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Q8IUX7

- AEBP1_HUMAN

UniProt

Q8IUX7 - AEBP1_HUMAN

Protein

Adipocyte enhancer-binding protein 1

Gene

AEBP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.By similarity

    GO - Molecular functioni

    1. carboxypeptidase activity Source: ProtInc
    2. metallocarboxypeptidase activity Source: InterPro
    3. RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
    4. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: NTNU_SB
    5. sequence-specific DNA binding transcription factor activity Source: ProtInc
    6. transcription corepressor activity Source: Ensembl
    7. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cell adhesion Source: InterPro
    2. muscle organ development Source: ProtInc
    3. negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    4. skeletal system development Source: ProtInc

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Calmodulin-binding, DNA-binding

    Protein family/group databases

    MEROPSiM14.951.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adipocyte enhancer-binding protein 1
    Short name:
    AE-binding protein 1
    Alternative name(s):
    Aortic carboxypeptidase-like protein
    Gene namesi
    Name:AEBP1
    Synonyms:ACLP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:303. AEBP1.

    Subcellular locationi

    Isoform 1 : Secreted By similarity
    Isoform 2 : Cytoplasm Curated. Nucleus Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular space Source: BHF-UCL
    3. extracellular vesicular exosome Source: UniProt
    4. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24604.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 11581133Adipocyte enhancer-binding protein 1PRO_0000333189Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi528 – 5281N-linked (GlcNAc...)1 Publication
    Glycosylationi922 – 9221N-linked (GlcNAc...)1 Publication

    Post-translational modificationi

    Phosphorylated by MAPK1 in vitro.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ8IUX7.
    PaxDbiQ8IUX7.
    PRIDEiQ8IUX7.

    PTM databases

    PhosphoSiteiQ8IUX7.

    Expressioni

    Tissue specificityi

    Expressed in osteoblast and visceral fat.1 Publication

    Gene expression databases

    ArrayExpressiQ8IUX7.
    BgeeiQ8IUX7.
    CleanExiHS_AEBP1.
    GenevestigatoriQ8IUX7.

    Organism-specific databases

    HPAiCAB009966.

    Interactioni

    Subunit structurei

    Interacts with GNG5, NFKBIA, MAPK1, MAPK3 and PTEN. May interact with calmodulin. Binds to DNA in vitro.By similarity

    Protein-protein interaction databases

    BioGridi106674. 1 interaction.
    IntActiQ8IUX7. 2 interactions.
    MINTiMINT-7034542.
    STRINGi9606.ENSP00000223357.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IUX7.
    SMRiQ8IUX7. Positions 387-542, 560-1018.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini383 – 540158F5/8 type CPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni390 – 555166Required for DNA-binding and interaction with NFKBIABy similarityAdd
    BLAST
    Regioni421 – 624204Interaction with MAPK1 and MAPK3By similarityAdd
    BLAST
    Regioni555 – 985431Interaction with PTENBy similarityAdd
    BLAST
    Regioni941 – 1158218Required for transcriptional repressionBy similarityAdd
    BLAST
    Regioni1006 – 1158153Interaction with MAPK1 and MAPK3By similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi47 – 326280Pro-richAdd
    BLAST
    Compositional biasi1079 – 113658Glu-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase M14 family.Curated
    Contains 1 F5/8 type C domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG292169.
    HOGENOMiHOG000232185.
    HOVERGENiHBG003410.
    InParanoidiQ8IUX7.
    OMAiLDYNDQI.
    OrthoDBiEOG7B8S32.
    PhylomeDBiQ8IUX7.
    TreeFamiTF315592.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    2.60.40.1120. 1 hit.
    InterProiIPR008969. CarboxyPept-like_regulatory.
    IPR014766. CarboxyPept_regulatory_dom.
    IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR008979. Galactose-bd-like.
    IPR000834. Peptidase_M14.
    [Graphical view]
    PfamiPF00754. F5_F8_type_C. 1 hit.
    PF00246. Peptidase_M14. 1 hit.
    [Graphical view]
    PRINTSiPR00765. CRBOXYPTASEA.
    SMARTiSM00231. FA58C. 1 hit.
    SM00631. Zn_pept. 1 hit.
    [Graphical view]
    SUPFAMiSSF49464. SSF49464. 1 hit.
    SSF49785. SSF49785. 1 hit.
    PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
    PS01285. FA58C_1. 1 hit.
    PS01286. FA58C_2. 1 hit.
    PS50022. FA58C_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IUX7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAVRGAPLL SCLLALLALC PGGRPQTVLT DDEIEEFLEG FLSELEPEPR     50
    EDDVEAPPPP EPTPRVRKAQ AGGKPGKRPG TAAEVPPEKT KDKGKKGKKD 100
    KGPKVPKESL EGSPRPPKKG KEKPPKATKK PKEKPPKATK KPKEKPPKAT 150
    KKPKEKPPKA TKKPPSGKRP PILAPSETLE WPLPPPPSPG PEELPQEGGA 200
    PLSNNWQNPG EETHVEAREH QPEPEEETEQ PTLDYNDQIE REDYEDFEYI 250
    RRQKQPRPPP SRRRRPERVW PEPPEEKAPA PAPEERIEPP VKPLLPPLPP 300
    DYGDGYVIPN YDDMDYYFGP PPPQKPDAER QTDEEKEELK KPKKEDSSPK 350
    EETDKWAVEK GKDHKEPRKG EELEEEWTPT EKVKCPPIGM ESHRIEDNQI 400
    RASSMLRHGL GAQRGRLNMQ TGATEDDYYD GAWCAEDDAR TQWIEVDTRR 450
    TTRFTGVITQ GRDSSIHDDF VTTFFVGFSN DSQTWVMYTN GYEEMTFHGN 500
    VDKDTPVLSE LPEPVVARFI RIYPLTWNGS LCMRLEVLGC SVAPVYSYYA 550
    QNEVVATDDL DFRHHSYKDM RQLMKVVNEE CPTITRTYSL GKSSRGLKIY 600
    AMEISDNPGE HELGEPEFRY TAGIHGNEVL GRELLLLLMQ YLCREYRDGN 650
    PRVRSLVQDT RIHLVPSLNP DGYEVAAQMG SEFGNWALGL WTEEGFDIFE 700
    DFPDLNSVLW GAEERKWVPY RVPNNNLPIP ERYLSPDATV STEVRAIIAW 750
    MEKNPFVLGA NLNGGERLVS YPYDMARTPT QEQLLAAAMA AARGEDEDEV 800
    SEAQETPDHA IFRWLAISFA SAHLTLTEPY RGGCQAQDYT GGMGIVNGAK 850
    WNPRTGTIND FSYLHTNCLE LSFYLGCDKF PHESELPREW ENNKEALLTF 900
    MEQVHRGIKG VVTDEQGIPI ANATISVSGI NHGVKTASGG DYWRILNPGE 950
    YRVTAHAEGY TPSAKTCNVD YDIGATQCNF ILARSNWKRI REIMAMNGNR 1000
    PIPHIDPSRP MTPQQRRLQQ RRLQHRLRLR AQMRLRRLNA TTTLGPHTVP 1050
    PTLPPAPATT LSTTIEPWGL IPPTTAGWEE SETETYTEVV TEFGTEVEPE 1100
    FGTKVEPEFE TQLEPEFETQ LEPEFEEEEE EEKEEEIATG QAFPFTTVET 1150
    YTVNFGDF 1158
    Length:1,158
    Mass (Da):130,929
    Last modified:March 1, 2003 - v1
    Checksum:i1D7F4A20451646AE
    GO
    Isoform 2 (identifier: Q8IUX7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-457: Missing.
         458-495: ITQGRDSSIH...VMYTNGYEEM → MRKWWAPCPG...STALRPASPQ
         543-544: AP → ARECGGLAGALSGGGVLGWASRHPAKDNPASLAA

    Note: No experimental confirmation available.

    Show »
    Length:733
    Mass (Da):82,183
    Checksum:iA749B43E37811E45
    GO

    Sequence cautioni

    The sequence BAD92981.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti145 – 1451K → E in AAC25585. (PubMed:9624159)Curated
    Sequence conflicti218 – 2181R → Q in AAC25585. (PubMed:9624159)Curated
    Sequence conflicti569 – 5691D → G in BAC87026. (PubMed:14702039)Curated
    Sequence conflicti715 – 7151R → G in BAC87026. (PubMed:14702039)Curated
    Sequence conflicti884 – 8841S → G in BAC87026. (PubMed:14702039)Curated
    Sequence conflicti1079 – 10791E → G in BAD92981. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti273 – 2731P → T.
    Corresponds to variant rs2537188 [ dbSNP | Ensembl ].
    VAR_043118
    Natural varianti648 – 6481D → E.
    Corresponds to variant rs11770649 [ dbSNP | Ensembl ].
    VAR_043119
    Natural varianti1001 – 10011P → L.
    Corresponds to variant rs4724285 [ dbSNP | Ensembl ].
    VAR_043120
    Natural varianti1133 – 11331K → E.1 Publication
    Corresponds to variant rs13928 [ dbSNP | Ensembl ].
    VAR_043121
    Natural varianti1148 – 11481V → I.
    Corresponds to variant rs13898 [ dbSNP | Ensembl ].
    VAR_043122

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 457457Missing in isoform 2. 1 PublicationVSP_033467Add
    BLAST
    Alternative sequencei458 – 49538ITQGR…GYEEM → MRKWWAPCPGSWLCSHCLGE GWALRGAGSTALRPASPQ in isoform 2. 1 PublicationVSP_033468Add
    BLAST
    Alternative sequencei543 – 5442AP → ARECGGLAGALSGGGVLGWA SRHPAKDNPASLAA in isoform 2. 1 PublicationVSP_033469

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF053944 mRNA. Translation: AAC25585.1.
    AK127541 mRNA. Translation: BAC87026.1.
    AB209744 mRNA. Translation: BAD92981.1. Different initiation.
    CH236960 Genomic DNA. Translation: EAL23768.1.
    CH471128 Genomic DNA. Translation: EAW61119.1.
    BC038588 mRNA. Translation: AAH38588.1.
    D86479 mRNA. Translation: BAA13094.1.
    CCDSiCCDS5476.1. [Q8IUX7-1]
    PIRiJC5256.
    RefSeqiNP_001120.3. NM_001129.4. [Q8IUX7-1]
    UniGeneiHs.439463.

    Genome annotation databases

    EnsembliENST00000223357; ENSP00000223357; ENSG00000106624. [Q8IUX7-1]
    ENST00000450684; ENSP00000398878; ENSG00000106624. [Q8IUX7-2]
    GeneIDi165.
    KEGGihsa:165.
    UCSCiuc003tkb.4. human. [Q8IUX7-1]
    uc003tkc.5. human. [Q8IUX7-2]

    Polymorphism databases

    DMDMi74728002.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF053944 mRNA. Translation: AAC25585.1 .
    AK127541 mRNA. Translation: BAC87026.1 .
    AB209744 mRNA. Translation: BAD92981.1 . Different initiation.
    CH236960 Genomic DNA. Translation: EAL23768.1 .
    CH471128 Genomic DNA. Translation: EAW61119.1 .
    BC038588 mRNA. Translation: AAH38588.1 .
    D86479 mRNA. Translation: BAA13094.1 .
    CCDSi CCDS5476.1. [Q8IUX7-1 ]
    PIRi JC5256.
    RefSeqi NP_001120.3. NM_001129.4. [Q8IUX7-1 ]
    UniGenei Hs.439463.

