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Protein

Armadillo repeat-containing protein 8

Gene

ARMC8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

ReactomeiR-HSA-6798695. Neutrophil degranulation.
SignaLinkiQ8IUR7.

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing protein 8
Gene namesi
Name:ARMC8
ORF Names:S863-2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24999. ARMC8.

Pathology & Biotechi

Organism-specific databases

DisGeNETi25852.
OpenTargetsiENSG00000114098.
PharmGKBiPA134984953.

Polymorphism and mutation databases

DMDMi145558852.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002844082 – 673Armadillo repeat-containing protein 8Add BLAST672

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei337PhosphoserineCombined sources1
Modified residuei512PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8IUR7.
MaxQBiQ8IUR7.
PaxDbiQ8IUR7.
PeptideAtlasiQ8IUR7.
PRIDEiQ8IUR7.

PTM databases

iPTMnetiQ8IUR7.
PhosphoSitePlusiQ8IUR7.

Expressioni

Gene expression databases

BgeeiENSG00000114098.
CleanExiHS_ARMC8.
ExpressionAtlasiQ8IUR7. baseline and differential.
GenevisibleiQ8IUR7. HS.

Organism-specific databases

HPAiHPA036996.
HPA044869.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TCF12Q990813EBI-1049469,EBI-722877

Protein-protein interaction databases

BioGridi117376. 52 interactors.
IntActiQ8IUR7. 22 interactors.
STRINGi9606.ENSP00000420333.

Structurei

3D structure databases

ProteinModelPortaliQ8IUR7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati51 – 92ARM 1Add BLAST42
Repeati95 – 134ARM 2Add BLAST40
Repeati138 – 176ARM 3Add BLAST39
Repeati178 – 217ARM 4Add BLAST40
Repeati224 – 265ARM 5Add BLAST42
Repeati269 – 309ARM 6Add BLAST41
Repeati313 – 352ARM 7Add BLAST40
Repeati374 – 413ARM 8Add BLAST40
Repeati416 – 455ARM 9Add BLAST40
Repeati458 – 497ARM 10Add BLAST40
Repeati501 – 540ARM 11Add BLAST40
Repeati543 – 585ARM 12Add BLAST43
Repeati588 – 627ARM 13Add BLAST40
Repeati634 – 673ARM 14Add BLAST40

Sequence similaritiesi

Contains 14 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1293. Eukaryota.
COG5369. LUCA.
GeneTreeiENSGT00390000003033.
HOGENOMiHOG000006962.
HOVERGENiHBG106422.
InParanoidiQ8IUR7.
OMAiGHSNVKL.
OrthoDBiEOG091G02YW.
PhylomeDBiQ8IUR7.
TreeFamiTF324806.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamiPF00514. Arm. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 9 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IUR7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MACLLETPIR MSVLSEVTAS SRHYVDRLFD PDPQKVLQGV IDMKNAVIGN
60 70 80 90 100
NKQKANLIVL GAVPRLLYLL QQETSSTELK TECAVVLGSL AMGTENNVKS
110 120 130 140 150
LLDCHIIPAL LQGLLSPDLK FIEACLRCLR TIFTSPVTPE ELLYTDATVI
160 170 180 190 200
PHLMALLSRS RYTQEYICQI FSHCCKGPDH QTILFNHGAV QNIAHLLTSL
210 220 230 240 250
SYKVRMQALK CFSVLAFENP QVSMTLVNVL VDGELLPQIF VKMLQRDKPI
260 270 280 290 300
EMQLTSAKCL TYMCRAGAIR TDDNCIVLKT LPCLVRMCSK ERLLEERVEG
310 320 330 340 350
AETLAYLIEP DVELQRIASI TDHLIAMLAD YFKYPSSVSA ITDIKRLDHD
360 370 380 390 400
LKHAHELRQA AFKLYASLGA NDEDIRKKII ETENMMDRIV TGLSESSVKV
410 420 430 440 450
RLAAVRCLHS LSRSVQQLRT SFQDHAVWKP LMKVLQNAPD EILVVASSML
460 470 480 490 500
CNLLLEFSPS KEPILESGAV ELLCGLTQSE NPALRVNGIW ALMNMAFQAE
510 520 530 540 550
QKIKADILRS LSTEQLFRLL SDSDLNVLMK TLGLLRNLLS TRPHIDKIMS
560 570 580 590 600
THGKQIMQAV TLILEGEHNI EVKEQTLCIL ANIADGTTAK DLIMTNDDIL
610 620 630 640 650
QKIKYYMGHS HVKLQLAAMF CISNLIWNEE EGSQERQDKL RDMGIVDILH
660 670
KLSQSPDSNL CDKAKMALQQ YLA
Length:673
Mass (Da):75,509
Last modified:April 17, 2007 - v2
Checksum:i726BAC0A373485E8
GO
Isoform 2 (identifier: Q8IUR7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-15: Missing.

