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Protein

Cytokine receptor-like factor 3

Gene

CRLF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the negative regulation of cell cycle progression.1 Publication

GO - Biological processi

  • G1/S transition of mitotic cell cycle Source: UniProtKB
  • negative regulation of cell growth Source: UniProtKB
  • positive regulation of cell cycle arrest Source: UniProtKB
  • positive regulation of JAK-STAT cascade Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytokine receptor-like factor 3
Alternative name(s):
Cytokine receptor-like molecule 9
Short name:
CREME-9
Cytokine receptor-related protein 4
Type I cytokine receptor-like factor p48
Gene namesi
Name:CRLF3
Synonyms:CREME9, CRLM9, CYTOR4, P48
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:17177. CRLF3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi51379.
OpenTargetsiENSG00000176390.
PharmGKBiPA26884.

Polymorphism and mutation databases

BioMutaiCRLF3.
DMDMi74762472.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002889361 – 442Cytokine receptor-like factor 3Add BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q8IUI8-2)
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8IUI8.
MaxQBiQ8IUI8.
PaxDbiQ8IUI8.
PeptideAtlasiQ8IUI8.
PRIDEiQ8IUI8.

2D gel databases

OGPiQ9Y6M8.

PTM databases

iPTMnetiQ8IUI8.
PhosphoSitePlusiQ8IUI8.

Expressioni

Tissue specificityi

Expressed in several embryonic and adult tissues, including adult and fetal brain, liver, spleen and pancreas. Expressed in adult, but not fetal kidney. Expressed in skin and squamous cell carcinoma (SCC) and in several other cancer types. Also detected in lesion actinic keratosis (AK).2 Publications

Gene expression databases

BgeeiENSG00000176390.
CleanExiHS_CRLF3.
ExpressionAtlasiQ8IUI8. baseline and differential.
GenevisibleiQ8IUI8. HS.

Organism-specific databases

HPAiHPA007596.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-2872414,EBI-2872414
LGALS14Q8TCE95EBI-2872414,EBI-10274069
VPS25Q9BRG15EBI-2872414,EBI-741945

Protein-protein interaction databases

BioGridi119511. 16 interactors.
IntActiQ8IUI8. 18 interactors.
STRINGi9606.ENSP00000318804.

Structurei

3D structure databases

ProteinModelPortaliQ8IUI8.
SMRiQ8IUI8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini181 – 274Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST94

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili10 – 57Sequence analysisAdd BLAST48

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410II83. Eukaryota.
ENOG4110NSY. LUCA.
GeneTreeiENSGT00390000014117.
HOGENOMiHOG000111973.
HOVERGENiHBG054457.
InParanoidiQ8IUI8.
OMAiDYRLQYR.
OrthoDBiEOG091G0GM2.
PhylomeDBiQ8IUI8.
TreeFamiTF328682.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IUI8-1) [UniParc]FASTAAdd to basket
Also known as: p48.6

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGAMELEPE LLLQEARENV EAAQSYRREL GHRLEGLREA RRQIKESASQ
60 70 80 90 100
TRDVLKQHFN DLKGTLGKLL DERLVTLLQE VDTIEQETIK PLDDCQKLIE
110 120 130 140 150
HGVNTAEDLV REGEIAMLGG VGEENEKLWS FTKKASHIQL DSLPEVPLLV
160 170 180 190 200
DVPCLSAQLD DSILNIVKDH IFKHGTVASR PPVQIEELIE KPGGIIVRWC
210 220 230 240 250
KVDDDFTAQD YRLQFRKCTS NHFEDVYVGS ETEFIVLHID PNVDYQFRVC
260 270 280 290 300
ARGDGRQEWS PWSVPQIGHS TLVPHEWTAG FEGYSLSSRR NIALRNDSES
310 320 330 340 350
SGVLYSRAPT YFCGQTLTFR VETVGQPDRR DSIGVCAEKQ DGYDSLQRDQ
360 370 380 390 400
AVCISTNGAV FVNGKEMTNQ LPAVTSGSTV TFDIEAVTLG TTSNNEGGHF
410 420 430 440
KLRVTISSNN REVVFDWLLD QSCGSLYFGC SFFYPGWKVL VF
Length:442
Mass (Da):49,766
Last modified:March 1, 2004 - v2
Checksum:i89F6CACD76397AF8
GO
Isoform 2 (identifier: Q8IUI8-2) [UniParc]FASTAAdd to basket
Also known as: p48.2

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: Missing.

Show »
Length:438
Mass (Da):49,350
Checksum:i212FAAC9E3152422
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42R → K in AAD02422 (Ref. 2) Curated1
Sequence conflicti66L → V in AAD31758 (Ref. 3) Curated1
Sequence conflicti189I → L in ABC55264 (PubMed:19427400).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049180202V → M.Corresponds to variant rs3764418dbSNPEnsembl.1
Natural variantiVAR_032539389L → P.Corresponds to variant rs11867457dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0446481 – 4Missing in isoform 2. 2 Publications4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ298450 mRNA. Translation: ABC55264.1.
AF046059 mRNA. Translation: AAD02422.1.
AF120151 mRNA. Translation: AAD31758.1.
AK313315 mRNA. Translation: BAG36120.1.
AC127024 Genomic DNA. No translation available.
BC023567 mRNA. Translation: AAH23567.2.
CCDSiCCDS32607.1. [Q8IUI8-1]
RefSeqiNP_057070.3. NM_015986.3. [Q8IUI8-1]
UniGeneiHs.649372.

Genome annotation databases

EnsembliENST00000324238; ENSP00000318804; ENSG00000176390. [Q8IUI8-1]
GeneIDi51379.
KEGGihsa:51379.
UCSCiuc002hfr.5. human. [Q8IUI8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ298450 mRNA. Translation: ABC55264.1.
AF046059 mRNA. Translation: AAD02422.1.
AF120151 mRNA. Translation: AAD31758.1.
AK313315 mRNA. Translation: BAG36120.1.
AC127024 Genomic DNA. No translation available.
BC023567 mRNA. Translation: AAH23567.2.
CCDSiCCDS32607.1. [Q8IUI8-1]
RefSeqiNP_057070.3. NM_015986.3. [Q8IUI8-1]
UniGeneiHs.649372.

3D structure databases

ProteinModelPortaliQ8IUI8.
SMRiQ8IUI8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119511. 16 interactors.
IntActiQ8IUI8. 18 interactors.
STRINGi9606.ENSP00000318804.

PTM databases

iPTMnetiQ8IUI8.
PhosphoSitePlusiQ8IUI8.

Polymorphism and mutation databases

BioMutaiCRLF3.
DMDMi74762472.

2D gel databases

OGPiQ9Y6M8.

Proteomic databases

EPDiQ8IUI8.
MaxQBiQ8IUI8.
PaxDbiQ8IUI8.
PeptideAtlasiQ8IUI8.
PRIDEiQ8IUI8.

Protocols and materials databases

DNASUi51379.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324238; ENSP00000318804; ENSG00000176390. [Q8IUI8-1]
GeneIDi51379.
KEGGihsa:51379.
UCSCiuc002hfr.5. human. [Q8IUI8-1]

Organism-specific databases

CTDi51379.
DisGeNETi51379.
GeneCardsiCRLF3.
HGNCiHGNC:17177. CRLF3.
HPAiHPA007596.
MIMi614853. gene.
neXtProtiNX_Q8IUI8.
OpenTargetsiENSG00000176390.
PharmGKBiPA26884.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II83. Eukaryota.
ENOG4110NSY. LUCA.
GeneTreeiENSGT00390000014117.
HOGENOMiHOG000111973.
HOVERGENiHBG054457.
InParanoidiQ8IUI8.
OMAiDYRLQYR.
OrthoDBiEOG091G0GM2.
PhylomeDBiQ8IUI8.
TreeFamiTF328682.

Miscellaneous databases

ChiTaRSiCRLF3. human.
GeneWikiiCRLF3.
GenomeRNAii51379.
PROiQ8IUI8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176390.
CleanExiHS_CRLF3.
ExpressionAtlasiQ8IUI8. baseline and differential.
GenevisibleiQ8IUI8. HS.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRLF3_HUMAN
AccessioniPrimary (citable) accession number: Q8IUI8
Secondary accession number(s): A6NJF3
, B2R8C3, Q2MLY7, Q9UNI3, Q9Y6M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 1, 2004
Last modified: November 30, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.