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Protein

Palmitoyltransferase ZDHHC17

Gene

ZDHHC17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD (PubMed:15603740, PubMed:15489887, PubMed:19139280). Palmitoylates MPP1 in erythrocytes (PubMed:22496366). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (PubMed:12393793). May play a role in Mg2+ transport (PubMed:18794299).6 Publications

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei467S-palmitoyl cysteine intermediate1 Publication1

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • magnesium ion transmembrane transporter activity Source: UniProtKB
  • palmitoyltransferase activity Source: UniProtKB
  • protein-cysteine S-palmitoyltransferase activity Source: UniProtKB
  • signal transducer activity Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • lipoprotein transport Source: UniProtKB
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  • protein palmitoylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.3.1.225. 2681.

Protein family/group databases

TCDBi9.B.37.1.1. the huntington-interacting protein 14 (hip14) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC17Curated (EC:2.3.1.2252 Publications)
Alternative name(s):
Huntingtin yeast partner H1 Publication
Huntingtin-interacting protein 141 Publication
Short name:
HIP-141 Publication
Huntingtin-interacting protein 3Imported
Short name:
HIP-3Imported
Huntingtin-interacting protein H1 Publication
Putative MAPK-activating protein PM111 Publication
Putative NF-kappa-B-activating protein 2051 Publication
Zinc finger DHHC domain-containing protein 17Imported
Short name:
DHHC-171 Publication
Gene namesi
Name:ZDHHC17Imported
Synonyms:HIP141 Publication, HIP3Imported, HYPH1 Publication, KIAA0946Imported
ORF Names:HSPC294Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:18412. ZDHHC17.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 304CytoplasmicSequence analysisAdd BLAST304
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21
Topological domaini347 – 357CytoplasmicSequence analysisAdd BLAST11
Transmembranei358 – 378HelicalSequence analysisAdd BLAST21
Topological domaini379 – 381LumenalSequence analysis3
Transmembranei382 – 402HelicalSequence analysisAdd BLAST21
Topological domaini403 – 480CytoplasmicSequence analysisAdd BLAST78
Transmembranei481 – 501HelicalSequence analysisAdd BLAST21
Topological domaini502 – 529LumenalSequence analysisAdd BLAST28
Transmembranei530 – 550HelicalSequence analysisAdd BLAST21
Topological domaini551 – 632CytoplasmicSequence analysisAdd BLAST82

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: HPA
  • cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  • Golgi apparatus Source: UniProtKB
  • Golgi-associated vesicle membrane Source: UniProtKB
  • Golgi membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • intracellular membrane-bounded organelle Source: HPA
  • presynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Golgi apparatus, Membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi467C → S: Abolishes palmitoyltransferase activity. 1 Publication1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi23390.
OpenTargetsiENSG00000186908.
PharmGKBiPA134991292.

Polymorphism and mutation databases

BioMutaiZDHHC17.
DMDMi46395885.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002129001 – 632Palmitoyltransferase ZDHHC17Add BLAST632

Post-translational modificationi

Autopalmitoylated (PubMed:15603740, PubMed:18794299). Autopalmitoylation has a regulatory role in ZDHHC17-mediated Mg2+ transport (PubMed:18794299).2 Publications

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiQ8IUH5.
MaxQBiQ8IUH5.
PaxDbiQ8IUH5.
PeptideAtlasiQ8IUH5.
PRIDEiQ8IUH5.

PTM databases

iPTMnetiQ8IUH5.
PhosphoSitePlusiQ8IUH5.
SwissPalmiQ8IUH5.

Expressioni

Tissue specificityi

Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney. ZDHHC17 is the only palmitoyltransferase in erythrocytes.2 Publications

Gene expression databases

BgeeiENSG00000186908.
CleanExiHS_ZDHHC17.
ExpressionAtlasiQ8IUH5. baseline and differential.
GenevisibleiQ8IUH5. HS.

Organism-specific databases

HPAiHPA016807.

