Q8IUZ5 (AT2L2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alanine--glyoxylate aminotransferase 2-like 2
EC=2.6.1.-

Gene names

Name:	AGXT2L2
ORF Names:	PP9286

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	450 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Cofactor	Pyridoxal phosphate Potential.
Subunit structure	Homotetramer By similarity.
Subcellular location	Mitochondrion Potential.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IUZ5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IUZ5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-343: Missing.

Isoform 3 (identifier: Q8IUZ5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-275: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 450	450	Alanine--glyoxylate aminotransferase 2-like 2		PRO_0000287667
Amino acid modifications
	Modified residue	278	1	N6-(pyridoxal phosphate)lysine By similarity
Natural variations
	Alternative sequence	1 – 343	343	Missing in isoform 2.		VSP_025585
	Alternative sequence	1 – 275	275	Missing in isoform 3.		VSP_025584
	Natural variant	126	1	H → R. Corresponds to variant rs7707147 [ dbSNP | Ensembl ].		VAR_048233

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 5EB28A6BDD44C429	FASTA	450	49,711
	10 20 30 40 50 60 MAADQRPKAD TLALRQRLIS SSCRLFFPED PVKIVRAQGQ YMYDEQGAEY IDCISNVAHV 70 80 90 100 110 120 GHCHPLVVQA AHEQNQVLNT NSRYLHDNIV DYAQRLSETL PEQLCVFYFL NSGSEANDLA 130 140 150 160 170 180 LRLARHYTGH QDVVVLDHAY HGHLSSLIDI SPYKFRNLDG QKEWVHVAPL PDTYRGPYRE 190 200 210 220 230 240 DHPNPAMAYA NEVKRVVSSA QEKGRKIAAF FAESLPSVGG QIIPPAGYFS QVAEHIRKAG 250 260 270 280 290 300 GVFVADEIQV GFGRVGKHFW AFQLQGKDFV PDIVTMGKSI GNGHPVACVA ATQPVARAFE 310 320 330 340 350 360 ATGVEYFNTF GGSPVSCAVG LAVLNVLEKE QLQDHATSVG SFLMQLLGQQ KIKHPIVGDV 370 380 390 400 410 420 RGVGLFIGVD LIKDEATRTP ATEEAAYLVS RLKENYVLLS TDGPGRNILK FKPPMCFSLD 430 440 450 NARQVVAKLD AILTDMEEKV RSCETLRLQP
	Isoform 2 [UniParc]. Checksum: 7BA80D803EBD1F58	FASTA	107	11,924
	10 20 30 40 50 60 MQLLGQQKIK HPIVGDVRGV GLFIGVDLIK DEATRTPATE EAAYLVSRLK ENYVLLSTDG 70 80 90 100 PGRNILKFKP PMCFSLDNAR QVVAKLDAIL TDMEEKVRSC ETLRLQP
	Isoform 3 [UniParc]. Checksum: 3E8449C54F503592	FASTA	175	18,857
	10 20 30 40 50 60 MGKSIGNGHP VACVAATQPV ARAFEATGVE YFNTFGGSPV SCAVGLAVLN VLEKEQLQDH 70 80 90 100 110 120 ATSVGSFLMQ LLGQQKIKHP IVGDVRGVGL FIGVDLIKDE ATRTPATEEA AYLVSRLKEN 130 140 150 160 170 YVLLSTDGPG RNILKFKPPM CFSLDNARQV VAKLDAILTD MEEKVRSCET LRLQP

References

[1]	"Large-scale cDNA transfection screening for genes related to cancer development and progression." Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J. Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed: 15498874] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Placenta.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Brain, Muscle and Pancreas.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF318375 mRNA. Translation: AAL55882.1. AK023470 mRNA. Translation: BAG51198.1. CH471165 Genomic DNA. Translation: EAW53836.1. CH471165 Genomic DNA. Translation: EAW53841.1. BC008009 mRNA. Translation: AAH08009.1. BC037567 mRNA. Translation: AAH37567.1. BC110335 mRNA. Translation: AAI10336.1.
IPI	IPI00170765. IPI00216928. IPI00845489.
RefSeq	NP_699204.1. NM_153373.2.
UniGene	Hs.248746.
3D structure databases
HSSP	HSSP built from PDB template 1VEF based on UniProtKB Q93R93.
ProteinModelPortal	Q8IUZ5.
SMR	Q8IUZ5. Positions 26-436.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IUZ5. 2 interactions.
MINT	MINT-1441286.
STRING	Q8IUZ5.
PTM databases
PhosphoSite	Q8IUZ5.
Polymorphism databases
DMDM	74750645.
Proteomic databases
PRIDE	Q8IUZ5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000308158; ENSP00000310978; ENSG00000175309.
GeneID	85007.
KEGG	hsa:85007.
NMPDR	fig|9606.3.peg.26282.
UCSC	uc003miy.1. human. uc003miz.1. human. uc003mjd.1. human.
Organism-specific databases
CTD	85007.
GeneCards	GC05M177635.
H-InvDB	HIX0019604.
HGNC	HGNC:28249. AGXT2L2.
HPA	HPA036461.
neXtProt	NX_Q8IUZ5.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17800.
GeneTree	ENSGT00530000062907.
HOGENOM	HBG725944.
HOVERGEN	HBG004196.
InParanoid	Q8IUZ5.
OMA	DGPGRNI.
OrthoDB	EOG4TTGHM.
PhylomeDB	Q8IUZ5.
Gene expression databases
ArrayExpress	Q8IUZ5.
Bgee	Q8IUZ5.
CleanEx	HS_AGXT2L2.
Genevestigator	Q8IUZ5.
Family and domain databases
InterPro	IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 2 hits.
KO	K14286.
PANTHER	PTHR11986. Aminotrans_3. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00160. L-Alanine. DB00114. Pyridoxal Phosphate.
NextBio	75608.

Entry information

Entry name

AT2L2_HUMAN

Accession

Primary (citable) accession number: Q8IUZ5
Secondary accession number(s): B3KN36 , D3DWP9, Q8WYS6, Q96HW8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.