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Protein

Cerebellin-2

Gene

CBLN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play role in synaptogenesis induction.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cerebellin-2
Gene namesi
Name:CBLN2
ORF Names:UNQ1892/PRO4338
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:1544. CBLN2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

Orphaneti275777. Heritable pulmonary arterial hypertension.
275766. Idiopathic pulmonary arterial hypertension.
PharmGKBiPA26119.

Polymorphism and mutation databases

BioMutaiCBLN2.
DMDMi46395886.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 5151Sequence analysisAdd
BLAST
Chaini52 – 224173Cerebellin-2PRO_0000003551Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)By similarity
Glycosylationi110 – 1101N-linked (GlcNAc...)By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8IUK8.
PaxDbiQ8IUK8.
PeptideAtlasiQ8IUK8.
PRIDEiQ8IUK8.

PTM databases

iPTMnetiQ8IUK8.
PhosphoSiteiQ8IUK8.

Expressioni

Gene expression databases

BgeeiENSG00000141668.
CleanExiHS_CBLN2.
ExpressionAtlasiQ8IUK8. baseline and differential.
GenevisibleiQ8IUK8. HS.

Interactioni

Subunit structurei

May form homooligomers or heterooligomers with CBLN1 and CBLN3 prior to secretion. Once secreted, does not interact with other CBLN family members. Interacts with GRID2, and more weakly with GRID1. Interacts with NRXN1 and NRXN2 long and short isoforms produced by alternative promoter usage. Weakly interacts with NRXN3 short isoform and not at all with NRXN3 long isoform (By similarity).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000269503.

Structurei

3D structure databases

ProteinModelPortaliQ8IUK8.
SMRiQ8IUK8. Positions 92-222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini88 – 224137C1qPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFXA. Eukaryota.
ENOG410Y16R. LUCA.
GeneTreeiENSGT00760000119052.
HOGENOMiHOG000085657.
HOVERGENiHBG108329.
InParanoidiQ8IUK8.
OMAiIQVNLMQ.
OrthoDBiEOG091G0XK2.
PhylomeDBiQ8IUK8.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IUK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAPGRGPLG LRLMMPGRRG ALREPGGCGS CLGVALALLL LLLPACCPVR
60 70 80 90 100
AQNDTEPIVL EGKCLVVCDS SPSADGAVTS SLGISVRSGS AKVAFSATRS
110 120 130 140 150
TNHEPSEMSN RTMTIYFDQV LVNIGNHFDL ASSIFVAPRK GIYSFSFHVV
160 170 180 190 200
KVYNRQTIQV SLMQNGYPVI SAFAGDQDVT REAASNGVLL LMEREDKVHL
210 220
KLERGNLMGG WKYSTFSGFL VFPL
Length:224
Mass (Da):24,084
Last modified:March 1, 2003 - v1
Checksum:iA08C8BB3D686A9C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291364 mRNA. Translation: BAF84053.1.
AY359074 mRNA. Translation: AAQ89433.1.
CH471117 Genomic DNA. Translation: EAW66527.1.
BC035789 mRNA. Translation: AAH35789.1.
CCDSiCCDS11999.1.
RefSeqiNP_872317.1. NM_182511.3.
XP_006722457.1. XM_006722394.3.
XP_011524126.1. XM_011525824.2.
UniGeneiHs.569851.

Genome annotation databases

EnsembliENST00000269503; ENSP00000269503; ENSG00000141668.
ENST00000585159; ENSP00000463771; ENSG00000141668.
GeneIDi147381.
KEGGihsa:147381.
UCSCiuc002lku.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291364 mRNA. Translation: BAF84053.1.
AY359074 mRNA. Translation: AAQ89433.1.
CH471117 Genomic DNA. Translation: EAW66527.1.
BC035789 mRNA. Translation: AAH35789.1.
CCDSiCCDS11999.1.
RefSeqiNP_872317.1. NM_182511.3.
XP_006722457.1. XM_006722394.3.
XP_011524126.1. XM_011525824.2.
UniGeneiHs.569851.

3D structure databases

ProteinModelPortaliQ8IUK8.
SMRiQ8IUK8. Positions 92-222.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000269503.

PTM databases

iPTMnetiQ8IUK8.
PhosphoSiteiQ8IUK8.

Polymorphism and mutation databases

BioMutaiCBLN2.
DMDMi46395886.

Proteomic databases

EPDiQ8IUK8.
PaxDbiQ8IUK8.
PeptideAtlasiQ8IUK8.
PRIDEiQ8IUK8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269503; ENSP00000269503; ENSG00000141668.
ENST00000585159; ENSP00000463771; ENSG00000141668.
GeneIDi147381.
KEGGihsa:147381.
UCSCiuc002lku.4. human.

Organism-specific databases

CTDi147381.
GeneCardsiCBLN2.
HGNCiHGNC:1544. CBLN2.
MIMi600433. gene.
neXtProtiNX_Q8IUK8.
Orphaneti275777. Heritable pulmonary arterial hypertension.
275766. Idiopathic pulmonary arterial hypertension.
PharmGKBiPA26119.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFXA. Eukaryota.
ENOG410Y16R. LUCA.
GeneTreeiENSGT00760000119052.
HOGENOMiHOG000085657.
HOVERGENiHBG108329.
InParanoidiQ8IUK8.
OMAiIQVNLMQ.
OrthoDBiEOG091G0XK2.
PhylomeDBiQ8IUK8.
TreeFamiTF329591.

Miscellaneous databases

GenomeRNAii147381.
PROiQ8IUK8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141668.
CleanExiHS_CBLN2.
ExpressionAtlasiQ8IUK8. baseline and differential.
GenevisibleiQ8IUK8. HS.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCBLN2_HUMAN
AccessioniPrimary (citable) accession number: Q8IUK8
Secondary accession number(s): Q53Z56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.