Note: No experimental confirmation available.
Show »
Length:659
Mass (Da):73,994
Checksum:i8A3314D9F0DF302F
GO
Isoform 3 (identifier: Q8IUR7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Note: No experimental confirmation available.
Show »
Length:631
Mass (Da):70,796
Checksum:i8DB486E356108D97
GO
Isoform 6 (identifier: Q8IUR7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-15: Missing.
     379-399: IIETENMMDRIVTGLSESSVK → VSLGEGRPPVLTASRQGVTST
     400-673: Missing.

Show »
Length:385
Mass (Da):42,984
Checksum:iBAE44225B08675A6
GO
Isoform 7 (identifier: Q8IUR7-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-176: Missing.

Note: No experimental confirmation available.
Show »
Length:642
Mass (Da):71,899
Checksum:iC22F37EEF0B56B93
GO
Isoform 8 (identifier: Q8IUR7-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     280-346: Missing.

Show »
Length:606
Mass (Da):67,900
Checksum:iC5946E9DC52A4AB9
GO

Sequence cautioni

The sequence BAA91861 differs from that shown. Reason: Frameshift at position 468.Curated
The sequence BAA91959 differs from that shown. Intron retention.Curated
The sequence CAB46423 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78E → G in BAA91861 (PubMed:14702039).Curated1
Sequence conflicti128C → R in BAH12439 (PubMed:14702039).Curated1
Sequence conflicti231V → A in AAH32661 (PubMed:15489334).Curated1
Sequence conflicti327M → V in BAA91861 (PubMed:14702039).Curated1
Sequence conflicti397S → N in BAA91959 (PubMed:14702039).Curated1
Sequence conflicti462E → G in BAH12439 (PubMed:14702039).Curated1
Sequence conflicti495M → I in BAH12439 (PubMed:14702039).Curated1
Sequence conflicti537N → S in BAA91959 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0245121 – 42Missing in isoform 3. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_0245092 – 15Missing in isoform 2 and isoform 6. 3 PublicationsAdd BLAST14
Alternative sequenceiVSP_044774146 – 176Missing in isoform 7. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_045137280 – 346Missing in isoform 8. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_024513379 – 399IIETE…ESSVK → VSLGEGRPPVLTASRQGVTS T in isoform 6. 3 PublicationsAdd BLAST21
Alternative sequenceiVSP_024514400 – 673Missing in isoform 6. 3 PublicationsAdd BLAST274

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109184 mRNA. Translation: AAQ13493.1.
AK001721 mRNA. Translation: BAA91861.1. Frameshift.
AK001882 mRNA. Translation: BAA91959.1. Sequence problems.
AK289577 mRNA. Translation: BAF82266.1.
AK296757 mRNA. Translation: BAH12427.1.
AK296837 mRNA. Translation: BAH12439.1.
AC022337 Genomic DNA. No translation available.
AC068777 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79076.1.
CH471052 Genomic DNA. Translation: EAW79075.1.
CH471052 Genomic DNA. Translation: EAW79079.1.
BC013424 mRNA. Translation: AAH13424.1.
BC032661 mRNA. Translation: AAH32661.1.
BC041699 mRNA. Translation: AAH41699.1.
AL096748 mRNA. Translation: CAB46423.1. Sequence problems.
CCDSiCCDS3098.1. [Q8IUR7-6]
CCDS54646.1. [Q8IUR7-2]
CCDS58853.1. [Q8IUR7-8]
CCDS58854.1. [Q8IUR7-7]
PIRiT12513.
RefSeqiNP_001253970.1. NM_001267041.2. [Q8IUR7-7]
NP_001253971.1. NM_001267042.2. [Q8IUR7-8]
NP_001269271.1. NM_001282342.1.
NP_054873.2. NM_014154.4. [Q8IUR7-6]
NP_056211.2. NM_015396.5. [Q8IUR7-2]
NP_998819.1. NM_213654.3. [Q8IUR7-6]
XP_006713627.1. XM_006713564.3. [Q8IUR7-1]
XP_006713628.1. XM_006713565.2. [Q8IUR7-2]
XP_006713629.1. XM_006713566.3. [Q8IUR7-3]
XP_011510934.1. XM_011512632.1. [Q8IUR7-3]
XP_011510935.1. XM_011512633.1. [Q8IUR7-3]
UniGeneiHs.744868.

Genome annotation databases

EnsembliENST00000358441; ENSP00000351221; ENSG00000114098. [Q8IUR7-6]
ENST00000461822; ENSP00000420706; ENSG00000114098. [Q8IUR7-8]
ENST00000469044; ENSP00000419413; ENSG00000114098. [Q8IUR7-1]
ENST00000471453; ENSP00000420440; ENSG00000114098. [Q8IUR7-6]
ENST00000481646; ENSP00000420333; ENSG00000114098. [Q8IUR7-2]
ENST00000491704; ENSP00000417304; ENSG00000114098. [Q8IUR7-3]
ENST00000538260; ENSP00000441592; ENSG00000114098. [Q8IUR7-7]
GeneIDi25852.
KEGGihsa:25852.
UCSCiuc003erw.6. human. [Q8IUR7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109184 mRNA. Translation: AAQ13493.1.
AK001721 mRNA. Translation: BAA91861.1. Frameshift.
AK001882 mRNA. Translation: BAA91959.1. Sequence problems.
AK289577 mRNA. Translation: BAF82266.1.
AK296757 mRNA. Translation: BAH12427.1.
AK296837 mRNA. Translation: BAH12439.1.
AC022337 Genomic DNA. No translation available.
AC068777 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79076.1.
CH471052 Genomic DNA. Translation: EAW79075.1.
CH471052 Genomic DNA. Translation: EAW79079.1.
BC013424 mRNA. Translation: AAH13424.1.
BC032661 mRNA. Translation: AAH32661.1.
BC041699 mRNA. Translation: AAH41699.1.
AL096748 mRNA. Translation: CAB46423.1. Sequence problems.
CCDSiCCDS3098.1. [Q8IUR7-6]
CCDS54646.1. [Q8IUR7-2]
CCDS58853.1. [Q8IUR7-8]
CCDS58854.1. [Q8IUR7-7]
PIRiT12513.
RefSeqiNP_001253970.1. NM_001267041.2. [Q8IUR7-7]
NP_001253971.1. NM_001267042.2. [Q8IUR7-8]
NP_001269271.1. NM_001282342.1.
NP_054873.2. NM_014154.4. [Q8IUR7-6]
NP_056211.2. NM_015396.5. [Q8IUR7-2]
NP_998819.1. NM_213654.3. [Q8IUR7-6]
XP_006713627.1. XM_006713564.3. [Q8IUR7-1]
XP_006713628.1. XM_006713565.2. [Q8IUR7-2]
XP_006713629.1. XM_006713566.3. [Q8IUR7-3]
XP_011510934.1. XM_011512632.1. [Q8IUR7-3]
XP_011510935.1. XM_011512633.1. [Q8IUR7-3]
UniGeneiHs.744868.

3D structure databases

ProteinModelPortaliQ8IUR7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117376. 52 interactors.
IntActiQ8IUR7. 22 interactors.
STRINGi9606.ENSP00000420333.

PTM databases

iPTMnetiQ8IUR7.
PhosphoSitePlusiQ8IUR7.

Polymorphism and mutation databases

DMDMi145558852.

Proteomic databases

EPDiQ8IUR7.
MaxQBiQ8IUR7.
PaxDbiQ8IUR7.
PeptideAtlasiQ8IUR7.
PRIDEiQ8IUR7.

Protocols and materials databases

DNASUi25852.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358441; ENSP00000351221; ENSG00000114098. [Q8IUR7-6]
ENST00000461822; ENSP00000420706; ENSG00000114098. [Q8IUR7-8]
ENST00000469044; ENSP00000419413; ENSG00000114098. [Q8IUR7-1]
ENST00000471453; ENSP00000420440; ENSG00000114098. [Q8IUR7-6]
ENST00000481646; ENSP00000420333; ENSG00000114098. [Q8IUR7-2]
ENST00000491704; ENSP00000417304; ENSG00000114098. [Q8IUR7-3]
ENST00000538260; ENSP00000441592; ENSG00000114098. [Q8IUR7-7]
GeneIDi25852.
KEGGihsa:25852.
UCSCiuc003erw.6. human. [Q8IUR7-1]

Organism-specific databases

CTDi25852.
DisGeNETi25852.
GeneCardsiARMC8.
H-InvDBHIX0003713.
HGNCiHGNC:24999. ARMC8.
HPAiHPA036996.
HPA044869.
neXtProtiNX_Q8IUR7.
OpenTargetsiENSG00000114098.
PharmGKBiPA134984953.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1293. Eukaryota.
COG5369. LUCA.
GeneTreeiENSGT00390000003033.
HOGENOMiHOG000006962.
HOVERGENiHBG106422.
InParanoidiQ8IUR7.
OMAiGHSNVKL.
OrthoDBiEOG091G02YW.
PhylomeDBiQ8IUR7.
TreeFamiTF324806.

Enzyme and pathway databases

ReactomeiR-HSA-6798695. Neutrophil degranulation.
SignaLinkiQ8IUR7.

Miscellaneous databases

ChiTaRSiARMC8. human.
GenomeRNAii25852.
PROiQ8IUR7.

Gene expression databases

BgeeiENSG00000114098.
CleanExiHS_ARMC8.
ExpressionAtlasiQ8IUR7. baseline and differential.
GenevisibleiQ8IUR7. HS.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamiPF00514. Arm. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 9 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARMC8_HUMAN
AccessioniPrimary (citable) accession number: Q8IUR7
Secondary accession number(s): A8K0L2
, B7Z441, B7Z453, D3DNE6, F5GWK4, Q6PIL2, Q96D19, Q96HZ5, Q9NV02, Q9NV94, Q9Y4R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: November 30, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.