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Protein

WD repeat-containing protein 49

Gene

WDR49

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ8IV35.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 49
Gene namesi
Name:WDR49
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:26587. WDR49.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134949512.

Polymorphism and mutation databases

BioMutaiWDR49.
DMDMi74762474.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 697697WD repeat-containing protein 49PRO_0000252428Add
BLAST

Proteomic databases

PaxDbiQ8IV35.
PRIDEiQ8IV35.

PTM databases

iPTMnetiQ8IV35.
PhosphoSiteiQ8IV35.

Expressioni

Gene expression databases

BgeeiQ8IV35.
CleanExiHS_WDR49.
ExpressionAtlasiQ8IV35. baseline and differential.
GenevisibleiQ8IV35. HS.

Organism-specific databases

HPAiHPA036225.

Interactioni

Protein-protein interaction databases

BioGridi127402. 1 interaction.
STRINGi9606.ENSP00000311343.

Structurei

3D structure databases

ProteinModelPortaliQ8IV35.
SMRiQ8IV35. Positions 30-448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati17 – 5640WD 1Add
BLAST
Repeati60 – 9940WD 2Add
BLAST
Repeati146 – 18742WD 3Add
BLAST
Repeati190 – 22940WD 4Add
BLAST
Repeati281 – 31939WD 5Add
BLAST
Repeati367 – 41448WD 6Add
BLAST
Repeati417 – 45741WD 7Add
BLAST
Repeati473 – 51442WD 8Add
BLAST

Sequence similaritiesi

Contains 8 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IE3U. Eukaryota.
ENOG410XTEG. LUCA.
GeneTreeiENSGT00530000063510.
HOGENOMiHOG000154848.
HOVERGENiHBG094159.
InParanoidiQ8IV35.
OMAiKYKERNI.
OrthoDBiEOG7992Q4.
PhylomeDBiQ8IV35.
TreeFamiTF324700.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 4 hits.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IV35-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWREKSKKR LNMTSFNIAQ GIHAFDYHSR LNLIATAGIN NKVCLWNPYV
60 70 80 90 100
VSKPVGVLWG HSASVIAVQF FVERKQLFSF SKDKVLRLWD IQHQLSIQRI
110 120 130 140 150
ACSFPKSQDF RCLFHFDEAH GRLFISFNNQ LALLAMKSEA SKRVKSHEKA
160 170 180 190 200
VTCVLYNSIL KQVISSDTGS TVSFWMIDTG QKIKQFTGCH GNAEISTMAL
210 220 230 240 250
DANETRLLTG STDGTVKIWD FNGYCHHTLN VGQDGAVDIS QILILKKKIL
260 270 280 290 300
VTGWERAITV FRPQNFNQFF IQPEEWKGGI QHHDDILCAA FLPPQTLVTG
310 320 330 340 350
SYDGEIVLWN NSTENAHHVL HPDYQRLLKS KLDTKPQKLL SAGRSQPSHP
360 370 380 390 400
MADHSTTGVR NFEIDTEGKN AVMRLCFLKA RKNTAVTGGA NLVSCGGSGY
410 420 430 440 450
VRFWDIYKKQ LLAEFLAHSG VGSIIMSTDK MNRYLTTGDL DGWLKIWNIE
460 470 480 490 500
EYCLNSSKNK ITKAPTLIRS FQPHEDRISS LEMCEPGGQL LIISSSADCS
510 520 530 540 550
ICVTGVCNAP VWIFGQAKHW HIENCLFLPK RDTNLVESEI QKEISLFSKE
560 570 580 590 600
ESCLDPTEHS LLNKKNKDDS TYNVRPSEDI NLDIKYKERS TCMKETQKPY
610 620 630 640 650
YGEVIKKSFS TFRSLNIGAL EELPEVNKPA FLLDPEKYFR KEPEEERPQI
660 670 680 690
LEAPSLFKTL KAVFDEKNLF PKEILHHERK AKQLCQEKSC EVKKNKK
Length:697
Mass (Da):79,295
Last modified:March 1, 2003 - v1
Checksum:i26B69950D315FF73
GO
Isoform 2 (identifier: Q8IV35-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.

Note: No experimental confirmation available.
Show »
Length:522
Mass (Da):59,231
Checksum:iC31E7B4E295E81DE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101R → H in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035889
Natural varianti651 – 6511L → P.
Corresponds to variant rs13060964 [ dbSNP | Ensembl ].
VAR_027858

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 175175Missing in isoform 2. 1 PublicationVSP_020962Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090939 mRNA. Translation: BAC03552.1.
BC035512 mRNA. Translation: AAH35512.1.
CCDSiCCDS3201.1. [Q8IV35-1]
RefSeqiNP_849146.1. NM_178824.3. [Q8IV35-1]
UniGeneiHs.213762.

Genome annotation databases

EnsembliENST00000308378; ENSP00000311343; ENSG00000174776. [Q8IV35-1]
GeneIDi151790.
KEGGihsa:151790.
UCSCiuc003feu.2. human. [Q8IV35-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090939 mRNA. Translation: BAC03552.1.
BC035512 mRNA. Translation: AAH35512.1.
CCDSiCCDS3201.1. [Q8IV35-1]
RefSeqiNP_849146.1. NM_178824.3. [Q8IV35-1]
UniGeneiHs.213762.

3D structure databases

ProteinModelPortaliQ8IV35.
SMRiQ8IV35. Positions 30-448.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127402. 1 interaction.
STRINGi9606.ENSP00000311343.

PTM databases

iPTMnetiQ8IV35.
PhosphoSiteiQ8IV35.

Polymorphism and mutation databases

BioMutaiWDR49.
DMDMi74762474.

Proteomic databases

PaxDbiQ8IV35.
PRIDEiQ8IV35.

Protocols and materials databases

DNASUi151790.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308378; ENSP00000311343; ENSG00000174776. [Q8IV35-1]
GeneIDi151790.
KEGGihsa:151790.
UCSCiuc003feu.2. human. [Q8IV35-1]

Organism-specific databases

CTDi151790.
GeneCardsiWDR49.
HGNCiHGNC:26587. WDR49.
HPAiHPA036225.
neXtProtiNX_Q8IV35.
PharmGKBiPA134949512.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE3U. Eukaryota.
ENOG410XTEG. LUCA.
GeneTreeiENSGT00530000063510.
HOGENOMiHOG000154848.
HOVERGENiHBG094159.
InParanoidiQ8IV35.
OMAiKYKERNI.
OrthoDBiEOG7992Q4.
PhylomeDBiQ8IV35.
TreeFamiTF324700.

Enzyme and pathway databases

SignaLinkiQ8IV35.

Miscellaneous databases

GenomeRNAii151790.
PROiQ8IV35.

Gene expression databases

BgeeiQ8IV35.
CleanExiHS_WDR49.
ExpressionAtlasiQ8IV35. baseline and differential.
GenevisibleiQ8IV35. HS.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 4 hits.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Amygdala.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-10.

Entry informationi

Entry nameiWDR49_HUMAN
AccessioniPrimary (citable) accession number: Q8IV35
Secondary accession number(s): Q8N297
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.