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Protein
Submitted name:

ADH6 protein

Gene

ADH6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Zn2+UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
ADH6 proteinImported
Submitted name:
Alcohol dehydrogenase 6Imported
Gene namesi
Name:ADH6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:255. ADH6.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172955.
PharmGKBiPA24576.

Expressioni

Gene expression databases

BgeeiENSG00000172955.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000378359.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 160ADH_NInterPro annotationAdd BLAST126
Domaini203 – 272ADH_zinc_NInterPro annotationAdd BLAST70

Sequence similaritiesi

Belongs to the zinc-containing alcohol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
GeneTreeiENSGT00430000030800.
HOGENOMiHOG000294674.
HOVERGENiHBG000195.
KOiK13952.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 2 hits.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IUN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTGQVIRC KAAILWKPGA PFSIEEVEVA PPKAKEVRIK VVATGLCGTE
60 70 80 90 100
MKVLGSKHLD LLYPTILGHE GAGIVESIGE GVSTVKPGDK VITLFLPQCG
110 120 130 140 150
ECTSCLNSEG NFCIQFKQSK TQLMSDGTSR FTCKGKSIYH FGNTSTFCEY
160 170 180 190 200
TVIKEISVAK IDAVAPLEKV CLISCGFSTG FGAAINTAKV TPGSTCAVFG
210 220 230 240 250
LGGVGLSVVM GCKAAGAARI IGVDVNKEKF KKAQELGATE CLNPQDLKKP
260 270 280 290
IQEVLFDMTD AGIDFCFEAI GNLDVLAGRA DSTSLNWLLI IWQRS
Length:295
Mass (Da):31,299
Last modified:March 1, 2003 - v1
Checksum:iDE4720D0B3B91962
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002026 Genomic DNA. No translation available.
KF457794 Genomic DNA. No translation available.
BC039065 mRNA. Translation: AAH39065.1.
RefSeqiNP_000663.1. NM_000672.3.
NP_001095940.1. NM_001102470.1.
UniGeneiHs.586161.

Genome annotation databases

EnsembliENST00000394897; ENSP00000378358; ENSG00000172955.
GeneIDi130.
KEGGihsa:130.
UCSCiuc010ile.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002026 Genomic DNA. No translation available.
KF457794 Genomic DNA. No translation available.
BC039065 mRNA. Translation: AAH39065.1.
RefSeqiNP_000663.1. NM_000672.3.
NP_001095940.1. NM_001102470.1.
UniGeneiHs.586161.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000378359.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394897; ENSP00000378358; ENSG00000172955.
GeneIDi130.
KEGGihsa:130.
UCSCiuc010ile.4. human.

Organism-specific databases

CTDi130.
HGNCiHGNC:255. ADH6.
OpenTargetsiENSG00000172955.
PharmGKBiPA24576.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
GeneTreeiENSGT00430000030800.
HOGENOMiHOG000294674.
HOVERGENiHBG000195.
KOiK13952.

Miscellaneous databases

GenomeRNAii130.

Gene expression databases

BgeeiENSG00000172955.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 2 hits.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ8IUN7_HUMAN
AccessioniPrimary (citable) accession number: Q8IUN7
Secondary accession number(s): E9PBI1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.