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Protein

Epoxide hydrolase 4

Gene

EPHX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei169 – 1691NucleophileBy similarity
Active sitei281 – 2811Proton donorBy similarity
Active sitei336 – 3361Proton acceptorBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

ESTHERihuman-EPHX4. Epoxide_hydrolase.
MEROPSiS33.978.

Names & Taxonomyi

Protein namesi
Recommended name:
Epoxide hydrolase 4 (EC:3.3.-.-)
Alternative name(s):
Abhydrolase domain-containing protein 7
Epoxide hydrolase-related protein
Gene namesi
Name:EPHX4
Synonyms:ABHD7, EPHXRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:23758. EPHX4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164719207.

Polymorphism and mutation databases

BioMutaiEPHX4.
DMDMi134035378.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Epoxide hydrolase 4PRO_0000281378Add
BLAST

Proteomic databases

MaxQBiQ8IUS5.
PaxDbiQ8IUS5.
PRIDEiQ8IUS5.

PTM databases

PhosphoSiteiQ8IUS5.

Expressioni

Gene expression databases

BgeeiQ8IUS5.
CleanExiHS_ABHD7.
GenevisibleiQ8IUS5. HS.

Organism-specific databases

HPAiHPA035067.

Interactioni

Protein-protein interaction databases

BioGridi128958. 1 interaction.
STRINGi9606.ENSP00000359410.

Structurei

3D structure databases

ProteinModelPortaliQ8IUS5.
SMRiQ8IUS5. Positions 76-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0596.
GeneTreeiENSGT00530000063213.
HOGENOMiHOG000028073.
InParanoidiQ8IUS5.
OMAiMIWGEND.
OrthoDBiEOG7VQJDV.
PhylomeDBiQ8IUS5.
TreeFamiTF314403.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PfamiPF12697. Abhydrolase_6. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IUS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARLRDCLPR LMLTLRSLLF WSLVYCYCGL CASIHLLKLL WSLGKGPAQT
60 70 80 90 100
FRRPAREHPP ACLSDPSLGT HCYVRIKDSG LRFHYVAAGE RGKPLMLLLH
110 120 130 140 150
GFPEFWYSWR YQLREFKSEY RVVALDLRGY GETDAPIHRQ NYKLDCLITD
160 170 180 190 200
IKDILDSLGY SKCVLIGHDW GGMIAWLIAI CYPEMVMKLI VINFPHPNVF
210 220 230 240 250
TEYILRHPAQ LLKSSYYYFF QIPWFPEFMF SINDFKVLKH LFTSHSTGIG
260 270 280 290 300
RKGCQLTTED LEAYIYVFSQ PGALSGPINH YRNIFSCLPL KHHMVTTPTL
310 320 330 340 350
LLWGENDAFM EVEMAEVTKI YVKNYFRLTI LSEASHWLQQ DQPDIVNKLI
360
WTFLKEETRK KD
Length:362
Mass (Da):42,324
Last modified:March 20, 2007 - v2
Checksum:iB0B359E0AF0EED7C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti285 – 2851F → I in BAC11230 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti321 – 3211Y → F.1 Publication
Corresponds to variant rs17854127 [ dbSNP | Ensembl ].
VAR_031235

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074822 mRNA. Translation: BAC11230.1.
BC041475 mRNA. Translation: AAH41475.1.
CCDSiCCDS736.1.
RefSeqiNP_775838.3. NM_173567.4.
UniGeneiHs.201555.

Genome annotation databases

EnsembliENST00000370383; ENSP00000359410; ENSG00000172031.
GeneIDi253152.
KEGGihsa:253152.
UCSCiuc001don.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074822 mRNA. Translation: BAC11230.1.
BC041475 mRNA. Translation: AAH41475.1.
CCDSiCCDS736.1.
RefSeqiNP_775838.3. NM_173567.4.
UniGeneiHs.201555.

3D structure databases

ProteinModelPortaliQ8IUS5.
SMRiQ8IUS5. Positions 76-356.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128958. 1 interaction.
STRINGi9606.ENSP00000359410.

Protein family/group databases

ESTHERihuman-EPHX4. Epoxide_hydrolase.
MEROPSiS33.978.

PTM databases

PhosphoSiteiQ8IUS5.

Polymorphism and mutation databases

BioMutaiEPHX4.
DMDMi134035378.

Proteomic databases

MaxQBiQ8IUS5.
PaxDbiQ8IUS5.
PRIDEiQ8IUS5.

Protocols and materials databases

DNASUi253152.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370383; ENSP00000359410; ENSG00000172031.
GeneIDi253152.
KEGGihsa:253152.
UCSCiuc001don.2. human.

Organism-specific databases

CTDi253152.
GeneCardsiGC01P092495.
HGNCiHGNC:23758. EPHX4.
HPAiHPA035067.
neXtProtiNX_Q8IUS5.
PharmGKBiPA164719207.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0596.
GeneTreeiENSGT00530000063213.
HOGENOMiHOG000028073.
InParanoidiQ8IUS5.
OMAiMIWGEND.
OrthoDBiEOG7VQJDV.
PhylomeDBiQ8IUS5.
TreeFamiTF314403.

Miscellaneous databases

GenomeRNAii253152.
NextBioi92067.
PROiQ8IUS5.

Gene expression databases

BgeeiQ8IUS5.
CleanExiHS_ABHD7.
GenevisibleiQ8IUS5. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PfamiPF12697. Abhydrolase_6. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-321.
    Tissue: Brain.

Entry informationi

Entry nameiEPHX4_HUMAN
AccessioniPrimary (citable) accession number: Q8IUS5
Secondary accession number(s): Q8NCC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: July 22, 2015
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.