##gff-version 3 Q8IUQ4 UniProtKB Chain 1 282 . . . ID=PRO_0000056163;Note=E3 ubiquitin-protein ligase SIAH1 Q8IUQ4 UniProtKB Zinc finger 41 76 . . . Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175 Q8IUQ4 UniProtKB Zinc finger 93 153 . . . Note=SIAH-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00455 Q8IUQ4 UniProtKB Region 1 22 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8IUQ4 UniProtKB Region 90 282 . . . Note=SBD;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P61092 Q8IUQ4 UniProtKB Binding site 98 98 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:28546513,ECO:0007744|PDB:5WZZ;Dbxref=PMID:28546513 Q8IUQ4 UniProtKB Binding site 105 105 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:28546513,ECO:0007744|PDB:5WZZ;Dbxref=PMID:28546513 Q8IUQ4 UniProtKB Binding site 117 117 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:28546513,ECO:0007744|PDB:5WZZ;Dbxref=PMID:28546513 Q8IUQ4 UniProtKB Binding site 121 121 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:28546513,ECO:0007744|PDB:5WZZ;Dbxref=PMID:28546513 Q8IUQ4 UniProtKB Binding site 128 128 . . . Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:16085652,ECO:0000269|PubMed:28546513,ECO:0007744|PDB:2A25,ECO:0007744|PDB:5WZZ;Dbxref=PMID:16085652,PMID:28546513 Q8IUQ4 UniProtKB Binding site 135 135 . . . Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:16085652,ECO:0000269|PubMed:28546513,ECO:0007744|PDB:2A25,ECO:0007744|PDB:5WZZ;Dbxref=PMID:16085652,PMID:28546513 Q8IUQ4 UniProtKB Binding site 147 147 . . . Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:16085652,ECO:0000269|PubMed:28546513,ECO:0007744|PDB:2A25,ECO:0007744|PDB:5WZZ;Dbxref=PMID:16085652,PMID:28546513 Q8IUQ4 UniProtKB Binding site 152 152 . . . Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:16085652,ECO:0000269|PubMed:28546513,ECO:0007744|PDB:2A25,ECO:0007744|PDB:5WZZ;Dbxref=PMID:16085652,PMID:28546513 Q8IUQ4 UniProtKB Modified residue 19 19 . . . Note=Phosphoserine%3B by ATM and ATR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18536714;Dbxref=PMID:18536714 Q8IUQ4 UniProtKB Alternative sequence 1 1 . . . ID=VSP_010166;Note=In isoform 2. M->MTGKATPPSLYSWRGVLFTCLPAARTRKRKEM;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 Q8IUQ4 UniProtKB Alternative sequence 193 195 . . . ID=VSP_029210;Note=In isoform 3. LEK->DLS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17420721;Dbxref=PMID:17420721 Q8IUQ4 UniProtKB Alternative sequence 196 282 . . . ID=VSP_029211;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17420721;Dbxref=PMID:17420721 Q8IUQ4 UniProtKB Natural variant 41 41 . . . ID=VAR_085780;Note=In BURHAS%3B loss of function in Wnt signaling pathway. C->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32430360;Dbxref=PMID:32430360 Q8IUQ4 UniProtKB Natural variant 50 50 . . . ID=VAR_085781;Note=In BURHAS. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32430360;Dbxref=PMID:32430360 Q8IUQ4 UniProtKB Natural variant 128 128 . . . ID=VAR_085782;Note=In BURHAS%3B loss of function in Wnt signaling pathway. C->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32430360;Dbxref=PMID:32430360 Q8IUQ4 UniProtKB Natural variant 168 168 . . . ID=VAR_085783;Note=In BURHAS%3B loss of function in Wnt signaling pathway. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32430360;Dbxref=PMID:32430360 Q8IUQ4 UniProtKB Natural variant 174 174 . . . ID=VAR_085784;Note=In BURHAS%3B loss of function in Wnt signaling pathway. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32430360;Dbxref=PMID:32430360 Q8IUQ4 UniProtKB Mutagenesis 19 19 . . . Note=Impaired ATM mediated phosphorylation%2C but normal interaction with HIPK2 and HIPK2 subsequent proteasomal degradation. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18536714;Dbxref=PMID:18536714 Q8IUQ4 UniProtKB Mutagenesis 19 19 . . . Note=Reduced interaction with HIPK2 and HIPK2 subsequent proteasomal degradation. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18536714;Dbxref=PMID:18536714 Q8IUQ4 UniProtKB Mutagenesis 40 40 . . . Note=Loss of function. E->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9858595;Dbxref=PMID:9858595 Q8IUQ4 UniProtKB Mutagenesis 41 41 . . . Note=Loss of function%3B when associated with S-44. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9858595;Dbxref=PMID:9858595 Q8IUQ4 UniProtKB Mutagenesis 44 44 . . . Note=Loss of function. C->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18536714,ECO:0000269|PubMed:9858595;Dbxref=PMID:18536714,PMID:9858595 Q8IUQ4 UniProtKB Mutagenesis 55 55 . . . Note=Loss of function%3B when associated with A-59 and S-72. C->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15064394,ECO:0000269|PubMed:9858595;Dbxref=PMID:15064394,PMID:9858595 Q8IUQ4 UniProtKB Mutagenesis 55 55 . . . Note=Loss of function%3B when associated with Y-59. C->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15064394,ECO:0000269|PubMed:9858595;Dbxref=PMID:15064394,PMID:9858595 Q8IUQ4 UniProtKB Mutagenesis 59 59 . . . Note=Loss of function%3B when associated with A-55 and S-72. H->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15064394,ECO:0000269|PubMed:9858595;Dbxref=PMID:15064394,PMID:9858595 Q8IUQ4 UniProtKB Mutagenesis 59 59 . . . Note=Loss of function. H->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15064394,ECO:0000269|PubMed:9858595;Dbxref=PMID:15064394,PMID:9858595 Q8IUQ4 UniProtKB Mutagenesis 66 66 . . . Note=Decreased activity%3B when associated with T-68. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9858595;Dbxref=PMID:9858595 Q8IUQ4 UniProtKB Mutagenesis 68 68 . . . Note=Decreased activity%3B when associated with L-66. K->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9858595;Dbxref=PMID:9858595 Q8IUQ4 UniProtKB Mutagenesis 72 72 . . . Note=Loss of function%3B when associated with A-55 and A-59. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15064394;Dbxref=PMID:15064394 Q8IUQ4 UniProtKB Mutagenesis 76 76 . . . Note=Decreased activity. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9858595;Dbxref=PMID:9858595 Q8IUQ4 UniProtKB Mutagenesis 124 124 . . . Note=In D%3B does not impair its ability to interact with CACYBP and degrade CTNNB1 and PML%3B when associated with A-214%3B A-215%3B A-231 and A-232. R->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12421809,ECO:0000269|PubMed:14645235;Dbxref=PMID:12421809,PMID:14645235 Q8IUQ4 UniProtKB Mutagenesis 142 142 . . . Note=In E%3B does not impair its ability to interact with CACYBP and degrade CTNNB1%3B when associated with A-151. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12421809;Dbxref=PMID:12421809 Q8IUQ4 UniProtKB Mutagenesis 151 151 . . . Note=In E%3B does not impair its ability to interact with CACYBP and degrade CTNNB1%3B when associated with A-142. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12421809;Dbxref=PMID:12421809 Q8IUQ4 UniProtKB Mutagenesis 152 152 . . . Note=Abolishes ability to degrade DCC. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9858595;Dbxref=PMID:9858595 Q8IUQ4 UniProtKB Mutagenesis 161 162 . . . Note=In A%3B does not impair its ability to degrade PML while it abolishes its ability to interact with CACYBP and degrade CTNNB1%3B when associated with A-226 and A-237. ED->AA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12421809,ECO:0000269|PubMed:14645235;Dbxref=PMID:12421809,PMID:14645235 Q8IUQ4 UniProtKB Mutagenesis 198 200 . . . Note=Impairs CTNNB1 degradation. KYD->GDG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16085652;Dbxref=PMID:16085652 Q8IUQ4 UniProtKB Mutagenesis 202 202 . . . Note=No effect. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9858595;Dbxref=PMID:9858595 Q8IUQ4 UniProtKB Mutagenesis 211 211 . . . Note=Abolishes ability to degrade DCC. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9858595;Dbxref=PMID:9858595 Q8IUQ4 UniProtKB Mutagenesis 214 215 . . . Note=In D%3B does not impair its ability to interact with CACYBP and degrade CTNNB1 and PML%3B when associated with A-124%3B A-231 and A-232. TR->AA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12421809,ECO:0000269|PubMed:14645235;Dbxref=PMID:12421809,PMID:14645235 Q8IUQ4 UniProtKB Mutagenesis 224 224 . . . Note=In C%3B does not impair its ability to interact with CACYBP and degrade CTNNB1%3B when associated with A-233. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12421809;Dbxref=PMID:12421809 Q8IUQ4 UniProtKB Mutagenesis 226 226 . . . Note=In A%3B does not impair its ability to degrade PML while it abolishes its ability to interact with CACYBP and degrade CTNNB1%3B when associated with A-161%3B A-162 and A-237. E->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12421809,ECO:0000269|PubMed:14645235;Dbxref=PMID:12421809,PMID:14645235 Q8IUQ4 UniProtKB Mutagenesis 231 232 . . . Note=In D%3B does not impair its ability to interact with CACYBP and degrade CTNNB1 and PML%3B when associated with A-124%3B A-214 and A-215. RR->AA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12421809,ECO:0000269|PubMed:14645235;Dbxref=PMID:12421809,PMID:14645235 Q8IUQ4 UniProtKB Mutagenesis 233 233 . . . Note=In C%3B does not impair its ability to interact with CACYBP and degrade CTNNB1%3B when associated with A-233. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12421809;Dbxref=PMID:12421809 Q8IUQ4 UniProtKB Mutagenesis 237 237 . . . Note=In A%3B does not impair its ability to degrade PML while it abolishes its ability to interact with CACYBP and degrade CTNNB1%3B when associated with A-161%3B A-162 and A-226. E->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12421809,ECO:0000269|PubMed:14645235;Dbxref=PMID:12421809,PMID:14645235 Q8IUQ4 UniProtKB Mutagenesis 252 252 . . . Note=Impairs CTNNB1 degradation. M->D%2CK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16085652;Dbxref=PMID:16085652 Q8IUQ4 UniProtKB Mutagenesis 253 253 . . . Note=In B%3B does not impair its ability to interact with CACYBP and degrade CTNNB1%3B when associated with A-265. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12421809;Dbxref=PMID:12421809 Q8IUQ4 UniProtKB Mutagenesis 265 265 . . . Note=In B%3B does not impair its ability to interact with CACYBP and degrade CTNNB1%3B when associated with A-253. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12421809;Dbxref=PMID:12421809 Q8IUQ4 UniProtKB Sequence conflict 173 173 . . . Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8IUQ4 UniProtKB Sequence conflict 245 245 . . . Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8IUQ4 UniProtKB Beta strand 95 97 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4X3G Q8IUQ4 UniProtKB Helix 101 103 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CA1 Q8IUQ4 UniProtKB Beta strand 108 110 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4X3G Q8IUQ4 UniProtKB Helix 111 120 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CA1 Q8IUQ4 UniProtKB Beta strand 122 124 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4I7B Q8IUQ4 UniProtKB Beta strand 130 134 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CA1 Q8IUQ4 UniProtKB Helix 141 143 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CA1 Q8IUQ4 UniProtKB Helix 144 151 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CA1 Q8IUQ4 UniProtKB Beta strand 156 167 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CA1 Q8IUQ4 UniProtKB Beta strand 172 184 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CA1 Q8IUQ4 UniProtKB Beta strand 187 197 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CA1 Q8IUQ4 UniProtKB Beta strand 199 201 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5WZZ Q8IUQ4 UniProtKB Beta strand 203 213 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CA1 Q8IUQ4 UniProtKB Helix 215 218 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CA1 Q8IUQ4 UniProtKB Beta strand 221 229 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CA1 Q8IUQ4 UniProtKB Beta strand 232 238 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CA1 Q8IUQ4 UniProtKB Turn 243 245 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CA1 Q8IUQ4 UniProtKB Helix 248 252 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CA1 Q8IUQ4 UniProtKB Beta strand 256 260 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CA1 Q8IUQ4 UniProtKB Helix 261 267 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CA1 Q8IUQ4 UniProtKB Beta strand 272 281 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CA1