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Protein

Spermatogenesis-associated protein 2-like protein

Gene

SPATA2L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatogenesis-associated protein 2-like protein
Short name:
SPATA2-like protein
Gene namesi
Name:SPATA2L
Synonyms:C16orf76
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:28393. SPATA2L.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162404411.

Polymorphism and mutation databases

BioMutaiSPATA2L.
DMDMi74727996.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Spermatogenesis-associated protein 2-like proteinPRO_0000297670Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei327 – 3271PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IUW3.
PaxDbiQ8IUW3.
PRIDEiQ8IUW3.

PTM databases

iPTMnetiQ8IUW3.
PhosphoSiteiQ8IUW3.

Expressioni

Gene expression databases

BgeeiQ8IUW3.
CleanExiHS_SPATA2L.
ExpressionAtlasiQ8IUW3. baseline and differential.
GenevisibleiQ8IUW3. HS.

Organism-specific databases

HPAiHPA041182.
HPA042453.

Interactioni

Protein-protein interaction databases

BioGridi125846. 5 interactions.
IntActiQ8IUW3. 4 interactions.
STRINGi9606.ENSP00000289805.

Structurei

3D structure databases

ProteinModelPortaliQ8IUW3.
SMRiQ8IUW3. Positions 33-168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPATA2 family.Curated

Phylogenomic databases

eggNOGiENOG410IF8A. Eukaryota.
ENOG410XW6I. LUCA.
GeneTreeiENSGT00530000063956.
HOGENOMiHOG000060210.
HOVERGENiHBG102025.
InParanoidiQ8IUW3.
KOiK17595.
OMAiVHVLKGA.
OrthoDBiEOG7NSB2S.
PhylomeDBiQ8IUW3.
TreeFamiTF328840.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IUW3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSSSLSEDY RQCLERELRR GRAGVCGDPS LRAVLWQILV EDFDLHGALQ
60 70 80 90 100
DDALALLTDG LWGRADLAPA LRGLARAFEL LELAAVHLYL LPWRKEFTTI
110 120 130 140 150
KTFSGGYVHV LKGVLSDDLL LKSFQKMGYV RRDSHRLMVT ALPPACQLVQ
160 170 180 190 200
VALGCFALRL ECEILGEVLA QLGTSVLPAE ELLQARRASG DVASCVAWLQ
210 220 230 240 250
QRLAQDEEPP PLPPRGSPAA YRAPLDLYRD LQEDEGSEDA SLYGEPSPGP
260 270 280 290 300
DSPPAELAYR PPLWEQSAKL WGTGGRAWEP PAEELPQASS PPYGALEEGL
310 320 330 340 350
EPEPSAFSFL SLRRELSRPG DLATPESSAA ASPRRIRAEG VPASAYRSVS
360 370 380 390 400
EPPGYQAHSC LSPGALPTLC CDTCRQLHAA HCAALPACRP GHSLRVLLGD
410 420
AQRRLWLQRA QMDTLLYNSP GARP
Length:424
Mass (Da):46,179
Last modified:March 1, 2003 - v1
Checksum:iBC52E883E8994BAA
GO
Isoform 2 (identifier: Q8IUW3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-152: VTALPPACQLVQVA → LCWSQSAGLCRVHG
     153-424: Missing.

Note: No experimental confirmation available.
Show »
Length:152
Mass (Da):17,058
Checksum:i3CEB3FB799515F86
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei139 – 15214VTALP…LVQVA → LCWSQSAGLCRVHG in isoform 2. 1 PublicationVSP_027332Add
BLAST
Alternative sequencei153 – 424272Missing in isoform 2. 1 PublicationVSP_027333Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471184 Genomic DNA. Translation: EAW66697.1.
CH471184 Genomic DNA. Translation: EAW66699.1.
CH471184 Genomic DNA. Translation: EAW66698.1.
BC027606 mRNA. Translation: AAH27606.1.
BC039608 mRNA. Translation: AAH39608.1.
BC053588 mRNA. Translation: AAH53588.1.
CCDSiCCDS10985.1. [Q8IUW3-1]
RefSeqiNP_689552.2. NM_152339.3. [Q8IUW3-1]
XP_005256336.1. XM_005256279.3. [Q8IUW3-1]
UniGeneiHs.374556.

Genome annotation databases

EnsembliENST00000289805; ENSP00000289805; ENSG00000158792. [Q8IUW3-1]
ENST00000335360; ENSP00000334006; ENSG00000158792. [Q8IUW3-2]
GeneIDi124044.
KEGGihsa:124044.
UCSCiuc002foj.4. human. [Q8IUW3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471184 Genomic DNA. Translation: EAW66697.1.
CH471184 Genomic DNA. Translation: EAW66699.1.
CH471184 Genomic DNA. Translation: EAW66698.1.
BC027606 mRNA. Translation: AAH27606.1.
BC039608 mRNA. Translation: AAH39608.1.
BC053588 mRNA. Translation: AAH53588.1.
CCDSiCCDS10985.1. [Q8IUW3-1]
RefSeqiNP_689552.2. NM_152339.3. [Q8IUW3-1]
XP_005256336.1. XM_005256279.3. [Q8IUW3-1]
UniGeneiHs.374556.

3D structure databases

ProteinModelPortaliQ8IUW3.
SMRiQ8IUW3. Positions 33-168.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125846. 5 interactions.
IntActiQ8IUW3. 4 interactions.
STRINGi9606.ENSP00000289805.

PTM databases

iPTMnetiQ8IUW3.
PhosphoSiteiQ8IUW3.

Polymorphism and mutation databases

BioMutaiSPATA2L.
DMDMi74727996.

Proteomic databases

EPDiQ8IUW3.
PaxDbiQ8IUW3.
PRIDEiQ8IUW3.

Protocols and materials databases

DNASUi124044.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289805; ENSP00000289805; ENSG00000158792. [Q8IUW3-1]
ENST00000335360; ENSP00000334006; ENSG00000158792. [Q8IUW3-2]
GeneIDi124044.
KEGGihsa:124044.
UCSCiuc002foj.4. human. [Q8IUW3-1]

Organism-specific databases

CTDi124044.
GeneCardsiSPATA2L.
HGNCiHGNC:28393. SPATA2L.
HPAiHPA041182.
HPA042453.
neXtProtiNX_Q8IUW3.
PharmGKBiPA162404411.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF8A. Eukaryota.
ENOG410XW6I. LUCA.
GeneTreeiENSGT00530000063956.
HOGENOMiHOG000060210.
HOVERGENiHBG102025.
InParanoidiQ8IUW3.
KOiK17595.
OMAiVHVLKGA.
OrthoDBiEOG7NSB2S.
PhylomeDBiQ8IUW3.
TreeFamiTF328840.

Miscellaneous databases

GenomeRNAii124044.
NextBioi81208.
PROiQ8IUW3.

Gene expression databases

BgeeiQ8IUW3.
CleanExiHS_SPATA2L.
ExpressionAtlasiQ8IUW3. baseline and differential.
GenevisibleiQ8IUW3. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Testis.

Entry informationi

Entry nameiSPA2L_HUMAN
AccessioniPrimary (citable) accession number: Q8IUW3
Secondary accession number(s): D3DX85, Q8NHV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.