Q8IUG5 (MY18B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Unconventional myosin-XVIIIb

Gene names

Name:

MYO18B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2567 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth. Ref.1
Subunit structure	Homodimer. May interact with F actin through the GPA motif (Gly/Pro/Ala-rich).
Subcellular location	Cytoplasm. Nucleus. Cytoplasm › myofibril › sarcomere. Note: Punctate pattern in undifferentiated myoblasts. Nuclear, on primary cardiomyocytes and adult muscle. A partial sarcomeric location was found in some cardiomyocytes.
Tissue specificity	Selectively expressed in cardiac and skeletal muscles. Weakly expressed in testis, pancreas, placenta, prostate, lung and thymus.
Developmental stage	Reaches an expression peak in the third day after induction and remains at similar level during successive myotubule maturation.
Miscellaneous	Frequently deleted, mutated, and hypermethylated in lung cancers.
Sequence similarities	Contains 1 IQ domain. Contains 1 myosin head-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	ATP-binding Actin-binding Nucleotide-binding
Molecular function	Motor protein Myosin
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA sarcomere Inferred from electronic annotation. Source: UniProtKB-SubCell unconventional myosin complex Inferred from direct assay Ref.2. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IUG5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IUG5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-487: Missing.
     488-503: PAPQEEGKGGQSRDSD → MGSGAICWFNLRDVGS

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2567	2567	Unconventional myosin-XVIIIb		PRO_0000123478
Regions
	Domain	573 – 1321	749	Myosin head-like
	Domain	1336 – 1365	30	IQ
	Nucleotide binding	660 – 667	8	ATP Potential
	Region	1213 – 1240	28	GPA Potential
	Region	1426 – 2083	658	Tail
	Coiled coil	1396 – 1783	388	Potential
	Coiled coil	1825 – 1961	137	Potential
	Coiled coil	2014 – 2090	77	Potential
	Compositional bias	71 – 114	44	Ser-rich
	Compositional bias	799 – 804	6	Poly-Ala
	Compositional bias	1217 – 1222	6	Poly-Pro
	Compositional bias	1643 – 1769	127	Gln-rich
	Compositional bias	2506 – 2514	9	Poly-Ser
Amino acid modifications
	Modified residue	1829	1	Phosphoserine Ref.10
Natural variations
	Alternative sequence	1 – 487	487	Missing in isoform 2.		VSP_007764
	Alternative sequence	488 – 503	16	PAPQE…SRDSD → MGSGAICWFNLRDVGS in isoform 2.		VSP_007765
	Natural variant	44	1	G → E. Corresponds to variant rs133885 [ dbSNP | Ensembl ].		VAR_056190
	Natural variant	177	1	P → L. Corresponds to variant rs13058434 [ dbSNP | Ensembl ].		VAR_056191
	Natural variant	234	1	G → V in a lung small cell carcinoma sample; somatic mutation. Ref.1		VAR_015862
	Natural variant	347	1	K → N in a lung small cell carcinoma sample; somatic mutation. Ref.1		VAR_015863
	Natural variant	379	1	R → Q in a lung small cell carcinoma sample; somatic mutation. Ref.1		VAR_015864
	Natural variant	389	1	W → C in a lung adenocarcinoma sample; somatic mutation. Ref.1		VAR_015865
	Natural variant	547	1	W → C. Ref.3 Ref.6 Corresponds to variant rs3859866 [ dbSNP | Ensembl ].		VAR_056192
	Natural variant	590	1	T → M in a lung large cell carcinoma sample; somatic mutation. Ref.1		VAR_015866
	Natural variant	661	1	R → W in a lung adenocarcinoma sample; somatic mutation. Ref.1 Ref.4 Corresponds to variant rs5761170 [ dbSNP | Ensembl ].		VAR_015867
	Natural variant	835	1	A → G in a lung squamous cell carcinoma sample; somatic mutation. Ref.1		VAR_015868
	Natural variant	925	1	S → L. Ref.2 Corresponds to variant rs9624909 [ dbSNP | Ensembl ].		VAR_056193
	Natural variant	1037	1	W → S. Corresponds to variant rs17704912 [ dbSNP | Ensembl ].		VAR_056194
	Natural variant	1095	1	R → L in a lung adenocarcinoma sample; somatic mutation. Ref.1		VAR_015869
	Natural variant	1119	1	H → Q. Ref.3 Ref.6 Corresponds to variant rs5761268 [ dbSNP | Ensembl ].		VAR_056195
	Natural variant	1195	1	R → Q in a lung small cell carcinoma sample; somatic mutation. Ref.1		VAR_015870
	Natural variant	1238	1	P → Q in a lung large cell carcinoma sample; somatic mutation. Ref.1		VAR_015871
	Natural variant	1238	1	P → T in a lung adenocarcinoma sample; somatic mutation. Ref.1		VAR_015872
	Natural variant	1390	1	S → F. Corresponds to variant rs35578357 [ dbSNP | Ensembl ].		VAR_056196
	Natural variant	1399	1	I → V. Corresponds to variant rs695633 [ dbSNP | Ensembl ].		VAR_056197
	Natural variant	1444	1	S → T. Corresponds to variant rs33928909 [ dbSNP | Ensembl ].		VAR_056198
	Natural variant	1708	1	E → K in a lung adenocarcinoma sample; somatic mutation. Ref.1		VAR_015873
	Natural variant	1715	1	E → D in a lung adenocarcinoma sample; somatic mutation. Ref.1		VAR_015874
	Natural variant	1970	1	A → E in a lung small cell carcinoma sample; somatic mutation. Ref.1		VAR_015875
	Natural variant	2294	1	A → D. Corresponds to variant rs35370367 [ dbSNP | Ensembl ].		VAR_056199
	Natural variant	2295	1	G → C in a lung small cell carcinoma sample; somatic mutation. Ref.1		VAR_015876
	Natural variant	2347	1	Q → R. Ref.6 Corresponds to variant rs2236005 [ dbSNP | Ensembl ].		VAR_015877
	Natural variant	2381	1	R → H in a lung adenocarcinoma sample; somatic mutation. Ref.1		VAR_015878
	Natural variant	2395	1	G → A. Corresponds to variant rs6004901 [ dbSNP | Ensembl ].		VAR_056200
	Natural variant	2513	1	G → S. Corresponds to variant rs7284177 [ dbSNP | Ensembl ].		VAR_056201
	Natural variant	2532	1	R → Q. Corresponds to variant rs34875296 [ dbSNP | Ensembl ].		VAR_056202
	Natural variant	2554	1	D → E in a lung large cell carcinoma sample; somatic mutation. Ref.1		VAR_015879
Experimental info
	Sequence conflict	3	1	I → M in CAC70712. Ref.2
	Sequence conflict	828	1	A → T in AAI50627. Ref.6
	Sequence conflict	828	1	A → T in AAI44598. Ref.6
	Sequence conflict	1020	1	Q → QQ in AAL75811. Ref.3
	Sequence conflict	1060	1	A → T in AAL75811. Ref.3
	Sequence conflict	1510	1	N → D in AAL75811. Ref.3
	Sequence conflict	1515	1	Missing in AAI50627. Ref.6
	Sequence conflict	1515	1	Missing in AAI44598. Ref.6
	Sequence conflict	2343 – 2344	2	KS → LT Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 9ABC2F64C644F110	FASTA	2,567	285,185
	10 20 30 40 50 60 MAISSRLALW EQKIREEDKS PPPSSPPPLF SVIPGGFIKQ LVRGTEKEAK EARQRKQLAV 70 80 90 100 110 120 ASPEREIPEI SISQPNSKSS SGTRSGSQQI SQDDQSSSPG SSDILGKESE GSRSPDPEQM 130 140 150 160 170 180 TSINGEKAQE LGSSATPTKK TVPFKRGVRR GDVLLMVAKL DPDSAKPEKT HPHDAPPCKT 190 200 210 220 230 240 SPPATDTGKE KKGETSRTPC GSQASTEILA PKAEKTRTGG LGDPGQGTVA LKKGEEGQSI 250 260 270 280 290 300 VGKGLGTPKT TELKEAEPQG KDRQGTRPQA QGPGEGVRPG KAEKEGAEPT NTVEKGNVSK 310 320 330 340 350 360 DVGSEGKHVR PQIPGRKWGG FLGRRSKWDG PQNKKDKEGV LLSKAEKTGE PQTQMEKTSQ 370 380 390 400 410 420 VQGELGDDLR MGEKAGELRS TTGKAGESWD KKEKMGQPQG KSGNAGEARS QTEKGCEAPK 430 440 450 460 470 480 EVSTMVESPA APGKGGWPGS RGQEAEEPCS RAGDGAGALE TELEGPSQPA LEKDAERPRI 490 500 510 520 530 540 RKENQDGPAP QEEGKGGQSR DSDQAPEDRW YEAEKVWLAQ KDGFTLATVL KPDEGTADLP 550 560 570 580 590 600 AGRVRLWIDA DKTITEVDEE HVHRANPPEL DQVEDLASLI SVNESSVLNT LLQRYKAQLL 610 620 630 640 650 660 HTCTGPDLIV LQPRGPSVPS AGKVPKGRRD GLPAHIGSMA QRAYWALLNQ RRDQSIVALG 670 680 690 700 710 720 RSGAGKTTCC EQVLEHLVGM AGSVDGRVSV EKIRATFTVL RAFGSVSMAH SRSATRFSMV 730 740 750 760 770 780 MSLDFNATGR ITAAQLQTML LEKSRVARQP EGESNFLVFS QMLAGLDLDL RTELNLHQMA 790 800 810 820 830 840 DSSSFGMGVW SKPEDKQKAA AAFAQLQGAM EMLGISESEQ RAVWRVLAAI YHLGAAGACK 850 860 870 880 890 900 VGRKQFMRFE WANYAAEALG CEYEELNTAT FKHHLRQIIQ QMTFGPSRWG LEDEETSSGL 910 920 930 940 950 960 KMTGVDCVEG MASGLYQELF AAVVSLINRS FSSHHLSMAS IMVVDSPGFQ NPRHQGKDRA 970 980 990 1000 1010 1020 ATFEELCHNY AHERLQLLFY QRTFVSTLQR YQEEGVPVQF DLPDPSPGTT VAVVDQNPSQ 1030 1040 1050 1060 1070 1080 VRLPAGGGAQ DARGLFWVLD EEVHVEGSSD SVVLERLCAA FEKKGAGTEG SSALRTCEQP 1090 1100 1110 1120 1130 1140 LQCEIFHQLG WDPVRYDLTG WLHRAKPNLS ALDAPQVLHQ SKREELRSLF QARAKLPPVC 1150 1160 1170 1180 1190 1200 RAVAGLEGTS QQALQRSRMV RRTFASSLAA VRRKAPCSQI KLQMDALTSM IKRSRLHFIH 1210 1220 1230 1240 1250 1260 CLVPNPVVES RSGQESPPPP QPGRDKPGAG GPLALDIPAL RVQLAGFHIL EALRLHRTGY 1270 1280 1290 1300 1310 1320 ADHMGLTRFR RQFQVLDAPL LKKLMSTSEG IDERKAVEEL LETLDLEKKA VAVGHSQVFL 1330 1340 1350 1360 1370 1380 KAGVISRLEK QREKLVSQSI VLFQAACKGF LSRQEFKKLK IRRLAAQCIQ KNVAVFLAVK 1390 1400 1410 1420 1430 1440 DWPWWQLLGS LQPLLSATIG TEQLRAKEEE LTTLRRKLEK SEKLRNELRQ NTDLLESKIA 1450 1460 1470 1480 1490 1500 DLTSDLADER FKGDVACQVL ESERAERLQA FREVQELKSK HEQVQKKLGD VNKQLEEAQQ 1510 1520 1530 1540 1550 1560 KIQLNDLERN PTGGADEWQM RFDCAQMENE FLRKRLQQCE ERLDSELTAR KELEQKLGEL 1570 1580 1590 1600 1610 1620 QSAYDGAKKM AHQLKRKCHH LTCDLEDTCV LLENQQSRNH ELEKKQKKFD LQLAQALGES 1630 1640 1650 1660 1670 1680 VFEKGLREKV TQENTSVRWE LGQLQQQLKQ KEQEASQLKQ QVEMLQDHKR ELLGSPSLGE 1690 1700 1710 1720 1730 1740 NCVAGLKERL WKLESSALEQ QKIQSQQENT IKQLEQLRQR FELEIERMKQ MHQKDREDQE 1750 1760 1770 1780 1790 1800 EELEDVRQSC QKRLHQLEMQ LEQEYEEKQM VLHEKQDLEG LIGTLCDQIG HRDFDVEKRL 1810 1820 1830 1840 1850 1860 RRDLRRTHAL LSDVQLLLGT MEDGKTSVSK EELEKVHSQL EQSEAKCEEA LKTQKVLTAD 1870 1880 1890 1900 1910 1920 LESMHSELEN MTRNKSLVDE QLYRLQFEKA DLLKRIDEDQ DDLNELMQKH KDLIAQSAAD 1930 1940 1950 1960 1970 1980 IGQIQELQLQ LEEAKKEKHK LQEQLQVAQM RIEYLEQSTV DRAIVSRQEA VICDLENKTE 1990 2000 2010 2020 2030 2040 FQKVQIKRFE VLVIRLRDSL IKMGEELSQA ATSESQQRES SQYYQRRLEE LKADMEELVQ 2050 2060 2070 2080 2090 2100 REAEASRRCM ELEKYVEELA AVRQTLQTDL ETSIRRIADL QAALEEVASS DSDTESVQTA 2110 2120 2130 2140 2150 2160 VDCGSSGRKE MDNVSILSSQ PEGSLQSWLS CTLSLATDTM RTPSRQSATS SRILSPRINE 2170 2180 2190 2200 2210 2220 EAGDTERTQS ALALSRARST NVHSKTSGDK PVSPHFVRRQ KYCHFGDGEV LAVQRKSTER 2230 2240 2250 2260 2270 2280 LEPASSPLAS RSTNTSPLSR EKLPSPSAAL SEFVEGLRRK RAQRGQGSTL GLEDWPTLPI 2290 2300 2310 2320 2330 2340 YQTTGASTLR RGRAGSDEGN LSLRVGAKSP LEIEGAAGGL LRSTSLKCIS SDGVGGTTLL 2350 2360 2370 2380 2390 2400 PEKSKTQFSS CESLLESRPS MGRKLSSPTT PRDMLLSPTL RPRRRCLESS VDDAGCPDLG 2410 2420 2430 2440 2450 2460 KEPLVFQNRQ FAHLMEEPLG SDPFSWKLPS LDYERKTKVD FDDFLPAIRK PQTPTSLAGS 2470 2480 2490 2500 2510 2520 AKGGQDGSQR SSIHFETEEA NRSFLSGIKT ILKKSPEPKE DPAHLSDSSS SSGSIVSFKS 2530 2540 2550 2560 ADSIKSRPGI PRLAGDGGER TSPERREPGT GRKDDDVASI MKKYLQK
	Isoform 2 [UniParc]. Checksum: F7ABF4EF5BD30755	FASTA	2,080	233,671
	10 20 30 40 50 60 MGSGAICWFN LRDVGSQAPE DRWYEAEKVW LAQKDGFTLA TVLKPDEGTA DLPAGRVRLW 70 80 90 100 110 120 IDADKTITEV DEEHVHRANP PELDQVEDLA SLISVNESSV LNTLLQRYKA QLLHTCTGPD 130 140 150 160 170 180 LIVLQPRGPS VPSAGKVPKG RRDGLPAHIG SMAQRAYWAL LNQRRDQSIV ALGRSGAGKT 190 200 210 220 230 240 TCCEQVLEHL VGMAGSVDGR VSVEKIRATF TVLRAFGSVS MAHSRSATRF SMVMSLDFNA 250 260 270 280 290 300 TGRITAAQLQ TMLLEKSRVA RQPEGESNFL VFSQMLAGLD LDLRTELNLH QMADSSSFGM 310 320 330 340 350 360 GVWSKPEDKQ KAAAAFAQLQ GAMEMLGISE SEQRAVWRVL AAIYHLGAAG ACKVGRKQFM 370 380 390 400 410 420 RFEWANYAAE ALGCEYEELN TATFKHHLRQ IIQQMTFGPS RWGLEDEETS SGLKMTGVDC 430 440 450 460 470 480 VEGMASGLYQ ELFAAVVSLI NRSFSSHHLS MASIMVVDSP GFQNPRHQGK DRAATFEELC 490 500 510 520 530 540 HNYAHERLQL LFYQRTFVST LQRYQEEGVP VQFDLPDPSP GTTVAVVDQN PSQVRLPAGG 550 560 570 580 590 600 GAQDARGLFW VLDEEVHVEG SSDSVVLERL CAAFEKKGAG TEGSSALRTC EQPLQCEIFH 610 620 630 640 650 660 QLGWDPVRYD LTGWLHRAKP NLSALDAPQV LHQSKREELR