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Q8IUN9

- CLC10_HUMAN

UniProt

Q8IUN9 - CLC10_HUMAN

Protein

C-type lectin domain family 10 member A

Gene

CLEC10A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.1 Publication

    GO - Molecular functioni

    1. carbohydrate binding Source: ProtInc

    GO - Biological processi

    1. endocytosis Source: UniProtKB-KW
    2. innate immune response Source: UniProtKB-KW

    Keywords - Biological processi

    Adaptive immunity, Endocytosis, Immunity, Innate immunity

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-type lectin domain family 10 member A
    Alternative name(s):
    C-type lectin superfamily member 14
    Macrophage lectin 2
    CD_antigen: CD301
    Gene namesi
    Name:CLEC10A
    Synonyms:CLECSF13, CLECSF14, HML
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:16916. CLEC10A.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134975011.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316C-type lectin domain family 10 member APRO_0000046639Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi181 ↔ 192PROSITE-ProRule annotation
    Disulfide bondi209 ↔ 304PROSITE-ProRule annotation
    Disulfide bondi282 ↔ 296PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8IUN9.
    PRIDEiQ8IUN9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8IUN9.
    BgeeiQ8IUN9.
    CleanExiHS_CLEC10A.
    GenevestigatoriQ8IUN9.

    Organism-specific databases

    HPAiHPA021937.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8IUN9. 1 interaction.
    STRINGi9606.ENSP00000254868.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IUN9.
    SMRiQ8IUN9. Positions 151-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3939CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini61 – 316256ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6021Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini188 – 305118C-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili85 – 17692Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi5 – 84Endocytosis signalSequence Analysis

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG259792.
    HOGENOMiHOG000034093.
    HOVERGENiHBG000270.
    InParanoidiQ8IUN9.
    KOiK06721.
    OMAiWVCEAGL.
    OrthoDBiEOG7XDBGR.
    PhylomeDBiQ8IUN9.
    TreeFamiTF352155.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR005640. Lectin_N.
    [Graphical view]
    PfamiPF00059. Lectin_C. 1 hit.
    PF03954. Lectin_N. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IUN9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTRTYENFQY LENKVKVQGF KNGPLPLQSL LQRLCSGPCH LLLSLGLGLL    50
    LLVIICVVGF QNSKFQRDLV TLRTDFSNFT SNTVAEIQAL TSQGSSLEET 100
    IASLKAEVEG FKQERQAGVS ELQEHTTQKA HLGHCPHCPS VCVPVHSEML 150
    LRVQQLVQDL KKLTCQVATL NNNASTEGTC CPVNWVEHQD SCYWFSHSGM 200
    SWAEAEKYCQ LKNAHLVVIN SREEQNFVQK YLGSAYTWMG LSDPEGAWKW 250
    VDGTDYATGF QNWKPGQPDD WQGHGLGGGE DCAHFHPDGR WNDDVCQRPY 300
    HWVCEAGLGQ TSQESH 316
    Length:316
    Mass (Da):35,446
    Last modified:March 1, 2003 - v1
    Checksum:iD3B7193E2E1F58AF
    GO
    Isoform 2 (identifier: Q8IUN9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         118-144: Missing.
         173-173: N → NGEE

    Show »
    Length:292
    Mass (Da):32,884
    Checksum:i5472EFF9EBC7AC19
    GO
    Isoform 3 (identifier: Q8IUN9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         118-144: Missing.
         226-283: NFVQKYLGSA...HGLGGGEDCA → VRASGTQFLR...IQRNISKLLS
         284-316: Missing.

    Show »
    Length:256
    Mass (Da):28,877
    Checksum:iBEB86B3B5CC8DCD0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti112 – 1121K → R in AAH27858. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti35 – 351C → R.1 Publication
    Corresponds to variant rs90951 [ dbSNP | Ensembl ].
    VAR_021262
    Natural varianti73 – 731R → K.
    Corresponds to variant rs16956478 [ dbSNP | Ensembl ].
    VAR_050113
    Natural varianti100 – 1001T → M.
    Corresponds to variant rs35318160 [ dbSNP | Ensembl ].
    VAR_050114
    Natural varianti203 – 2031A → G.
    Corresponds to variant rs35101468 [ dbSNP | Ensembl ].
    VAR_050115

