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Protein

Cyclin-J-like protein

Gene

CCNJL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Keywords - Molecular functioni

Cyclin

Enzyme and pathway databases

SignaLinkiQ8IV13.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-J-like protein
Gene namesi
Name:CCNJL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:25876. CCNJL.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596449.

Polymorphism and mutation databases

BioMutaiCCNJL.
DMDMi121946266.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Cyclin-J-like proteinPRO_0000309319Add
BLAST

Proteomic databases

PaxDbiQ8IV13.
PRIDEiQ8IV13.

PTM databases

iPTMnetiQ8IV13.

Expressioni

Gene expression databases

BgeeiQ8IV13.
CleanExiHS_CCNJL.
ExpressionAtlasiQ8IV13. baseline and differential.
GenevisibleiQ8IV13. HS.

Organism-specific databases

HPAiHPA049970.

Interactioni

Protein-protein interaction databases

BioGridi122749. 39 interactions.
STRINGi9606.ENSP00000377547.

Structurei

3D structure databases

ProteinModelPortaliQ8IV13.
SMRiQ8IV13. Positions 14-298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 191178Cyclin N-terminalAdd
BLAST

Sequence similaritiesi

Belongs to the cyclin family. Cyclin J subfamily.Curated
Contains 1 cyclin N-terminal domain.Curated

Phylogenomic databases

eggNOGiENOG410IEPY. Eukaryota.
ENOG410Y1BM. LUCA.
GeneTreeiENSGT00390000001183.
HOGENOMiHOG000006591.
HOVERGENiHBG106031.
InParanoidiQ8IV13.
OMAiVASDVHC.
OrthoDBiEOG74R1R8.
PhylomeDBiQ8IV13.
TreeFamiTF101009.

Family and domain databases

Gene3Di1.10.472.10. 3 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IV13-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMDEPWWEGR VASDVHCTLR EKELKLPTFR AHSPLLKSRR FFVDILTLLS
60 70 80 90 100
SHCQLCPAAR HLAVYLLDHF MDRYNVTTSK QLYTVAVSCL LLANGVSLLS
110 120 130 140 150
PRLKCSGMIS AHCNLHLPGS SNSPASAPHP PPTPPQVAET TGKFEDREDH
160 170 180 190 200
VPKLEQINST RILSSQNFTL TKKELLSTEL LLLEAFSWNL CLPTPAHFLD
210 220 230 240 250
YYLLASVSQK DHHCHTWPTT CPRKTKECLK EYAHYFLEVT LQDHIFYKFQ
260 270 280 290 300
PSVVAAACVG ASRICLQLSP YWTRDLQRIS SYSLEHLSTC IEILLVVYDN
310 320 330 340 350
VLKDAVAVKS QALAMVPGTP PTPTQVLFQP PAYPALGQPA TTLAQFQTPV
360 370 380 390 400
QDLCLAYRDS LQAHRSGSLL SGSTGSSLHT PYQPLQPLDM CPVPVPASLS
410 420 430
MHMAIAAEPR HCLATTYGSS YFSGSHMFPT GCFDR
Length:435
Mass (Da):48,406
Last modified:September 19, 2006 - v3
Checksum:i1AC6A15E632C6680
GO
Isoform 2 (identifier: Q8IV13-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MMDEPWWEGRVASDVHCTLREKE → MRHTSKRKPQ...QLSEQLRLQE
     94-121: NGVSLLSPRLKCSGMISAHCNLHLPGSS → SRNKGSGSPVPTRSAQQCRQTWARGSPW
     122-435: Missing.

Show »
Length:166
Mass (Da):18,877
Checksum:i7860DCABE04A5FC8
GO

Sequence cautioni

The sequence AAH13353.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB14856.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti234 – 2341H → Y.
Corresponds to variant rs13362036 [ dbSNP | Ensembl ].
VAR_053053

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2323MMDEP…LREKE → MRHTSKRKPQYYEAEMVLKY YKHLEEGSVSLCCPGWSAVA QSRLTAASTFGAQVILLFQL SEQLRLQE in isoform 2. 1 PublicationVSP_029130Add
BLAST
Alternative sequencei94 – 12128NGVSL…LPGSS → SRNKGSGSPVPTRSAQQCRQ TWARGSPW in isoform 2. 1 PublicationVSP_029131Add
BLAST
Alternative sequencei122 – 435314Missing in isoform 2. 1 PublicationVSP_029132Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024228 mRNA. Translation: BAB14856.1. Different initiation.
AK131381 mRNA. Translation: BAD18532.1.
BC013353 mRNA. Translation: AAH13353.1. Different initiation.
BC035871 mRNA. Translation: AAH35871.3.
CCDSiCCDS4350.2. [Q8IV13-1]
RefSeqiNP_001295102.1. NM_001308173.1.
NP_078841.3. NM_024565.6. [Q8IV13-1]
UniGeneiHs.14070.

Genome annotation databases

EnsembliENST00000393977; ENSP00000377547; ENSG00000135083. [Q8IV13-1]
GeneIDi79616.
KEGGihsa:79616.
UCSCiuc003lyb.2. human. [Q8IV13-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024228 mRNA. Translation: BAB14856.1. Different initiation.
AK131381 mRNA. Translation: BAD18532.1.
BC013353 mRNA. Translation: AAH13353.1. Different initiation.
BC035871 mRNA. Translation: AAH35871.3.
CCDSiCCDS4350.2. [Q8IV13-1]
RefSeqiNP_001295102.1. NM_001308173.1.
NP_078841.3. NM_024565.6. [Q8IV13-1]
UniGeneiHs.14070.

3D structure databases

ProteinModelPortaliQ8IV13.
SMRiQ8IV13. Positions 14-298.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122749. 39 interactions.
STRINGi9606.ENSP00000377547.

PTM databases

iPTMnetiQ8IV13.

Polymorphism and mutation databases

BioMutaiCCNJL.
DMDMi121946266.

Proteomic databases

PaxDbiQ8IV13.
PRIDEiQ8IV13.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393977; ENSP00000377547; ENSG00000135083. [Q8IV13-1]
GeneIDi79616.
KEGGihsa:79616.
UCSCiuc003lyb.2. human. [Q8IV13-1]

Organism-specific databases

CTDi79616.
GeneCardsiCCNJL.
HGNCiHGNC:25876. CCNJL.
HPAiHPA049970.
neXtProtiNX_Q8IV13.
PharmGKBiPA144596449.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEPY. Eukaryota.
ENOG410Y1BM. LUCA.
GeneTreeiENSGT00390000001183.
HOGENOMiHOG000006591.
HOVERGENiHBG106031.
InParanoidiQ8IV13.
OMAiVASDVHC.
OrthoDBiEOG74R1R8.
PhylomeDBiQ8IV13.
TreeFamiTF101009.

Enzyme and pathway databases

SignaLinkiQ8IV13.

Miscellaneous databases

ChiTaRSiCCNJL. human.
GenomeRNAii79616.
PROiQ8IV13.

Gene expression databases

BgeeiQ8IV13.
CleanExiHS_CCNJL.
ExpressionAtlasiQ8IV13. baseline and differential.
GenevisibleiQ8IV13. HS.

Family and domain databases

Gene3Di1.10.472.10. 3 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 248-435 (ISOFORM 1).
    Tissue: Brain and Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Lung.

Entry informationi

Entry nameiCCNJL_HUMAN
AccessioniPrimary (citable) accession number: Q8IV13
Secondary accession number(s): Q6ZN43, Q9H7W8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: September 19, 2006
Last modified: June 8, 2016
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.