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Q8IUN9 (CLC10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-type lectin domain family 10 member A
Alternative name(s):
C-type lectin superfamily member 14
Macrophage lectin 2
CD_antigen=CD301
Gene names
Name:CLEC10A
Synonyms:CLECSF13, CLECSF14, HML
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells. Ref.1

Subcellular location

Membrane; Single-pass type II membrane protein Probable.

Sequence similarities

Contains 1 C-type lectin domain.

Ontologies

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IUN9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IUN9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     118-144: Missing.
     173-173: N → NGEE
Isoform 3 (identifier: Q8IUN9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     118-144: Missing.
     226-283: NFVQKYLGSA...HGLGGGEDCA → VRASGTQFLR...IQRNISKLLS
     284-316: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316C-type lectin domain family 10 member A
PRO_0000046639

Regions

Topological domain1 – 3939Cytoplasmic Potential
Transmembrane40 – 6021Helical; Signal-anchor for type II membrane protein; Potential
Topological domain61 – 316256Extracellular Potential
Domain188 – 305118C-type lectin
Coiled coil85 – 17692 Potential
Motif5 – 84Endocytosis signal Potential

Amino acid modifications

Glycosylation781N-linked (GlcNAc...) Potential
Glycosylation1731N-linked (GlcNAc...) Potential
Disulfide bond181 ↔ 192 By similarity
Disulfide bond209 ↔ 304 By similarity
Disulfide bond282 ↔ 296 By similarity

Natural variations

Alternative sequence118 – 14427Missing in isoform 2 and isoform 3.
VSP_012848
Alternative sequence1731N → NGEE in isoform 2.
VSP_012849
Alternative sequence226 – 28358NFVQK…GEDCA → VRASGTQFLRHVPFREMVLK LGRTLESSGSFQNDCHLCHT LRDLIGLSIQRNISKLLS in isoform 3.
VSP_012850
Alternative sequence284 – 31633Missing in isoform 3.
VSP_012851
Natural variant351C → R. Ref.1
Corresponds to variant rs90951 [ dbSNP | Ensembl ].
VAR_021262
Natural variant731R → K.
Corresponds to variant rs16956478 [ dbSNP | Ensembl ].
VAR_050113
Natural variant1001T → M.
Corresponds to variant rs35318160 [ dbSNP | Ensembl ].
VAR_050114
Natural variant2031A → G.
Corresponds to variant rs35101468 [ dbSNP | Ensembl ].
VAR_050115

Experimental info

Sequence conflict1121K → R in AAH27858. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: D3B7193E2E1F58AF

FASTA31635,446
        10         20         30         40         50         60 
MTRTYENFQY LENKVKVQGF KNGPLPLQSL LQRLCSGPCH LLLSLGLGLL LLVIICVVGF 

        70         80         90        100        110        120 
QNSKFQRDLV TLRTDFSNFT SNTVAEIQAL TSQGSSLEET IASLKAEVEG FKQERQAGVS 

       130        140        150        160        170        180 
ELQEHTTQKA HLGHCPHCPS VCVPVHSEML LRVQQLVQDL KKLTCQVATL NNNASTEGTC 

       190        200        210        220        230        240 
CPVNWVEHQD SCYWFSHSGM SWAEAEKYCQ LKNAHLVVIN SREEQNFVQK YLGSAYTWMG 

       250        260        270        280        290        300 
LSDPEGAWKW VDGTDYATGF QNWKPGQPDD WQGHGLGGGE DCAHFHPDGR WNDDVCQRPY 

       310 
HWVCEAGLGQ TSQESH 

« Hide

Isoform 2 [UniParc].

Checksum: 5472EFF9EBC7AC19
Show »

FASTA29232,884
Isoform 3 [UniParc].

Checksum: BEB86B3B5CC8DCD0
Show »

FASTA25628,877

References

« Hide 'large scale' references
[1]"Molecular cloning and expression of cDNA encoding human macrophage c-type lectin: its unique carbohydrate binding specificity for Tn antigen."
Suzuki N., Yamamoto K., Toyoshima S., Osawa T., Irimura T.
J. Immunol. 156:128-135(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, VARIANT ARG-35.
Tissue: Peripheral blood monocyte.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D50532 mRNA. Translation: BAA09101.1.
AK292363 mRNA. Translation: BAF85052.1.
BC027858 mRNA. Translation: AAH27858.1.
BC039011 mRNA. Translation: AAH39011.1.
CCDSCCDS11087.1. [Q8IUN9-1]
CCDS45597.1. [Q8IUN9-2]
RefSeqNP_006335.2. NM_006344.2. [Q8IUN9-2]
NP_878910.1. NM_182906.2. [Q8IUN9-1]
UniGeneHs.54403.

3D structure databases

ProteinModelPortalQ8IUN9.
SMRQ8IUN9. Positions 151-308.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8IUN9. 1 interaction.
STRING9606.ENSP00000254868.

Polymorphism databases

DMDM59797948.

Proteomic databases

PaxDbQ8IUN9.
PRIDEQ8IUN9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000254868; ENSP00000254868; ENSG00000132514. [Q8IUN9-1]
ENST00000571664; ENSP00000460252; ENSG00000132514. [Q8IUN9-2]
ENST00000576617; ENSP00000458728; ENSG00000132514. [Q8IUN9-3]
GeneID10462.
KEGGhsa:10462.
UCSCuc002gej.3. human. [Q8IUN9-2]
uc002gek.3. human. [Q8IUN9-1]
uc010clv.2. human. [Q8IUN9-3]

Organism-specific databases

CTD10462.
GeneCardsGC17M006977.
HGNCHGNC:16916. CLEC10A.
HPAHPA021937.
MIM605999. gene.
neXtProtNX_Q8IUN9.
PharmGKBPA134975011.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG259792.
HOGENOMHOG000034093.
HOVERGENHBG000270.
InParanoidQ8IUN9.
KOK06721.
OMAWVCEAGL.
OrthoDBEOG7XDBGR.
PhylomeDBQ8IUN9.
TreeFamTF352155.

Gene expression databases

ArrayExpressQ8IUN9.
BgeeQ8IUN9.
CleanExHS_CLEC10A.
GenevestigatorQ8IUN9.

Family and domain databases

Gene3D3.10.100.10. 1 hit.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR005640. Lectin_N.
[Graphical view]
PfamPF00059. Lectin_C. 1 hit.
PF03954. Lectin_N. 1 hit.
[Graphical view]
SMARTSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMSSF56436. SSF56436. 1 hit.
PROSITEPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCLEC10A.
GenomeRNAi10462.
NextBio39671.
PROQ8IUN9.
SOURCESearch...

Entry information

Entry nameCLC10_HUMAN
AccessionPrimary (citable) accession number: Q8IUN9
Secondary accession number(s): A8K8J8, Q14538, Q6PIW3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries