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Q8IUS5

- EPHX4_HUMAN

UniProt

Q8IUS5 - EPHX4_HUMAN

Protein

Epoxide hydrolase 4

Gene

EPHX4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei169 – 1691NucleophileBy similarity
    Active sitei281 – 2811Proton donorBy similarity
    Active sitei336 – 3361Proton acceptorBy similarity

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Protein family/group databases

    MEROPSiS33.974.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Epoxide hydrolase 4 (EC:3.3.-.-)
    Alternative name(s):
    Abhydrolase domain-containing protein 7
    Epoxide hydrolase-related protein
    Gene namesi
    Name:EPHX4
    Synonyms:ABHD7, EPHXRP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:23758. EPHX4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164719207.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 362362Epoxide hydrolase 4PRO_0000281378Add
    BLAST

    Proteomic databases

    MaxQBiQ8IUS5.
    PaxDbiQ8IUS5.
    PRIDEiQ8IUS5.

    PTM databases

    PhosphoSiteiQ8IUS5.

    Expressioni

    Gene expression databases

    BgeeiQ8IUS5.
    CleanExiHS_ABHD7.
    GenevestigatoriQ8IUS5.

    Organism-specific databases

    HPAiHPA035067.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000359410.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IUS5.
    SMRiQ8IUS5. Positions 76-356.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0596.
    HOGENOMiHOG000028073.
    InParanoidiQ8IUS5.
    OMAiTGPINHY.
    OrthoDBiEOG7VQJDV.
    PhylomeDBiQ8IUS5.
    TreeFamiTF314403.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR000073. AB_hydrolase_1.
    IPR000639. Epox_hydrolase-like.
    [Graphical view]
    PRINTSiPR00111. ABHYDROLASE.
    PR00412. EPOXHYDRLASE.
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8IUS5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARLRDCLPR LMLTLRSLLF WSLVYCYCGL CASIHLLKLL WSLGKGPAQT    50
    FRRPAREHPP ACLSDPSLGT HCYVRIKDSG LRFHYVAAGE RGKPLMLLLH 100
    GFPEFWYSWR YQLREFKSEY RVVALDLRGY GETDAPIHRQ NYKLDCLITD 150
    IKDILDSLGY SKCVLIGHDW GGMIAWLIAI CYPEMVMKLI VINFPHPNVF 200
    TEYILRHPAQ LLKSSYYYFF QIPWFPEFMF SINDFKVLKH LFTSHSTGIG 250
    RKGCQLTTED LEAYIYVFSQ PGALSGPINH YRNIFSCLPL KHHMVTTPTL 300
    LLWGENDAFM EVEMAEVTKI YVKNYFRLTI LSEASHWLQQ DQPDIVNKLI 350
    WTFLKEETRK KD 362
    Length:362
    Mass (Da):42,324
    Last modified:March 20, 2007 - v2
    Checksum:iB0B359E0AF0EED7C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti285 – 2851F → I in BAC11230. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti321 – 3211Y → F.1 Publication
    Corresponds to variant rs17854127 [ dbSNP | Ensembl ].
    VAR_031235

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074822 mRNA. Translation: BAC11230.1.
    BC041475 mRNA. Translation: AAH41475.1.
    CCDSiCCDS736.1.
    RefSeqiNP_775838.3. NM_173567.4.
    UniGeneiHs.201555.

    Genome annotation databases

    EnsembliENST00000370383; ENSP00000359410; ENSG00000172031.
    GeneIDi253152.
    KEGGihsa:253152.
    UCSCiuc001don.2. human.

    Polymorphism databases

    DMDMi134035378.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074822 mRNA. Translation: BAC11230.1 .
    BC041475 mRNA. Translation: AAH41475.1 .
    CCDSi CCDS736.1.
    RefSeqi NP_775838.3. NM_173567.4.
    UniGenei Hs.201555.

    3D structure databases

    ProteinModelPortali Q8IUS5.
    SMRi Q8IUS5. Positions 76-356.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000359410.

    Protein family/group databases

    MEROPSi S33.974.

    PTM databases

    PhosphoSitei Q8IUS5.

    Polymorphism databases

    DMDMi 134035378.

    Proteomic databases

    MaxQBi Q8IUS5.
    PaxDbi Q8IUS5.
    PRIDEi Q8IUS5.

    Protocols and materials databases

    DNASUi 253152.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370383 ; ENSP00000359410 ; ENSG00000172031 .
    GeneIDi 253152.
    KEGGi hsa:253152.
    UCSCi uc001don.2. human.

    Organism-specific databases

    CTDi 253152.
    GeneCardsi GC01P092495.
    HGNCi HGNC:23758. EPHX4.
    HPAi HPA035067.
    neXtProti NX_Q8IUS5.
    PharmGKBi PA164719207.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0596.
    HOGENOMi HOG000028073.
    InParanoidi Q8IUS5.
    OMAi TGPINHY.
    OrthoDBi EOG7VQJDV.
    PhylomeDBi Q8IUS5.
    TreeFami TF314403.

    Miscellaneous databases

    GenomeRNAii 253152.
    NextBioi 92067.
    PROi Q8IUS5.

    Gene expression databases

    Bgeei Q8IUS5.
    CleanExi HS_ABHD7.
    Genevestigatori Q8IUS5.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR000073. AB_hydrolase_1.
    IPR000639. Epox_hydrolase-like.
    [Graphical view ]
    PRINTSi PR00111. ABHYDROLASE.
    PR00412. EPOXHYDRLASE.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Teratocarcinoma.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-321.
      Tissue: Brain.

    Entry informationi

    Entry nameiEPHX4_HUMAN
    AccessioniPrimary (citable) accession number: Q8IUS5
    Secondary accession number(s): Q8NCC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3