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Protein

Signal peptide peptidase-like 2C

Gene

SPPL2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Intramembrane-cleaving aspartic protease (I-CLiP) that may be able to cleave type II membrane signal peptides in the hydrophobic plane of the membrane.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei386By similarity1
Active sitei448By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Protein family/group databases

MEROPSiA22.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptide peptidase-like 2C1 Publication (EC:3.4.23.-)
Short name:
SPP-like 2C1 Publication
Short name:
SPPL2c1 Publication
Alternative name(s):
Intramembrane protease 51 Publication
Short name:
IMP-51 Publication
Gene namesi
Name:SPPL2C1 Publication
Synonyms:IMP51 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28902. SPPL2C.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 186Lumenal1 PublicationAdd BLAST165
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Topological domaini208 – 253CytoplasmicSequence analysisAdd BLAST46
Transmembranei254 – 274HelicalSequence analysisAdd BLAST21
Topological domaini275 – 276LumenalSequence analysis2
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Topological domaini298 – 319CytoplasmicSequence analysisAdd BLAST22
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Topological domaini341 – 346LumenalSequence analysis6
Transmembranei347 – 365HelicalSequence analysisAdd BLAST19
Topological domaini366 – 376CytoplasmicSequence analysisAdd BLAST11
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Topological domaini398 – 439Lumenal1 PublicationAdd BLAST42
Transmembranei440 – 460HelicalSequence analysisAdd BLAST21
Topological domaini461 – 472CytoplasmicSequence analysisAdd BLAST12
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21
Topological domaini494 – 495LumenalSequence analysis2
Transmembranei496 – 516HelicalSequence analysisAdd BLAST21
Topological domaini517 – 684Cytoplasmic1 PublicationAdd BLAST168

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi162540.
OpenTargetsiENSG00000185294.

Polymorphism and mutation databases

BioMutaiSPPL2C.
DMDMi269849676.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000031479722 – 684Signal peptide peptidase-like 2CAdd BLAST663

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...)1 Publication1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8IUH8.
PeptideAtlasiQ8IUH8.
PRIDEiQ8IUH8.

PTM databases

iPTMnetiQ8IUH8.
PhosphoSitePlusiQ8IUH8.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000185294.
GenevisibleiQ8IUH8. HS.

Interactioni

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

STRINGi9606.ENSP00000332488.

Structurei

3D structure databases

ProteinModelPortaliQ8IUH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 163PAAdd BLAST81

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi499 – 501PAL3

Domaini

The PAL motif is required for normal active site conformation. The catalytic domains embedded in the membrane are in the opposite orientation to that of the presenilin protein family; therefore, it is predicted to cleave type II-oriented substrate peptides like the prototypic protease SPP.By similarity

Sequence similaritiesi

Belongs to the peptidase A22B family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2442. Eukaryota.
ENOG410ZP52. LUCA.
GeneTreeiENSGT00530000062920.
HOGENOMiHOG000231496.
HOVERGENiHBG024193.
InParanoidiQ8IUH8.
KOiK14212.
OMAiILWVAYR.
OrthoDBiEOG091G05NG.
PhylomeDBiQ8IUH8.
TreeFamiTF319186.

