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Protein

Synaptotagmin-12

Gene

SYT12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-6794361. Interactions of neurexins and neuroligins at synapses.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-12
Alternative name(s):
Synaptotagmin XII
Short name:
SytXII
Gene namesi
Name:SYT12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:18381. SYT12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18VesicularSequence analysisAdd BLAST18
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Topological domaini40 – 421CytoplasmicSequence analysisAdd BLAST382

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi91683.
OpenTargetsiENSG00000173227.
PharmGKBiPA38321.

Polymorphism and mutation databases

BioMutaiSYT12.
DMDMi33151152.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839721 – 421Synaptotagmin-12Add BLAST421

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei97PhosphoserineBy similarity1
Modified residuei99PhosphoserineBy similarity1
Modified residuei214PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8IV01.
PeptideAtlasiQ8IV01.
PRIDEiQ8IV01.

PTM databases

iPTMnetiQ8IV01.
PhosphoSitePlusiQ8IV01.

Expressioni

Gene expression databases

BgeeiENSG00000173227.
CleanExiHS_SYT12.
ExpressionAtlasiQ8IV01. baseline and differential.
GenevisibleiQ8IV01. HS.

Organism-specific databases

HPAiHPA011006.

Interactioni

Subunit structurei

Homodimer. Can also form heterodimers (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124864. 17 interactors.
STRINGi9606.ENSP00000377520.

Structurei

3D structure databases

ProteinModelPortaliQ8IV01.
SMRiQ8IV01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 272C2 1PROSITE-ProRule annotationAdd BLAST105
Domaini285 – 388C2 2PROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IT3K. Eukaryota.
ENOG411011E. LUCA.
GeneTreeiENSGT00830000128339.
HOGENOMiHOG000063703.
HOVERGENiHBG057176.
InParanoidiQ8IV01.
KOiK19912.
OMAiWTSGSFP.
OrthoDBiEOG091G07FE.
PhylomeDBiQ8IV01.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR030537. SYT12.
[Graphical view]
PANTHERiPTHR10024:SF252. PTHR10024:SF252. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IV01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVDVAEYHL SVIKSPPGWE VGVYAAGALA LLGIAAVSLW KLWTSGSFPS
60 70 80 90 100
PSPFPNYDYR YLQQKYGESC AEAREKRVPA WNAQRASTRG PPSRKGSLSI
110 120 130 140 150
EDTFESISEL GPLELMGREL DLAPYGTLRK SQSADSLNSI SSVSNTFGQD
160 170 180 190 200
FTLGQVEVSM EYDTASHTLN VAVMQGKDLL EREEASFESC FMRVSLLPDE
210 220 230 240 250
QIVGISRIQR NAYSIFFDEK FSIPLDPTAL EEKSLRFSVF GIDEDERNVS
260 270 280 290 300
TGVVELKLSV LDLPLQPFSG WLYLQDQNKA ADAVGEILLS LSYLPTAERL
310 320 330 340 350
TVVVVKAKNL IWTNDKTTAD PFVKVYLLQD GRKMSKKKTA VKRDDPNPVF
360 370 380 390 400
NEAMIFSVPA IVLQDLSLRV TVAESSSDGR GDNVGHVIIG PSASGMGTTH
410 420
WNQMLATLRR PVSMWHAVRR N
Length:421
Mass (Da):46,537
Last modified:March 1, 2003 - v1
Checksum:i9E1B3ACE0023F973
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034532170N → H.Corresponds to variant rs11227664dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC037406 mRNA. Translation: AAH37406.1.
CCDSiCCDS8154.1.
RefSeqiNP_001171351.1. NM_001177880.1.
NP_808878.1. NM_177963.3.
XP_011543649.1. XM_011545347.1.
UniGeneiHs.287636.

Genome annotation databases

EnsembliENST00000393946; ENSP00000377520; ENSG00000173227.
ENST00000525457; ENSP00000431400; ENSG00000173227.
ENST00000527043; ENSP00000435316; ENSG00000173227.
GeneIDi91683.
KEGGihsa:91683.
UCSCiuc001oju.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC037406 mRNA. Translation: AAH37406.1.
CCDSiCCDS8154.1.
RefSeqiNP_001171351.1. NM_001177880.1.
NP_808878.1. NM_177963.3.
XP_011543649.1. XM_011545347.1.
UniGeneiHs.287636.

3D structure databases

ProteinModelPortaliQ8IV01.
SMRiQ8IV01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124864. 17 interactors.
STRINGi9606.ENSP00000377520.

PTM databases

iPTMnetiQ8IV01.
PhosphoSitePlusiQ8IV01.

Polymorphism and mutation databases

BioMutaiSYT12.
DMDMi33151152.

Proteomic databases

PaxDbiQ8IV01.
PeptideAtlasiQ8IV01.
PRIDEiQ8IV01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393946; ENSP00000377520; ENSG00000173227.
ENST00000525457; ENSP00000431400; ENSG00000173227.
ENST00000527043; ENSP00000435316; ENSG00000173227.
GeneIDi91683.
KEGGihsa:91683.
UCSCiuc001oju.4. human.

Organism-specific databases

CTDi91683.
DisGeNETi91683.
GeneCardsiSYT12.
HGNCiHGNC:18381. SYT12.
HPAiHPA011006.
MIMi606436. gene.
neXtProtiNX_Q8IV01.
OpenTargetsiENSG00000173227.
PharmGKBiPA38321.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IT3K. Eukaryota.
ENOG411011E. LUCA.
GeneTreeiENSGT00830000128339.
HOGENOMiHOG000063703.
HOVERGENiHBG057176.
InParanoidiQ8IV01.
KOiK19912.
OMAiWTSGSFP.
OrthoDBiEOG091G07FE.
PhylomeDBiQ8IV01.
TreeFamiTF315600.

Enzyme and pathway databases

ReactomeiR-HSA-6794361. Interactions of neurexins and neuroligins at synapses.

Miscellaneous databases

ChiTaRSiSYT12. human.
GenomeRNAii91683.
PROiQ8IV01.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173227.
CleanExiHS_SYT12.
ExpressionAtlasiQ8IV01. baseline and differential.
GenevisibleiQ8IV01. HS.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR030537. SYT12.
[Graphical view]
PANTHERiPTHR10024:SF252. PTHR10024:SF252. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYT12_HUMAN
AccessioniPrimary (citable) accession number: Q8IV01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.