Interactioni

Subunit structurei

Interacts (via ANK repeats) with CLIP3 (PubMed:26198635). Interacts (via ANK repeats) with HTT; this interaction is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease (PubMed:12393793, PubMed:9700202, PubMed:26198635). Interacts (via ANK repeats) with DNAJC5 (via C-terminus) (By similarity). Interacts (via ANK repeats) with MAP6 (PubMed:26198635). Interacts (via ANK repeats) with SNAP23 (By similarity). Interacts (via ANK repeats) with SNAP25 (By similarity).By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself6EBI-524753,EBI-524753
Q7Z7833EBI-524753,EBI-9088990
APBB1IPQ7Z5R62EBI-524753,EBI-2818084
ARFGAP3Q9NP612EBI-524753,EBI-2875816
ATF2P153363EBI-524753,EBI-1170906
BAIAP2Q9UQB8-33EBI-524753,EBI-9091996
BAIAP2Q9UQB8-62EBI-524753,EBI-9092016
CAPN2P176552EBI-524753,EBI-1028956
CDCA7LQ96GN5-22EBI-524753,EBI-9091443
CSNK1DP48730-23EBI-524753,EBI-9087876
EEF1A1P681042EBI-524753,EBI-352162
EIF3EP602282EBI-524753,EBI-347740
EVLQ9UI08-22EBI-524753,EBI-6448852
FEZ2Q9UHY84EBI-524753,EBI-396453
GOLGA2Q083793EBI-524753,EBI-618309
GOLPH3LQ9H4A52EBI-524753,EBI-4403434
GPM6AP516745EBI-524753,EBI-7187133
GSK3AP498403EBI-524753,EBI-1044067
HTTP4285812EBI-524753,EBI-466029
IFT20Q8IY31-33EBI-524753,EBI-9091197
IFT57Q9NWB72EBI-524753,EBI-725672
KLK8O602593EBI-524753,EBI-3915857
LASP1Q14847-23EBI-524753,EBI-9088686
OPTNQ96CV9-22EBI-524753,EBI-9091423
PDE4DQ08499-82EBI-524753,EBI-9090666
PDPK1O15530-43EBI-524753,EBI-9087775
PIK3R1P27986-22EBI-524753,EBI-9090282
PLEKHB1Q9UF11-44EBI-524753,EBI-9089825
PPP2R5EQ165372EBI-524753,EBI-968374
RAB39BQ96DA23EBI-524753,EBI-9089467
SETDB1Q15047-23EBI-524753,EBI-9090795
SLC9A9Q8IVB42EBI-524753,EBI-9092184
SNAP23O001614EBI-524753,EBI-745000
SNAP25P608803EBI-524753,EBI-524785
SPRED1Q7Z6993EBI-524753,EBI-5235340
SPRED2Q7Z6983EBI-524753,EBI-7082156
SPRY2O435973EBI-524753,EBI-742487
SPRY4Q9C0042EBI-524753,EBI-354861
USP32Q8NFA02EBI-524753,EBI-2511075
WASF2Q9Y6W52EBI-524753,EBI-4290615

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi116965. 241 interactors.
IntActiQ8IUH5. 226 interactors.
MINTiMINT-1537511.
STRINGi9606.ENSP00000403397.

Structurei

Secondary structure

1632
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi56 – 58Combined sources3
Helixi61 – 66Combined sources6
Helixi70 – 78Combined sources9
Helixi93 – 99Combined sources7
Helixi103 – 111Combined sources9
Turni121 – 124Combined sources4
Helixi127 – 134Combined sources8
Helixi137 – 145Combined sources9
Helixi160 – 166Combined sources7
Helixi170 – 178Combined sources9
Helixi193 – 200Combined sources8
Helixi207 – 212Combined sources6
Turni222 – 224Combined sources3
Helixi228 – 235Combined sources8
Helixi238 – 247Combined sources10
Helixi261 – 267Combined sources7
Helixi271 – 280Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EU9X-ray1.99A/B/C51-288[»]
ProteinModelPortaliQ8IUH5.
SMRiQ8IUH5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IUH5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati51 – 86ANK 11 PublicationAdd BLAST36
Repeati89 – 118ANK 2Sequence analysisAdd BLAST30
Repeati123 – 152ANK 3Sequence analysisAdd BLAST30
Repeati156 – 185ANK 4Sequence analysisAdd BLAST30
Repeati189 – 219ANK 5Sequence analysisAdd BLAST31
Repeati224 – 253ANK 6Sequence analysisAdd BLAST30
Repeati257 – 286ANK 7Sequence analysisAdd BLAST30
Domaini437 – 487DHHCPROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni11 – 305Necessary and sufficient for interaction with DNAJC5 and SNAP25By similarityAdd BLAST295

Domaini

The DHHC domain is required for palmitoyltransferase activity.1 Publication

Sequence similaritiesi

Contains 7 ANK repeats.PROSITE-ProRule annotation1 Publication
Contains 1 DHHC domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0509. Eukaryota.
COG0666. LUCA.
COG5273. LUCA.
GeneTreeiENSGT00530000063074.
HOVERGENiHBG051907.
InParanoidiQ8IUH5.
KOiK20032.
OMAiIMQLARI.
OrthoDBiEOG091G056H.
PhylomeDBiQ8IUH5.
TreeFamiTF317342.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR030289. ZDHHC17.
IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PANTHERiPTHR24161:SF18. PTHR24161:SF18. 1 hit.
PfamiPF12796. Ank_2. 2 hits.
PF01529. zf-DHHC. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50216. DHHC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IUH5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQREEGFNTK MADGPDEYDT EAGCVPLLHP EEIKPQSHYN HGYGEPLGRK
60 70 80 90 100
THIDDYSTWD IVKATQYGIY ERCRELVEAG YDVRQPDKEN VTLLHWAAIN
110 120 130 140 150
NRIDLVKYYI SKGAIVDQLG GDLNSTPLHW ATRQGHLSMV VQLMKYGADP
160 170 180 190 200
SLIDGEGCSC IHLAAQFGHT SIVAYLIAKG QDVDMMDQNG MTPLMWAAYR
210 220 230 240 250
THSVDPTRLL LTFNVSVNLG DKYHKNTALH WAVLAGNTTV ISLLLEAGAN
260 270 280 290 300
VDAQNIKGES ALDLAKQRKN VWMINHLQEA RQAKGYDNPS FLRKLKADKE
310 320 330 340 350
FRQKVMLGTP FLVIWLVGFI ADLNIDSWLI KGLMYGGVWA TVQFLSKSFF
360 370 380 390 400
DHSMHSALPL GIYLATKFWM YVTWFFWFWN DLNFLFIHLP FLANSVALFY
410 420 430 440 450
NFGKSWKSDP GIIKATEEQK KKTIVELAET GSLDLSIFCS TCLIRKPVRS
460 470 480 490 500
KHCGVCNRCI AKFDHHCPWV GNCVGAGNHR YFMGYLFFLL FMICWMIYGC
510 520 530 540 550
ISYWGLHCET TYTKDGFWTY ITQIATCSPW MFWMFLNSVF HFMWVAVLLM
560 570 580 590 600
CQMYQISCLG ITTNERMNAR RYKHFKVTTT SIESPFNHGC VRNIIDFFEF
610 620 630
RCCGLFRPVI VDWTRQYTIE YDQISGSGYQ LV
Length:632
Mass (Da):72,640
Last modified:April 13, 2004 - v2
Checksum:i3FD5FD592F2C617F
GO
Isoform 2 (identifier: Q8IUH5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.
     51-66: THIDDYSTWDIVKATQ → MSTIPKRAVCPFSTQR
     258-266: GESALDLAK → AILRCHMAL
     267-632: Missing.

Show »
Length:216
Mass (Da):23,941
Checksum:iA07B4620B70A6593
GO
Isoform 3 (identifier: Q8IUH5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     204-632: Missing.

Note: No experimental confirmation available.
Show »
Length:203
Mass (Da):22,845
Checksum:iF37602D7183923C5
GO

Sequence cautioni

The sequence AAF28972 differs from that shown. Reason: Frameshift at positions 183 and 191.Curated
The sequence AAH30990 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA76790 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC77366 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC77388 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3R → G in AAF28972 (Ref. 7) Curated1
Sequence conflicti39Y → F in BAC22089 (PubMed:12393793).Curated1
Sequence conflicti173V → VV in BAC22089 (PubMed:12393793).Curated1
Sequence conflicti182D → E in AAF28972 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052978383N → S.Corresponds to variant rs33996476dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0100211 – 50Missing in isoform 2. 2 PublicationsAdd BLAST50
Alternative sequenceiVSP_01002251 – 66THIDD…VKATQ → MSTIPKRAVCPFSTQR in isoform 2. 2 PublicationsAdd BLAST16
Alternative sequenceiVSP_010023204 – 632Missing in isoform 3. 1 PublicationAdd BLAST429
Alternative sequenceiVSP_010024258 – 266GESALDLAK → AILRCHMAL in isoform 2. 2 Publications9
Alternative sequenceiVSP_010025267 – 632Missing in isoform 2. 2 PublicationsAdd BLAST366

