Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Carabin

Gene

TBC1D10C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei137Arginine fingerBy similarity1
Sitei178Glutamine fingerBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Carabin
Alternative name(s):
TBC1 domain family member 10C
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:24702. TBC1D10C.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GOC
  • endomembrane system Source: GO_Central
  • filopodium membrane Source: UniProtKB
  • membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi141R → A: Loss of GAP activity. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000175463.
PharmGKBiPA142670836.

Polymorphism and mutation databases

BioMutaiTBC1D10C.
DMDMi74728014.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002844671 – 446CarabinAdd BLAST446

Proteomic databases

EPDiQ8IV04.
MaxQBiQ8IV04.
PaxDbiQ8IV04.
PeptideAtlasiQ8IV04.
PRIDEiQ8IV04.

PTM databases

iPTMnetiQ8IV04.
PhosphoSitePlusiQ8IV04.

Expressioni

Tissue specificityi

Most abundant in spleen and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000175463.
CleanExiHS_TBC1D10C.
ExpressionAtlasiQ8IV04. baseline and differential.
GenevisibleiQ8IV04. HS.

Organism-specific databases

HPAiHPA069743.

Interactioni

Subunit structurei

Interacts with both calcineurin and HRAS.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HOXA1P496393EBI-10261452,EBI-740785
KLHL12Q53G595EBI-10261452,EBI-740929
KRTAP5-9P263713EBI-10261452,EBI-3958099
NOTCH2NLQ7Z3S93EBI-10261452,EBI-945833

GO - Molecular functioni

Protein-protein interaction databases

BioGridi131899. 6 interactors.
DIPiDIP-60264N.
IntActiQ8IV04. 4 interactors.
STRINGi9606.ENSP00000310193.

Structurei

3D structure databases

ProteinModelPortaliQ8IV04.
SMRiQ8IV04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 280Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST189

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni406 – 446Interaction with calcineurinAdd BLAST41

Domaini

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.By similarity

Sequence similaritiesi

Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2221. Eukaryota.
ENOG410XPSR. LUCA.
GeneTreeiENSGT00860000133698.
HOGENOMiHOG000007561.
HOVERGENiHBG070028.
InParanoidiQ8IV04.
KOiK19944.
OMAiMSQVHSV.
OrthoDBiEOG091G07CB.
PhylomeDBiQ8IV04.
TreeFamiTF313293.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IV04-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQALGEDLV QPPELQDDSS SLGSDSELSG PGPYRQADRY GFIGGSSAEP
60 70 80 90 100
GPGHPPADLI RQREMKWVEM TSHWEKTMSR RYKKVKMQCR KGIPSALRAR
110 120 130 140 150
CWPLLCGAHV CQKNSPGTYQ ELAEAPGDPQ WMETIGRDLH RQFPLHEMFV
160 170 180 190 200
SPQGHGQQGL LQVLKAYTLY RPEQGYCQAQ GPVAAVLLMH LPPEEAFWCL
210 220 230 240 250
VQICEVYLPG YYGPHMEAVR LDAEVFMALL RRLLPHVHKH LQQVGVGPLL
260 270 280 290 300
YLPEWFLCLF ARSLPFPTVL RVWDAFLSEG ARVLFRVGLT LVRLALGTAE
310 320 330 340 350
QRGACPGLLE TLGALRAIPP AQLQEEAFMS QVHSVVLSER DLQREIKAQL
360 370 380 390 400
AQLPDSAPGP PPRPQVRLAG AQAIFEAQQL AGVRRGAKPE VPRIVVQPPE
410 420 430 440
EPRPPRRKPQ TRGKTFHGLL TRARGPPIEG PPRPQRGSTS FLDTRF
Length:446
Mass (Da):49,712
Last modified:March 1, 2003 - v1
Checksum:i3ADD1D4C8CDBA1D7
GO
Isoform 2 (identifier: Q8IV04-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-310: QQGLLQVLKA...QRGACPGLLE → RGSCRCSRPT...GPPRRGPSHL
     311-446: Missing.

Note: No experimental confirmation available.
Show »
Length:310
Mass (Da):32,887
Checksum:i567F3BDD2A0D22B1
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045992157 – 310QQGLL…PGLLE → RGSCRCSRPTPCIDRSRATA RPRGPWLLCCSCTCPQRRPS GAWCRSVRSTSLGTTGPTWC QSTVPCGADTGAPGAGHCRA ARGLPWPPGDTGSPSSHPPR AAAGGGLHVTGAQRGAVRAG PAAGDQGPAGPAARFRAGTP APATGPPRRGPSHL in isoform 2. 1 PublicationAdd BLAST154
Alternative sequenceiVSP_045993311 – 446Missing in isoform 2. 1 PublicationAdd BLAST136

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003419 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74613.1.
BC035630 mRNA. No translation available.
BC036873 mRNA. Translation: AAH36873.3.
BC062999 mRNA. Translation: AAH62999.1.
CCDSiCCDS58150.1. [Q8IV04-2]
CCDS8162.1. [Q8IV04-1]
RefSeqiNP_001243437.1. NM_001256508.1. [Q8IV04-2]
NP_940919.1. NM_198517.3. [Q8IV04-1]
XP_006718601.1. XM_006718538.3. [Q8IV04-1]
XP_006718602.1. XM_006718539.3. [Q8IV04-1]
XP_006718603.1. XM_006718540.3. [Q8IV04-1]
UniGeneiHs.534648.

Genome annotation databases

EnsembliENST00000312390; ENSP00000310193; ENSG00000175463. [Q8IV04-2]
ENST00000526387; ENSP00000435543; ENSG00000175463. [Q8IV04-2]
ENST00000542590; ENSP00000443654; ENSG00000175463. [Q8IV04-1]
GeneIDi374403.
KEGGihsa:374403.
UCSCiuc001okz.5. human. [Q8IV04-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003419 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74613.1.
BC035630 mRNA. No translation available.
BC036873 mRNA. Translation: AAH36873.3.
BC062999 mRNA. Translation: AAH62999.1.
CCDSiCCDS58150.1. [Q8IV04-2]
CCDS8162.1. [Q8IV04-1]
RefSeqiNP_001243437.1. NM_001256508.1. [Q8IV04-2]
NP_940919.1. NM_198517.3. [Q8IV04-1]
XP_006718601.1. XM_006718538.3. [Q8IV04-1]
XP_006718602.1. XM_006718539.3. [Q8IV04-1]
XP_006718603.1. XM_006718540.3. [Q8IV04-1]
UniGeneiHs.534648.

3D structure databases

ProteinModelPortaliQ8IV04.
SMRiQ8IV04.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131899. 6 interactors.
DIPiDIP-60264N.
IntActiQ8IV04. 4 interactors.
STRINGi9606.ENSP00000310193.

PTM databases

iPTMnetiQ8IV04.
PhosphoSitePlusiQ8IV04.

Polymorphism and mutation databases

BioMutaiTBC1D10C.
DMDMi74728014.

Proteomic databases

EPDiQ8IV04.
MaxQBiQ8IV04.
PaxDbiQ8IV04.
PeptideAtlasiQ8IV04.
PRIDEiQ8IV04.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312390; ENSP00000310193; ENSG00000175463. [Q8IV04-2]
ENST00000526387; ENSP00000435543; ENSG00000175463. [Q8IV04-2]
ENST00000542590; ENSP00000443654; ENSG00000175463. [Q8IV04-1]
GeneIDi374403.
KEGGihsa:374403.
UCSCiuc001okz.5. human. [Q8IV04-1]

Organism-specific databases

CTDi374403.
GeneCardsiTBC1D10C.
HGNCiHGNC:24702. TBC1D10C.
HPAiHPA069743.
MIMi610831. gene.
neXtProtiNX_Q8IV04.
OpenTargetsiENSG00000175463.
PharmGKBiPA142670836.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2221. Eukaryota.
ENOG410XPSR. LUCA.
GeneTreeiENSGT00860000133698.
HOGENOMiHOG000007561.
HOVERGENiHBG070028.
InParanoidiQ8IV04.
KOiK19944.
OMAiMSQVHSV.
OrthoDBiEOG091G07CB.
PhylomeDBiQ8IV04.
TreeFamiTF313293.

Enzyme and pathway databases

ReactomeiR-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

GenomeRNAii374403.
PROiQ8IV04.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175463.
CleanExiHS_TBC1D10C.
ExpressionAtlasiQ8IV04. baseline and differential.
GenevisibleiQ8IV04. HS.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTB10C_HUMAN
AccessioniPrimary (citable) accession number: Q8IV04
Secondary accession number(s): G3V1D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.