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei118 – 14427Missing in isoform 2 and isoform 3. 3 PublicationsVSP_012848Add
    BLAST
    Alternative sequencei173 – 1731N → NGEE in isoform 2. 1 PublicationVSP_012849
    Alternative sequencei226 – 28358NFVQK…GEDCA → VRASGTQFLRHVPFREMVLK LGRTLESSGSFQNDCHLCHT LRDLIGLSIQRNISKLLS in isoform 3. 2 PublicationsVSP_012850Add
    BLAST
    Alternative sequencei284 – 31633Missing in isoform 3. 2 PublicationsVSP_012851Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50532 mRNA. Translation: BAA09101.1.
    AK292363 mRNA. Translation: BAF85052.1.
    BC027858 mRNA. Translation: AAH27858.1.
    BC039011 mRNA. Translation: AAH39011.1.
    CCDSiCCDS11087.1. [Q8IUN9-1]
    CCDS45597.1. [Q8IUN9-2]
    RefSeqiNP_006335.2. NM_006344.2. [Q8IUN9-2]
    NP_878910.1. NM_182906.2. [Q8IUN9-1]
    UniGeneiHs.54403.

    Genome annotation databases

    EnsembliENST00000254868; ENSP00000254868; ENSG00000132514. [Q8IUN9-1]
    ENST00000571664; ENSP00000460252; ENSG00000132514. [Q8IUN9-2]
    ENST00000576617; ENSP00000458728; ENSG00000132514. [Q8IUN9-3]
    GeneIDi10462.
    KEGGihsa:10462.
    UCSCiuc002gej.3. human. [Q8IUN9-2]
    uc002gek.3. human. [Q8IUN9-1]
    uc010clv.2. human. [Q8IUN9-3]

    Polymorphism databases

    DMDMi59797948.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    MGL

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50532 mRNA. Translation: BAA09101.1 .
    AK292363 mRNA. Translation: BAF85052.1 .
    BC027858 mRNA. Translation: AAH27858.1 .
    BC039011 mRNA. Translation: AAH39011.1 .
    CCDSi CCDS11087.1. [Q8IUN9-1 ]
    CCDS45597.1. [Q8IUN9-2 ]
    RefSeqi NP_006335.2. NM_006344.2. [Q8IUN9-2 ]
    NP_878910.1. NM_182906.2. [Q8IUN9-1 ]
    UniGenei Hs.54403.

    3D structure databases

    ProteinModelPortali Q8IUN9.
    SMRi Q8IUN9. Positions 151-308.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8IUN9. 1 interaction.
    STRINGi 9606.ENSP00000254868.

    Polymorphism databases

    DMDMi 59797948.

    Proteomic databases

    PaxDbi Q8IUN9.
    PRIDEi Q8IUN9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000254868 ; ENSP00000254868 ; ENSG00000132514 . [Q8IUN9-1 ]
    ENST00000571664 ; ENSP00000460252 ; ENSG00000132514 . [Q8IUN9-2 ]
    ENST00000576617 ; ENSP00000458728 ; ENSG00000132514 . [Q8IUN9-3 ]
    GeneIDi 10462.
    KEGGi hsa:10462.
    UCSCi uc002gej.3. human. [Q8IUN9-2 ]
    uc002gek.3. human. [Q8IUN9-1 ]
    uc010clv.2. human. [Q8IUN9-3 ]

    Organism-specific databases

    CTDi 10462.
    GeneCardsi GC17M006977.
    HGNCi HGNC:16916. CLEC10A.
    HPAi HPA021937.
    MIMi 605999. gene.
    neXtProti NX_Q8IUN9.
    PharmGKBi PA134975011.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG259792.
    HOGENOMi HOG000034093.
    HOVERGENi HBG000270.
    InParanoidi Q8IUN9.
    KOi K06721.
    OMAi WVCEAGL.
    OrthoDBi EOG7XDBGR.
    PhylomeDBi Q8IUN9.
    TreeFami TF352155.

    Miscellaneous databases

    GeneWikii CLEC10A.
    GenomeRNAii 10462.
    NextBioi 39671.
    PROi Q8IUN9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IUN9.
    Bgeei Q8IUN9.
    CleanExi HS_CLEC10A.
    Genevestigatori Q8IUN9.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR005640. Lectin_N.
    [Graphical view ]
    Pfami PF00059. Lectin_C. 1 hit.
    PF03954. Lectin_N. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of cDNA encoding human macrophage c-type lectin: its unique carbohydrate binding specificity for Tn antigen."
      Suzuki N., Yamamoto K., Toyoshima S., Osawa T., Irimura T.
      J. Immunol. 156:128-135(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, VARIANT ARG-35.
      Tissue: Peripheral blood monocyte.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Brain.

    Entry informationi

    Entry nameiCLC10_HUMAN
    AccessioniPrimary (citable) accession number: Q8IUN9
    Secondary accession number(s): A8K8J8, Q14538, Q6PIW3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3