SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8IUS5

- EPHX4_HUMAN

UniProt

Q8IUS5 - EPHX4_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Epoxide hydrolase 4
Gene
EPHX4, ABHD7, EPHXRP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei169 – 1691Nucleophile By similarity
Active sitei281 – 2811Proton donor By similarity
Active sitei336 – 3361Proton acceptor By similarity

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

MEROPSiS33.974.

Names & Taxonomyi

Protein namesi
Recommended name:
Epoxide hydrolase 4 (EC:3.3.-.-)
Alternative name(s):
Abhydrolase domain-containing protein 7
Epoxide hydrolase-related protein
Gene namesi
Name:EPHX4
Synonyms:ABHD7, EPHXRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:23758. EPHX4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164719207.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Epoxide hydrolase 4
PRO_0000281378Add
BLAST

Proteomic databases

MaxQBiQ8IUS5.
PaxDbiQ8IUS5.
PRIDEiQ8IUS5.

PTM databases

PhosphoSiteiQ8IUS5.

Expressioni

Gene expression databases

BgeeiQ8IUS5.
CleanExiHS_ABHD7.
GenevestigatoriQ8IUS5.

Organism-specific databases

HPAiHPA035067.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000359410.

Structurei

3D structure databases

ProteinModelPortaliQ8IUS5.
SMRiQ8IUS5. Positions 76-356.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0596.
HOGENOMiHOG000028073.
InParanoidiQ8IUS5.
OMAiTGPINHY.
OrthoDBiEOG7VQJDV.
PhylomeDBiQ8IUS5.
TreeFamiTF314403.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IUS5-1 [UniParc]FASTAAdd to Basket

« Hide

MARLRDCLPR LMLTLRSLLF WSLVYCYCGL CASIHLLKLL WSLGKGPAQT    50
FRRPAREHPP ACLSDPSLGT HCYVRIKDSG LRFHYVAAGE RGKPLMLLLH 100
GFPEFWYSWR YQLREFKSEY RVVALDLRGY GETDAPIHRQ NYKLDCLITD 150
IKDILDSLGY SKCVLIGHDW GGMIAWLIAI CYPEMVMKLI VINFPHPNVF 200
TEYILRHPAQ LLKSSYYYFF QIPWFPEFMF SINDFKVLKH LFTSHSTGIG 250
RKGCQLTTED LEAYIYVFSQ PGALSGPINH YRNIFSCLPL KHHMVTTPTL 300
LLWGENDAFM EVEMAEVTKI YVKNYFRLTI LSEASHWLQQ DQPDIVNKLI 350
WTFLKEETRK KD 362
Length:362
Mass (Da):42,324
Last modified:March 20, 2007 - v2
Checksum:iB0B359E0AF0EED7C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti321 – 3211Y → F.1 Publication
Corresponds to variant rs17854127 [ dbSNP | Ensembl ].
VAR_031235

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti285 – 2851F → I in BAC11230. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK074822 mRNA. Translation: BAC11230.1.
BC041475 mRNA. Translation: AAH41475.1.
CCDSiCCDS736.1.
RefSeqiNP_775838.3. NM_173567.4.
UniGeneiHs.201555.

Genome annotation databases

EnsembliENST00000370383; ENSP00000359410; ENSG00000172031.
GeneIDi253152.
KEGGihsa:253152.
UCSCiuc001don.2. human.

Polymorphism databases

DMDMi134035378.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK074822 mRNA. Translation: BAC11230.1 .
BC041475 mRNA. Translation: AAH41475.1 .
CCDSi CCDS736.1.
RefSeqi NP_775838.3. NM_173567.4.
UniGenei Hs.201555.

3D structure databases

ProteinModelPortali Q8IUS5.
SMRi Q8IUS5. Positions 76-356.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000359410.

Protein family/group databases

MEROPSi S33.974.

PTM databases

PhosphoSitei Q8IUS5.

Polymorphism databases

DMDMi 134035378.

Proteomic databases

MaxQBi Q8IUS5.
PaxDbi Q8IUS5.
PRIDEi Q8IUS5.

Protocols and materials databases

DNASUi 253152.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370383 ; ENSP00000359410 ; ENSG00000172031 .
GeneIDi 253152.
KEGGi hsa:253152.
UCSCi uc001don.2. human.

Organism-specific databases

CTDi 253152.
GeneCardsi GC01P092495.
HGNCi HGNC:23758. EPHX4.
HPAi HPA035067.
neXtProti NX_Q8IUS5.
PharmGKBi PA164719207.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0596.
HOGENOMi HOG000028073.
InParanoidi Q8IUS5.
OMAi TGPINHY.
OrthoDBi EOG7VQJDV.
PhylomeDBi Q8IUS5.
TreeFami TF314403.

Miscellaneous databases

GenomeRNAii 253152.
NextBioi 92067.
PROi Q8IUS5.

Gene expression databases

Bgeei Q8IUS5.
CleanExi HS_ABHD7.
Genevestigatori Q8IUS5.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view ]
PRINTSi PR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-321.
    Tissue: Brain.

Entry informationi

Entry nameiEPHX4_HUMAN
AccessioniPrimary (citable) accession number: Q8IUS5
Secondary accession number(s): Q8NCC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: July 9, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi