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Protein

RNA-binding protein 45

Gene

RBM45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein with binding specificity for poly(C). May play an important role in neural development.By similarity1 Publication

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 45
Alternative name(s):
Developmentally-regulated RNA-binding protein 1
Short name:
RB-1
RNA-binding motif protein 45
Gene namesi
Name:RBM45
Synonyms:DRB1Imported, DRBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24468. RBM45.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400809.

Polymorphism and mutation databases

BioMutaiRBM45.
DMDMi59797947.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476RNA-binding protein 45PRO_0000081572Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei199 – 1991PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IUH3.
MaxQBiQ8IUH3.
PaxDbiQ8IUH3.
PRIDEiQ8IUH3.

PTM databases

iPTMnetiQ8IUH3.
PhosphoSiteiQ8IUH3.

Expressioni

Gene expression databases

BgeeiQ8IUH3.
CleanExiHS_RBM45.
ExpressionAtlasiQ8IUH3. baseline and differential.
GenevisibleiQ8IUH3. HS.

Organism-specific databases

HPAiHPA020448.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FANCLQ9NW383EBI-2512147,EBI-2339898
MEMO1Q9Y3163EBI-2512147,EBI-1104564
TRAF1Q130773EBI-2512147,EBI-359224
TXN2Q997573EBI-2512147,EBI-2932492

Protein-protein interaction databases

BioGridi126210. 40 interactions.
IntActiQ8IUH3. 30 interactions.
MINTiMINT-3036574.
STRINGi9606.ENSP00000286070.

Structurei

3D structure databases

ProteinModelPortaliQ8IUH3.
SMRiQ8IUH3. Positions 5-179, 389-466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 10681RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini121 – 19575RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini392 – 46473RRM 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEKU. Eukaryota.
ENOG410XP9Z. LUCA.
GeneTreeiENSGT00680000100059.
HOGENOMiHOG000231828.
HOVERGENiHBG051404.
InParanoidiQ8IUH3.
OMAiDDPPNSR.
OrthoDBiEOG7P8P83.
PhylomeDBiQ8IUH3.
TreeFamiTF324216.

Family and domain databases

Gene3Di3.30.70.330. 4 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 4 hits.
[Graphical view]
SMARTiSM00360. RRM. 4 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q8IUH3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDEAGSSASG GGFRPGVDSL DEPPNSRIFL VISKYTPESV LRERFSPFGD
60 70 80 90 100
IQDIWVVRDK HTKESKGIAF VKFARSSQAC RAMEEMHGQC LGPNDTKPIK
110 120 130 140 150
VFIAQSRSSG SHRDVEDEEL TRIFVMIPKS YTEEDLREKF KVYGDIEYCS
160 170 180 190 200
IIKNKVTGES KGLGYVRYLK PSQAAQAIEN CDRSFRAILA EPKNKASESS
210 220 230 240 250
EQDYYSNMRQ EALGHEPRVN MFPFVGEQQS EFSSFDKNDS RGQEAISKRL
260 270 280 290 300
SVVSRVPFTE EQLFSIFDIV PGLEYCEVQR DPYSNYGHGV VQYFNVASAI
310 320 330 340 350
YAKYKLHGFQ YPPGNRIGVS FIDDGSNATD LLRKMATQMV AAQLASMVWN
360 370 380 390 400
NPSQQQFMQF GGSSGSQLPQ IQTDVVLPSC KKKAPAETPV KERLFIVFNP
410 420 430 440 450
HPLPLDVLED IFCRFGNLIE VYLVSGKNVG YAKYADRISA NDAIATLHGK
460 470
ILNGVRLKVM LADSPREESN KRQRTY
Length:476
Mass (Da):53,502
Last modified:March 1, 2003 - v1
Checksum:i06C7806D9079D391
GO
Isoform 2 (identifier: Q8IUH3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-226: Missing.
     330-330: D → E
     331-476: Missing.

Note: May be due to an intron retention.Curated
Show »
Length:328
Mass (Da):37,072
Checksum:i6E4235DD01819743
GO
Isoform 3 (identifier: Q8IUH3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-226: Missing.

Show »
Length:474
Mass (Da):53,346
Checksum:iEE89C9691FBC63A9
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei225 – 2262Missing in isoform 2 and isoform 3. 2 PublicationsVSP_021005
Alternative sequencei330 – 3301D → E in isoform 2. 1 PublicationVSP_051661
Alternative sequencei331 – 476146Missing in isoform 2. 1 PublicationVSP_051662Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036991 mRNA. Translation: BAC16207.1.
AF526533 mRNA. Translation: AAM88417.1.
BC066549 mRNA. Translation: AAH66549.1.
CCDSiCCDS33335.1. [Q8IUH3-3]
RefSeqiNP_694453.2. NM_152945.3. [Q8IUH3-3]
XP_005246344.1. XM_005246287.3. [Q8IUH3-1]
XP_006712324.1. XM_006712261.2. [Q8IUH3-1]
UniGeneiHs.377257.

Genome annotation databases

EnsembliENST00000286070; ENSP00000286070; ENSG00000155636. [Q8IUH3-3]
ENST00000616198; ENSP00000482083; ENSG00000155636. [Q8IUH3-1]
GeneIDi129831.
KEGGihsa:129831.
UCSCiuc002ulv.4. human. [Q8IUH3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036991 mRNA. Translation: BAC16207.1.
AF526533 mRNA. Translation: AAM88417.1.
BC066549 mRNA. Translation: AAH66549.1.
CCDSiCCDS33335.1. [Q8IUH3-3]
RefSeqiNP_694453.2. NM_152945.3. [Q8IUH3-3]
XP_005246344.1. XM_005246287.3. [Q8IUH3-1]
XP_006712324.1. XM_006712261.2. [Q8IUH3-1]
UniGeneiHs.377257.

3D structure databases

ProteinModelPortaliQ8IUH3.
SMRiQ8IUH3. Positions 5-179, 389-466.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126210. 40 interactions.
IntActiQ8IUH3. 30 interactions.
MINTiMINT-3036574.
STRINGi9606.ENSP00000286070.

PTM databases

iPTMnetiQ8IUH3.
PhosphoSiteiQ8IUH3.

Polymorphism and mutation databases

BioMutaiRBM45.
DMDMi59797947.

Proteomic databases

EPDiQ8IUH3.
MaxQBiQ8IUH3.
PaxDbiQ8IUH3.
PRIDEiQ8IUH3.

Protocols and materials databases

DNASUi129831.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286070; ENSP00000286070; ENSG00000155636. [Q8IUH3-3]
ENST00000616198; ENSP00000482083; ENSG00000155636. [Q8IUH3-1]
GeneIDi129831.
KEGGihsa:129831.
UCSCiuc002ulv.4. human. [Q8IUH3-1]

Organism-specific databases

CTDi129831.
GeneCardsiRBM45.
HGNCiHGNC:24468. RBM45.
HPAiHPA020448.
MIMi608888. gene.
neXtProtiNX_Q8IUH3.
PharmGKBiPA162400809.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEKU. Eukaryota.
ENOG410XP9Z. LUCA.
GeneTreeiENSGT00680000100059.
HOGENOMiHOG000231828.
HOVERGENiHBG051404.
InParanoidiQ8IUH3.
OMAiDDPPNSR.
OrthoDBiEOG7P8P83.
PhylomeDBiQ8IUH3.
TreeFamiTF324216.

Miscellaneous databases

ChiTaRSiRBM45. human.
GenomeRNAii129831.
PROiQ8IUH3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IUH3.
CleanExiHS_RBM45.
ExpressionAtlasiQ8IUH3. baseline and differential.
GenevisibleiQ8IUH3. HS.

Family and domain databases

Gene3Di3.30.70.330. 4 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 4 hits.
[Graphical view]
SMARTiSM00360. RRM. 4 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and characterization of Drb1, a new member of RRM-type neural RNA-binding protein."
    Tamada H., Sakashita E., Shimazaki K., Ueno E., Hamamoto T., Kagawa Y., Endo H.
    Biochem. Biophys. Res. Commun. 297:96-104(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION.
    Tissue: BrainImported.
  2. Chen X.G., Li Y.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: HeartImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: PancreasImported.

Entry informationi

Entry nameiRBM45_HUMAN
AccessioniPrimary (citable) accession number: Q8IUH3
Secondary accession number(s): Q6NYL0, Q8NFC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.