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Protein

Cerebellin-2

Gene

CBLN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play role in synaptogenesis induction.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cerebellin-2
Gene namesi
Name:CBLN2
ORF Names:UNQ1892/PRO4338
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:1544. CBLN2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi147381.
OpenTargetsiENSG00000141668.
Orphaneti275777. Heritable pulmonary arterial hypertension.
275766. Idiopathic pulmonary arterial hypertension.
PharmGKBiPA26119.

Polymorphism and mutation databases

BioMutaiCBLN2.
DMDMi46395886.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 51Sequence analysisAdd BLAST51
ChainiPRO_000000355152 – 224Cerebellin-2Add BLAST173

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi110N-linked (GlcNAc...) asparagineBy similarity1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8IUK8.
PaxDbiQ8IUK8.
PeptideAtlasiQ8IUK8.
PRIDEiQ8IUK8.

PTM databases

iPTMnetiQ8IUK8.
PhosphoSitePlusiQ8IUK8.

Expressioni

Gene expression databases

BgeeiENSG00000141668.
CleanExiHS_CBLN2.
ExpressionAtlasiQ8IUK8. baseline and differential.
GenevisibleiQ8IUK8. HS.

Organism-specific databases

HPAiHPA056335.

Interactioni

Subunit structurei

May form homooligomers or heterooligomers with CBLN1 and CBLN3 prior to secretion. Once secreted, does not interact with other CBLN family members. Interacts with GRID2, and more weakly with GRID1. Interacts with NRXN1 and NRXN2 long and short isoforms produced by alternative promoter usage. Weakly interacts with NRXN3 short isoform and not at all with NRXN3 long isoform (By similarity).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000269503.

Structurei

3D structure databases

ProteinModelPortaliQ8IUK8.
SMRiQ8IUK8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini88 – 224C1qPROSITE-ProRule annotationAdd BLAST137

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFXA. Eukaryota.
ENOG410Y16R. LUCA.
GeneTreeiENSGT00760000119052.
HOGENOMiHOG000085657.
HOVERGENiHBG108329.
InParanoidiQ8IUK8.
OMAiQVNLMQN.
OrthoDBiEOG091G0XK2.
PhylomeDBiQ8IUK8.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiView protein in InterPro
IPR001073. C1q_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
PfamiView protein in Pfam
PF00386. C1q. 1 hit.
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiView protein in SMART
SM00110. C1Q. 1 hit.
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiView protein in PROSITE
PS50871. C1Q. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IUK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAPGRGPLG LRLMMPGRRG ALREPGGCGS CLGVALALLL LLLPACCPVR
60 70 80 90 100
AQNDTEPIVL EGKCLVVCDS SPSADGAVTS SLGISVRSGS AKVAFSATRS
110 120 130 140 150
TNHEPSEMSN RTMTIYFDQV LVNIGNHFDL ASSIFVAPRK GIYSFSFHVV
160 170 180 190 200
KVYNRQTIQV SLMQNGYPVI SAFAGDQDVT REAASNGVLL LMEREDKVHL
210 220
KLERGNLMGG WKYSTFSGFL VFPL
Length:224
Mass (Da):24,084
Last modified:March 1, 2003 - v1
Checksum:iA08C8BB3D686A9C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291364 mRNA. Translation: BAF84053.1.
AY359074 mRNA. Translation: AAQ89433.1.
CH471117 Genomic DNA. Translation: EAW66527.1.
BC035789 mRNA. Translation: AAH35789.1.
CCDSiCCDS11999.1.
RefSeqiNP_872317.1. NM_182511.3.
XP_006722457.1. XM_006722394.3.
XP_011524126.1. XM_011525824.2.
XP_016881048.1. XM_017025559.1.
XP_016881049.1. XM_017025560.1.
UniGeneiHs.569851.

Genome annotation databases

EnsembliENST00000269503; ENSP00000269503; ENSG00000141668.
ENST00000585159; ENSP00000463771; ENSG00000141668.
GeneIDi147381.
KEGGihsa:147381.
UCSCiuc002lku.4. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCBLN2_HUMAN
AccessioniPrimary (citable) accession number: Q8IUK8
Secondary accession number(s): Q53Z56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: June 7, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot