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Q8IUI8

- CRLF3_HUMAN

UniProt

Q8IUI8 - CRLF3_HUMAN

Protein

Cytokine receptor-like factor 3

Gene

CRLF3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (01 Mar 2004)
      Previous versions | rss
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    Functioni

    May play a role in the negative regulation of cell cycle progression.1 Publication

    GO - Biological processi

    1. G1/S transition of mitotic cell cycle Source: UniProtKB
    2. negative regulation of cell growth Source: UniProtKB
    3. positive regulation of cell cycle arrest Source: UniProtKB
    4. positive regulation of JAK-STAT cascade Source: UniProtKB
    5. positive regulation of transcription, DNA-templated Source: UniProtKB
    6. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytokine receptor-like factor 3
    Alternative name(s):
    Cytokine receptor-like molecule 9
    Short name:
    CREME-9
    Cytokine receptor-related protein 4
    Type I cytokine receptor-like factor p48
    Gene namesi
    Name:CRLF3
    Synonyms:CREME9, CRLM9, CYTOR4, P48
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:17177. CRLF3.

    Subcellular locationi

    Cytoplasm 1 Publication
    Note: The EGFP- and MYC-tagged protein has been shown to be cytoplasmic.1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26884.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 442442Cytokine receptor-like factor 3PRO_0000288936Add
    BLAST

    Proteomic databases

    MaxQBiQ8IUI8.
    PaxDbiQ8IUI8.
    PRIDEiQ8IUI8.

    2D gel databases

    OGPiQ9Y6M8.

    PTM databases

    PhosphoSiteiQ8IUI8.

    Expressioni

    Tissue specificityi

    Expressed in several embryonic and adult tissues, including adult and fetal brain, liver, spleen and pancreas. Expressed in adult, but not fetal kidney. Expressed in skin and squamous cell carcinoma (SCC) and in several other cancer types. Also detected in lesion actinic keratosis (AK).2 Publications

    Gene expression databases

    ArrayExpressiQ8IUI8.
    BgeeiQ8IUI8.
    CleanExiHS_CRLF3.
    GenevestigatoriQ8IUI8.

    Organism-specific databases

    HPAiHPA007596.

    Interactioni

    Protein-protein interaction databases

    BioGridi119511. 11 interactions.
    IntActiQ8IUI8. 10 interactions.
    STRINGi9606.ENSP00000318804.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IUI8.
    SMRiQ8IUI8. Positions 177-265.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini181 – 27494Fibronectin type-IIIPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili10 – 5748Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG71415.
    HOGENOMiHOG000111973.
    HOVERGENiHBG054457.
    InParanoidiQ8IUI8.
    OMAiTNNNEGG.
    PhylomeDBiQ8IUI8.
    TreeFamiTF328682.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    [Graphical view]
    SMARTiSM00060. FN3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    PROSITEiPS50853. FN3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IUI8-1) [UniParc]FASTAAdd to Basket

    Also known as: p48.6

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRGAMELEPE LLLQEARENV EAAQSYRREL GHRLEGLREA RRQIKESASQ    50
    TRDVLKQHFN DLKGTLGKLL DERLVTLLQE VDTIEQETIK PLDDCQKLIE 100
    HGVNTAEDLV REGEIAMLGG VGEENEKLWS FTKKASHIQL DSLPEVPLLV 150
    DVPCLSAQLD DSILNIVKDH IFKHGTVASR PPVQIEELIE KPGGIIVRWC 200
    KVDDDFTAQD YRLQFRKCTS NHFEDVYVGS ETEFIVLHID PNVDYQFRVC 250
    ARGDGRQEWS PWSVPQIGHS TLVPHEWTAG FEGYSLSSRR NIALRNDSES 300
    SGVLYSRAPT YFCGQTLTFR VETVGQPDRR DSIGVCAEKQ DGYDSLQRDQ 350
    AVCISTNGAV FVNGKEMTNQ LPAVTSGSTV TFDIEAVTLG TTSNNEGGHF 400
    KLRVTISSNN REVVFDWLLD QSCGSLYFGC SFFYPGWKVL VF 442
    Length:442
    Mass (Da):49,766
    Last modified:March 1, 2004 - v2
    Checksum:i89F6CACD76397AF8
    GO
    Isoform 2 (identifier: Q8IUI8-2) [UniParc]FASTAAdd to Basket

    Also known as: p48.2

    The sequence of this isoform differs from the canonical sequence as follows:
         1-4: Missing.

