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Q8IUR7 (ARMC8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Armadillo repeat-containing protein 8
Gene names
Name:ARMC8
ORF Names:S863-2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length673 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 14 ARM repeats.

Sequence caution

The sequence BAA91861.1 differs from that shown. Reason: Frameshift at position 468.

The sequence BAA91959.1 differs from that shown. Reason: Intron retention.

The sequence CAB46423.1 differs from that shown. Reason: Intron retention.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainRepeat
   PTMAcetylation
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IUR7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IUR7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2-15: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8IUR7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
Note: No experimental confirmation available.
Isoform 6 (identifier: Q8IUR7-6)

The sequence of this isoform differs from the canonical sequence as follows:
     2-15: Missing.
     379-399: IIETENMMDRIVTGLSESSVK → VSLGEGRPPVLTASRQGVTST
     400-673: Missing.
Isoform 7 (identifier: Q8IUR7-7)

The sequence of this isoform differs from the canonical sequence as follows:
     146-176: Missing.
Note: No experimental confirmation available.
Isoform 8 (identifier: Q8IUR7-8)

The sequence of this isoform differs from the canonical sequence as follows:
     280-346: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.6
Chain2 – 673672Armadillo repeat-containing protein 8
PRO_0000284408

Regions

Repeat51 – 9242ARM 1
Repeat95 – 13440ARM 2
Repeat138 – 17639ARM 3
Repeat178 – 21740ARM 4
Repeat224 – 26542ARM 5
Repeat269 – 30941ARM 6
Repeat313 – 35240ARM 7
Repeat374 – 41340ARM 8
Repeat416 – 45540ARM 9
Repeat458 – 49740ARM 10
Repeat501 – 54040ARM 11
Repeat543 – 58543ARM 12
Repeat588 – 62740ARM 13
Repeat634 – 67340ARM 14

Amino acid modifications

Modified residue21N-acetylalanine Ref.6

Natural variations

Alternative sequence1 – 4242Missing in isoform 3.
VSP_024512
Alternative sequence2 – 1514Missing in isoform 2 and isoform 6.
VSP_024509
Alternative sequence146 – 17631Missing in isoform 7.
VSP_044774
Alternative sequence280 – 34667Missing in isoform 8.
VSP_045137
Alternative sequence379 – 39921IIETE…ESSVK → VSLGEGRPPVLTASRQGVTS T in isoform 6.
VSP_024513
Alternative sequence400 – 673274Missing in isoform 6.
VSP_024514

Experimental info

Sequence conflict781E → G in BAA91861. Ref.2
Sequence conflict1281C → R in BAH12439. Ref.2
Sequence conflict2311V → A in AAH32661. Ref.5
Sequence conflict3271M → V in BAA91861. Ref.2
Sequence conflict3971S → N in BAA91959. Ref.2
Sequence conflict4621E → G in BAH12439. Ref.2
Sequence conflict4951M → I in BAH12439. Ref.2
Sequence conflict5371N → S in BAA91959. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 17, 2007. Version 2.
Checksum: 726BAC0A373485E8

FASTA67375,509
        10         20         30         40         50         60 
MACLLETPIR MSVLSEVTAS SRHYVDRLFD PDPQKVLQGV IDMKNAVIGN NKQKANLIVL 

        70         80         90        100        110        120 
GAVPRLLYLL QQETSSTELK TECAVVLGSL AMGTENNVKS LLDCHIIPAL LQGLLSPDLK 

       130        140        150        160        170        180 
FIEACLRCLR TIFTSPVTPE ELLYTDATVI PHLMALLSRS RYTQEYICQI FSHCCKGPDH 

       190        200        210        220        230        240 
QTILFNHGAV QNIAHLLTSL SYKVRMQALK CFSVLAFENP QVSMTLVNVL VDGELLPQIF 

       250        260        270        280        290        300 
VKMLQRDKPI EMQLTSAKCL TYMCRAGAIR TDDNCIVLKT LPCLVRMCSK ERLLEERVEG 

       310        320        330        340        350        360 
AETLAYLIEP DVELQRIASI TDHLIAMLAD YFKYPSSVSA ITDIKRLDHD LKHAHELRQA 

       370        380        390        400        410        420 
AFKLYASLGA NDEDIRKKII ETENMMDRIV TGLSESSVKV RLAAVRCLHS LSRSVQQLRT 

       430        440        450        460        470        480 
SFQDHAVWKP LMKVLQNAPD EILVVASSML CNLLLEFSPS KEPILESGAV ELLCGLTQSE 

       490        500        510        520        530        540 
NPALRVNGIW ALMNMAFQAE QKIKADILRS LSTEQLFRLL SDSDLNVLMK TLGLLRNLLS 

       550        560        570        580        590        600 
TRPHIDKIMS THGKQIMQAV TLILEGEHNI EVKEQTLCIL ANIADGTTAK DLIMTNDDIL 

       610        620        630        640        650        660 
QKIKYYMGHS HVKLQLAAMF CISNLIWNEE EGSQERQDKL RDMGIVDILH KLSQSPDSNL 

       670 
CDKAKMALQQ YLA 

« Hide

Isoform 2 [UniParc].

Checksum: 8A3314D9F0DF302F
Show »

FASTA65973,994
Isoform 3 [UniParc].

Checksum: 8DB486E356108D97
Show »

FASTA63170,796
Isoform 6 [UniParc].

