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Reviewed, UniProtKB/Swiss-Prot Q8IUN9 (CLC10_HUMAN)

Last modified June 16, 2009. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    C-type lectin domain family 10 member A
Alternative name(s):
    C-type lectin superfamily member 14
    Macrophage lectin 2
    CD_antigen=CD301
Gene names
Name: CLEC10A
Synonyms: CLECSF13, CLECSF14, HML
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells. Ref.1

Subcellular location

Membrane; Single-pass type II membrane protein Probable.

Sequence similarities

Contains 1 C-type lectin domain.

Ontologies

Keywords
   Biological processEndocytosis
Immune response
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
Signal-anchor
Transmembrane
   LigandLectin
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Biological processendocytosis

Inferred from electronic annotation. Source: UniProtKB-KW

immune response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane Ref.1

Traceable author statement. Source: ProtInc

   Molecular functionsugar binding Ref.1

Traceable author statement. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IUN9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IUN9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     118-144: Missing.
     173-173: N → NGEE
Isoform 3 (identifier: Q8IUN9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     118-144: Missing.
     226-283: NFVQKYLGSA...HGLGGGEDCA → VRASGTQFLR...IQRNISKLLS
     284-316: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316C-type lectin domain family 10 member A
PRO_0000046639

Regions

Topological domain1 – 3939Cytoplasmic Potential
Transmembrane40 – 6021Signal-anchor for type II membrane protein Potential
Topological domain61 – 316256Extracellular Potential
Domain188 – 305118C-type lectin
Coiled coil85 – 17692 Potential
Motif5 – 84Endocytosis signal Potential

Amino acid modifications

Glycosylation781N-linked (GlcNAc...) Potential
Glycosylation1731N-linked (GlcNAc...) Potential
Disulfide bond181 ↔ 192 By similarity
Disulfide bond209 ↔ 304 By similarity
Disulfide bond282 ↔ 296 By similarity

Natural variations

Alternative sequence118 – 14427Missing in isoform 2 and isoform 3.
VSP_012848
Alternative sequence1731N → NGEE in isoform 2.
VSP_012849
Alternative sequence226 – 28358NFVQK…GEDCA → VRASGTQFLRHVPFREMVLK LGRTLESSGSFQNDCHLCHT LRDLIGLSIQRNISKLLS in isoform 3.
VSP_012850
Alternative sequence284 – 31633Missing in isoform 3.
VSP_012851
Natural variant351C → R: dbSNP rs90951. Ref.1
VAR_021262
Natural variant731R → K: dbSNP rs16956478.
VAR_050113
Natural variant1001T → M: dbSNP rs35318160.
VAR_050114
Natural variant2031A → G: dbSNP rs35101468.
VAR_050115

Experimental info

Sequence conflict1121K → R in AAH27858. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: D3B7193E2E1F58AF

FASTA31635,446
        10         20         30         40         50         60 
MTRTYENFQY LENKVKVQGF KNGPLPLQSL LQRLCSGPCH LLLSLGLGLL LLVIICVVGF 

        70         80         90        100        110        120 
QNSKFQRDLV TLRTDFSNFT SNTVAEIQAL TSQGSSLEET IASLKAEVEG FKQERQAGVS 

       130        140        150        160        170        180 
ELQEHTTQKA HLGHCPHCPS VCVPVHSEML LRVQQLVQDL KKLTCQVATL NNNASTEGTC 

       190        200        210        220        230        240 
CPVNWVEHQD SCYWFSHSGM SWAEAEKYCQ LKNAHLVVIN SREEQNFVQK YLGSAYTWMG 

       250        260        270        280        290        300 
LSDPEGAWKW VDGTDYATGF QNWKPGQPDD WQGHGLGGGE DCAHFHPDGR WNDDVCQRPY 

       310 
HWVCEAGLGQ TSQESH 

« Hide

Isoform 2.

Checksum: 5472EFF9EBC7AC19
Show »

FASTA29232,884
Isoform 3.

Checksum: BEB86B3B5CC8DCD0
Show »

FASTA25628,877

References

« Hide 'large scale' references
[1]"Molecular cloning and expression of cDNA encoding human macrophage c-type lectin: its unique carbohydrate binding specificity for Tn antigen."
Suzuki N., Yamamoto K., Toyoshima S., Osawa T., Irimura T.
J. Immunol. 156:128-135(1996) [PubMed: 8598452] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, VARIANT ARG-35.
Tissue: Peripheral blood monocyte.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Tissue: Brain.

Cross-references

Sequence databases

D50532 mRNA. Translation: BAA09101.1.
AK292363 mRNA. Translation: BAF85052.1.
BC027858 mRNA. Translation: AAH27858.1.
BC039011 mRNA. Translation: AAH39011.1.
IPIIPI00216794.
IPI00337367.
IPI00448891.
RefSeqNP_006335.2.
NP_878910.1.
UniGeneHs.54403

3D structure databases

HSSPHSSP built from PDB template 1DV8 based on UniProtKB P07306.
SMRQ8IUN9. Positions 181-308.
ModBaseSearch...

Proteomic databases

PRIDEQ8IUN9.

Genome annotation databases

EnsemblENSG00000132514. Homo sapiens. [Contig view]
GeneID10462.
KEGGhsa:10462.

Organism-specific databases

GeneCardsGC17M006919.
H-InvDBHIX0027188.
HGNCHGNC:16916. CLEC10A.
MIM605999. gene.
PharmGKBPA134975011.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ8IUN9.
HOVERGENQ8IUN9.
OMAQ8IUN9. GSSYTWM.

Gene expression databases

ArrayExpressQ8IUN9.
BgeeQ8IUN9.
CleanExHS_CLEC10A.
GermOnlineENSG00000132514. Homo sapiens.

Family and domain databases

InterProIPR002353. AntifreezeII.
IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR005640. Lectin_N.
[Graphical view]
Gene3DG3DSA:3.10.100.10. C-type_lectin-like. 1 hit.
PfamPF00059. Lectin_C. 1 hit.
PF03954. Lectin_N. 1 hit.
[Graphical view]
PRINTSPR00356. ANTIFREEZEII.
SMARTSM00034. CLECT. 1 hit.
[Graphical view]
PROSITEPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio39671.
SOURCESearch...

Entry information

Entry nameCLC10_HUMAN
AccessionPrimary (citable) accession number: Q8IUN9
Secondary accession number(s): A8K8J8, Q14538, Q6PIW3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2003
Last modified: June 16, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents