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Q8IV32

- CCD71_HUMAN

UniProt

Q8IV32 - CCD71_HUMAN

Protein

Coiled-coil domain-containing protein 71

Gene

CCDC71

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 3 (11 Jan 2011)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coiled-coil domain-containing protein 71
    Gene namesi
    Name:CCDC71
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:25760. CCDC71.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485422.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 467467Coiled-coil domain-containing protein 71PRO_0000234421Add
    BLAST

    Proteomic databases

    MaxQBiQ8IV32.
    PaxDbiQ8IV32.
    PRIDEiQ8IV32.

    PTM databases

    PhosphoSiteiQ8IV32.

    Expressioni

    Gene expression databases

    BgeeiQ8IV32.
    CleanExiHS_CCDC71.
    GenevestigatoriQ8IV32.

    Organism-specific databases

    HPAiHPA047547.

    Interactioni

    Protein-protein interaction databases

    BioGridi122347. 4 interactions.
    STRINGi9606.ENSP00000319006.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IV32.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili279 – 35981Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG45674.
    HOGENOMiHOG000111433.
    HOVERGENiHBG061228.
    InParanoidiQ8IV32.
    OMAiSPVIRLQ.
    OrthoDBiEOG7B05DF.
    PhylomeDBiQ8IV32.
    TreeFamiTF336191.

    Family and domain databases

    InterProiIPR026695. Ccdc71/71L.
    [Graphical view]
    PANTHERiPTHR14484. PTHR14484. 1 hit.
    PfamiPF15374. CCDC71L. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8IV32-1 [UniParc]FASTAAdd to Basket

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    MSVVVQHVEE KAVHSWSRIS TAGKKALEEA LLVFNPMSQD LSATEAQLVA    50
    FLQGLRDDGF QPTILRSGDV YGYSSCTANP PSQTKLQARA PNPTATSPPA 100
    SAPRTAMRLP AGRATLLPMP LSGRLAKAST PALAKHATTN LLLSSLKQSS 150
    ASHARGAAVG FPTHLYPGVY PAMRLSVVLE ALVPLKTPMP CLGAKHKAQS 200
    LQLSLADSPL KLRKSSGKGP GNPRPKAPRK TTSKGPKCLT RKGPGAGPRR 250
    GSGHQSKTNR ATGSPSVRRM KGGSALGTKT AQAKVARTLA KAARAQAKVA 300
    RTQAKAAKAR AKAKAAQVKA KAKAKAAQVK AKAKVMAAWA KAKAKAKAVR 350
    AKAKVARTQP RGRGRPKGSA KARTTRKGQK NRPETVGQKR KRAEEAKDLP 400
    PKKRTRLGPR SPKAWLGPGT AKLLKFRAIK VDRRSSDDEV RQRAQRILRV 450
    NLSPVIRLQP LLPYSAV 467
    Length:467
    Mass (Da):49,648
    Last modified:January 11, 2011 - v3
    Checksum:i287B1BF4CF30B1A1
    GO

    Sequence cautioni

    The sequence BAB14642.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti317 – 3171Q → L.2 Publications
    Corresponds to variant rs4955419 [ dbSNP | Ensembl ].
    VAR_026236
    Natural varianti339 – 3391W → R.2 Publications
    Corresponds to variant rs4955418 [ dbSNP | Ensembl ].
    VAR_026237

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022862 mRNA. Translation: BAB14278.1.
    AK023691 mRNA. Translation: BAB14642.1. Different initiation.
    AC135506 Genomic DNA. No translation available.
    BC035516 mRNA. Translation: AAH35516.1.
    BC071960 mRNA. Translation: AAH71960.1.
    CCDSiCCDS2790.1.
    RefSeqiNP_075054.3. NM_022903.3.
    UniGeneiHs.211472.

    Genome annotation databases

    EnsembliENST00000321895; ENSP00000319006; ENSG00000177352.
    GeneIDi64925.
    KEGGihsa:64925.
    UCSCiuc003cwg.4. human.

    Polymorphism databases

    DMDMi317373459.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022862 mRNA. Translation: BAB14278.1 .
    AK023691 mRNA. Translation: BAB14642.1 . Different initiation.
    AC135506 Genomic DNA. No translation available.
    BC035516 mRNA. Translation: AAH35516.1 .
    BC071960 mRNA. Translation: AAH71960.1 .
    CCDSi CCDS2790.1.
    RefSeqi NP_075054.3. NM_022903.3.
    UniGenei Hs.211472.

    3D structure databases

    ProteinModelPortali Q8IV32.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122347. 4 interactions.
    STRINGi 9606.ENSP00000319006.

    PTM databases

    PhosphoSitei Q8IV32.

    Polymorphism databases

    DMDMi 317373459.

    Proteomic databases

    MaxQBi Q8IV32.
    PaxDbi Q8IV32.
    PRIDEi Q8IV32.

    Protocols and materials databases

    DNASUi 64925.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000321895 ; ENSP00000319006 ; ENSG00000177352 .
    GeneIDi 64925.
    KEGGi hsa:64925.
    UCSCi uc003cwg.4. human.

    Organism-specific databases

    CTDi 64925.
    GeneCardsi GC03M049199.
    HGNCi HGNC:25760. CCDC71.
    HPAi HPA047547.
    neXtProti NX_Q8IV32.
    PharmGKBi PA143485422.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45674.
    HOGENOMi HOG000111433.
    HOVERGENi HBG061228.
    InParanoidi Q8IV32.
    OMAi SPVIRLQ.
    OrthoDBi EOG7B05DF.
    PhylomeDBi Q8IV32.
    TreeFami TF336191.

    Miscellaneous databases

    ChiTaRSi CCDC71. human.
    GenomeRNAii 64925.
    NextBioi 67077.
    PROi Q8IV32.

    Gene expression databases

    Bgeei Q8IV32.
    CleanExi HS_CCDC71.
    Genevestigatori Q8IV32.

    Family and domain databases

    InterProi IPR026695. Ccdc71/71L.
    [Graphical view ]
    PANTHERi PTHR14484. PTHR14484. 1 hit.
    Pfami PF15374. CCDC71L. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-317 AND ARG-339.
      Tissue: Placenta.
    2. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-317 AND ARG-339.
      Tissue: Ovary and Pancreas.

    Entry informationi

    Entry nameiCCD71_HUMAN
    AccessioniPrimary (citable) accession number: Q8IV32
    Secondary accession number(s): Q6IPE2, Q9H8H4, Q9H9F1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 83 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3