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024494 mRNA. Translation: BAC22089.1.
AB023163 mRNA. Translation: BAA76790.1. Different initiation.
AB097013 mRNA. Translation: BAC77366.1. Different initiation.
AB097035 mRNA. Translation: BAC77388.1. Different initiation.
AK299089 mRNA. Translation: BAG61151.1.
BC030990 mRNA. Translation: AAH30990.1. Different initiation.
BC050324 mRNA. Translation: AAH50324.1.
AF049612 mRNA. Translation: AAC26848.1.
AF161412 mRNA. Translation: AAF28972.1. Frameshift.
CCDSiCCDS44946.1. [Q8IUH5-1]
RefSeqiNP_056151.2. NM_015336.2. [Q8IUH5-1]
UniGeneiHs.4014.

Genome annotation databases

EnsembliENST00000426126; ENSP00000403397; ENSG00000186908. [Q8IUH5-1]
GeneIDi23390.
KEGGihsa:23390.
UCSCiuc001syk.2. human. [Q8IUH5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024494 mRNA. Translation: BAC22089.1.
AB023163 mRNA. Translation: BAA76790.1. Different initiation.
AB097013 mRNA. Translation: BAC77366.1. Different initiation.
AB097035 mRNA. Translation: BAC77388.1. Different initiation.
AK299089 mRNA. Translation: BAG61151.1.
BC030990 mRNA. Translation: AAH30990.1. Different initiation.
BC050324 mRNA. Translation: AAH50324.1.
AF049612 mRNA. Translation: AAC26848.1.
AF161412 mRNA. Translation: AAF28972.1. Frameshift.
CCDSiCCDS44946.1. [Q8IUH5-1]
RefSeqiNP_056151.2. NM_015336.2. [Q8IUH5-1]
UniGeneiHs.4014.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EU9X-ray1.99A/B/C51-288[»]
ProteinModelPortaliQ8IUH5.
SMRiQ8IUH5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116965. 241 interactors.
IntActiQ8IUH5. 226 interactors.
MINTiMINT-1537511.
STRINGi9606.ENSP00000403397.

Protein family/group databases

TCDBi9.B.37.1.1. the huntington-interacting protein 14 (hip14) family.

PTM databases

iPTMnetiQ8IUH5.
PhosphoSitePlusiQ8IUH5.
SwissPalmiQ8IUH5.

Polymorphism and mutation databases

BioMutaiZDHHC17.
DMDMi46395885.

Proteomic databases

EPDiQ8IUH5.
MaxQBiQ8IUH5.
PaxDbiQ8IUH5.
PeptideAtlasiQ8IUH5.
PRIDEiQ8IUH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000426126; ENSP00000403397; ENSG00000186908. [Q8IUH5-1]
GeneIDi23390.
KEGGihsa:23390.
UCSCiuc001syk.2. human. [Q8IUH5-1]

Organism-specific databases

CTDi23390.
DisGeNETi23390.
GeneCardsiZDHHC17.
HGNCiHGNC:18412. ZDHHC17.
HPAiHPA016807.
MIMi607799. gene.
neXtProtiNX_Q8IUH5.
OpenTargetsiENSG00000186908.
PharmGKBiPA134991292.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0509. Eukaryota.
COG0666. LUCA.
COG5273. LUCA.
GeneTreeiENSGT00530000063074.
HOVERGENiHBG051907.
InParanoidiQ8IUH5.
KOiK20032.
OMAiIMQLARI.
OrthoDBiEOG091G056H.
PhylomeDBiQ8IUH5.
TreeFamiTF317342.

Enzyme and pathway databases

BRENDAi2.3.1.225. 2681.

Miscellaneous databases

ChiTaRSiZDHHC17. human.
EvolutionaryTraceiQ8IUH5.
GeneWikiiZDHHC17.
GenomeRNAii23390.
PROiQ8IUH5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186908.
CleanExiHS_ZDHHC17.
ExpressionAtlasiQ8IUH5. baseline and differential.
GenevisibleiQ8IUH5. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR030289. ZDHHC17.
IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PANTHERiPTHR24161:SF18. PTHR24161:SF18. 1 hit.
PfamiPF12796. Ank_2. 2 hits.
PF01529. zf-DHHC. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50216. DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZDH17_HUMAN
AccessioniPrimary (citable) accession number: Q8IUH5
Secondary accession number(s): B4DR39
, O75407, Q7Z2I0, Q86W89, Q86YK0, Q9P088, Q9UPZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: November 2, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.