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Q8IUI8 (CRLF3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytokine receptor-like factor 3
Alternative name(s):
Cytokine receptor-like molecule 9
Short name=CREME-9
Cytokine receptor-related protein 4
Type I cytokine receptor-like factor p48
Gene names
Name:CRLF3
Synonyms:CREME9, CRLM9, CYTOR4, P48
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length442 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in the negative regulation of cell cycle progression. Ref.1

Subcellular location

Cytoplasm. Note: The EGFP- and MYC-tagged protein has been shown to be cytoplasmic (Ref.1). Ref.1

Tissue specificity

Expressed in several embryonic and adult tissues, including adult and fetal brain, liver, spleen and pancreas. Expressed in adult, but not fetal kidney. Expressed in skin and squamous cell carcinoma (SCC) and in several other cancer types. Also detected in lesion actinic keratosis (AK). Ref.1 Ref.7

Sequence similarities

Belongs to the cytokine receptor-like factor 3 family.

Contains 1 fibronectin type-III domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IUI8-1)

Also known as: p48.6;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IUI8-2)

Also known as: p48.2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 442442Cytokine receptor-like factor 3
PRO_0000288936

Regions

Domain181 – 27494Fibronectin type-III
Coiled coil10 – 5748 Potential

Natural variations

Alternative sequence1 – 44Missing in isoform 2.
VSP_044648
Natural variant2021V → M.
Corresponds to variant rs3764418 [ dbSNP | Ensembl ].
VAR_049180
Natural variant3891L → P.
Corresponds to variant rs11867457 [ dbSNP | Ensembl ].
VAR_032539

Experimental info

Sequence conflict421R → K in AAD02422. Ref.2
Sequence conflict661L → V in AAD31758. Ref.3
Sequence conflict1891I → L in ABC55264. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (p48.6) [UniParc].

Last modified March 1, 2004. Version 2.
Checksum: 89F6CACD76397AF8

FASTA44249,766
        10         20         30         40         50         60 
MRGAMELEPE LLLQEARENV EAAQSYRREL GHRLEGLREA RRQIKESASQ TRDVLKQHFN 

        70         80         90        100        110        120 
DLKGTLGKLL DERLVTLLQE VDTIEQETIK PLDDCQKLIE HGVNTAEDLV REGEIAMLGG 

       130        140        150        160        170        180 
VGEENEKLWS FTKKASHIQL DSLPEVPLLV DVPCLSAQLD DSILNIVKDH IFKHGTVASR 

       190        200        210        220        230        240 
PPVQIEELIE KPGGIIVRWC KVDDDFTAQD YRLQFRKCTS NHFEDVYVGS ETEFIVLHID 

       250        260        270        280        290        300 
PNVDYQFRVC ARGDGRQEWS PWSVPQIGHS TLVPHEWTAG FEGYSLSSRR NIALRNDSES 

       310        320        330        340        350        360 
SGVLYSRAPT YFCGQTLTFR VETVGQPDRR DSIGVCAEKQ DGYDSLQRDQ AVCISTNGAV 

       370        380        390        400        410        420 
FVNGKEMTNQ LPAVTSGSTV TFDIEAVTLG TTSNNEGGHF KLRVTISSNN REVVFDWLLD 

       430        440 
QSCGSLYFGC SFFYPGWKVL VF 

« Hide

Isoform 2 (p48.2) [UniParc].

Checksum: 212FAAC9E3152422
Show »

FASTA43849,350

References

« Hide 'large scale' references
[1]"Cloning and characterization of a novel intracellular protein p48.2 that negatively regulates cell cycle progression."
Yang F., Xu Y.P., Li J., Duan S.S., Fu Y.J., Zhang Y., Zhao Y., Qiao W.T., Chen Q.M., Geng Y.Q., Che C.Y., Cao Y.L., Wang Y., Zhang L., Long L., He J., Cui Q.C., Chen S.C., Wang S.H., Liu L.
Int. J. Biochem. Cell Biol. 41:2240-2250(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Erythroleukemia.
[2]"An extended gap penalty scheme for profiles results in the discovery of a novel cytokine receptor related transcript in an EST database."
Farrah T., Adams R., Kho C.-J., Yamagiwa T.M., Madden K.L., Whitmore T., Jelmberg A., Pownder T., Lofton-Day C.E., Lok S.
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Cloning of a novel cytokine receptor-like molecule."
Maeda M., Nomura H.
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Liver.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Synovial cell.
[5]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: B-cell.
[7]"Identification of dysregulated genes in cutaneous squamous cell carcinoma."
Dang C., Gottschling M., Manning K., O'Currain E., Schneider S., Sterry W., Stockfleth E., Nindl I.
Oncol. Rep. 16:513-519(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ298450 mRNA. Translation: ABC55264.1.
AF046059 mRNA. Translation: AAD02422.1.
AF120151 mRNA. Translation: AAD31758.1.
AK313315 mRNA. Translation: BAG36120.1.
AC127024 Genomic DNA. No translation available.
BC023567 mRNA. Translation: AAH23567.2.
RefSeqNP_057070.3. NM_015986.3.
UniGeneHs.649372.

3D structure databases

ProteinModelPortalQ8IUI8.
SMRQ8IUI8. Positions 175-268.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119511. 10 interactions.
IntActQ8IUI8. 10 interactions.
STRING9606.ENSP00000318804.

PTM databases

PhosphoSiteQ8IUI8.

Polymorphism databases

DMDM74762472.

2D gel databases

OGPQ9Y6M8.

Proteomic databases

PaxDbQ8IUI8.
PRIDEQ8IUI8.

Protocols and materials databases

DNASU51379.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000324238; ENSP00000318804; ENSG00000176390. [Q8IUI8-1]
GeneID51379.
KEGGhsa:51379.
UCSCuc002hfr.4. human. [Q8IUI8-1]

Organism-specific databases

CTD51379.
GeneCardsGC17M029096.
HGNCHGNC:17177. CRLF3.
HPAHPA007596.
MIM614853. gene.
neXtProtNX_Q8IUI8.
PharmGKBPA26884.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG71415.
HOGENOMHOG000111973.
HOVERGENHBG054457.
InParanoidQ8IUI8.
OMATNNNEGG.
PhylomeDBQ8IUI8.
TreeFamTF328682.

Gene expression databases

ArrayExpressQ8IUI8.
BgeeQ8IUI8.
CleanExHS_CRLF3.
GenevestigatorQ8IUI8.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]
SMARTSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 1 hit.
PROSITEPS50853. FN3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCRLF3. human.
GeneWikiCRLF3.
GenomeRNAi51379.
NextBio54883.
PROQ8IUI8.
SOURCESearch...

Entry information

Entry nameCRLF3_HUMAN
AccessionPrimary (citable) accession number: Q8IUI8
Secondary accession number(s): A6NJF3 expand/collapse secondary AC list , B2R8C3, Q2MLY7, Q9UNI3, Q9Y6M8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 1, 2004
Last modified: April 16, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM