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Protein

Trafficking protein particle complex subunit 5

Gene

TRAPPC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 5
Gene namesi
Name:TRAPPC5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000181029.8.
HGNCiHGNC:23067. TRAPPC5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000181029.
PharmGKBiPA134875218.

Chemistry databases

DrugBankiDB08342. S-PALMITOYL-L-CYSTEINE.

Polymorphism and mutation databases

BioMutaiTRAPPC5.
DMDMi71153352.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002115791 – 188Trafficking protein particle complex subunit 5Add BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IUR0.
MaxQBiQ8IUR0.
PaxDbiQ8IUR0.
PeptideAtlasiQ8IUR0.
PRIDEiQ8IUR0.

PTM databases

iPTMnetiQ8IUR0.
PhosphoSitePlusiQ8IUR0.

Expressioni

Gene expression databases

BgeeiENSG00000181029.
CleanExiHS_TRAPPC5.
ExpressionAtlasiQ8IUR0. baseline and differential.
GenevisibleiQ8IUR0. HS.

Organism-specific databases

HPAiHPA042221.
HPA049064.

Interactioni

Subunit structurei

Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125945. 44 interactors.
CORUMiQ8IUR0.
IntActiQ8IUR0. 9 interactors.
STRINGi9606.ENSP00000316990.

Structurei

3D structure databases

ProteinModelPortaliQ8IUR0.
SMRiQ8IUR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3315. Eukaryota.
COG5128. LUCA.
GeneTreeiENSGT00390000000976.
HOGENOMiHOG000176758.
HOVERGENiHBG055535.
InParanoidiQ8IUR0.
KOiK20280.
OMAiQYTQKRV.
OrthoDBiEOG091G0NH9.
PhylomeDBiQ8IUR0.
TreeFamiTF313795.

Family and domain databases

CDDicd14943. TRAPPC5_Trs31. 1 hit.
InterProiView protein in InterPro
IPR024096. NO_sig/Golgi_transp_ligand-bd.
IPR016696. TRAPP-I_su5.
IPR007194. TRAPP_component.
PANTHERiPTHR20902. PTHR20902. 1 hit.
PfamiView protein in Pfam
PF04051. TRAPP. 1 hit.
PIRSFiPIRSF017479. TRAPP_I_complex_Trs31. 1 hit.
SUPFAMiSSF111126. SSF111126. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IUR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEARFTRGKS ALLERALARP RTEVSLSAFA LLFSELVQHC QSRVFSVAEL
60 70 80 90 100
QSRLAALGRQ VGARVLDALV AREKGARRET KVLGALLFVK GAVWKALFGK
110 120 130 140 150
EADKLEQAND DARTFYIIER EPLINTYISV PKENSTLNCA SFTAGIVEAV
160 170 180
LTHSGFPAKV TAHWHKGTTL MIKFEEAVIA RDRALEGR
Length:188
Mass (Da):20,783
Last modified:March 1, 2003 - v1
Checksum:iBBB876232286CE28
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05239852S → A. Corresponds to variant dbSNP:rs6952Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292001 mRNA. Translation: BAF84690.1.
CH471139 Genomic DNA. Translation: EAW69012.1.
BC042161 mRNA. Translation: AAH42161.1.
CCDSiCCDS42490.1.
RefSeqiNP_001035926.1. NM_001042461.2.
NP_001035927.1. NM_001042462.1.
NP_777554.1. NM_174894.2.
UniGeneiHs.432413.

Genome annotation databases

EnsembliENST00000317378; ENSP00000316990; ENSG00000181029.
ENST00000426877; ENSP00000399025; ENSG00000181029.
ENST00000596148; ENSP00000470262; ENSG00000181029.
GeneIDi126003.
KEGGihsa:126003.
UCSCiuc002mhi.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTPPC5_HUMAN
AccessioniPrimary (citable) accession number: Q8IUR0
Secondary accession number(s): A8K7I6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2003
Last modified: September 27, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families