Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Palmitoyltransferase ZDHHC13

Gene

ZDHHC13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Palmitoyltransferase for HD and GAD2. May play a role in Mg2+ transport.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei456S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Protein family/group databases

TCDBi9.B.37.3.1. the huntington-interacting protein 14 (hip14) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC13Curated (EC:2.3.1.225By similarity)
Alternative name(s):
Huntingtin-interacting protein 14-related protein1 Publication
Short name:
HIP14-related protein1 Publication
Huntingtin-interacting protein HIP3RPImported
Putative MAPK-activating protein PM03Imported
Putative NF-kappa-B-activating protein 209Imported
Zinc finger DHHC domain-containing protein 13Imported
Short name:
DHHC-13By similarity
Gene namesi
Name:ZDHHC13Imported
Synonyms:HIP14L1 Publication, HIP3RPImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:18413. ZDHHC13.

Subcellular locationi

  • Golgi apparatus membrane By similarity; Multi-pass membrane protein Sequence analysis
  • Cytoplasmic vesicle membrane By similarity; Multi-pass membrane protein Sequence analysis

  • Note: Low extracellular Mg2+ induces increase in Golgi and in post-Golgi vesicles.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Transmembranei371 – 391HelicalSequence analysisAdd BLAST21
Transmembranei471 – 491HelicalSequence analysisAdd BLAST21
Transmembranei519 – 539HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54503.
OpenTargetsiENSG00000177054.
PharmGKBiPA134955878.

Polymorphism and mutation databases

BioMutaiZDHHC13.
DMDMi269849714.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128871 – 622Palmitoyltransferase ZDHHC13Add BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate

Proteomic databases

EPDiQ8IUH4.
MaxQBiQ8IUH4.
PaxDbiQ8IUH4.
PeptideAtlasiQ8IUH4.
PRIDEiQ8IUH4.

PTM databases

iPTMnetiQ8IUH4.
PhosphoSitePlusiQ8IUH4.
SwissPalmiQ8IUH4.

Expressioni

Gene expression databases

BgeeiENSG00000177054.
CleanExiHS_ZDHHC13.
GenevisibleiQ8IUH4. HS.

Organism-specific databases

HPAiHPA016759.
HPA018791.

Interactioni

Subunit structurei

Interacts (via ANK repeats) with CLIP3 (PubMed:26198635). Interacts (via ANK repeats) with DNAJC5 (via C-terminus) (By similarity). Interacts (via ANK repeats) with HTT (PubMed:26198635). Interacts (via ANK repeats) with MAP6 (PubMed:26198635). Interacts (via ANK repeats) with SNAP23 (By similarity). Interacts (via ANK repeats) with SNAP25 (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi119999. 6 interactors.
STRINGi9606.ENSP00000400113.

Structurei

3D structure databases

ProteinModelPortaliQ8IUH4.
SMRiQ8IUH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 78ANK 1By similarityAdd BLAST36
Repeati81 – 110ANK 2Sequence analysisAdd BLAST30
Repeati115 – 144ANK 3Sequence analysisAdd BLAST30
Repeati148 – 177ANK 4Sequence analysisAdd BLAST30
Repeati181 – 211ANK 5Sequence analysisAdd BLAST31
Repeati216 – 245ANK 6Sequence analysisAdd BLAST30
Repeati249 – 277ANK 7Sequence analysisAdd BLAST29
Domaini426 – 476DHHCPROSITE-ProRule annotationAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi328 – 391Phe-richAdd BLAST64

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Contains 7 ANK repeats.PROSITE-ProRule annotation
Contains 1 DHHC domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0509. Eukaryota.
COG0666. LUCA.
COG5273. LUCA.
GeneTreeiENSGT00530000063074.
HOGENOMiHOG000290181.
HOVERGENiHBG051907.
InParanoidiQ8IUH4.
KOiK20032.
OMAiHCATTFR.
OrthoDBiEOG091G056H.
PhylomeDBiQ8IUH4.
TreeFamiTF317342.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR030290. ZDHHC13.
IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PANTHERiPTHR24161:SF16. PTHR24161:SF16. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF01529. zf-DHHC. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50216. DHHC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IUH4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGPGLGSQC RNHSHGPHPP GFGRYGICAH ENKELANARE ALPLIEDSSN
60 70 80 90 100
CDIVKATQYG IFERCKELVE AGYDVRQPDK ENVSLLHWAA INNRLDLVKF
110 120 130 140 150
YISKGAVVDQ LGGDLNSTPL HWAIRQGHLP MVILLLQHGA DPTLIDGEGF
160 170 180 190 200
SSIHLAVLFQ HMPIIAYLIS KGQSVNMTDV NGQTPLMLSA HKVIGPEPTG
210 220 230 240 250
FLLKFNPSLN VVDKIHQNTP LHWAVAAGNV NAVDKLLEAG SSLDIQNVKG
260 270 280 290 300
ETPLDMALQN KNQLIIHMLK TEAKMRANQK FRLWRWLQKC ELFLLLMLSV
310 320 330 340 350
ITMWAIGYIL DFNSDSWLLK GCLLVTLFFL TSLFPRFLVG YKNLVYLPTA
360 370 380 390 400
FLLSSVFWIF MTWFILFFPD LAGAPFYFSF IFSIVAFLYF FYKTWATDPG
410 420 430 440 450
FTKASEEEKK VNIITLAETG SLDFRTFCTS CLIRKPLRSL HCHVCNCCVA
460 470 480 490 500
RYDQHCLWTG RCIGFGNHHY YIFFLFFLSM VCGWIIYGSF IYLSSHCATT
510 520 530 540 550
FKEDGLWTYL NQIVACSPWV LYILMLATFH FSWSTFLLLN QLFQIAFLGL
560 570 580 590 600
TSHERISLQK QSKHMKQTLS LRKTPYNLGF MQNLADFFQC GCFGLVKPCV
610 620
VDWTSQYTMV FHPAREKVLR SV
Length:622
Mass (Da):70,861
Last modified:November 24, 2009 - v3
Checksum:iFD366E02728A0358
GO
Isoform 2 (identifier: Q8IUH4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-176: Missing.

Show »
Length:446
Mass (Da):51,538
Checksum:iBD173DCAAB8F3156
GO
Isoform 3 (identifier: Q8IUH4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-130: Missing.

Show »
Length:492
Mass (Da):56,509
Checksum:i2968E15C91C3F213
GO

Sequence cautioni

The sequence BAA91856 differs from that shown. Reason: Erroneous termination at position 482. Translated as Cys.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti467N → T in BAC22090 (PubMed:12393793).Curated1
Sequence conflicti583N → D in BAA91856 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02383599K → R.3 PublicationsCorresponds to variant rs2271001dbSNPEnsembl.1
Natural variantiVAR_057490392Y → C.Corresponds to variant rs12798330dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0100291 – 176Missing in isoform 2. 1 PublicationAdd BLAST176
Alternative sequenceiVSP_0100281 – 130Missing in isoform 3. 1 PublicationAdd BLAST130

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024495 mRNA. Translation: BAC22090.1.
AB097014 mRNA. Translation: BAC77367.1.
AB097027 mRNA. Translation: BAC77380.1.
AK001714 mRNA. Translation: BAA91856.1. Sequence problems.
AK001831 mRNA. Translation: BAA91930.1.
AC009652 Genomic DNA. No translation available.
BC050690 mRNA. Translation: AAH50690.2.
BC036020 mRNA. Translation: AAH36020.1.
BC056152 mRNA. Translation: AAH56152.1.
CCDSiCCDS44550.1. [Q8IUH4-1]
CCDS44551.1. [Q8IUH4-3]
RefSeqiNP_001001483.1. NM_001001483.2. [Q8IUH4-3]
NP_061901.2. NM_019028.2. [Q8IUH4-1]
XP_005253053.1. XM_005252996.2. [Q8IUH4-3]
XP_011518497.1. XM_011520195.1. [Q8IUH4-3]
UniGeneiHs.188569.

Genome annotation databases

EnsembliENST00000399351; ENSP00000382288; ENSG00000177054. [Q8IUH4-3]
ENST00000446113; ENSP00000400113; ENSG00000177054. [Q8IUH4-1]
GeneIDi54503.
KEGGihsa:54503.
UCSCiuc001mpi.4. human. [Q8IUH4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024495 mRNA. Translation: BAC22090.1.
AB097014 mRNA. Translation: BAC77367.1.
AB097027 mRNA. Translation: BAC77380.1.
AK001714 mRNA. Translation: BAA91856.1. Sequence problems.
AK001831 mRNA. Translation: BAA91930.1.
AC009652 Genomic DNA. No translation available.
BC050690 mRNA. Translation: AAH50690.2.
BC036020 mRNA. Translation: AAH36020.1.
BC056152 mRNA. Translation: AAH56152.1.
CCDSiCCDS44550.1. [Q8IUH4-1]
CCDS44551.1. [Q8IUH4-3]
RefSeqiNP_001001483.1. NM_001001483.2. [Q8IUH4-3]
NP_061901.2. NM_019028.2. [Q8IUH4-1]
XP_005253053.1. XM_005252996.2. [Q8IUH4-3]
XP_011518497.1. XM_011520195.1. [Q8IUH4-3]
UniGeneiHs.188569.

3D structure databases

ProteinModelPortaliQ8IUH4.
SMRiQ8IUH4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119999. 6 interactors.
STRINGi9606.ENSP00000400113.

Protein family/group databases

TCDBi9.B.37.3.1. the huntington-interacting protein 14 (hip14) family.

PTM databases

iPTMnetiQ8IUH4.
PhosphoSitePlusiQ8IUH4.
SwissPalmiQ8IUH4.

Polymorphism and mutation databases

BioMutaiZDHHC13.
DMDMi269849714.

Proteomic databases

EPDiQ8IUH4.
MaxQBiQ8IUH4.
PaxDbiQ8IUH4.
PeptideAtlasiQ8IUH4.
PRIDEiQ8IUH4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399351; ENSP00000382288; ENSG00000177054. [Q8IUH4-3]
ENST00000446113; ENSP00000400113; ENSG00000177054. [Q8IUH4-1]
GeneIDi54503.
KEGGihsa:54503.
UCSCiuc001mpi.4. human. [Q8IUH4-1]

Organism-specific databases

CTDi54503.
DisGeNETi54503.
GeneCardsiZDHHC13.
HGNCiHGNC:18413. ZDHHC13.
HPAiHPA016759.
HPA018791.
MIMi612815. gene.
neXtProtiNX_Q8IUH4.
OpenTargetsiENSG00000177054.
PharmGKBiPA134955878.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0509. Eukaryota.
COG0666. LUCA.
COG5273. LUCA.
GeneTreeiENSGT00530000063074.
HOGENOMiHOG000290181.
HOVERGENiHBG051907.
InParanoidiQ8IUH4.
KOiK20032.
OMAiHCATTFR.
OrthoDBiEOG091G056H.
PhylomeDBiQ8IUH4.
TreeFamiTF317342.

Miscellaneous databases

GenomeRNAii54503.
PROiQ8IUH4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177054.
CleanExiHS_ZDHHC13.
GenevisibleiQ8IUH4. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR030290. ZDHHC13.
IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PANTHERiPTHR24161:SF16. PTHR24161:SF16. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF01529. zf-DHHC. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50216. DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZDH13_HUMAN
AccessioniPrimary (citable) accession number: Q8IUH4
Secondary accession number(s): Q7Z2D3
, Q86VK2, Q9NV30, Q9NV99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 24, 2009
Last modified: November 2, 2016
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.