    Show »
    Length:438
    Mass (Da):49,350
    Checksum:i212FAAC9E3152422
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 421R → K in AAD02422. 1 PublicationCurated
    Sequence conflicti66 – 661L → V in AAD31758. 1 PublicationCurated
    Sequence conflicti189 – 1891I → L in ABC55264. (PubMed:19427400)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti202 – 2021V → M.
    Corresponds to variant rs3764418 [ dbSNP | Ensembl ].
    VAR_049180
    Natural varianti389 – 3891L → P.
    Corresponds to variant rs11867457 [ dbSNP | Ensembl ].
    VAR_032539

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 44Missing in isoform 2. 2 PublicationsVSP_044648

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ298450 mRNA. Translation: ABC55264.1.
    AF046059 mRNA. Translation: AAD02422.1.
    AF120151 mRNA. Translation: AAD31758.1.
    AK313315 mRNA. Translation: BAG36120.1.
    AC127024 Genomic DNA. No translation available.
    BC023567 mRNA. Translation: AAH23567.2.
    CCDSiCCDS32607.1. [Q8IUI8-1]
    RefSeqiNP_057070.3. NM_015986.3. [Q8IUI8-1]
    UniGeneiHs.649372.

    Genome annotation databases

    EnsembliENST00000324238; ENSP00000318804; ENSG00000176390. [Q8IUI8-1]
    GeneIDi51379.
    KEGGihsa:51379.
    UCSCiuc002hfr.4. human. [Q8IUI8-1]

    Polymorphism databases

    DMDMi74762472.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ298450 mRNA. Translation: ABC55264.1 .
    AF046059 mRNA. Translation: AAD02422.1 .
    AF120151 mRNA. Translation: AAD31758.1 .
    AK313315 mRNA. Translation: BAG36120.1 .
    AC127024 Genomic DNA. No translation available.
    BC023567 mRNA. Translation: AAH23567.2 .
    CCDSi CCDS32607.1. [Q8IUI8-1 ]
    RefSeqi NP_057070.3. NM_015986.3. [Q8IUI8-1 ]
    UniGenei Hs.649372.

    3D structure databases

    ProteinModelPortali Q8IUI8.
    SMRi Q8IUI8. Positions 177-265.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119511. 11 interactions.
    IntActi Q8IUI8. 10 interactions.
    STRINGi 9606.ENSP00000318804.

    PTM databases

    PhosphoSitei Q8IUI8.

    Polymorphism databases

    DMDMi 74762472.

    2D gel databases

    OGPi Q9Y6M8.

    Proteomic databases

    MaxQBi Q8IUI8.
    PaxDbi Q8IUI8.
    PRIDEi Q8IUI8.

    Protocols and materials databases

    DNASUi 51379.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000324238 ; ENSP00000318804 ; ENSG00000176390 . [Q8IUI8-1 ]
    GeneIDi 51379.
    KEGGi hsa:51379.
    UCSCi uc002hfr.4. human. [Q8IUI8-1 ]

    Organism-specific databases

    CTDi 51379.
    GeneCardsi GC17M029096.
    HGNCi HGNC:17177. CRLF3.
    HPAi HPA007596.
    MIMi 614853. gene.
    neXtProti NX_Q8IUI8.
    PharmGKBi PA26884.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG71415.
    HOGENOMi HOG000111973.
    HOVERGENi HBG054457.
    InParanoidi Q8IUI8.
    OMAi TNNNEGG.
    PhylomeDBi Q8IUI8.
    TreeFami TF328682.

    Miscellaneous databases

    ChiTaRSi CRLF3. human.
    GeneWikii CRLF3.
    GenomeRNAii 51379.
    NextBioi 54883.
    PROi Q8IUI8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IUI8.
    Bgeei Q8IUI8.
    CleanExi HS_CRLF3.
    Genevestigatori Q8IUI8.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    SMARTi SM00060. FN3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    PROSITEi PS50853. FN3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel intracellular protein p48.2 that negatively regulates cell cycle progression."
      Yang F., Xu Y.P., Li J., Duan S.S., Fu Y.J., Zhang Y., Zhao Y., Qiao W.T., Chen Q.M., Geng Y.Q., Che C.Y., Cao Y.L., Wang Y., Zhang L., Long L., He J., Cui Q.C., Chen S.C., Wang S.H., Liu L.
      Int. J. Biochem. Cell Biol. 41:2240-2250(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Erythroleukemia.
    2. "An extended gap penalty scheme for profiles results in the discovery of a novel cytokine receptor related transcript in an EST database."
      Farrah T., Adams R., Kho C.-J., Yamagiwa T.M., Madden K.L., Whitmore T., Jelmberg A., Pownder T., Lofton-Day C.E., Lok S.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Cloning of a novel cytokine receptor-like molecule."
      Maeda M., Nomura H.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Liver.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Synovial cell.
    5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: B-cell.
    7. "Identification of dysregulated genes in cutaneous squamous cell carcinoma."
      Dang C., Gottschling M., Manning K., O'Currain E., Schneider S., Sterry W., Stockfleth E., Nindl I.
      Oncol. Rep. 16:513-519(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCRLF3_HUMAN
    AccessioniPrimary (citable) accession number: Q8IUI8
    Secondary accession number(s): A6NJF3
    , B2R8C3, Q2MLY7, Q9UNI3, Q9Y6M8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: March 1, 2004
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3