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Protein

Cartilage intermediate layer protein 2

Gene

CILP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in cartilage scaffolding.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Cartilage intermediate layer protein 2
Short name:
CILP-2
Cleaved into the following 2 chains:
Gene namesi
Name:CILP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000160161.9
HGNCiHGNC:24213 CILP2
MIMi612419 gene
neXtProtiNX_Q8IUL8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi148113
OpenTargetsiENSG00000160161
PharmGKBiPA134970563

Polymorphism and mutation databases

BioMutaiCILP2
DMDMi68565198

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001467821 – 1156Cartilage intermediate layer protein 2Add BLAST1136
ChainiPRO_000001467921 – ?709Cartilage intermediate layer protein 2 C1Sequence analysisAdd BLAST689
ChainiPRO_0000014680?710 – 1156Cartilage intermediate layer protein 2 C2Sequence analysisAdd BLAST447

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi158 ↔ 191By similarity
Disulfide bondi162 ↔ 196By similarity
Disulfide bondi173 ↔ 181By similarity
Glycosylationi276N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi308N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi313 ↔ 359By similarity
Glycosylationi329N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

May be cleaved into 2 chains possibly by a furin-like protease upon or preceding secretion.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8IUL8
PaxDbiQ8IUL8
PeptideAtlasiQ8IUL8
PRIDEiQ8IUL8

PTM databases

iPTMnetiQ8IUL8
PhosphoSitePlusiQ8IUL8

Miscellaneous databases

PMAP-CutDBiQ8IUL8

Expressioni

Tissue specificityi

Expressed in articular chondrocytes but not in knee meniscal cartilage cells (PubMed:12746903). Localizes to the intermediate to deep zone of articular cartilage (PubMed:21880736).2 Publications

Gene expression databases

BgeeiENSG00000160161
CleanExiHS_CILP2
ExpressionAtlasiQ8IUL8 baseline and differential
GenevisibleiQ8IUL8 HS

Organism-specific databases

HPAiHPA041847

Interactioni

Protein-protein interaction databases

BioGridi127119, 5 interactors
STRINGi9606.ENSP00000291495

Structurei

3D structure databases

ProteinModelPortaliQ8IUL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini146 – 197TSP type-1PROSITE-ProRule annotationAdd BLAST52
Domaini292 – 376Ig-like C2-typeAdd BLAST85

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410IJBD Eukaryota
ENOG410XXZR LUCA
GeneTreeiENSGT00390000008152
HOGENOMiHOG000111676
HOVERGENiHBG081175
InParanoidiQ8IUL8
PhylomeDBiQ8IUL8
TreeFamiTF330132

Family and domain databases

Gene3Di2.20.100.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR008969 CarboxyPept-like_regulatory
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR025155 WxxW_domain
PfamiView protein in Pfam
PF13330 Mucin2_WxxW, 1 hit
PF00090 TSP_1, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00209 TSP1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49464 SSF49464, 1 hit
SSF82895 SSF82895, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS50092 TSP1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IUL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLLPLLCL CVVAAHLAGA RDATPTEEPM ATALGLERRS VYTGQPSPAL
60 70 80 90 100
EDWEEASEWT SWFNVDHPGG DGDFESLAAI RFYYGPARVC PRPLALEART
110 120 130 140 150
TDWALPSAVG ERVHLNPTRG FWCLNREQPR GRRCSNYHVR FRCPLEASWG
160 170 180 190 200
AWGPWGPCSG SCGPGRRLRR RHCPSPAGDA CPGRPLEAQK CVRPRCPGCS
210 220 230 240 250
LDTCECPDHI LLGSVVTPSG QPLLGARVSL RDQPGTVATS DAHGTFRVPG
260 270 280 290 300
VCADSRANIR AQMDGFSAGE AQAQANGSIS VVTIILDKLE KPYLVKHPES
310 320 330 340 350
RVREAGQNVT FCCKASGTPM PKKYSWFHNG TLLDRRAHGY GAHLELRGLR
360 370 380 390 400
PDQAGIYHCK AWNEAGAVRS GTARLTVLAP GQPACDPRPR EYLIKLPEDC
410 420 430 440 450
GQPGSGPAYL DVGLCPDTRC PSLAGSSPRC GDASSRCCSV RRLERREIHC
460 470 480 490 500
PGYVLPVKVV AECGCQKCLP PRGLVRGRVV AADSGEPLRF ARILLGQEPI
510 520 530 540 550
GFTAYQGDFT IEVPPSTQRL VVTFVDPSGE FMDAVRVLPF DPRGAGVYHE
560 570 580 590 600
VKAMRKKAPV ILHTSQSNTI PLGELEDEAP LGELVLPSGA FRRADGKPYS
610 620 630 640 650
GPVEARVTFV DPRDLTSAAS APSDLRFVDS DGELAPLRTY GMFSVDLRAP
660 670 680 690 700
GSAEQLQVGP VAVRVAASQI HMPGHVEALK LWSLNPETGL WEEESGFRRE
710 720 730 740 750
GSSGPRVRRE ERVFLVGNVE IRERRLFNLD VPERRRCFVK VRAYANDKFT
760 770 780 790 800
PSEQVEGVVV TLVNLEPAPG FSANPRAWGR FDSAVTGPNG ACLPAFCDAD
810 820 830 840 850
RPDAYTALVT ATLGGEELEP APSLPRPLPA TVGVTQPYLD RLGYRRTDHD
860 870 880 890 900
DPAFKRNGFR INLAKPRPGD PAEANGPVYP WRSLRECQGA PVTASHFRFA
910 920 930 940 950
RVEADKYEYN VVPFREGTPA SWTGDLLAWW PNPQEFRACF LKVKIQGPQE
960 970 980 990 1000
YMVRSHNAGG SHPRTRGQLY GLRDARSVRD PERPGTSAAC VEFKCSGMLF
1010 1020 1030 1040 1050
DQRQVDRTLV TIMPQGSCRR VAVNGLLRDY LTRHPPPVPA EDPAAFSMLA
1060 1070 1080 1090 1100
PLDPLGHNYG VYTVTDQSPR LAKEIAIGRC FDGSSDGFSR EMKADAGTAV
1110 1120 1130 1140 1150
TFQCREPPAG RPSLFQRLLE SPATALGDIR REMSEAAQAQ ARASGPLRTR

RGRVRQ
Length:1,156
Mass (Da):126,291
Last modified:July 5, 2005 - v2
Checksum:iCE4AAB47841C07F9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti768A → G in AAN17826 (PubMed:12746903).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF542080 mRNA Translation: AAN17826.1
BC018939 mRNA Translation: AAH18939.2
BC034926 mRNA Translation: AAH34926.2
CCDSiCCDS12405.1
RefSeqiNP_694953.2, NM_153221.2
UniGeneiHs.279574

Genome annotation databases

EnsembliENST00000291495; ENSP00000291495; ENSG00000160161
GeneIDi148113
KEGGihsa:148113
UCSCiuc002nmv.4 human

Similar proteinsi

Entry informationi

Entry nameiCILP2_HUMAN
AccessioniPrimary (citable) accession number: Q8IUL8
Secondary accession number(s): Q6NV88, Q8N4A6, Q8WV21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: March 28, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health