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Protein

Transmembrane protein 139

Gene

TMEM139

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in cellular trafficking of proteins such as SLC4A1.1 Publication

Protein family/group databases

TCDBi8.A.60.1.1. the transmembrane protein 139 (tmem139) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 139
Gene namesi
Name:TMEM139
ORF Names:UNQ1932/PRO4407
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22058. TMEM139.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 34ExtracellularSequence analysis9
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Topological domaini56 – 216CytoplasmicSequence analysisAdd BLAST161

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi135932.
OpenTargetsiENSG00000178826.
PharmGKBiPA144596260.

Polymorphism and mutation databases

BioMutaiTMEM139.
DMDMi74728027.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000028594826 – 216Transmembrane protein 139Add BLAST191

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei146PhosphoserineCombined sources1
Modified residuei155PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8IV31.
PeptideAtlasiQ8IV31.
PRIDEiQ8IV31.

PTM databases

iPTMnetiQ8IV31.
PhosphoSitePlusiQ8IV31.

Expressioni

Gene expression databases

BgeeiENSG00000178826.
CleanExiHS_TMEM139.
GenevisibleiQ8IV31. HS.

Organism-specific databases

HPAiHPA036982.
HPA036983.

Interactioni

Subunit structurei

Interacts with isoform 2 of SLC4A1 (PubMed:26049106).1 Publication

Protein-protein interaction databases

BioGridi126439. 3 interactors.
IntActiQ8IV31. 1 interactor.
MINTiMINT-1193541.
STRINGi9606.ENSP00000352284.

Structurei

3D structure databases

ProteinModelPortaliQ8IV31.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW7A. Eukaryota.
ENOG41116AZ. LUCA.
GeneTreeiENSGT00390000002723.
HOGENOMiHOG000059642.
HOVERGENiHBG070074.
InParanoidiQ8IV31.
OMAiESQCRPQ.
OrthoDBiEOG091G0UMO.
PhylomeDBiQ8IV31.
TreeFamiTF338466.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IV31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPMHLLGRL EKPLLLLCCA SFLLGLALLG IKTDITPVAY FFLTLGGFFL
60 70 80 90 100
FAYLLVRFLE WGLRSQLQSM QTESPGPSGN ARDNEAFEVP VYEEAVVGLE
110 120 130 140 150
SQCRPQELDQ PPPYSTVVIP PAPEEEQPSH PEGSRRAKLE QRRMASEGSM
160 170 180 190 200
AQEGSPGRAP INLRLRGPRA VSTAPDLQSL AAVPTLEPLT PPPAYDVCFG
210
HPDDDSVFYE DNWAPP
Length:216
Mass (Da):23,729
Last modified:March 1, 2003 - v1
Checksum:iDF5A7DB1E4126063
GO

Sequence cautioni

The sequence AAH16719 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti203D → G in BAD18786 (PubMed:14702039).Curated1
Sequence conflicti209Y → C in BAC11382 (PubMed:16303743).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358781 mRNA. Translation: AAQ89141.1.
AK172816 mRNA. Translation: BAD18786.1.
AK075067 mRNA. Translation: BAC11382.1.
AK315170 mRNA. Translation: BAG37612.1.
CH236959 Genomic DNA. Translation: EAL23784.1.
CH471198 Genomic DNA. Translation: EAW51871.1.
CH471198 Genomic DNA. Translation: EAW51873.1.
CH471198 Genomic DNA. Translation: EAW51875.1.
BC016719 mRNA. Translation: AAH16719.1. Different initiation.
BC035517 mRNA. Translation: AAH35517.1.
CCDSiCCDS5878.1.
RefSeqiNP_001229702.1. NM_001242773.2.
NP_001229703.1. NM_001242774.2.
NP_001229704.1. NM_001242775.2.
NP_001269805.1. NM_001282876.1.
NP_001269806.1. NM_001282877.1.
NP_699176.1. NM_153345.3.
UniGeneiHs.17558.
Hs.731832.

Genome annotation databases

EnsembliENST00000359333; ENSP00000352284; ENSG00000178826.
ENST00000409102; ENSP00000386879; ENSG00000178826.
ENST00000409244; ENSP00000386335; ENSG00000178826.
ENST00000409541; ENSP00000387044; ENSG00000178826.
ENST00000410004; ENSP00000386564; ENSG00000178826.
GeneIDi135932.
KEGGihsa:135932.
UCSCiuc003wck.6. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358781 mRNA. Translation: AAQ89141.1.
AK172816 mRNA. Translation: BAD18786.1.
AK075067 mRNA. Translation: BAC11382.1.
AK315170 mRNA. Translation: BAG37612.1.
CH236959 Genomic DNA. Translation: EAL23784.1.
CH471198 Genomic DNA. Translation: EAW51871.1.
CH471198 Genomic DNA. Translation: EAW51873.1.
CH471198 Genomic DNA. Translation: EAW51875.1.
BC016719 mRNA. Translation: AAH16719.1. Different initiation.
BC035517 mRNA. Translation: AAH35517.1.
CCDSiCCDS5878.1.
RefSeqiNP_001229702.1. NM_001242773.2.
NP_001229703.1. NM_001242774.2.
NP_001229704.1. NM_001242775.2.
NP_001269805.1. NM_001282876.1.
NP_001269806.1. NM_001282877.1.
NP_699176.1. NM_153345.3.
UniGeneiHs.17558.
Hs.731832.

3D structure databases

ProteinModelPortaliQ8IV31.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126439. 3 interactors.
IntActiQ8IV31. 1 interactor.
MINTiMINT-1193541.
STRINGi9606.ENSP00000352284.

Protein family/group databases

TCDBi8.A.60.1.1. the transmembrane protein 139 (tmem139) family.

PTM databases

iPTMnetiQ8IV31.
PhosphoSitePlusiQ8IV31.

Polymorphism and mutation databases

BioMutaiTMEM139.
DMDMi74728027.

Proteomic databases

PaxDbiQ8IV31.
PeptideAtlasiQ8IV31.
PRIDEiQ8IV31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359333; ENSP00000352284; ENSG00000178826.
ENST00000409102; ENSP00000386879; ENSG00000178826.
ENST00000409244; ENSP00000386335; ENSG00000178826.
ENST00000409541; ENSP00000387044; ENSG00000178826.
ENST00000410004; ENSP00000386564; ENSG00000178826.
GeneIDi135932.
KEGGihsa:135932.
UCSCiuc003wck.6. human.

Organism-specific databases

CTDi135932.
DisGeNETi135932.
GeneCardsiTMEM139.
HGNCiHGNC:22058. TMEM139.
HPAiHPA036982.
HPA036983.
MIMi616524. gene.
neXtProtiNX_Q8IV31.
OpenTargetsiENSG00000178826.
PharmGKBiPA144596260.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW7A. Eukaryota.
ENOG41116AZ. LUCA.
GeneTreeiENSGT00390000002723.
HOGENOMiHOG000059642.
HOVERGENiHBG070074.
InParanoidiQ8IV31.
OMAiESQCRPQ.
OrthoDBiEOG091G0UMO.
PhylomeDBiQ8IV31.
TreeFamiTF338466.

Miscellaneous databases

GenomeRNAii135932.
PROiQ8IV31.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178826.
CleanExiHS_TMEM139.
GenevisibleiQ8IV31. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiTM139_HUMAN
AccessioniPrimary (citable) accession number: Q8IV31
Secondary accession number(s): B2RCL5
, D3DXD4, Q6ZME2, Q8NC22, Q96AU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.