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Q8IV32 (CCD71_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coiled-coil domain-containing protein 71
Gene names
Name:CCDC71
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length467 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence caution

The sequence BAB14642.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 467467Coiled-coil domain-containing protein 71
PRO_0000234421

Regions

Coiled coil279 – 35981 Potential

Natural variations

Natural variant3171Q → L. Ref.1 Ref.3
Corresponds to variant rs4955419 [ dbSNP | Ensembl ].
VAR_026236
Natural variant3391W → R. Ref.1 Ref.3
Corresponds to variant rs4955418 [ dbSNP | Ensembl ].
VAR_026237

Sequences

Sequence LengthMass (Da)Tools
Q8IV32 [UniParc].

Last modified January 11, 2011. Version 3.
Checksum: 287B1BF4CF30B1A1

FASTA46749,648
        10         20         30         40         50         60 
MSVVVQHVEE KAVHSWSRIS TAGKKALEEA LLVFNPMSQD LSATEAQLVA FLQGLRDDGF 

        70         80         90        100        110        120 
QPTILRSGDV YGYSSCTANP PSQTKLQARA PNPTATSPPA SAPRTAMRLP AGRATLLPMP 

       130        140        150        160        170        180 
LSGRLAKAST PALAKHATTN LLLSSLKQSS ASHARGAAVG FPTHLYPGVY PAMRLSVVLE 

       190        200        210        220        230        240 
ALVPLKTPMP CLGAKHKAQS LQLSLADSPL KLRKSSGKGP GNPRPKAPRK TTSKGPKCLT 

       250        260        270        280        290        300 
RKGPGAGPRR GSGHQSKTNR ATGSPSVRRM KGGSALGTKT AQAKVARTLA KAARAQAKVA 

       310        320        330        340        350        360 
RTQAKAAKAR AKAKAAQVKA KAKAKAAQVK AKAKVMAAWA KAKAKAKAVR AKAKVARTQP 

       370        380        390        400        410        420 
RGRGRPKGSA KARTTRKGQK NRPETVGQKR KRAEEAKDLP PKKRTRLGPR SPKAWLGPGT 

       430        440        450        460 
AKLLKFRAIK VDRRSSDDEV RQRAQRILRV NLSPVIRLQP LLPYSAV 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-317 AND ARG-339.
Tissue: Placenta.
[2]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-317 AND ARG-339.
Tissue: Ovary and Pancreas.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK022862 mRNA. Translation: BAB14278.1.
AK023691 mRNA. Translation: BAB14642.1. Different initiation.
AC135506 Genomic DNA. No translation available.
BC035516 mRNA. Translation: AAH35516.1.
BC071960 mRNA. Translation: AAH71960.1.
RefSeqNP_075054.3. NM_022903.3.
UniGeneHs.211472.

3D structure databases

ProteinModelPortalQ8IV32.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122347. 3 interactions.
STRING9606.ENSP00000319006.

PTM databases

PhosphoSiteQ8IV32.

Polymorphism databases

DMDM317373459.

Proteomic databases

PaxDbQ8IV32.
PRIDEQ8IV32.

Protocols and materials databases

DNASU64925.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000321895; ENSP00000319006; ENSG00000177352.
GeneID64925.
KEGGhsa:64925.
UCSCuc003cwg.4. human.

Organism-specific databases

CTD64925.
GeneCardsGC03M049199.
HGNCHGNC:25760. CCDC71.
HPAHPA047547.
neXtProtNX_Q8IV32.
PharmGKBPA143485422.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45674.
HOGENOMHOG000111433.
HOVERGENHBG061228.
InParanoidQ8IV32.
OMAAKVARTQ.
OrthoDBEOG7B05DF.
PhylomeDBQ8IV32.
TreeFamTF336191.

Gene expression databases

BgeeQ8IV32.
CleanExHS_CCDC71.
GenevestigatorQ8IV32.

Family and domain databases

InterProIPR026695. Ccdc71/71L.
[Graphical view]
PANTHERPTHR14484. PTHR14484. 1 hit.
PfamPF15374. CCDC71L. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCCDC71. human.
GenomeRNAi64925.
NextBio67077.
PROQ8IV32.

Entry information

Entry nameCCD71_HUMAN
AccessionPrimary (citable) accession number: Q8IV32
Secondary accession number(s): Q6IPE2, Q9H8H4, Q9H9F1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: January 11, 2011
Last modified: April 16, 2014
This is version 79 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM