Q8IV01 (SYT12_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Synaptotagmin-12

Alternative name(s):
Synaptotagmin XII
Short name=SytXII

Gene names

Name:

SYT12

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis By similarity.
Subunit structure	Homodimer. Can also form heterodimers By similarity.
Subcellular location	Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Single-pass membrane protein By similarity.
Sequence similarities	Belongs to the synaptotagmin family. Contains 2 C2 domains.

Ontologies

Keywords
Cellular component	Cell junction Cytoplasmic vesicle Membrane Synapse
Coding sequence diversity	Polymorphism
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW synaptic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 421	421	Synaptotagmin-12		PRO_0000183972
Regions
	Topological domain	1 – 18	18	Vesicular Potential
	Transmembrane	19 – 39	21	Helical; Potential
	Topological domain	40 – 421	382	Cytoplasmic Potential
	Domain	168 – 272	105	C2 1
	Domain	285 – 388	104	C2 2
Natural variations
	Natural variant	170	1	N → H. Corresponds to variant rs11227664 [ dbSNP | Ensembl ].		VAR_034532

Sequences

	Sequence		Length	Mass (Da)
	Q8IV01 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 9E1B3ACE0023F973	FASTA	421	46,537
	10 20 30 40 50 60 MAVDVAEYHL SVIKSPPGWE VGVYAAGALA LLGIAAVSLW KLWTSGSFPS PSPFPNYDYR 70 80 90 100 110 120 YLQQKYGESC AEAREKRVPA WNAQRASTRG PPSRKGSLSI EDTFESISEL GPLELMGREL 130 140 150 160 170 180 DLAPYGTLRK SQSADSLNSI SSVSNTFGQD FTLGQVEVSM EYDTASHTLN VAVMQGKDLL 190 200 210 220 230 240 EREEASFESC FMRVSLLPDE QIVGISRIQR NAYSIFFDEK FSIPLDPTAL EEKSLRFSVF 250 260 270 280 290 300 GIDEDERNVS TGVVELKLSV LDLPLQPFSG WLYLQDQNKA ADAVGEILLS LSYLPTAERL 310 320 330 340 350 360 TVVVVKAKNL IWTNDKTTAD PFVKVYLLQD GRKMSKKKTA VKRDDPNPVF NEAMIFSVPA 370 380 390 400 410 420 IVLQDLSLRV TVAESSSDGR GDNVGHVIIG PSASGMGTTH WNQMLATLRR PVSMWHAVRR N

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC037406 mRNA. Translation: AAH37406.1.
IPI	IPI00219472.
RefSeq	NP_001171351.1. NM_001177880.1. NP_808878.1. NM_177963.3.
UniGene	Hs.287636.
3D structure databases
ProteinModelPortal	Q8IV01.
SMR	Q8IV01. Positions 152-420.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8IV01.
PTM databases
PhosphoSite	Q8IV01.
Polymorphism databases
DMDM	33151152.
Proteomic databases
PRIDE	Q8IV01.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000393946; ENSP00000377520; ENSG00000173227.
GeneID	91683.
KEGG	hsa:91683.
UCSC	uc001oju.1. human.
Organism-specific databases
CTD	91683.
GeneCards	GC11P066791.
HGNC	HGNC:18381. SYT12.
HPA	HPA011006.
MIM	606436. gene.
neXtProt	NX_Q8IV01.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG05392.
HOGENOM	HBG445851.
HOVERGEN	HBG057176.
InParanoid	Q8IV01.
OMA	EYHLSVI.
OrthoDB	EOG4DV5MC.
PhylomeDB	Q8IV01.
Gene expression databases
ArrayExpress	Q8IV01.
Bgee	Q8IV01.
CleanEx	HS_SYT12.
Genevestigator	Q8IV01.
GermOnline	ENSG00000173227. Homo sapiens.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. [Graphical view]
Pfam	PF00168. C2. 2 hits. [Graphical view]
SMART	SM00239. C2. 2 hits. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 2 hits.
PROSITE	PS50004. C2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	77391.
SOURCE	Search...

Entry information

Entry name

SYT12_HUMAN

Accession

Primary (citable) accession number: Q8IV01

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.