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Protein

Spermatogenesis-associated protein 2-like protein

Gene

SPATA2L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatogenesis-associated protein 2-like protein
Short name:
SPATA2-like protein
Gene namesi
Name:SPATA2L
Synonyms:C16orf76
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000158792.15
HGNCiHGNC:28393 SPATA2L
neXtProtiNX_Q8IUW3

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000158792
PharmGKBiPA162404411

Polymorphism and mutation databases

BioMutaiSPATA2L
DMDMi74727996

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002976701 – 424Spermatogenesis-associated protein 2-like proteinAdd BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei327PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8IUW3
PeptideAtlasiQ8IUW3
PRIDEiQ8IUW3

PTM databases

iPTMnetiQ8IUW3
PhosphoSitePlusiQ8IUW3

Expressioni

Gene expression databases

BgeeiENSG00000158792
CleanExiHS_SPATA2L
ExpressionAtlasiQ8IUW3 baseline and differential
GenevisibleiQ8IUW3 HS

Organism-specific databases

HPAiHPA041182
HPA042453

Interactioni

Protein-protein interaction databases

BioGridi125846, 6 interactors
IntActiQ8IUW3, 6 interactors
STRINGi9606.ENSP00000289805

Structurei

3D structure databases

ProteinModelPortaliQ8IUW3
SMRiQ8IUW3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPATA2 family.Curated

Phylogenomic databases

eggNOGiENOG410IF8A Eukaryota
ENOG410XW6I LUCA
GeneTreeiENSGT00530000063956
HOGENOMiHOG000060210
HOVERGENiHBG102025
InParanoidiQ8IUW3
KOiK17595
OMAiVHVLKGA
OrthoDBiEOG091G09LM
PhylomeDBiQ8IUW3
TreeFamiTF328840

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IUW3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSSSLSEDY RQCLERELRR GRAGVCGDPS LRAVLWQILV EDFDLHGALQ
60 70 80 90 100
DDALALLTDG LWGRADLAPA LRGLARAFEL LELAAVHLYL LPWRKEFTTI
110 120 130 140 150
KTFSGGYVHV LKGVLSDDLL LKSFQKMGYV RRDSHRLMVT ALPPACQLVQ
160 170 180 190 200
VALGCFALRL ECEILGEVLA QLGTSVLPAE ELLQARRASG DVASCVAWLQ
210 220 230 240 250
QRLAQDEEPP PLPPRGSPAA YRAPLDLYRD LQEDEGSEDA SLYGEPSPGP
260 270 280 290 300
DSPPAELAYR PPLWEQSAKL WGTGGRAWEP PAEELPQASS PPYGALEEGL
310 320 330 340 350
EPEPSAFSFL SLRRELSRPG DLATPESSAA ASPRRIRAEG VPASAYRSVS
360 370 380 390 400
EPPGYQAHSC LSPGALPTLC CDTCRQLHAA HCAALPACRP GHSLRVLLGD
410 420
AQRRLWLQRA QMDTLLYNSP GARP
Length:424
Mass (Da):46,179
Last modified:March 1, 2003 - v1
Checksum:iBC52E883E8994BAA
GO
Isoform 2 (identifier: Q8IUW3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-152: VTALPPACQLVQVA → LCWSQSAGLCRVHG
     153-424: Missing.

Note: No experimental confirmation available.
Show »
Length:152
Mass (Da):17,058
Checksum:i3CEB3FB799515F86
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027332139 – 152VTALP…LVQVA → LCWSQSAGLCRVHG in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_027333153 – 424Missing in isoform 2. 1 PublicationAdd BLAST272

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471184 Genomic DNA Translation: EAW66697.1
CH471184 Genomic DNA Translation: EAW66699.1
CH471184 Genomic DNA Translation: EAW66698.1
BC027606 mRNA Translation: AAH27606.1
BC039608 mRNA Translation: AAH39608.1
BC053588 mRNA Translation: AAH53588.1
CCDSiCCDS10985.1 [Q8IUW3-1]
RefSeqiNP_689552.2, NM_152339.3 [Q8IUW3-1]
XP_005256336.1, XM_005256279.4 [Q8IUW3-1]
UniGeneiHs.374556

Genome annotation databases

EnsembliENST00000289805; ENSP00000289805; ENSG00000158792 [Q8IUW3-1]
ENST00000335360; ENSP00000334006; ENSG00000158792 [Q8IUW3-2]
GeneIDi124044
KEGGihsa:124044
UCSCiuc002foj.4 human [Q8IUW3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSPA2L_HUMAN
AccessioniPrimary (citable) accession number: Q8IUW3
Secondary accession number(s): D3DX85, Q8NHV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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