##gff-version 3 Q8IV16 UniProtKB Signal peptide 1 20 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8IV16 UniProtKB Chain 21 151 . . . ID=PRO_0000318208;Note=Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 Q8IV16 UniProtKB Propeptide 152 184 . . . ID=PRO_0000429858;Note=Removed in mature form;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8IV16 UniProtKB Domain 63 148 . . . Note=UPAR/Ly6 Q8IV16 UniProtKB Region 21 35 . . . Note=Disordered;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26725083;Dbxref=PMID:26725083 Q8IV16 UniProtKB Region 27 50 . . . Note=Important for LPL transport to the lumenal surface of endothelial cells;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9D1N2 Q8IV16 UniProtKB Region 103 109 . . . Note=Important for interaction with LPL;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:26725083,ECO:0000269|PubMed:30559189;Dbxref=PMID:26725083,PMID:30559189 Q8IV16 UniProtKB Compositional bias 24 50 . . . Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8IV16 UniProtKB Modified residue 38 38 . . . Note=Sulfotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29899144;Dbxref=PMID:29899144 Q8IV16 UniProtKB Lipidation 151 151 . . . Note=GPI-anchor amidated glycine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9D1N2 Q8IV16 UniProtKB Glycosylation 78 78 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:29899144,ECO:0000269|PubMed:30559189,ECO:0007744|PDB:6E7K;Dbxref=PMID:29899144,PMID:30559189 Q8IV16 UniProtKB Disulfide bond 65 89 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:30559189,ECO:0007744|PDB:6E7K;Dbxref=PMID:30559189 Q8IV16 UniProtKB Disulfide bond 68 77 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:30559189,ECO:0007744|PDB:6E7K;Dbxref=PMID:30559189 Q8IV16 UniProtKB Disulfide bond 83 110 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:30559189,ECO:0007744|PDB:6E7K;Dbxref=PMID:30559189 Q8IV16 UniProtKB Disulfide bond 114 130 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:30559189,ECO:0007744|PDB:6E7K;Dbxref=PMID:30559189 Q8IV16 UniProtKB Disulfide bond 131 136 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:30559189,ECO:0007744|PDB:6E7K;Dbxref=PMID:30559189 Q8IV16 UniProtKB Natural variant 14 14 . . . ID=VAR_044503;Note=It may act as a disease modifier preserving from severe HLPP1D%3B when associated in cis with R-68%3B does not affect interaction with LPL when associated in cis with R-68. F->C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:21816778,ECO:0000269|PubMed:23831619,ECO:0000269|Ref.1,ECO:0000269|Ref.2;Dbxref=dbSNP:rs11538389,PMID:15489334,PMID:21816778,PMID:23831619 Q8IV16 UniProtKB Natural variant 56 56 . . . ID=VAR_044504;Note=No discernible effect on interaction with LPL%2C chylomicrons or APOA5. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17883852,ECO:0000269|PubMed:17997385;Dbxref=dbSNP:rs587777636,PMID:17883852,PMID:17997385 Q8IV16 UniProtKB Natural variant 65 65 . . . ID=VAR_071881;Note=In HLPP1D%3B does not affect protein expression at the cell surface%3B does not interact with LPL%3B promotes formation of dimers and oligomers severely reducing number of monomers. C->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20026666,ECO:0000269|PubMed:25387803;Dbxref=dbSNP:rs587777638,PMID:20026666,PMID:25387803 Q8IV16 UniProtKB Natural variant 65 65 . . . ID=VAR_077634;Note=In HLPP1D%3B does not interact with LPL%3B promotes formation of dimers and oligomers severely reducing number of monomers. C->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22239554,ECO:0000269|PubMed:25387803;Dbxref=dbSNP:rs587777638,PMID:22239554,PMID:25387803 Q8IV16 UniProtKB Natural variant 68 68 . . . ID=VAR_071882;Note=In HLPP1D%3B does not affect protein expression at the cell surface%3B does not interact with LPL%3B promotes formation of dimers and oligomers reducing number of monomers. C->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20026666,ECO:0000269|PubMed:25387803;Dbxref=dbSNP:rs587777639,PMID:20026666,PMID:25387803 Q8IV16 UniProtKB Natural variant 68 68 . . . ID=VAR_077635;Note=In HLPP1D%3B uncertain significance%3B results in decreased GPIHBP1 expression%3B promotes formation of dimers and oligomers severely reducing number of monomers%3B does not affect interaction with LPL when associated in cis with F-14. C->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23831619,ECO:0000269|PubMed:25387803;Dbxref=dbSNP:rs587777639,PMID:23831619,PMID:25387803 Q8IV16 UniProtKB Natural variant 68 68 . . . ID=VAR_077636;Note=In HLPP1D%3B does not interact with LPL%3B promotes formation of dimers and oligomers severely reducing number of monomers. C->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21314738,ECO:0000269|PubMed:25387803;Dbxref=PMID:21314738,PMID:25387803 Q8IV16 UniProtKB Natural variant 83 83 . . . ID=VAR_077637;Note=In HLPP1D. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27578123;Dbxref=PMID:27578123 Q8IV16 UniProtKB Natural variant 89 89 . . . ID=VAR_071883;Note=In HLPP1D%3B drastically affects interaction with LPL%3B promotes formation of dimers and oligomers reducing number of monomers. C->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21816778,ECO:0000269|PubMed:25387803;Dbxref=dbSNP:rs587777640,PMID:21816778,PMID:25387803 Q8IV16 UniProtKB Natural variant 108 108 . . . ID=VAR_077638;Note=In HLPP1D%3B does not interact with LPL%3B promotes formation of dimers and oligomers reducing number of monomers. T->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22239554,ECO:0000269|PubMed:25387803;Dbxref=PMID:22239554,PMID:25387803 Q8IV16 UniProtKB Natural variant 115 115 . . . ID=VAR_058086;Note=In HLPP1D%3B a patient with chylomicronemia%3B no effect on protein expression at the cell surface%3B loss of interaction with LPL%3B loss of interaction with chylomicrons%3B promotes formation of dimers and oligomers reducing number of monomers. Q->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19304573,ECO:0000269|PubMed:22239554,ECO:0000269|PubMed:25387803;Dbxref=dbSNP:rs587777637,PMID:19304573,PMID:22239554,PMID:25387803 Q8IV16 UniProtKB Natural variant 144 144 . . . ID=VAR_077639;Note=In HLPP1D. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22239554;Dbxref=dbSNP:rs78367243,PMID:22239554 Q8IV16 UniProtKB Natural variant 175 175 . . . ID=VAR_071884;Note=In HLPP1D%3B affects protein expression at the cell surface%3B reduces interaction with LPL. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21816778;Dbxref=dbSNP:rs145844329,PMID:21816778 Q8IV16 UniProtKB Mutagenesis 38 38 . . . Note=Loss of sulfotyrosine formation. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29899144;Dbxref=PMID:29899144 Q8IV16 UniProtKB Mutagenesis 66 66 . . . Note=Promotes formation of dimers and oligomers reducing number of monomers. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25387803;Dbxref=PMID:25387803 Q8IV16 UniProtKB Mutagenesis 71 71 . . . Note=Promotes formation of dimers and oligomers reducing number of monomers. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25387803;Dbxref=PMID:25387803 Q8IV16 UniProtKB Mutagenesis 91 91 . . . Note=Promotes formation of dimers and oligomers reducing number of monomers. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25387803;Dbxref=PMID:25387803 Q8IV16 UniProtKB Mutagenesis 92 92 . . . Note=Only slightly increased formation of dimers and oligomers. No effect on number of monomers. Loss of LPL interaction. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25387803;Dbxref=PMID:25387803 Q8IV16 UniProtKB Mutagenesis 93 93 . . . Note=Promotes formation of dimers and oligomers reducing number of monomers. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25387803;Dbxref=PMID:25387803 Q8IV16 UniProtKB Mutagenesis 101 101 . . . Note=Promotes formation of dimers and oligomers reducing number of monomers. Retained some interaction with LPL. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25387803;Dbxref=PMID:25387803 Q8IV16 UniProtKB Mutagenesis 104 104 . . . Note=Promotes formation of dimers and oligomers reducing number of monomers. Retained some interaction with LPL. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25387803;Dbxref=PMID:25387803 Q8IV16 UniProtKB Mutagenesis 105 105 . . . Note=Promotes formation of dimers and oligomers reducing number of monomers. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25387803;Dbxref=PMID:25387803 Q8IV16 UniProtKB Mutagenesis 106 106 . . . Note=Promotes formation of dimers and oligomers severely reducing number of monomers. H->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25387803;Dbxref=PMID:25387803 Q8IV16 UniProtKB Mutagenesis 107 107 . . . Note=Promotes formation of dimers and oligomers reducing number of monomers. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25387803;Dbxref=PMID:25387803 Q8IV16 UniProtKB Mutagenesis 108 108 . . . Note=Retained some interaction with LPL. No effect on number of monomers. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25387803;Dbxref=PMID:25387803 Q8IV16 UniProtKB Mutagenesis 109 109 . . . Note=Promotes formation of dimers and oligomers reducing number of monomers. Loss of LPL interaction. W->C%2CP%2CT;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25387803;Dbxref=PMID:25387803 Q8IV16 UniProtKB Mutagenesis 109 109 . . . Note=Loss of interaction with LPL. Only slightly increased formation of dimers and oligomers. No effect on number of monomers. W->S%2CY%2CH%2CA%2CF;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25387803,ECO:0000269|PubMed:26725083,ECO:0000269|PubMed:27811232,ECO:0000269|PubMed:30559189;Dbxref=PMID:25387803,PMID:26725083,PMID:27811232,PMID:30559189 Q8IV16 UniProtKB Mutagenesis 115 115 . . . Note=No effect on number of monomers. Q->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25387803;Dbxref=PMID:25387803 Q8IV16 UniProtKB Mutagenesis 126 126 . . . Note=Promotes formation of dimers and oligomers reducing number of monomers. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25387803;Dbxref=PMID:25387803 Q8IV16 UniProtKB Beta strand 64 66 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6OAU Q8IV16 UniProtKB Beta strand 68 72 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6OAU Q8IV16 UniProtKB Beta strand 80 82 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6OAU Q8IV16 UniProtKB Beta strand 88 98 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6OAU Q8IV16 UniProtKB Beta strand 101 113 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6OAU Q8IV16 UniProtKB Beta strand 117 120 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6OAU Q8IV16 UniProtKB Beta strand 122 131 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6OAU Q8IV16 UniProtKB Turn 140 142 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6OAU