    3D structure databases

    ProteinModelPortali Q8IUX7.
    SMRi Q8IUX7. Positions 387-542, 560-1018.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106674. 1 interaction.
    IntActi Q8IUX7. 2 interactions.
    MINTi MINT-7034542.
    STRINGi 9606.ENSP00000223357.

    Protein family/group databases

    MEROPSi M14.951.

    PTM databases

    PhosphoSitei Q8IUX7.

    Polymorphism databases

    DMDMi 74728002.

    Proteomic databases

    MaxQBi Q8IUX7.
    PaxDbi Q8IUX7.
    PRIDEi Q8IUX7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000223357 ; ENSP00000223357 ; ENSG00000106624 . [Q8IUX7-1 ]
    ENST00000450684 ; ENSP00000398878 ; ENSG00000106624 . [Q8IUX7-2 ]
    GeneIDi 165.
    KEGGi hsa:165.
    UCSCi uc003tkb.4. human. [Q8IUX7-1 ]
    uc003tkc.5. human. [Q8IUX7-2 ]

    Organism-specific databases

    CTDi 165.
    GeneCardsi GC07P044143.
    HGNCi HGNC:303. AEBP1.
    HPAi CAB009966.
    MIMi 602981. gene.
    neXtProti NX_Q8IUX7.
    PharmGKBi PA24604.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG292169.
    HOGENOMi HOG000232185.
    HOVERGENi HBG003410.
    InParanoidi Q8IUX7.
    OMAi LDYNDQI.
    OrthoDBi EOG7B8S32.
    PhylomeDBi Q8IUX7.
    TreeFami TF315592.

    Miscellaneous databases

    ChiTaRSi AEBP1. human.
    GenomeRNAii 165.
    NextBioi 665.
    PROi Q8IUX7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IUX7.
    Bgeei Q8IUX7.
    CleanExi HS_AEBP1.
    Genevestigatori Q8IUX7.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    2.60.40.1120. 1 hit.
    InterProi IPR008969. CarboxyPept-like_regulatory.
    IPR014766. CarboxyPept_regulatory_dom.
    IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR008979. Galactose-bd-like.
    IPR000834. Peptidase_M14.
    [Graphical view ]
    Pfami PF00754. F5_F8_type_C. 1 hit.
    PF00246. Peptidase_M14. 1 hit.
    [Graphical view ]
    PRINTSi PR00765. CRBOXYPTASEA.
    SMARTi SM00231. FA58C. 1 hit.
    SM00631. Zn_pept. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49464. SSF49464. 1 hit.
    SSF49785. SSF49785. 1 hit.
    PROSITEi PS00132. CARBOXYPEPT_ZN_1. 1 hit.
    PS01285. FA58C_1. 1 hit.
    PS01286. FA58C_2. 1 hit.
    PS50022. FA58C_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Aortic carboxypeptidase-like protein, a novel protein with discoidin and carboxypeptidase-like domains, is up-regulated during vascular smooth muscle cell differentiation."
      Layne M.D., Endege W.O., Jain M.K., Yet S.-F., Hsieh C.-M., Chin M.T., Perrella M.A., Blanar M.A., Haber E., Lee M.-E.
      J. Biol. Chem. 273:15654-15660(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Aortic smooth muscle.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLU-1133.
      Tissue: Aortic endothelium.
    4. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    7. "A cDNA cloning of human AEBP1 from primary cultured osteoblasts and its expression in a differentiating osteoblastic cell line."
      Ohno I., Hashimoto J., Shimizu K., Takaoka K., Ochi T., Matsubara K., Okubo K.
      Biochem. Biophys. Res. Commun. 228:411-414(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 314-1158 (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Cancellous bone.
    8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-528 AND ASN-922.
      Tissue: Liver.

    Entry informationi

    Entry nameiAEBP1_HUMAN
    AccessioniPrimary (citable) accession number: Q8IUX7
    Secondary accession number(s): Q14113
    , Q59ER7, Q6ZSC7, Q7KZ79
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

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