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Protein

C-type lectin domain family 10 member A

Gene

CLEC10A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.1 Publication

GO - Molecular functioni

  • carbohydrate binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Endocytosis, Immunity, Innate immunity

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 10 member A
Alternative name(s):
C-type lectin superfamily member 14
Macrophage lectin 2
CD_antigen: CD301
Gene namesi
Name:CLEC10A
Synonyms:CLECSF13, CLECSF14, HML
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:16916. CLEC10A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39CytoplasmicSequence analysisAdd BLAST39
Transmembranei40 – 60Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini61 – 316ExtracellularSequence analysisAdd BLAST256

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10462.
OpenTargetsiENSG00000132514.
PharmGKBiPA134975011.

Polymorphism and mutation databases

BioMutaiCLEC10A.
DMDMi59797948.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466391 – 316C-type lectin domain family 10 member AAdd BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi78N-linked (GlcNAc...)Sequence analysis1
Glycosylationi173N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi181 ↔ 192PROSITE-ProRule annotation
Disulfide bondi209 ↔ 304PROSITE-ProRule annotation
Disulfide bondi282 ↔ 296PROSITE-ProRule annotation
Modified residuei312PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8IUN9.
PaxDbiQ8IUN9.
PRIDEiQ8IUN9.

PTM databases

iPTMnetiQ8IUN9.
PhosphoSitePlusiQ8IUN9.

Expressioni

Gene expression databases

BgeeiENSG00000132514.
CleanExiHS_CLEC10A.
ExpressionAtlasiQ8IUN9. baseline and differential.
GenevisibleiQ8IUN9. HS.

Organism-specific databases

HPAiHPA021937.

Interactioni

Protein-protein interaction databases

BioGridi115725. 2 interactors.
IntActiQ8IUN9. 1 interactor.
STRINGi9606.ENSP00000254868.

Structurei

3D structure databases

ProteinModelPortaliQ8IUN9.
SMRiQ8IUN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini188 – 305C-type lectinPROSITE-ProRule annotationAdd BLAST118

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili85 – 176Sequence analysisAdd BLAST92

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi5 – 8Endocytosis signalSequence analysis4

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS30. Eukaryota.
ENOG410ZDP5. LUCA.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000034093.
HOVERGENiHBG000270.
InParanoidiQ8IUN9.
KOiK06721.
OMAiHPDGRWN.
OrthoDBiEOG091G062T.
PhylomeDBiQ8IUN9.
TreeFamiTF352155.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR005640. Lectin_N.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF03954. Lectin_N. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IUN9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTRTYENFQY LENKVKVQGF KNGPLPLQSL LQRLCSGPCH LLLSLGLGLL
60 70 80 90 100
LLVIICVVGF QNSKFQRDLV TLRTDFSNFT SNTVAEIQAL TSQGSSLEET
110 120 130 140 150
IASLKAEVEG FKQERQAGVS ELQEHTTQKA HLGHCPHCPS VCVPVHSEML
160 170 180 190 200
LRVQQLVQDL KKLTCQVATL NNNASTEGTC CPVNWVEHQD SCYWFSHSGM
210 220 230 240 250
SWAEAEKYCQ LKNAHLVVIN SREEQNFVQK YLGSAYTWMG LSDPEGAWKW
260 270 280 290 300
VDGTDYATGF QNWKPGQPDD WQGHGLGGGE DCAHFHPDGR WNDDVCQRPY
310
HWVCEAGLGQ TSQESH
Length:316
Mass (Da):35,446
Last modified:March 1, 2003 - v1
Checksum:iD3B7193E2E1F58AF
GO
Isoform 2 (identifier: Q8IUN9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-144: Missing.
     173-173: N → NGEE

Show »
Length:292
Mass (Da):32,884
Checksum:i5472EFF9EBC7AC19
GO
Isoform 3 (identifier: Q8IUN9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-144: Missing.
     226-283: NFVQKYLGSA...HGLGGGEDCA → VRASGTQFLR...IQRNISKLLS
     284-316: Missing.

