Q8IV32 (CCD71_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Coiled-coil domain-containing protein 71

Gene names

Name:

CCDC71

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence caution

The sequence BAB14642.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 467	467	Coiled-coil domain-containing protein 71		PRO_0000234421
Regions
	Coiled coil	279 – 359	81	Potential
Natural variations
	Natural variant	317	1	Q → L. Ref.1 Ref.3 Corresponds to variant rs4955419 [ dbSNP | Ensembl ].		VAR_026236
	Natural variant	339	1	W → R. Ref.1 Ref.3 Corresponds to variant rs4955418 [ dbSNP | Ensembl ].		VAR_026237

Sequences

	Sequence		Length	Mass (Da)
	Q8IV32 [UniParc]. Last modified January 11, 2011. Version 3. Checksum: 287B1BF4CF30B1A1	FASTA	467	49,648
	10 20 30 40 50 60 MSVVVQHVEE KAVHSWSRIS TAGKKALEEA LLVFNPMSQD LSATEAQLVA FLQGLRDDGF 70 80 90 100 110 120 QPTILRSGDV YGYSSCTANP PSQTKLQARA PNPTATSPPA SAPRTAMRLP AGRATLLPMP 130 140 150 160 170 180 LSGRLAKAST PALAKHATTN LLLSSLKQSS ASHARGAAVG FPTHLYPGVY PAMRLSVVLE 190 200 210 220 230 240 ALVPLKTPMP CLGAKHKAQS LQLSLADSPL KLRKSSGKGP GNPRPKAPRK TTSKGPKCLT 250 260 270 280 290 300 RKGPGAGPRR GSGHQSKTNR ATGSPSVRRM KGGSALGTKT AQAKVARTLA KAARAQAKVA 310 320 330 340 350 360 RTQAKAAKAR AKAKAAQVKA KAKAKAAQVK AKAKVMAAWA KAKAKAKAVR AKAKVARTQP 370 380 390 400 410 420 RGRGRPKGSA KARTTRKGQK NRPETVGQKR KRAEEAKDLP PKKRTRLGPR SPKAWLGPGT 430 440 450 460 AKLLKFRAIK VDRRSSDDEV RQRAQRILRV NLSPVIRLQP LLPYSAV

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-317 AND ARG-339. Tissue: Placenta.
[2]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-317 AND ARG-339. Tissue: Ovary and Pancreas.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK022862 mRNA. Translation: BAB14278.1. AK023691 mRNA. Translation: BAB14642.1. Different initiation. AC135506 Genomic DNA. No translation available. BC035516 mRNA. Translation: AAH35516.1. BC071960 mRNA. Translation: AAH71960.1.
IPI	IPI00026233.
RefSeq	NP_075054.3. NM_022903.3.
UniGene	Hs.211472.
3D structure databases
ProteinModelPortal	Q8IV32.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000319006.
PTM databases
PhosphoSite	Q8IV32.
Polymorphism databases
DMDM	97046068.
Proteomic databases
PaxDb	Q8IV32.
PRIDE	Q8IV32.
Protocols and materials databases
DNASU	64925.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000321895; ENSP00000319006; ENSG00000177352.
GeneID	64925.
KEGG	hsa:64925.
UCSC	uc003cwg.4. human.
Organism-specific databases
CTD	64925.
GeneCards	GC03M049199.
HGNC	HGNC:25760. CCDC71.
HPA	HPA047547.
neXtProt	NX_Q8IV32.
PharmGKB	PA143485422.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45674.
HOGENOM	HOG000111433.
HOVERGEN	HBG061228.
InParanoid	Q8IV32.
OMA	AKVARTQ.
OrthoDB	EOG41RPVS.
PhylomeDB	Q8IV32.
Gene expression databases
Bgee	Q8IV32.
CleanEx	HS_CCDC71.
Genevestigator	Q8IV32.
GermOnline	ENSG00000177352. Homo sapiens.
Family and domain databases
InterPro	IPR026695. Ccdc71/71L. [Graphical view]
PANTHER	PTHR14484. PTHR14484. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	CCDC71. human.
GenomeRNAi	64925.
NextBio	67077.

Entry information

Entry name

CCD71_HUMAN

Accession

Primary (citable) accession number: Q8IV32
Secondary accession number(s): Q6IPE2, Q9H8H4, Q9H9F1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	January 11, 2011
Last modified:	April 3, 2013
This is version 72 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.