Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Laccase domain-containing protein 1

Gene

LACC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Central regulator of the metabolic function and bioenergetic state of macrophages. In macrophages, promotes flux through de novo lipogenesis to concomitantly drive high levels of both fatty-acid oxidation and glycolysis.By similarity

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase domain-containing protein 1
Alternative name(s):
Fatty acid metabolism-immunity nexus1 Publication
Gene namesi
Name:LACC11 PublicationImported
Synonyms:C13orf31, FAMIN1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000179630.10
HGNCiHGNC:26789 LACC1
MIMi613409 gene
neXtProtiNX_Q8IV20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Involvement in diseasei

Rheumatoid arthritis systemic juvenile (RASJ)1 Publication
The gene represented in this entry may be involved in disease pathogenesis.
Disease descriptionAn inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
See also OMIM:604302
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073274284C → R in RASJ; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs730880295EnsemblClinVar.1

Organism-specific databases

DisGeNETi144811
MalaCardsiLACC1
MIMi604302 phenotype
OpenTargetsiENSG00000179630
PharmGKBiPA147358522

Polymorphism and mutation databases

BioMutaiLACC1
DMDMi32171848

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001631871 – 430Laccase domain-containing protein 1Add BLAST430

Proteomic databases

MaxQBiQ8IV20
PaxDbiQ8IV20
PeptideAtlasiQ8IV20
PRIDEiQ8IV20

PTM databases

iPTMnetiQ8IV20
PhosphoSitePlusiQ8IV20

Expressioni

Gene expression databases

BgeeiENSG00000179630
CleanExiHS_C13orf31
ExpressionAtlasiQ8IV20 baseline and differential
GenevisibleiQ8IV20 HS

Organism-specific databases

HPAiCAB034228
HPA040150
HPA044211

Interactioni

Subunit structurei

Interacts with FASN.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
FASNP493278EBI-12508070,EBI-356658

Protein-protein interaction databases

BioGridi126879, 38 interactors
IntActiQ8IV20, 34 interactors
STRINGi9606.ENSP00000317619

Structurei

3D structure databases

ProteinModelPortaliQ8IV20
SMRiQ8IV20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LACC1 family.Curated

Phylogenomic databases

eggNOGiENOG410IHUK Eukaryota
COG1496 LUCA
GeneTreeiENSGT00390000000693
HOGENOMiHOG000230933
HOVERGENiHBG040925
InParanoidiQ8IV20
KOiK05810
OMAiIPDIFIH
OrthoDBiEOG091G06GG
PhylomeDBiQ8IV20
TreeFamiTF328389

Family and domain databases

CDDicd16833 YfiH, 1 hit
Gene3Di3.60.140.10, 1 hit
InterProiView protein in InterPro
IPR003730 Cu_polyphenol_OxRdtase
IPR038371 Cu_polyphenol_OxRdtase_sf
IPR011324 Cytotoxic_necrot_fac-like_cat
PANTHERiPTHR30616 PTHR30616, 1 hit
PfamiView protein in Pfam
PF02578 Cu-oxidase_4, 1 hit
SUPFAMiSSF64438 SSF64438, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IV20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAVLIDLF GLKLNSQKNC HQTLLKTLNA VQYHHAAKAK FLCIMCCSNI
60 70 80 90 100
SYERDGEQDN CEIETSNGLS ALLEEFEIVS CPSMAATLYT IKQKIDEKNL
110 120 130 140 150
SSIKVIVPRH RKTLMKAFID QLFTDVYNFE FEDLQVTFRG GLFKQSIEIN
160 170 180 190 200
VITAQELRGI QNEIETFLRS LPALRGKLTI ITSSLIPDIF IHGFTTRTGG
210 220 230 240 250
ISYIPTLSSF NLFSSSKRRD PKVVVQENLR RLANAAGFNV EKFYRIKTHH
260 270 280 290 300
SNDIWIMGRK EPDSYDGITT NQRGVTIAAL GADCIPIVFA DPVKKACGVA
310 320 330 340 350
HAGWKGTLLG VAMATVNAMI AEYGCSLEDI VVVLGPSVGP CCFTLPRESA
360 370 380 390 400
EAFHNLHPAC VQLFDSPNPC IDIRKATRIL LEQGGILPQN IQDQNQDLNL
410 420 430
CTSCHPDKFF SHVRDGLNFG TQIGFISIKE
Length:430
Mass (Da):47,780
Last modified:March 1, 2003 - v1
Checksum:i369324C4B4A685A4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052943254I → V Polymorphism; does not change interaction with FASN. 2 PublicationsCorresponds to variant dbSNP:rs3764147Ensembl.1
Natural variantiVAR_073274284C → R in RASJ; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs730880295EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096044 mRNA Translation: BAC04686.1
AL512506 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08701.1
BC035749 mRNA Translation: AAH35749.1
CCDSiCCDS9391.1
RefSeqiNP_001121775.1, NM_001128303.1
NP_694950.2, NM_153218.2
XP_005266318.1, XM_005266261.3
XP_006719829.1, XM_006719766.3
XP_011533235.1, XM_011534933.2
XP_011533236.1, XM_011534934.2
XP_016875883.1, XM_017020394.1
UniGeneiHs.210586

Genome annotation databases

EnsembliENST00000325686; ENSP00000317619; ENSG00000179630
ENST00000441843; ENSP00000391747; ENSG00000179630
GeneIDi144811
KEGGihsa:144811
UCSCiuc001uzf.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLACC1_HUMAN
AccessioniPrimary (citable) accession number: Q8IV20
Secondary accession number(s): A2A3Z6, Q8N8X5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health