SLFQARAKLP PVCRAVAGLE 670 680 690 700 710 720 GTSQQALQRS RMVRRTFASS LAAVRRKAPC SQIKLQMDAL TSMIKRSRLH FIHCLVPNPV 730 740 750 760 770 780 VESRSGQESP PPPQPGRDKP GAGGPLALDI PALRVQLAGF HILEALRLHR TGYADHMGLT 790 800 810 820 830 840 RFRRQFQVLD APLLKKLMST SEGIDERKAV EELLETLDLE KKAVAVGHSQ VFLKAGVISR 850 860 870 880 890 900 LEKQREKLVS QSIVLFQAAC KGFLSRQEFK KLKIRRLAAQ CIQKNVAVFL AVKDWPWWQL 910 920 930 940 950 960 LGSLQPLLSA TIGTEQLRAK EEELTTLRRK LEKSEKLRNE LRQNTDLLES KIADLTSDLA 970 980 990 1000 1010 1020 DERFKGDVAC QVLESERAER LQAFREVQEL KSKHEQVQKK LGDVNKQLEE AQQKIQLNDL 1030 1040 1050 1060 1070 1080 ERNPTGGADE WQMRFDCAQM ENEFLRKRLQ QCEERLDSEL TARKELEQKL GELQSAYDGA 1090 1100 1110 1120 1130 1140 KKMAHQLKRK CHHLTCDLED TCVLLENQQS RNHELEKKQK KFDLQLAQAL GESVFEKGLR 1150 1160 1170 1180 1190 1200 EKVTQENTSV RWELGQLQQQ LKQKEQEASQ LKQQVEMLQD HKRELLGSPS LGENCVAGLK 1210 1220 1230 1240 1250 1260 ERLWKLESSA LEQQKIQSQQ ENTIKQLEQL RQRFELEIER MKQMHQKDRE DQEEELEDVR 1270 1280 1290 1300 1310 1320 QSCQKRLHQL EMQLEQEYEE KQMVLHEKQD LEGLIGTLCD QIGHRDFDVE KRLRRDLRRT 1330 1340 1350 1360 1370 1380 HALLSDVQLL LGTMEDGKTS VSKEELEKVH SQLEQSEAKC EEALKTQKVL TADLESMHSE 1390 1400 1410 1420 1430 1440 LENMTRNKSL VDEQLYRLQF EKADLLKRID EDQDDLNELM QKHKDLIAQS AADIGQIQEL 1450 1460 1470 1480 1490 1500 QLQLEEAKKE KHKLQEQLQV AQMRIEYLEQ STVDRAIVSR QEAVICDLEN KTEFQKVQIK 1510 1520 1530 1540 1550 1560 RFEVLVIRLR DSLIKMGEEL SQAATSESQQ RESSQYYQRR LEELKADMEE LVQREAEASR 1570 1580 1590 1600 1610 1620 RCMELEKYVE ELAAVRQTLQ TDLETSIRRI ADLQAALEEV ASSDSDTESV QTAVDCGSSG 1630 1640 1650 1660 1670 1680 RKEMDNVSIL SSQPEGSLQS WLSCTLSLAT DTMRTPSRQS ATSSRILSPR INEEAGDTER 1690 1700 1710 1720 1730 1740 TQSALALSRA RSTNVHSKTS GDKPVSPHFV RRQKYCHFGD GEVLAVQRKS TERLEPASSP 1750 1760 1770 1780 1790 1800 LASRSTNTSP LSREKLPSPS AALSEFVEGL RRKRAQRGQG STLGLEDWPT LPIYQTTGAS 1810 1820 1830 1840 1850 1860 TLRRGRAGSD EGNLSLRVGA KSPLEIEGAA GGLLRSTSLK CISSDGVGGT TLLPEKSKTQ 1870 1880 1890 1900 1910 1920 FSSCESLLES RPSMGRKLSS PTTPRDMLLS PTLRPRRRCL ESSVDDAGCP DLGKEPLVFQ 1930 1940 1950 1960 1970 1980 NRQFAHLMEE PLGSDPFSWK LPSLDYERKT KVDFDDFLPA IRKPQTPTSL AGSAKGGQDG 1990 2000 2010 2020 2030 2040 SQRSSIHFET EEANRSFLSG IKTILKKSPE PKEDPAHLSD SSSSSGSIVS FKSADSIKSR 2050 2060 2070 2080 PGIPRLAGDG GERTSPERRE PGTGRKDDDV ASIMKKYLQK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer." Nishioka M., Kohno T., Tani M., Yanaihara N., Tomizawa Y., Otsuka A., Sasaki S., Kobayashi K., Niki T., Maeshima A., Sekido Y., Minna J.D., Sone S., Yokota J. Proc. Natl. Acad. Sci. U.S.A. 99:12269-12274(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), VARIANTS VAL-234; ASN-347; GLN-379; CYS-389; MET-590; TRP-661; GLY-835; LEU-1095; GLN-1195; GLN-1238; THR-1238; LYS-1708; ASP-1715; GLU-1970; CYS-2295; HIS-2381 AND GLU-2554, POSSIBLE ROLE IN TUMOR SUPPRESSION. Tissue: Skeletal muscle.
[2]	"Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation." Salamon M., Millino C., Raffaello A., Mongillo M., Sandri C., Bean C., Negrisolo E., Pallavicini A., Valle G., Zaccolo M., Schiaffino S., Lanfranchi G. J. Mol. Biol. 326:137-149(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), CHARACTERIZATION, VARIANT LEU-925. Tissue: Skeletal muscle.
[3]	"Myosin-like gene expressed in human heart and muscle." Gu Y., Ji Y., Penn S.G., Hanzel D.K., Rank D.R., Chen W., Shannon M.E. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS CYS-547 AND GLN-1119.
[4]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT TRP-661.
[5]	"Full-length sequencing of 100 cDNA clones from human adult skeletal muscle." Stanchi F., Lanfranchi G. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2343-2567. Tissue: Skeletal muscle.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS CYS-547; GLN-1119 AND ARG-2347.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2359-2567. Tissue: Testis.
[8]	"Genetic alterations responsible for metastatic phenotypes of lung cancer cells." Yokota J., Nishioka M., Tani M., Kohno T. Clin. Exp. Metastasis 20:189-193(2003) [PubMed] [Europe PMC] [Abstract] Cited for: POSSIBLE INVOLVEMENT IN SUPPRESSION OF CELL ANCHORAGE-INDEPENDENT GROWTH.
[9]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Platelet.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1829, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB075376 mRNA. Translation: BAC16363.1. AB042648 mRNA. Translation: BAB55550.2. AJ310931 mRNA. Translation: CAC70712.2. AJ310932 Genomic DNA. Translation: CAC70714.3. AY077700 mRNA. Translation: AAL75811.1. Z98949 Genomic DNA. No translation available. AL080245 Genomic DNA. No translation available. AL022329 Genomic DNA. No translation available. AL079300 Genomic DNA. No translation available. BC144597 mRNA. Translation: AAI44598.1. BC150626 mRNA. Translation: AAI50627.1. AJ271918 mRNA. Translation: CAC81082.1. AL833890 mRNA. Translation: CAD38746.1.
IPI	IPI00874168. IPI01015401.
RefSeq	NP_115997.5. NM_032608.5.
UniGene	Hs.417959.
3D structure databases
ProteinModelPortal	Q8IUG5.
SMR	Q8IUG5. Positions 503-1451.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IUG5. 3 interactions.
MINT	MINT-7242569.
STRING	9606.ENSP00000386096.
PTM databases
PhosphoSite	Q8IUG5.
Polymorphism databases
DMDM	32699565.
Proteomic databases
PaxDb	Q8IUG5.
PRIDE	Q8IUG5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000540454; ENSP00000441301; ENSG00000133454.
GeneID	84700.
KEGG	hsa:84700.
UCSC	uc011aka.1. human.
Organism-specific databases
CTD	84700.
GeneCards	GC22P026138.
H-InvDB	HIX0016319.
HGNC	HGNC:18150. MYO18B.
HPA	HPA000953.
MIM	607295. gene.
neXtProt	NX_Q8IUG5.
PharmGKB	PA38300.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5022.
HOVERGEN	HBG052544.
KO	K10362.
Gene expression databases
ArrayExpress	Q8IUG5.
Bgee	Q8IUG5.
CleanEx	HS_MYO18B.
Genevestigator	Q8IUG5.
GermOnline	ENSG00000133454. Homo sapiens.
Family and domain databases
InterPro	IPR000048. IQ_motif_EF-hand-BS. IPR001609. Myosin_head_motor_dom. [Graphical view]
Pfam	PF00063. Myosin_head. 2 hits. [Graphical view]
PRINTS	PR00193. MYOSINHEAVY.
SMART	SM00015. IQ. 1 hit. SM00242. MYSc. 1 hit. [Graphical view]
PROSITE	PS50096. IQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	84700.
NextBio	74784.
SOURCE	Search...

Entry information

Entry name

MY18B_HUMAN

Accession

Primary (citable) accession number: Q8IUG5
Secondary accession number(s): B2RWP3 , F5GYU7, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.