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Protein

Laccase domain-containing protein 1

Gene

LACC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Central regulator of the metabolic function and bioenergetic state of macrophages. In macrophages, promotes flux through de novo lipogenesis to concomitantly drive high levels of both fatty-acid oxidation and glycolysis.By similarity

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase domain-containing protein 1
Alternative name(s):
Fatty acid metabolism-immunity nexus1 Publication
Gene namesi
Name:LACC11 PublicationImported
Synonyms:C13orf31, FAMIN1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000179630.10.
HGNCiHGNC:26789. LACC1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Involvement in diseasei

Rheumatoid arthritis systemic juvenile (RASJ)1 Publication
The gene represented in this entry may be involved in disease pathogenesis.
Disease descriptionAn inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
See also OMIM:604302
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073274284C → R in RASJ; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs730880295Ensembl.1

Organism-specific databases

DisGeNETi144811.
MalaCardsiLACC1.
MIMi604302. phenotype.
OpenTargetsiENSG00000179630.
PharmGKBiPA147358522.

Polymorphism and mutation databases

BioMutaiLACC1.
DMDMi32171848.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001631871 – 430Laccase domain-containing protein 1Add BLAST430

Proteomic databases

EPDiQ8IV20.
MaxQBiQ8IV20.
PaxDbiQ8IV20.
PeptideAtlasiQ8IV20.
PRIDEiQ8IV20.

PTM databases

iPTMnetiQ8IV20.
PhosphoSitePlusiQ8IV20.

Expressioni

Gene expression databases

BgeeiENSG00000179630.
CleanExiHS_C13orf31.
ExpressionAtlasiQ8IV20. baseline and differential.
GenevisibleiQ8IV20. HS.

Organism-specific databases

HPAiCAB034228.
HPA040150.
HPA044211.

Interactioni

Subunit structurei

Interacts with FASN.1 Publication

Protein-protein interaction databases

BioGridi126879. 38 interactors.
STRINGi9606.ENSP00000317619.

Structurei

3D structure databases

ProteinModelPortaliQ8IV20.
SMRiQ8IV20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LACC1 family.Curated

Phylogenomic databases

eggNOGiENOG410IHUK. Eukaryota.
COG1496. LUCA.
GeneTreeiENSGT00390000000693.
HOGENOMiHOG000230933.
HOVERGENiHBG040925.
InParanoidiQ8IV20.
KOiK05810.
OMAiIPDIFIH.
OrthoDBiEOG091G06GG.
PhylomeDBiQ8IV20.
TreeFamiTF328389.

Family and domain databases

CDDicd16833. YfiH. 1 hit.
InterProiView protein in InterPro
IPR003730. Cu_polyphenol_OxRdtase.
IPR011324. Cytotoxic_necrot_fac-like_cat.
PANTHERiPTHR30616. PTHR30616. 1 hit.
PfamiView protein in Pfam
PF02578. Cu-oxidase_4. 1 hit.
SUPFAMiSSF64438. SSF64438. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IV20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAVLIDLF GLKLNSQKNC HQTLLKTLNA VQYHHAAKAK FLCIMCCSNI
60 70 80 90 100
SYERDGEQDN CEIETSNGLS ALLEEFEIVS CPSMAATLYT IKQKIDEKNL
110 120 130 140 150
SSIKVIVPRH RKTLMKAFID QLFTDVYNFE FEDLQVTFRG GLFKQSIEIN
160 170 180 190 200
VITAQELRGI QNEIETFLRS LPALRGKLTI ITSSLIPDIF IHGFTTRTGG
210 220 230 240 250
ISYIPTLSSF NLFSSSKRRD PKVVVQENLR RLANAAGFNV EKFYRIKTHH
260 270 280 290 300
SNDIWIMGRK EPDSYDGITT NQRGVTIAAL GADCIPIVFA DPVKKACGVA
310 320 330 340 350
HAGWKGTLLG VAMATVNAMI AEYGCSLEDI VVVLGPSVGP CCFTLPRESA
360 370 380 390 400
EAFHNLHPAC VQLFDSPNPC IDIRKATRIL LEQGGILPQN IQDQNQDLNL
410 420 430
CTSCHPDKFF SHVRDGLNFG TQIGFISIKE
Length:430
Mass (Da):47,780
Last modified:March 1, 2003 - v1
Checksum:i369324C4B4A685A4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052943254I → V Polymorphism; does not change interaction with FASN. 2 PublicationsCorresponds to variant dbSNP:rs3764147Ensembl.1
Natural variantiVAR_073274284C → R in RASJ; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs730880295Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096044 mRNA. Translation: BAC04686.1.
AL512506 Genomic DNA. No translation available.
CH471075 Genomic DNA. Translation: EAX08701.1.
BC035749 mRNA. Translation: AAH35749.1.
CCDSiCCDS9391.1.
RefSeqiNP_001121775.1. NM_001128303.1.
NP_694950.2. NM_153218.2.
XP_005266318.1. XM_005266261.3.
XP_006719829.1. XM_006719766.3.
XP_011533235.1. XM_011534933.2.
XP_011533236.1. XM_011534934.2.
XP_016875883.1. XM_017020394.1.
UniGeneiHs.210586.

Genome annotation databases

EnsembliENST00000325686; ENSP00000317619; ENSG00000179630.
ENST00000441843; ENSP00000391747; ENSG00000179630.
GeneIDi144811.
KEGGihsa:144811.
UCSCiuc001uzf.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLACC1_HUMAN
AccessioniPrimary (citable) accession number: Q8IV20
Secondary accession number(s): A2A3Z6, Q8N8X5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: March 1, 2003
Last modified: November 22, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries