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Protein

CREB3 regulatory factor

Gene

CREBRF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Stress response, Transcription, Transcription regulation, Transport, Unfolded protein response

Names & Taxonomyi

Protein namesi
Recommended name:
CREB3 regulatory factor
Alternative name(s):
Luman recruitment factor
Short name:
LRF
Gene namesi
Name:CREBRF
Synonyms:C5orf41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:24050. CREBRF.

Subcellular locationi

  • Nucleus 1 Publication

  • Note: Colocalizes with CREB3 in nuclear foci.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nuclear body Source: UniProtKB
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi153222.
OpenTargetsiENSG00000164463.
PharmGKBiPA162380187.

Polymorphism and mutation databases

BioMutaiCREBRF.
DMDMi158563850.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002993061 – 639CREB3 regulatory factorAdd BLAST639

Post-translational modificationi

Probably degraded by the proteasome.

Proteomic databases

EPDiQ8IUR6.
MaxQBiQ8IUR6.
PaxDbiQ8IUR6.
PeptideAtlasiQ8IUR6.
PRIDEiQ8IUR6.

PTM databases

iPTMnetiQ8IUR6.
PhosphoSitePlusiQ8IUR6.

Expressioni

Inductioni

Up-regulated by endoplasmic reticulum stress.1 Publication

Gene expression databases

BgeeiENSG00000164463.
CleanExiHS_C5orf41.
ExpressionAtlasiQ8IUR6. baseline and differential.
GenevisibleiQ8IUR6. HS.

Organism-specific databases

HPAiHPA015819.

Interactioni

Subunit structurei

Interacts (via leucine-zipper domain) with CREB3 (via leucine-zipper domain); the interaction promotes CREB3 degradation.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CREB3O43889-24EBI-1042699,EBI-625022

Protein-protein interaction databases

BioGridi127485. 3 interactors.
IntActiQ8IUR6. 3 interactors.
STRINGi9606.ENSP00000296953.

Structurei

3D structure databases

ProteinModelPortaliQ8IUR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini521 – 584bZIPAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni523 – 532Basic motifBy similarity10
Regioni533 – 540Leucine-zipperBy similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi355 – 393Glu-richAdd BLAST39

Sequence similaritiesi

Belongs to the bZIP family. CREBRF subfamily.Curated

Phylogenomic databases

eggNOGiENOG410IHZR. Eukaryota.
ENOG410Y9V2. LUCA.
GeneTreeiENSGT00390000007125.
HOVERGENiHBG106858.
InParanoidiQ8IUR6.
OMAiLASCDIW.
OrthoDBiEOG091G0WU2.
PhylomeDBiQ8IUR6.
TreeFamiTF330810.

Family and domain databases

InterProiIPR004827. bZIP.
[Graphical view]
PROSITEiPS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IUR6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPQPSVSGMD PPFGDAFRSH TFSEQTLMST DLLANSSDPD FMYELDREMN
60 70 80 90 100
YQQNPRDNFL SLEDCKDIEN LESFTDVLDN EGALTSNWEQ WDTYCEDLTK
110 120 130 140 150
YTKLTSCDIW GTKEVDYLGL DDFSSPYQDE EVISKTPTLA QLNSEDSQSV
160 170 180 190 200
SDSLYYPDSL FSVKQNPLPS SFPGKKITSR AAAPVCSSKT LQAEVPLSDC
210 220 230 240 250
VQKASKPTSS TQIMVKTNMY HNEKVNFHVE CKDYVKKAKV KINPVQQSRP
260 270 280 290 300
LLSQIHTDAA KENTCYCGAV AKRQEKKGME PLQGHATPAL PFKETQELLL
310 320 330 340 350
SPLPQEGPGS LAAGESSSLS ASTSVSDSSQ KKEEHNYSLF VSDNLGEQPT
360 370 380 390 400
KCSPEEDEED EEDVDDEDHD EGFGSEHELS ENEEEEEEEE DYEDDKDDDI
410 420 430 440 450
SDTFSEPGYE NDSVEDLKEV TSISSRKRGK RRYFWEYSEQ LTPSQQERML
460 470 480 490 500
RPSEWNRDTL PSNMYQKNGL HHGKYAVKKS RRTDVEDLTP NPKKLLQIGN
510 520 530 540 550
ELRKLNKVIS DLTPVSELPL TARPRSRKEK NKLASRACRL KKKAQYEANK
560 570 580 590 600
VKLWGLNTEY DNLLFVINSI KQEIVNRVQN PRDERGPNMG QKLEILIKDT
610 620 630
LGLPVAGQTS EFVNQVLEKT AEGNPTGGLV GLRIPTSKV
Length:639
Mass (Da):72,149
Last modified:September 11, 2007 - v2
Checksum:i878B8F6FFB9A67CA
GO
Isoform 2 (identifier: Q8IUR6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     409-417: YENDSVEDL → IIMLASLPD
     418-639: Missing.

