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Q8IUN9

- CLC10_HUMAN

UniProt

Q8IUN9 - CLC10_HUMAN

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Protein
C-type lectin domain family 10 member A
Gene
CLEC10A, CLECSF13, CLECSF14, HML
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.1 Publication

GO - Molecular functioni

  1. carbohydrate binding Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. endocytosis Source: UniProtKB-KW
  2. innate immune response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Endocytosis, Immunity, Innate immunity

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 10 member A
Alternative name(s):
C-type lectin superfamily member 14
Macrophage lectin 2
CD_antigen: CD301
Gene namesi
Name:CLEC10A
Synonyms:CLECSF13, CLECSF14, HML
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:16916. CLEC10A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei40 – 6021Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini61 – 316256Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134975011.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316C-type lectin domain family 10 member A
PRO_0000046639Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi78 – 781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi173 – 1731N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi181 ↔ 192 By similarity
Disulfide bondi209 ↔ 304 By similarity
Disulfide bondi282 ↔ 296 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8IUN9.
PRIDEiQ8IUN9.

Expressioni

Gene expression databases

ArrayExpressiQ8IUN9.
BgeeiQ8IUN9.
CleanExiHS_CLEC10A.
GenevestigatoriQ8IUN9.

Organism-specific databases

HPAiHPA021937.

Interactioni

Protein-protein interaction databases

IntActiQ8IUN9. 1 interaction.
STRINGi9606.ENSP00000254868.

Structurei

3D structure databases

ProteinModelPortaliQ8IUN9.
SMRiQ8IUN9. Positions 151-308.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini188 – 305118C-type lectin
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili85 – 17692 Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi5 – 84Endocytosis signal Reviewed prediction

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG259792.
HOGENOMiHOG000034093.
HOVERGENiHBG000270.
InParanoidiQ8IUN9.
KOiK06721.
OMAiWVCEAGL.
OrthoDBiEOG7XDBGR.
PhylomeDBiQ8IUN9.
TreeFamiTF352155.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR005640. Lectin_N.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF03954. Lectin_N. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IUN9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTRTYENFQY LENKVKVQGF KNGPLPLQSL LQRLCSGPCH LLLSLGLGLL    50
LLVIICVVGF QNSKFQRDLV TLRTDFSNFT SNTVAEIQAL TSQGSSLEET 100
IASLKAEVEG FKQERQAGVS ELQEHTTQKA HLGHCPHCPS VCVPVHSEML 150
LRVQQLVQDL KKLTCQVATL NNNASTEGTC CPVNWVEHQD SCYWFSHSGM 200
SWAEAEKYCQ LKNAHLVVIN SREEQNFVQK YLGSAYTWMG LSDPEGAWKW 250
VDGTDYATGF QNWKPGQPDD WQGHGLGGGE DCAHFHPDGR WNDDVCQRPY 300
HWVCEAGLGQ TSQESH 316
Length:316
Mass (Da):35,446
Last modified:March 1, 2003 - v1
Checksum:iD3B7193E2E1F58AF
GO
Isoform 2 (identifier: Q8IUN9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-144: Missing.
     173-173: N → NGEE

Show »
Length:292
Mass (Da):32,884
Checksum:i5472EFF9EBC7AC19
GO
Isoform 3 (identifier: Q8IUN9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-144: Missing.
     226-283: NFVQKYLGSA...HGLGGGEDCA → VRASGTQFLR...IQRNISKLLS
     284-316: Missing.

Show »
Length:256
Mass (Da):28,877
Checksum:iBEB86B3B5CC8DCD0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti35 – 351C → R.1 Publication
Corresponds to variant rs90951 [ dbSNP | Ensembl ].
VAR_021262
Natural varianti73 – 731R → K.
Corresponds to variant rs16956478 [ dbSNP | Ensembl ].
VAR_050113
Natural varianti100 – 1001T → M.
Corresponds to variant rs35318160 [ dbSNP | Ensembl ].
VAR_050114
Natural varianti203 – 2031A → G.
Corresponds to variant rs35101468 [ dbSNP | Ensembl ].
VAR_050115

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei118 – 14427Missing in isoform 2 and isoform 3.
VSP_012848Add
BLAST
Alternative sequencei173 – 1731N → NGEE in isoform 2.
VSP_012849
Alternative sequencei226 – 28358NFVQK…GEDCA → VRASGTQFLRHVPFREMVLK LGRTLESSGSFQNDCHLCHT LRDLIGLSIQRNISKLLS in isoform 3.
VSP_012850Add
BLAST
Alternative sequencei284 – 31633Missing in isoform 3.
VSP_012851Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti112 – 1121K → R in AAH27858. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50532 mRNA. Translation: BAA09101.1.
AK292363 mRNA. Translation: BAF85052.1.
BC027858 mRNA. Translation: AAH27858.1.
BC039011 mRNA. Translation: AAH39011.1.
CCDSiCCDS11087.1. [Q8IUN9-1]
CCDS45597.1. [Q8IUN9-2]
RefSeqiNP_006335.2. NM_006344.2. [Q8IUN9-2]
NP_878910.1. NM_182906.2. [Q8IUN9-1]
UniGeneiHs.54403.

Genome annotation databases

EnsembliENST00000254868; ENSP00000254868; ENSG00000132514. [Q8IUN9-1]
ENST00000571664; ENSP00000460252; ENSG00000132514. [Q8IUN9-2]
ENST00000576617; ENSP00000458728; ENSG00000132514. [Q8IUN9-3]
GeneIDi10462.
KEGGihsa:10462.
UCSCiuc002gej.3. human. [Q8IUN9-2]
uc002gek.3. human. [Q8IUN9-1]
uc010clv.2. human. [Q8IUN9-3]

Polymorphism databases

DMDMi59797948.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

MGL

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50532 mRNA. Translation: BAA09101.1 .
AK292363 mRNA. Translation: BAF85052.1 .
BC027858 mRNA. Translation: AAH27858.1 .
BC039011 mRNA. Translation: AAH39011.1 .
CCDSi CCDS11087.1. [Q8IUN9-1 ]
CCDS45597.1. [Q8IUN9-2 ]
RefSeqi NP_006335.2. NM_006344.2. [Q8IUN9-2 ]
NP_878910.1. NM_182906.2. [Q8IUN9-1 ]
UniGenei Hs.54403.

3D structure databases

ProteinModelPortali Q8IUN9.
SMRi Q8IUN9. Positions 151-308.
ModBasei Search...

Protein-protein interaction databases

IntActi Q8IUN9. 1 interaction.
STRINGi 9606.ENSP00000254868.

Polymorphism databases

DMDMi 59797948.

Proteomic databases

PaxDbi Q8IUN9.
PRIDEi Q8IUN9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000254868 ; ENSP00000254868 ; ENSG00000132514 . [Q8IUN9-1 ]
ENST00000571664 ; ENSP00000460252 ; ENSG00000132514 . [Q8IUN9-2 ]
ENST00000576617 ; ENSP00000458728 ; ENSG00000132514 . [Q8IUN9-3 ]
GeneIDi 10462.
KEGGi hsa:10462.
UCSCi uc002gej.3. human. [Q8IUN9-2 ]
uc002gek.3. human. [Q8IUN9-1 ]
uc010clv.2. human. [Q8IUN9-3 ]

Organism-specific databases

CTDi 10462.
GeneCardsi GC17M006977.
HGNCi HGNC:16916. CLEC10A.
HPAi HPA021937.
MIMi 605999. gene.
neXtProti NX_Q8IUN9.
PharmGKBi PA134975011.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG259792.
HOGENOMi HOG000034093.
HOVERGENi HBG000270.
InParanoidi Q8IUN9.
KOi K06721.
OMAi WVCEAGL.
OrthoDBi EOG7XDBGR.
PhylomeDBi Q8IUN9.
TreeFami TF352155.

Miscellaneous databases

GeneWikii CLEC10A.
GenomeRNAii 10462.
NextBioi 39671.
PROi Q8IUN9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8IUN9.
Bgeei Q8IUN9.
CleanExi HS_CLEC10A.
Genevestigatori Q8IUN9.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR005640. Lectin_N.
[Graphical view ]
Pfami PF00059. Lectin_C. 1 hit.
PF03954. Lectin_N. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of cDNA encoding human macrophage c-type lectin: its unique carbohydrate binding specificity for Tn antigen."
    Suzuki N., Yamamoto K., Toyoshima S., Osawa T., Irimura T.
    J. Immunol. 156:128-135(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, VARIANT ARG-35.
    Tissue: Peripheral blood monocyte.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Brain.

Entry informationi

Entry nameiCLC10_HUMAN
AccessioniPrimary (citable) accession number: Q8IUN9
Secondary accession number(s): A8K8J8, Q14538, Q6PIW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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