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Protein

Protein Wnt

Gene

WNT4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors.UniRule annotation

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinUniRule annotationSAAS annotation

Keywords - Biological processi

Wnt signaling pathwayUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein WntUniRule annotation
Gene namesi
Name:WNT4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Secretedextracellular spaceextracellular matrix UniRule annotation

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrixSAAS annotation, Secreted

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG001595.

Family and domain databases

InterProiIPR005817. Wnt.
IPR009142. Wnt4.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01844. WNT4PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IUM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPRSCLRSL RLLVFAVFSA AASNWLYLAK LSSVGSISEE ETCEKLKGLI
60 70 80 90 100
QRQVQMCKRN LEVMDSVRRG AQLAIEECQY QFRNRRWNCS TLDSLPVFGK
110 120 130 140 150
VVTQGTREAA FVYAISSAGV AFAVTRACSS GELEKCGCDR TVHGVTPQGF
160 170 180 190 200
QWSGCSDNIA YGVAFSQSFV DVRERSKGAS SSRALMNLHN NEAGRKAILT
210 220 230 240 250
HMRVECKCHG VSGSCEVKTC WRAVPPFRQV GHALKEKFDG ATEVEPRRVG
260 270 280 290 300
SSRALVPRNA QFKPHTDEDL VYLEPSPDFC EQDMRSGVLG TRGRTCNKTS
310 320 330 340 350
KAIDGCELLC CGRGFHTAQV ELAERCSCKF HWCCFVKCRQ CQRLVELHTC

R
Length:351
Mass (Da):39,066
Last modified:March 1, 2003 - v1
Checksum:iE1080A52099AA020
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB061675 mRNA. Translation: BAC23080.1.
UniGeneiHs.25766.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB061675 mRNA. Translation: BAC23080.1.
UniGeneiHs.25766.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG001595.

Family and domain databases

InterProiIPR005817. Wnt.
IPR009142. Wnt4.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01844. WNT4PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and characterization of WNT4 on human chromosome 1p35.1-p36.23."
    Saitoh T., Hirai M., Katoh M.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Fetal tissuesImported.

Entry informationi

Entry nameiQ8IUM6_HUMAN
AccessioniPrimary (citable) accession number: Q8IUM6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: February 4, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.