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Q8IUI8

- CRLF3_HUMAN

UniProt

Q8IUI8 - CRLF3_HUMAN

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Protein

Cytokine receptor-like factor 3

Gene

CRLF3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in the negative regulation of cell cycle progression.1 Publication

GO - Biological processi

  1. G1/S transition of mitotic cell cycle Source: UniProtKB
  2. negative regulation of cell growth Source: UniProtKB
  3. positive regulation of cell cycle arrest Source: UniProtKB
  4. positive regulation of JAK-STAT cascade Source: UniProtKB
  5. positive regulation of transcription, DNA-templated Source: UniProtKB
  6. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytokine receptor-like factor 3
Alternative name(s):
Cytokine receptor-like molecule 9
Short name:
CREME-9
Cytokine receptor-related protein 4
Type I cytokine receptor-like factor p48
Gene namesi
Name:CRLF3
Synonyms:CREME9, CRLM9, CYTOR4, P48
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:17177. CRLF3.

Subcellular locationi

Cytoplasm 1 Publication
Note: The EGFP- and MYC-tagged protein has been shown to be cytoplasmic.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26884.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442Cytokine receptor-like factor 3PRO_0000288936Add
BLAST

Proteomic databases

MaxQBiQ8IUI8.
PaxDbiQ8IUI8.
PRIDEiQ8IUI8.

2D gel databases

OGPiQ9Y6M8.

PTM databases

PhosphoSiteiQ8IUI8.

Expressioni

Tissue specificityi

Expressed in several embryonic and adult tissues, including adult and fetal brain, liver, spleen and pancreas. Expressed in adult, but not fetal kidney. Expressed in skin and squamous cell carcinoma (SCC) and in several other cancer types. Also detected in lesion actinic keratosis (AK).2 Publications

Gene expression databases

BgeeiQ8IUI8.
CleanExiHS_CRLF3.
ExpressionAtlasiQ8IUI8. baseline and differential.
GenevestigatoriQ8IUI8.

Organism-specific databases

HPAiHPA007596.

Interactioni

Protein-protein interaction databases

BioGridi119511. 12 interactions.
IntActiQ8IUI8. 10 interactions.
STRINGi9606.ENSP00000318804.

Structurei

3D structure databases

ProteinModelPortaliQ8IUI8.
SMRiQ8IUI8. Positions 176-267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini181 – 27494Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili10 – 5748Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG71415.
GeneTreeiENSGT00390000014117.
HOGENOMiHOG000111973.
HOVERGENiHBG054457.
InParanoidiQ8IUI8.
OMAiTNNNEGG.
PhylomeDBiQ8IUI8.
TreeFamiTF328682.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IUI8-1) [UniParc]FASTAAdd to Basket

Also known as: p48.6

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGAMELEPE LLLQEARENV EAAQSYRREL GHRLEGLREA RRQIKESASQ
60 70 80 90 100
TRDVLKQHFN DLKGTLGKLL DERLVTLLQE VDTIEQETIK PLDDCQKLIE
110 120 130 140 150
HGVNTAEDLV REGEIAMLGG VGEENEKLWS FTKKASHIQL DSLPEVPLLV
160 170 180 190 200
DVPCLSAQLD DSILNIVKDH IFKHGTVASR PPVQIEELIE KPGGIIVRWC
210 220 230 240 250
KVDDDFTAQD YRLQFRKCTS NHFEDVYVGS ETEFIVLHID PNVDYQFRVC
260 270 280 290 300
ARGDGRQEWS PWSVPQIGHS TLVPHEWTAG FEGYSLSSRR NIALRNDSES
310 320 330 340 350
SGVLYSRAPT YFCGQTLTFR VETVGQPDRR DSIGVCAEKQ DGYDSLQRDQ
360 370 380 390 400
AVCISTNGAV FVNGKEMTNQ LPAVTSGSTV TFDIEAVTLG TTSNNEGGHF
410 420 430 440
KLRVTISSNN REVVFDWLLD QSCGSLYFGC SFFYPGWKVL VF
Length:442
Mass (Da):49,766
Last modified:March 1, 2004 - v2
Checksum:i89F6CACD76397AF8
GO
Isoform 2 (identifier: Q8IUI8-2) [UniParc]FASTAAdd to Basket

Also known as: p48.2

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: Missing.

