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Protein

Cartilage intermediate layer protein 2

Gene

CILP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in cartilage scaffolding.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Cartilage intermediate layer protein 2
Short name:
CILP-2
Cleaved into the following 2 chains:
Gene namesi
Name:CILP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:24213. CILP2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134970563.

Polymorphism and mutation databases

BioMutaiCILP2.
DMDMi68565198.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 11561136Cartilage intermediate layer protein 2PRO_0000014678Add
BLAST
Chaini21 – ?709689Cartilage intermediate layer protein 2 C1Sequence analysisPRO_0000014679Add
BLAST
Chaini?710 – 1156447Cartilage intermediate layer protein 2 C2Sequence analysisPRO_0000014680Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi158 ↔ 191By similarity
Disulfide bondi162 ↔ 196By similarity
Disulfide bondi173 ↔ 181By similarity
Glycosylationi276 – 2761N-linked (GlcNAc...)Sequence analysis
Glycosylationi308 – 3081N-linked (GlcNAc...)Sequence analysis
Disulfide bondi313 ↔ 359By similarity
Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

May be cleaved into 2 chains possibly by a furin-like protease upon or preceding secretion.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8IUL8.
PaxDbiQ8IUL8.
PeptideAtlasiQ8IUL8.
PRIDEiQ8IUL8.

PTM databases

iPTMnetiQ8IUL8.
PhosphoSiteiQ8IUL8.

Miscellaneous databases

PMAP-CutDBQ8IUL8.

Expressioni

Tissue specificityi

Expressed in articular chondrocytes but not in knee meniscal cartilage cells.1 Publication

Gene expression databases

BgeeiQ8IUL8.
CleanExiHS_CILP2.
ExpressionAtlasiQ8IUL8. baseline and differential.
GenevisibleiQ8IUL8. HS.

Organism-specific databases

HPAiHPA041847.

Interactioni

Protein-protein interaction databases

BioGridi127119. 5 interactions.
STRINGi9606.ENSP00000291495.

Structurei

3D structure databases

ProteinModelPortaliQ8IUL8.
SMRiQ8IUL8. Positions 145-202, 264-366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini146 – 19752TSP type-1PROSITE-ProRule annotationAdd
BLAST
Domaini292 – 37685Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Contains 1 TSP type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410IJBD. Eukaryota.
ENOG410XXZR. LUCA.
GeneTreeiENSGT00390000008152.
HOGENOMiHOG000111676.
HOVERGENiHBG081175.
InParanoidiQ8IUL8.
OrthoDBiEOG780RKM.
PhylomeDBiQ8IUL8.
TreeFamiTF330132.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR008969. CarboxyPept-like_regulatory.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR000884. TSP1_rpt.
IPR025155. WxxW_domain.
[Graphical view]
PfamiPF13330. Mucin2_WxxW. 1 hit.
PF00090. TSP_1. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00209. TSP1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49464. SSF49464. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS50092. TSP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IUL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLLPLLCL CVVAAHLAGA RDATPTEEPM ATALGLERRS VYTGQPSPAL
60 70 80 90 100
EDWEEASEWT SWFNVDHPGG DGDFESLAAI RFYYGPARVC PRPLALEART
110 120 130 140 150
TDWALPSAVG ERVHLNPTRG FWCLNREQPR GRRCSNYHVR FRCPLEASWG
160 170 180 190 200
AWGPWGPCSG SCGPGRRLRR RHCPSPAGDA CPGRPLEAQK CVRPRCPGCS
210 220 230 240 250
LDTCECPDHI LLGSVVTPSG QPLLGARVSL RDQPGTVATS DAHGTFRVPG
260 270 280 290 300
VCADSRANIR AQMDGFSAGE AQAQANGSIS VVTIILDKLE KPYLVKHPES
310 320 330 340 350
RVREAGQNVT FCCKASGTPM PKKYSWFHNG TLLDRRAHGY GAHLELRGLR
360 370 380 390 400
PDQAGIYHCK AWNEAGAVRS GTARLTVLAP GQPACDPRPR EYLIKLPEDC
410 420 430 440 450
GQPGSGPAYL DVGLCPDTRC PSLAGSSPRC GDASSRCCSV RRLERREIHC
460 470 480 490 500
PGYVLPVKVV AECGCQKCLP PRGLVRGRVV AADSGEPLRF ARILLGQEPI
510 520 530 540 550
GFTAYQGDFT IEVPPSTQRL VVTFVDPSGE FMDAVRVLPF DPRGAGVYHE
560 570 580 590 600
VKAMRKKAPV ILHTSQSNTI PLGELEDEAP LGELVLPSGA FRRADGKPYS
610 620 630 640 650
GPVEARVTFV DPRDLTSAAS APSDLRFVDS DGELAPLRTY GMFSVDLRAP
660 670 680 690 700
GSAEQLQVGP VAVRVAASQI HMPGHVEALK LWSLNPETGL WEEESGFRRE
710 720 730 740 750
GSSGPRVRRE ERVFLVGNVE IRERRLFNLD VPERRRCFVK VRAYANDKFT
760 770 780 790 800
PSEQVEGVVV TLVNLEPAPG FSANPRAWGR FDSAVTGPNG ACLPAFCDAD
810 820 830 840 850
RPDAYTALVT ATLGGEELEP APSLPRPLPA TVGVTQPYLD RLGYRRTDHD
860 870 880 890 900
DPAFKRNGFR INLAKPRPGD PAEANGPVYP WRSLRECQGA PVTASHFRFA
910 920 930 940 950
RVEADKYEYN VVPFREGTPA SWTGDLLAWW PNPQEFRACF LKVKIQGPQE
960 970 980 990 1000
YMVRSHNAGG SHPRTRGQLY GLRDARSVRD PERPGTSAAC VEFKCSGMLF
1010 1020 1030 1040 1050
DQRQVDRTLV TIMPQGSCRR VAVNGLLRDY LTRHPPPVPA EDPAAFSMLA
1060 1070 1080 1090 1100
PLDPLGHNYG VYTVTDQSPR LAKEIAIGRC FDGSSDGFSR EMKADAGTAV
1110 1120 1130 1140 1150
TFQCREPPAG RPSLFQRLLE SPATALGDIR REMSEAAQAQ ARASGPLRTR

RGRVRQ
Length:1,156
Mass (Da):126,291
Last modified:July 5, 2005 - v2
Checksum:iCE4AAB47841C07F9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti768 – 7681A → G in AAN17826 (PubMed:12746903).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF542080 mRNA. Translation: AAN17826.1.
BC018939 mRNA. Translation: AAH18939.2.
BC034926 mRNA. Translation: AAH34926.2.
CCDSiCCDS12405.1.
RefSeqiNP_694953.2. NM_153221.2.
UniGeneiHs.279574.

Genome annotation databases

EnsembliENST00000291495; ENSP00000291495; ENSG00000160161.
GeneIDi148113.
KEGGihsa:148113.
UCSCiuc002nmv.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF542080 mRNA. Translation: AAN17826.1.
BC018939 mRNA. Translation: AAH18939.2.
BC034926 mRNA. Translation: AAH34926.2.
CCDSiCCDS12405.1.
RefSeqiNP_694953.2. NM_153221.2.
UniGeneiHs.279574.

3D structure databases

ProteinModelPortaliQ8IUL8.
SMRiQ8IUL8. Positions 145-202, 264-366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127119. 5 interactions.
STRINGi9606.ENSP00000291495.

PTM databases

iPTMnetiQ8IUL8.
PhosphoSiteiQ8IUL8.

Polymorphism and mutation databases

BioMutaiCILP2.
DMDMi68565198.

Proteomic databases

EPDiQ8IUL8.
PaxDbiQ8IUL8.
PeptideAtlasiQ8IUL8.
PRIDEiQ8IUL8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291495; ENSP00000291495; ENSG00000160161.
GeneIDi148113.
KEGGihsa:148113.
UCSCiuc002nmv.4. human.

Organism-specific databases

CTDi148113.
GeneCardsiCILP2.
H-InvDBHIX0027466.
HGNCiHGNC:24213. CILP2.
HPAiHPA041847.
MIMi612419. gene.
neXtProtiNX_Q8IUL8.
PharmGKBiPA134970563.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJBD. Eukaryota.
ENOG410XXZR. LUCA.
GeneTreeiENSGT00390000008152.
HOGENOMiHOG000111676.
HOVERGENiHBG081175.
InParanoidiQ8IUL8.
OrthoDBiEOG780RKM.
PhylomeDBiQ8IUL8.
TreeFamiTF330132.

Miscellaneous databases

GenomeRNAii148113.
PMAP-CutDBQ8IUL8.
PROiQ8IUL8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IUL8.
CleanExiHS_CILP2.
ExpressionAtlasiQ8IUL8. baseline and differential.
GenevisibleiQ8IUL8. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR008969. CarboxyPept-like_regulatory.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR000884. TSP1_rpt.
IPR025155. WxxW_domain.
[Graphical view]
PfamiPF13330. Mucin2_WxxW. 1 hit.
PF00090. TSP_1. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00209. TSP1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49464. SSF49464. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS50092. TSP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist."
    Johnson K., Farley D., Hu S.-I., Terkeltaub R.
    Arthritis Rheum. 48:1302-1314(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Osteoarthritic cartilage.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCILP2_HUMAN
AccessioniPrimary (citable) accession number: Q8IUL8
Secondary accession number(s): Q6NV88, Q8N4A6, Q8WV21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: July 6, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.