Show »
Length:417
Mass (Da):46,580
Checksum:i9DBD37B07C14556B
GO
Isoform 3 (identifier: Q8IUR6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     472-472: H → HGK

Note: No experimental confirmation available.
Show »
Length:641
Mass (Da):72,334
Checksum:i55C01360988DB471
GO

Sequence cautioni

The sequence AC008378 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti232K → R in CAI46104 (PubMed:17974005).Curated1
Sequence conflicti561D → G in AAN28956 (PubMed:18391022).Curated1
Sequence conflicti588N → D in CAI46104 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034795483T → A.1 PublicationCorresponds to variant rs17854147dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027601409 – 417YENDSVEDL → IIMLASLPD in isoform 2. 2 Publications9
Alternative sequenceiVSP_027602418 – 639Missing in isoform 2. 2 PublicationsAdd BLAST222
Alternative sequenceiVSP_027603472H → HGK in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY139008 mRNA. Translation: AAN28956.1.
AY174896 mRNA. Translation: AAO18732.1.
AY635785 mRNA. Translation: AAV34175.1.
AK124117 mRNA. Translation: BAG54011.1.
AC008378 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61414.1.
CH471062 Genomic DNA. Translation: EAW61415.1.
BC041709 mRNA. Translation: AAH41709.1.
BX647768 mRNA. Translation: CAI46039.1.
BX647573 mRNA. Translation: CAI46104.1.
CCDSiCCDS34293.1. [Q8IUR6-1]
CCDS54948.1. [Q8IUR6-2]
RefSeqiNP_001161865.1. NM_001168393.1. [Q8IUR6-2]
NP_001161866.1. NM_001168394.1. [Q8IUR6-2]
NP_705835.2. NM_153607.2. [Q8IUR6-1]
XP_006714885.1. XM_006714822.3. [Q8IUR6-1]
UniGeneiHs.484195.

Genome annotation databases

EnsembliENST00000296953; ENSP00000296953; ENSG00000164463. [Q8IUR6-1]
ENST00000520420; ENSP00000428290; ENSG00000164463. [Q8IUR6-2]
ENST00000522692; ENSP00000431107; ENSG00000164463. [Q8IUR6-2]
GeneIDi153222.
KEGGihsa:153222.
UCSCiuc003mcf.3. human. [Q8IUR6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY139008 mRNA. Translation: AAN28956.1.
AY174896 mRNA. Translation: AAO18732.1.
AY635785 mRNA. Translation: AAV34175.1.
AK124117 mRNA. Translation: BAG54011.1.
AC008378 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61414.1.
CH471062 Genomic DNA. Translation: EAW61415.1.
BC041709 mRNA. Translation: AAH41709.1.
BX647768 mRNA. Translation: CAI46039.1.
BX647573 mRNA. Translation: CAI46104.1.
CCDSiCCDS34293.1. [Q8IUR6-1]
CCDS54948.1. [Q8IUR6-2]
RefSeqiNP_001161865.1. NM_001168393.1. [Q8IUR6-2]
NP_001161866.1. NM_001168394.1. [Q8IUR6-2]
NP_705835.2. NM_153607.2. [Q8IUR6-1]
XP_006714885.1. XM_006714822.3. [Q8IUR6-1]
UniGeneiHs.484195.

3D structure databases

ProteinModelPortaliQ8IUR6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127485. 3 interactors.
IntActiQ8IUR6. 3 interactors.
STRINGi9606.ENSP00000296953.

PTM databases

iPTMnetiQ8IUR6.
PhosphoSitePlusiQ8IUR6.

Polymorphism and mutation databases

BioMutaiCREBRF.
DMDMi158563850.

Proteomic databases

EPDiQ8IUR6.
MaxQBiQ8IUR6.
PaxDbiQ8IUR6.
PeptideAtlasiQ8IUR6.
PRIDEiQ8IUR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296953; ENSP00000296953; ENSG00000164463. [Q8IUR6-1]
ENST00000520420; ENSP00000428290; ENSG00000164463. [Q8IUR6-2]
ENST00000522692; ENSP00000431107; ENSG00000164463. [Q8IUR6-2]
GeneIDi153222.
KEGGihsa:153222.
UCSCiuc003mcf.3. human. [Q8IUR6-1]

Organism-specific databases

CTDi153222.
DisGeNETi153222.
GeneCardsiCREBRF.
H-InvDBHIX0024811.
HGNCiHGNC:24050. CREBRF.
HPAiHPA015819.
neXtProtiNX_Q8IUR6.
OpenTargetsiENSG00000164463.
PharmGKBiPA162380187.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHZR. Eukaryota.
ENOG410Y9V2. LUCA.
GeneTreeiENSGT00390000007125.
HOVERGENiHBG106858.
InParanoidiQ8IUR6.
OMAiLASCDIW.
OrthoDBiEOG091G0WU2.
PhylomeDBiQ8IUR6.
TreeFamiTF330810.

Miscellaneous databases

ChiTaRSiCREBRF. human.
GenomeRNAii153222.
PROiQ8IUR6.

Gene expression databases

BgeeiENSG00000164463.
CleanExiHS_C5orf41.
ExpressionAtlasiQ8IUR6. baseline and differential.
GenevisibleiQ8IUR6. HS.

Family and domain databases

InterProiIPR004827. bZIP.
[Graphical view]
PROSITEiPS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRERF_HUMAN
AccessioniPrimary (citable) accession number: Q8IUR6
Secondary accession number(s): B3DFH2
, B3KW49, D3DQM2, F5GXN3, Q5HYG4, Q5HYK0, Q86YR3, Q8IZG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 30, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.