Family and domain databases

InterProiIPR007369. Peptidase_A22B_SPP.
IPR006639. Preselin/SPP.
IPR033150. SPPL2C.
[Graphical view]
PANTHERiPTHR12174. PTHR12174. 1 hit.
PTHR12174:SF38. PTHR12174:SF38. 1 hit.
PfamiPF04258. Peptidase_A22B. 1 hit.
[Graphical view]
SMARTiSM00730. PSN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IUH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACLGFLLPV GFLLLISTVA GGKYGVAHVV SENWSKDYCI LFSSDYITLP
60 70 80 90 100
RDLHHAPLLP LYDGTKAPWC PGEDSPHQAQ LRSPSQRPLR QTTAMVMRGN
110 120 130 140 150
CSFHTKGWLA QGQGAHGLLI VSRVSDQQCS DTTLAPQDPR QPLADLTIPV
160 170 180 190 200
AMLHYADMLD ILSHTRGEAV VRVAMYAPPE PIIDYNMLVI FILAVGTVAA
210 220 230 240 250
GGYWAGLTEA NRLQRRRARR GGGSGGHHQL QEAAAAEGAQ KEDNEDIPVD
260 270 280 290 300
FTPAMTGVVV TLSCSLMLLL YFFYDHFVYV TIGIFGLGAG IGLYSCLSPL
310 320 330 340 350
VCRLSLRQYQ RPPHSLWASL PLPLLLLASL CATVIIFWVA YRNEDRWAWL
360 370 380 390 400
LQDTLGISYC LFVLHRVRLP TLKNCSSFLL ALLAFDVFFV FVTPFFTKTG
410 420 430 440 450
ESIMAQVALG PAESSSHERL PMVLKVPRLR VSALTLCSQP FSILGFGDIV
460 470 480 490 500
VPGFLVAYCC RFDVQVCSRQ IYFVACTVAY AVGLLVTFMA MVLMQMGQPA
510 520 530 540 550
LLYLVSSTLL TSLAVAACRQ ELSLFWTGQG RAKMCGLGCA PSAGSRQKQE
560 570 580 590 600
GAADAHTAST LERGTSRGAG DLDSNPGEDT TEIVTISENE ATNPEDRSDS
610 620 630 640 650
SEGWSDAHLD PNELPFIPPG ASEELMPLMP MAMLIPLMPL MPPPSELGHV
660 670 680
HAQAQAHETG LPWAGLHKRK GLKVRKSMST QAPL
Length:684
Mass (Da):74,503
Last modified:November 24, 2009 - v3
Checksum:i578DA60509765667
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038048123R → Q.Corresponds to variant rs17763658dbSNPEnsembl.1
Natural variantiVAR_038049303R → H.2 PublicationsCorresponds to variant rs242944dbSNPEnsembl.1
Natural variantiVAR_038050461R → P.Corresponds to variant rs12185233dbSNPEnsembl.1
Natural variantiVAR_038051471I → V.Corresponds to variant rs12185268dbSNPEnsembl.1
Natural variantiVAR_038052601S → P.Corresponds to variant rs12373123dbSNPEnsembl.1
Natural variantiVAR_038053620G → R.Corresponds to variant rs12373139dbSNPEnsembl.1
Natural variantiVAR_060590626M → V.1 PublicationCorresponds to variant rs17852270dbSNPEnsembl.1
Natural variantiVAR_038054643P → R.Corresponds to variant rs12373142dbSNPEnsembl.1
Natural variantiVAR_057147659T → I.Corresponds to variant rs16940694dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY169316 Genomic DNA. Translation: AAO12541.1.
AC003662 Genomic DNA. No translation available.
AC217770 Genomic DNA. No translation available.
AC217771 Genomic DNA. No translation available.
BC022041 mRNA. Translation: AAH22041.2.
BC025401 mRNA. Translation: AAH25401.1.
CCDSiCCDS32673.1.
RefSeqiNP_787078.2. NM_175882.2.
UniGeneiHs.144491.

Genome annotation databases

EnsembliENST00000329196; ENSP00000332488; ENSG00000185294.
GeneIDi162540.
KEGGihsa:162540.
UCSCiuc010wka.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY169316 Genomic DNA. Translation: AAO12541.1.
AC003662 Genomic DNA. No translation available.
AC217770 Genomic DNA. No translation available.
AC217771 Genomic DNA. No translation available.
BC022041 mRNA. Translation: AAH22041.2.
BC025401 mRNA. Translation: AAH25401.1.
CCDSiCCDS32673.1.
RefSeqiNP_787078.2. NM_175882.2.
UniGeneiHs.144491.

3D structure databases

ProteinModelPortaliQ8IUH8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000332488.

Protein family/group databases

MEROPSiA22.006.

PTM databases

iPTMnetiQ8IUH8.
PhosphoSitePlusiQ8IUH8.

Polymorphism and mutation databases

BioMutaiSPPL2C.
DMDMi269849676.

Proteomic databases

PaxDbiQ8IUH8.
PeptideAtlasiQ8IUH8.
PRIDEiQ8IUH8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329196; ENSP00000332488; ENSG00000185294.
GeneIDi162540.
KEGGihsa:162540.
UCSCiuc010wka.3. human.

Organism-specific databases

CTDi162540.
DisGeNETi162540.
GeneCardsiSPPL2C.
H-InvDBHIX0013905.
HGNCiHGNC:28902. SPPL2C.
MIMi608284. gene.
neXtProtiNX_Q8IUH8.
OpenTargetsiENSG00000185294.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2442. Eukaryota.
ENOG410ZP52. LUCA.
GeneTreeiENSGT00530000062920.
HOGENOMiHOG000231496.
HOVERGENiHBG024193.
InParanoidiQ8IUH8.
KOiK14212.
OMAiILWVAYR.
OrthoDBiEOG091G05NG.
PhylomeDBiQ8IUH8.
TreeFamiTF319186.

Miscellaneous databases

GenomeRNAii162540.
PROiQ8IUH8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185294.
GenevisibleiQ8IUH8. HS.

Family and domain databases

InterProiIPR007369. Peptidase_A22B_SPP.
IPR006639. Preselin/SPP.
IPR033150. SPPL2C.
[Graphical view]
PANTHERiPTHR12174. PTHR12174. 1 hit.
PTHR12174:SF38. PTHR12174:SF38. 1 hit.
PfamiPF04258. Peptidase_A22B. 1 hit.
[Graphical view]
SMARTiSM00730. PSN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPP2C_HUMAN
AccessioniPrimary (citable) accession number: Q8IUH8
Secondary accession number(s): Q8TC67, Q8WVZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 24, 2009
Last modified: November 2, 2016
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.