Show »
Length:256
Mass (Da):28,877
Checksum:iBEB86B3B5CC8DCD0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti112K → R in AAH27858 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02126235C → R.1 PublicationCorresponds to variant rs90951dbSNPEnsembl.1
Natural variantiVAR_05011373R → K.Corresponds to variant rs16956478dbSNPEnsembl.1
Natural variantiVAR_050114100T → M.Corresponds to variant rs35318160dbSNPEnsembl.1
Natural variantiVAR_050115203A → G.Corresponds to variant rs35101468dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012848118 – 144Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST27
Alternative sequenceiVSP_012849173N → NGEE in isoform 2. 1 Publication1
Alternative sequenceiVSP_012850226 – 283NFVQK…GEDCA → VRASGTQFLRHVPFREMVLK LGRTLESSGSFQNDCHLCHT LRDLIGLSIQRNISKLLS in isoform 3. 2 PublicationsAdd BLAST58
Alternative sequenceiVSP_012851284 – 316Missing in isoform 3. 2 PublicationsAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50532 mRNA. Translation: BAA09101.1.
AK292363 mRNA. Translation: BAF85052.1.
BC027858 mRNA. Translation: AAH27858.1.
BC039011 mRNA. Translation: AAH39011.1.
CCDSiCCDS11087.1. [Q8IUN9-1]
CCDS45597.1. [Q8IUN9-2]
RefSeqiNP_006335.2. NM_006344.3. [Q8IUN9-2]
NP_878910.1. NM_182906.3. [Q8IUN9-1]
UniGeneiHs.54403.

Genome annotation databases

EnsembliENST00000254868; ENSP00000254868; ENSG00000132514. [Q8IUN9-1]
ENST00000571664; ENSP00000460252; ENSG00000132514. [Q8IUN9-2]
ENST00000576617; ENSP00000458728; ENSG00000132514. [Q8IUN9-3]
GeneIDi10462.
KEGGihsa:10462.
UCSCiuc002gej.4. human. [Q8IUN9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

MGL

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50532 mRNA. Translation: BAA09101.1.
AK292363 mRNA. Translation: BAF85052.1.
BC027858 mRNA. Translation: AAH27858.1.
BC039011 mRNA. Translation: AAH39011.1.
CCDSiCCDS11087.1. [Q8IUN9-1]
CCDS45597.1. [Q8IUN9-2]
RefSeqiNP_006335.2. NM_006344.3. [Q8IUN9-2]
NP_878910.1. NM_182906.3. [Q8IUN9-1]
UniGeneiHs.54403.

3D structure databases

ProteinModelPortaliQ8IUN9.
SMRiQ8IUN9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115725. 2 interactors.
IntActiQ8IUN9. 1 interactor.
STRINGi9606.ENSP00000254868.

PTM databases

iPTMnetiQ8IUN9.
PhosphoSitePlusiQ8IUN9.

Polymorphism and mutation databases

BioMutaiCLEC10A.
DMDMi59797948.

Proteomic databases

MaxQBiQ8IUN9.
PaxDbiQ8IUN9.
PRIDEiQ8IUN9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254868; ENSP00000254868; ENSG00000132514. [Q8IUN9-1]
ENST00000571664; ENSP00000460252; ENSG00000132514. [Q8IUN9-2]
ENST00000576617; ENSP00000458728; ENSG00000132514. [Q8IUN9-3]
GeneIDi10462.
KEGGihsa:10462.
UCSCiuc002gej.4. human. [Q8IUN9-1]

Organism-specific databases

CTDi10462.
DisGeNETi10462.
GeneCardsiCLEC10A.
HGNCiHGNC:16916. CLEC10A.
HPAiHPA021937.
MIMi605999. gene.
neXtProtiNX_Q8IUN9.
OpenTargetsiENSG00000132514.
PharmGKBiPA134975011.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IS30. Eukaryota.
ENOG410ZDP5. LUCA.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000034093.
HOVERGENiHBG000270.
InParanoidiQ8IUN9.
KOiK06721.
OMAiHPDGRWN.
OrthoDBiEOG091G062T.
PhylomeDBiQ8IUN9.
TreeFamiTF352155.

Miscellaneous databases

GeneWikiiCLEC10A.
GenomeRNAii10462.
PROiQ8IUN9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132514.
CleanExiHS_CLEC10A.
ExpressionAtlasiQ8IUN9. baseline and differential.
GenevisibleiQ8IUN9. HS.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR005640. Lectin_N.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF03954. Lectin_N. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLC10_HUMAN
AccessioniPrimary (citable) accession number: Q8IUN9
Secondary accession number(s): A8K8J8, Q14538, Q6PIW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.