Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Epoxide hydrolase 4

Gene

EPHX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei169NucleophileBy similarity1
Active sitei281Proton donorBy similarity1
Active sitei336Proton acceptorBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Protein family/group databases

ESTHERihuman-EPHX4 Epoxide_hydrolase
MEROPSiS33.978

Names & Taxonomyi

Protein namesi
Recommended name:
Epoxide hydrolase 4 (EC:3.3.-.-)
Alternative name(s):
Abhydrolase domain-containing protein 7
Epoxide hydrolase-related protein
Gene namesi
Name:EPHX4
Synonyms:ABHD7, EH4, EPHXRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000172031.6
HGNCiHGNC:23758 EPHX4
MIMi617401 gene
neXtProtiNX_Q8IUS5

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 37Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi253152
OpenTargetsiENSG00000172031
PharmGKBiPA164719207

Polymorphism and mutation databases

BioMutaiEPHX4
DMDMi134035378

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002813781 – 362Epoxide hydrolase 4Add BLAST362

Proteomic databases

MaxQBiQ8IUS5
PaxDbiQ8IUS5
PeptideAtlasiQ8IUS5
PRIDEiQ8IUS5

PTM databases

iPTMnetiQ8IUS5
PhosphoSitePlusiQ8IUS5

Expressioni

Gene expression databases

BgeeiENSG00000172031
CleanExiHS_ABHD7
GenevisibleiQ8IUS5 HS

Organism-specific databases

HPAiHPA035067

Interactioni

Protein-protein interaction databases

BioGridi128958, 1 interactor
STRINGi9606.ENSP00000359410

Structurei

3D structure databases

ProteinModelPortaliQ8IUS5
SMRiQ8IUS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 211AB hydrolase-1Sequence analysisAdd BLAST118

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INND Eukaryota
ENOG410XRPK LUCA
GeneTreeiENSGT00530000063213
HOGENOMiHOG000028073
InParanoidiQ8IUS5
KOiK22369
OMAiGPWTHRD
OrthoDBiEOG091G0ASI
PhylomeDBiQ8IUS5
TreeFamiTF314403

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR000639 Epox_hydrolase-like
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PRINTSiPR00111 ABHYDROLASE
PR00412 EPOXHYDRLASE
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IUS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARLRDCLPR LMLTLRSLLF WSLVYCYCGL CASIHLLKLL WSLGKGPAQT
60 70 80 90 100
FRRPAREHPP ACLSDPSLGT HCYVRIKDSG LRFHYVAAGE RGKPLMLLLH
110 120 130 140 150
GFPEFWYSWR YQLREFKSEY RVVALDLRGY GETDAPIHRQ NYKLDCLITD
160 170 180 190 200
IKDILDSLGY SKCVLIGHDW GGMIAWLIAI CYPEMVMKLI VINFPHPNVF
210 220 230 240 250
TEYILRHPAQ LLKSSYYYFF QIPWFPEFMF SINDFKVLKH LFTSHSTGIG
260 270 280 290 300
RKGCQLTTED LEAYIYVFSQ PGALSGPINH YRNIFSCLPL KHHMVTTPTL
310 320 330 340 350
LLWGENDAFM EVEMAEVTKI YVKNYFRLTI LSEASHWLQQ DQPDIVNKLI
360
WTFLKEETRK KD
Length:362
Mass (Da):42,324
Last modified:March 20, 2007 - v2
Checksum:iB0B359E0AF0EED7C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti285F → I in BAC11230 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031235321Y → F1 PublicationCorresponds to variant dbSNP:rs17854127Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074822 mRNA Translation: BAC11230.1
BC041475 mRNA Translation: AAH41475.1
CCDSiCCDS736.1
RefSeqiNP_775838.3, NM_173567.4
UniGeneiHs.201555

Genome annotation databases

EnsembliENST00000370383; ENSP00000359410; ENSG00000172031
GeneIDi253152
KEGGihsa:253152
UCSCiuc001don.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiEPHX4_HUMAN
AccessioniPrimary (citable) accession number: Q8IUS5
Secondary accession number(s): Q8NCC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: March 28, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health