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Protein

Trafficking protein particle complex subunit 5

Gene

TRAPPC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 5
Gene namesi
Name:TRAPPC5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23067. TRAPPC5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134875218.

Polymorphism and mutation databases

BioMutaiTRAPPC5.
DMDMi71153352.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Trafficking protein particle complex subunit 5PRO_0000211579Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IUR0.
MaxQBiQ8IUR0.
PaxDbiQ8IUR0.
PeptideAtlasiQ8IUR0.
PRIDEiQ8IUR0.

PTM databases

iPTMnetiQ8IUR0.
PhosphoSiteiQ8IUR0.

Expressioni

Gene expression databases

BgeeiQ8IUR0.
CleanExiHS_TRAPPC5.
ExpressionAtlasiQ8IUR0. baseline and differential.
GenevisibleiQ8IUR0. HS.

Organism-specific databases

HPAiHPA049064.

Interactioni

Subunit structurei

Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952733EBI-3246160,EBI-748961

Protein-protein interaction databases

BioGridi125945. 38 interactions.
IntActiQ8IUR0. 5 interactions.
STRINGi9606.ENSP00000316990.

Structurei

3D structure databases

ProteinModelPortaliQ8IUR0.
SMRiQ8IUR0. Positions 22-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3315. Eukaryota.
COG5128. LUCA.
GeneTreeiENSGT00390000000976.
HOGENOMiHOG000176758.
HOVERGENiHBG055535.
InParanoidiQ8IUR0.
OMAiGKTIYHR.
OrthoDBiEOG7JT6XK.
PhylomeDBiQ8IUR0.
TreeFamiTF313795.

Family and domain databases

InterProiIPR024096. NO_sig/Golgi_transp_ligand-bd.
IPR016696. TRAPP-I_su5.
IPR007194. TRAPP_component.
[Graphical view]
PANTHERiPTHR20902. PTHR20902. 1 hit.
PfamiPF04051. TRAPP. 1 hit.
[Graphical view]
PIRSFiPIRSF017479. TRAPP_I_complex_Trs31. 1 hit.
SUPFAMiSSF111126. SSF111126. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IUR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEARFTRGKS ALLERALARP RTEVSLSAFA LLFSELVQHC QSRVFSVAEL
60 70 80 90 100
QSRLAALGRQ VGARVLDALV AREKGARRET KVLGALLFVK GAVWKALFGK
110 120 130 140 150
EADKLEQAND DARTFYIIER EPLINTYISV PKENSTLNCA SFTAGIVEAV
160 170 180
LTHSGFPAKV TAHWHKGTTL MIKFEEAVIA RDRALEGR
Length:188
Mass (Da):20,783
Last modified:March 1, 2003 - v1
Checksum:iBBB876232286CE28
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti52 – 521S → A.
Corresponds to variant rs6952 [ dbSNP | Ensembl ].
VAR_052398

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292001 mRNA. Translation: BAF84690.1.
CH471139 Genomic DNA. Translation: EAW69012.1.
BC042161 mRNA. Translation: AAH42161.1.
CCDSiCCDS42490.1.
RefSeqiNP_001035926.1. NM_001042461.2.
NP_001035927.1. NM_001042462.1.
NP_777554.1. NM_174894.2.
UniGeneiHs.432413.

Genome annotation databases

EnsembliENST00000317378; ENSP00000316990; ENSG00000181029.
ENST00000426877; ENSP00000399025; ENSG00000181029.
ENST00000596148; ENSP00000470262; ENSG00000181029.
GeneIDi126003.
KEGGihsa:126003.
UCSCiuc002mhi.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292001 mRNA. Translation: BAF84690.1.
CH471139 Genomic DNA. Translation: EAW69012.1.
BC042161 mRNA. Translation: AAH42161.1.
CCDSiCCDS42490.1.
RefSeqiNP_001035926.1. NM_001042461.2.
NP_001035927.1. NM_001042462.1.
NP_777554.1. NM_174894.2.
UniGeneiHs.432413.

3D structure databases

ProteinModelPortaliQ8IUR0.
SMRiQ8IUR0. Positions 22-188.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125945. 38 interactions.
IntActiQ8IUR0. 5 interactions.
STRINGi9606.ENSP00000316990.

PTM databases

iPTMnetiQ8IUR0.
PhosphoSiteiQ8IUR0.

Polymorphism and mutation databases

BioMutaiTRAPPC5.
DMDMi71153352.

Proteomic databases

EPDiQ8IUR0.
MaxQBiQ8IUR0.
PaxDbiQ8IUR0.
PeptideAtlasiQ8IUR0.
PRIDEiQ8IUR0.

Protocols and materials databases

DNASUi126003.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317378; ENSP00000316990; ENSG00000181029.
ENST00000426877; ENSP00000399025; ENSG00000181029.
ENST00000596148; ENSP00000470262; ENSG00000181029.
GeneIDi126003.
KEGGihsa:126003.
UCSCiuc002mhi.2. human.

Organism-specific databases

CTDi126003.
GeneCardsiTRAPPC5.
HGNCiHGNC:23067. TRAPPC5.
HPAiHPA049064.
neXtProtiNX_Q8IUR0.
PharmGKBiPA134875218.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3315. Eukaryota.
COG5128. LUCA.
GeneTreeiENSGT00390000000976.
HOGENOMiHOG000176758.
HOVERGENiHBG055535.
InParanoidiQ8IUR0.
OMAiGKTIYHR.
OrthoDBiEOG7JT6XK.
PhylomeDBiQ8IUR0.
TreeFamiTF313795.

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Miscellaneous databases

ChiTaRSiTRAPPC5. human.
GenomeRNAii126003.
PROiQ8IUR0.

Gene expression databases

BgeeiQ8IUR0.
CleanExiHS_TRAPPC5.
ExpressionAtlasiQ8IUR0. baseline and differential.
GenevisibleiQ8IUR0. HS.

Family and domain databases

InterProiIPR024096. NO_sig/Golgi_transp_ligand-bd.
IPR016696. TRAPP-I_su5.
IPR007194. TRAPP_component.
[Graphical view]
PANTHERiPTHR20902. PTHR20902. 1 hit.
PfamiPF04051. TRAPP. 1 hit.
[Graphical view]
PIRSFiPIRSF017479. TRAPP_I_complex_Trs31. 1 hit.
SUPFAMiSSF111126. SSF111126. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Small intestine.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking."
    Scrivens P.J., Noueihed B., Shahrzad N., Hul S., Brunet S., Sacher M.
    Mol. Biol. Cell 22:2083-2093(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN TRAPP COMPLEX.
  6. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.

Entry informationi

Entry nameiTPPC5_HUMAN
AccessioniPrimary (citable) accession number: Q8IUR0
Secondary accession number(s): A8K7I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.