Checksum: BAE44225B08675A6
Show »

FASTA38542,984
Isoform 7 [UniParc].

Checksum: C22F37EEF0B56B93
Show »

FASTA64271,899
Isoform 8 [UniParc].

Checksum: C5946E9DC52A4AB9
Show »

FASTA60667,900

References

« Hide 'large scale' references
[1]Liu B., Zhao B., Wang X.Y., Xu Y.Y., Liu Y.Q., Song L., Ye J., Sheng H., Gao Y., Zhang C.L., Wei Y.J., Zhang J., Song L., Jiang Y.X., Zhao Z.W., Ding J.F., Liu L.S., Gao R.L. expand/collapse author list , Wu Q.Y., Qiang B.Q., Yuan J.G., Liew C.C., Zhao M.S., Hui R.T.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
Tissue: Aorta.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 6; 7 AND 8), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 243-673 (ISOFORMS 1/2/3).
Tissue: Cerebellum, Placenta, Teratocarcinoma and Tongue.
[3]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 6).
Tissue: Brain, Lung and Uterus.
[6]Bienvenut W.V., Lempens A., Norman J.C.
Submitted (OCT-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-22; 36-44; 55-65; 247-258; 364-376; 379-399; 510-530; 591-602 AND 642-651, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Ovarian carcinoma.
[7]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 432-673 (ISOFORMS 1/2/3).
Tissue: Testis.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF109184 mRNA. Translation: AAQ13493.1.
AK001721 mRNA. Translation: BAA91861.1. Frameshift.
AK001882 mRNA. Translation: BAA91959.1. Sequence problems.
AK289577 mRNA. Translation: BAF82266.1.
AK296757 mRNA. Translation: BAH12427.1.
AK296837 mRNA. Translation: BAH12439.1.
AC022337 Genomic DNA. No translation available.
AC068777 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79076.1.
CH471052 Genomic DNA. Translation: EAW79075.1.
CH471052 Genomic DNA. Translation: EAW79079.1.
BC013424 mRNA. Translation: AAH13424.1.
BC032661 mRNA. Translation: AAH32661.1.
BC041699 mRNA. Translation: AAH41699.1.
AL096748 mRNA. Translation: CAB46423.1. Sequence problems.
PIRT12513.
RefSeqNP_001253970.1. NM_001267041.2.
NP_001253971.1. NM_001267042.2.
NP_001269271.1. NM_001282342.1.
NP_054873.2. NM_014154.4.
NP_056211.2. NM_015396.5.
NP_998819.1. NM_213654.3.
UniGeneHs.744868.

3D structure databases

ProteinModelPortalQ8IUR7.
SMRQ8IUR7. Positions 25-208, 384-625.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117376. 16 interactions.
IntActQ8IUR7. 3 interactions.
STRING9606.ENSP00000351221.

PTM databases

PhosphoSiteQ8IUR7.

Polymorphism databases

DMDM145558852.

Proteomic databases

PaxDbQ8IUR7.
PRIDEQ8IUR7.

Protocols and materials databases

DNASU25852.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000358441; ENSP00000351221; ENSG00000114098. [Q8IUR7-6]
ENST00000461822; ENSP00000420706; ENSG00000114098. [Q8IUR7-8]
ENST00000469044; ENSP00000419413; ENSG00000114098. [Q8IUR7-1]
ENST00000471453; ENSP00000420440; ENSG00000114098. [Q8IUR7-6]
ENST00000481646; ENSP00000420333; ENSG00000114098. [Q8IUR7-2]
ENST00000491704; ENSP00000417304; ENSG00000114098. [Q8IUR7-3]
ENST00000538260; ENSP00000441592; ENSG00000114098. [Q8IUR7-7]
GeneID25852.
KEGGhsa:25852.
UCSCuc003erw.4. human. [Q8IUR7-6]
uc003esa.2. human. [Q8IUR7-2]
uc003esb.2. human. [Q8IUR7-1]
uc011bmg.2. human.

Organism-specific databases

CTD25852.
GeneCardsGC03P137906.
H-InvDBHIX0003713.
HGNCHGNC:24999. ARMC8.
HPAHPA036996.
neXtProtNX_Q8IUR7.
PharmGKBPA134984953.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG307826.
HOVERGENHBG106422.
InParanoidQ8IUR7.
OMAGHSNVKL.
OrthoDBEOG73V6K3.
PhylomeDBQ8IUR7.
TreeFamTF324806.

Enzyme and pathway databases

SignaLinkQ8IUR7.

Gene expression databases

ArrayExpressQ8IUR7.
BgeeQ8IUR7.
CleanExHS_ARMC8.
GenevestigatorQ8IUR7.

Family and domain databases

Gene3D1.25.10.10. 3 hits.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamPF00514. Arm. 1 hit.
[Graphical view]
SMARTSM00185. ARM. 7 hits.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
PROSITEPS50176. ARM_REPEAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSARMC8. human.
GenomeRNAi25852.
NextBio47196.
PROQ8IUR7.

Entry information

Entry nameARMC8_HUMAN
AccessionPrimary (citable) accession number: Q8IUR7
Secondary accession number(s): A8K0L2 expand/collapse secondary AC list , B7Z441, B7Z453, D3DNE6, F5GWK4, Q6PIL2, Q96D19, Q96HZ5, Q9NV02, Q9NV94, Q9Y4R9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: April 16, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM