP_005257283.1. XM_005257226.1. [Q8IV36-2]
UniGeneiHs.11067.

3D structure databases

ProteinModelPortaliQ8IV36.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129720. 7 interactors.
IntActiQ8IV36. 9 interactors.
STRINGi9606.ENSP00000413520.

PTM databases

iPTMnetiQ8IV36.
PhosphoSitePlusiQ8IV36.

Polymorphism and mutation databases

BioMutaiHID1.
DMDMi68565199.

Proteomic databases

MaxQBiQ8IV36.
PaxDbiQ8IV36.
PeptideAtlasiQ8IV36.
PRIDEiQ8IV36.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000425042; ENSP00000413520; ENSG00000167861. [Q8IV36-1]
GeneIDi283987.
KEGGihsa:283987.
UCSCiuc002jmj.5. human. [Q8IV36-1]

Organism-specific databases

CTDi283987.
DisGeNETi283987.
GeneCardsiHID1.
H-InvDBHIX0022256.
HGNCiHGNC:15736. HID1.
HPAiHPA023095.
HPA031406.
MIMi605752. gene.
neXtProtiNX_Q8IV36.
OpenTargetsiENSG00000167861.
PharmGKBiPA25583.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2226. Eukaryota.
ENOG410XPB2. LUCA.
GeneTreeiENSGT00390000003070.
HOGENOMiHOG000231062.
HOVERGENiHBG061276.
InParanoidiQ8IV36.
OMAiITVFHKI.
OrthoDBiEOG091G02BK.
PhylomeDBiQ8IV36.
TreeFamiTF314291.

Miscellaneous databases

GenomeRNAii283987.
PROiQ8IV36.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167861.
CleanExiHS_C17orf28.
HS_DMC1.
ExpressionAtlasiQ8IV36. baseline and differential.
GenevisibleiQ8IV36. HS.

Family and domain databases

InterProiIPR026705. Hid-1/Ecm30.
[Graphical view]
PANTHERiPTHR21575. PTHR21575. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHID1_HUMAN
AccessioniPrimary (citable) accession number: Q8IV36
Secondary accession number(s): Q8N5L6, Q8TE83, Q9NT34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.