Show »
Length:438
Mass (Da):49,350
Checksum:i212FAAC9E3152422
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421R → K in AAD02422. 1 PublicationCurated
Sequence conflicti66 – 661L → V in AAD31758. 1 PublicationCurated
Sequence conflicti189 – 1891I → L in ABC55264. (PubMed:19427400)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti202 – 2021V → M.
Corresponds to variant rs3764418 [ dbSNP | Ensembl ].
VAR_049180
Natural varianti389 – 3891L → P.
Corresponds to variant rs11867457 [ dbSNP | Ensembl ].
VAR_032539

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 44Missing in isoform 2. 2 PublicationsVSP_044648

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ298450 mRNA. Translation: ABC55264.1.
AF046059 mRNA. Translation: AAD02422.1.
AF120151 mRNA. Translation: AAD31758.1.
AK313315 mRNA. Translation: BAG36120.1.
AC127024 Genomic DNA. No translation available.
BC023567 mRNA. Translation: AAH23567.2.
CCDSiCCDS32607.1. [Q8IUI8-1]
RefSeqiNP_057070.3. NM_015986.3. [Q8IUI8-1]
UniGeneiHs.649372.

Genome annotation databases

EnsembliENST00000324238; ENSP00000318804; ENSG00000176390. [Q8IUI8-1]
GeneIDi51379.
KEGGihsa:51379.
UCSCiuc002hfr.4. human. [Q8IUI8-1]

Polymorphism databases

DMDMi74762472.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ298450 mRNA. Translation: ABC55264.1 .
AF046059 mRNA. Translation: AAD02422.1 .
AF120151 mRNA. Translation: AAD31758.1 .
AK313315 mRNA. Translation: BAG36120.1 .
AC127024 Genomic DNA. No translation available.
BC023567 mRNA. Translation: AAH23567.2 .
CCDSi CCDS32607.1. [Q8IUI8-1 ]
RefSeqi NP_057070.3. NM_015986.3. [Q8IUI8-1 ]
UniGenei Hs.649372.

3D structure databases

ProteinModelPortali Q8IUI8.
SMRi Q8IUI8. Positions 176-267.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119511. 12 interactions.
IntActi Q8IUI8. 10 interactions.
STRINGi 9606.ENSP00000318804.

PTM databases

PhosphoSitei Q8IUI8.

Polymorphism databases

DMDMi 74762472.

2D gel databases

OGPi Q9Y6M8.

Proteomic databases

MaxQBi Q8IUI8.
PaxDbi Q8IUI8.
PRIDEi Q8IUI8.

Protocols and materials databases

DNASUi 51379.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000324238 ; ENSP00000318804 ; ENSG00000176390 . [Q8IUI8-1 ]
GeneIDi 51379.
KEGGi hsa:51379.
UCSCi uc002hfr.4. human. [Q8IUI8-1 ]

Organism-specific databases

CTDi 51379.
GeneCardsi GC17M029096.
HGNCi HGNC:17177. CRLF3.
HPAi HPA007596.
MIMi 614853. gene.
neXtProti NX_Q8IUI8.
PharmGKBi PA26884.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG71415.
GeneTreei ENSGT00390000014117.
HOGENOMi HOG000111973.
HOVERGENi HBG054457.
InParanoidi Q8IUI8.
OMAi TNNNEGG.
PhylomeDBi Q8IUI8.
TreeFami TF328682.

Miscellaneous databases

ChiTaRSi CRLF3. human.
GeneWikii CRLF3.
GenomeRNAii 51379.
NextBioi 54883.
PROi Q8IUI8.
SOURCEi Search...

Gene expression databases

Bgeei Q8IUI8.
CleanExi HS_CRLF3.
ExpressionAtlasi Q8IUI8. baseline and differential.
Genevestigatori Q8IUI8.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view ]
SMARTi SM00060. FN3. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
PROSITEi PS50853. FN3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel intracellular protein p48.2 that negatively regulates cell cycle progression."
    Yang F., Xu Y.P., Li J., Duan S.S., Fu Y.J., Zhang Y., Zhao Y., Qiao W.T., Chen Q.M., Geng Y.Q., Che C.Y., Cao Y.L., Wang Y., Zhang L., Long L., He J., Cui Q.C., Chen S.C., Wang S.H., Liu L.
    Int. J. Biochem. Cell Biol. 41:2240-2250(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Erythroleukemia.
  2. "An extended gap penalty scheme for profiles results in the discovery of a novel cytokine receptor related transcript in an EST database."
    Farrah T., Adams R., Kho C.-J., Yamagiwa T.M., Madden K.L., Whitmore T., Jelmberg A., Pownder T., Lofton-Day C.E., Lok S.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Cloning of a novel cytokine receptor-like molecule."
    Maeda M., Nomura H.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Liver.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Synovial cell.
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: B-cell.
  7. "Identification of dysregulated genes in cutaneous squamous cell carcinoma."
    Dang C., Gottschling M., Manning K., O'Currain E., Schneider S., Sterry W., Stockfleth E., Nindl I.
    Oncol. Rep. 16:513-519(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCRLF3_HUMAN
AccessioniPrimary (citable) accession number: Q8IUI8
Secondary accession number(s): A6NJF3
, B2R8C3, Q2MLY7, Q9UNI3, Q9Y6M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 1, 2004
Last modified: October 29, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3