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Protein

Unconventional myosin-XVIIIb

Gene

MYO18B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi660 – 6678ATPSequence Analysis

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-XVIIIb
Gene namesi
Name:MYO18B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:18150. MYO18B.

Subcellular locationi

  • Cytoplasm
  • Nucleus
  • Cytoplasmmyofibrilsarcomere

  • Note: Punctate pattern in undifferentiated myoblasts. Nuclear, on primary cardiomyocytes and adult muscle. A partial sarcomeric location was found in some cardiomyocytes.

GO - Cellular componenti

  • centrosome Source: HPA
  • nucleoplasm Source: HPA
  • sarcomere Source: UniProtKB-SubCell
  • unconventional myosin complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38300.

Polymorphism and mutation databases

BioMutaiMYO18B.
DMDMi32699565.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 25672567Unconventional myosin-XVIIIbPRO_0000123478Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1829 – 18291Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IUG5.
PaxDbiQ8IUG5.
PRIDEiQ8IUG5.

PTM databases

PhosphoSiteiQ8IUG5.

Expressioni

Tissue specificityi

Selectively expressed in cardiac and skeletal muscles. Weakly expressed in testis, pancreas, placenta, prostate, lung and thymus.

Developmental stagei

Reaches an expression peak in the third day after induction and remains at similar level during successive myotubule maturation.

Gene expression databases

BgeeiQ8IUG5.
CleanExiHS_MYO18B.
ExpressionAtlasiQ8IUG5. baseline.
GenevestigatoriQ8IUG5.

Organism-specific databases

HPAiHPA000953.

Interactioni

Subunit structurei

Homodimer. May interact with F actin through the GPA motif (Gly/Pro/Ala-rich).

Protein-protein interaction databases

BioGridi124214. 2 interactions.
IntActiQ8IUG5. 3 interactions.
STRINGi9606.ENSP00000386096.

Structurei

3D structure databases

ProteinModelPortaliQ8IUG5.
SMRiQ8IUG5. Positions 505-1395.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini571 – 1333763Myosin motorAdd
BLAST
Domaini1336 – 136530IQPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1213 – 124028GPASequence AnalysisAdd
BLAST
Regioni1426 – 2083658TailAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1396 – 1783388Sequence AnalysisAdd
BLAST
Coiled coili1825 – 1961137Sequence AnalysisAdd
BLAST
Coiled coili2014 – 209077Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi71 – 11444Ser-richAdd
BLAST
Compositional biasi799 – 8046Poly-Ala
Compositional biasi1217 – 12226Poly-Pro
Compositional biasi1643 – 1769127Gln-richAdd
BLAST
Compositional biasi2506 – 25149Poly-Ser

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5022.
HOVERGENiHBG052544.
InParanoidiQ8IUG5.
KOiK10362.
OrthoDBiEOG71P29W.
PhylomeDBiQ8IUG5.
TreeFamiTF339614.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR028561. MYO18B.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR13140:SF254. PTHR13140:SF254. 1 hit.
PfamiPF00063. Myosin_head. 2 hits.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IUG5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAISSRLALW EQKIREEDKS PPPSSPPPLF SVIPGGFIKQ LVRGTEKEAK
60 70 80 90 100
EARQRKQLAV ASPEREIPEI SISQPNSKSS SGTRSGSQQI SQDDQSSSPG
110 120 130 140 150
SSDILGKESE GSRSPDPEQM TSINGEKAQE LGSSATPTKK TVPFKRGVRR
160 170 180 190 200
GDVLLMVAKL DPDSAKPEKT HPHDAPPCKT SPPATDTGKE KKGETSRTPC
210 220 230 240 250
GSQASTEILA PKAEKTRTGG LGDPGQGTVA LKKGEEGQSI VGKGLGTPKT
260 270 280 290 300
TELKEAEPQG KDRQGTRPQA QGPGEGVRPG KAEKEGAEPT NTVEKGNVSK
310 320 330 340 350
DVGSEGKHVR PQIPGRKWGG FLGRRSKWDG PQNKKDKEGV LLSKAEKTGE
360 370 380 390 400
PQTQMEKTSQ VQGELGDDLR MGEKAGELRS TTGKAGESWD KKEKMGQPQG
410 420 430 440 450
KSGNAGEARS QTEKGCEAPK EVSTMVESPA APGKGGWPGS RGQEAEEPCS
460 470 480 490 500
RAGDGAGALE TELEGPSQPA LEKDAERPRI RKENQDGPAP QEEGKGGQSR
510 520 530 540 550
DSDQAPEDRW YEAEKVWLAQ KDGFTLATVL KPDEGTADLP AGRVRLWIDA
560 570 580 590 600
DKTITEVDEE HVHRANPPEL DQVEDLASLI SVNESSVLNT LLQRYKAQLL
610 620 630 640 650
HTCTGPDLIV LQPRGPSVPS AGKVPKGRRD GLPAHIGSMA QRAYWALLNQ
660 670 680 690 700
RRDQSIVALG RSGAGKTTCC EQVLEHLVGM AGSVDGRVSV EKIRATFTVL
710 720 730 740 750
RAFGSVSMAH SRSATRFSMV MSLDFNATGR ITAAQLQTML LEKSRVARQP
760 770 780 790 800
EGESNFLVFS QMLAGLDLDL RTELNLHQMA DSSSFGMGVW SKPEDKQKAA
810 820 830 840 850
AAFAQLQGAM EMLGISESEQ RAVWRVLAAI YHLGAAGACK VGRKQFMRFE
860 870 880 890 900
WANYAAEALG CEYEELNTAT FKHHLRQIIQ QMTFGPSRWG LEDEETSSGL
910 920 930 940 950
KMTGVDCVEG MASGLYQELF AAVVSLINRS FSSHHLSMAS IMVVDSPGFQ
960 970 980 990 1000
NPRHQGKDRA ATFEELCHNY AHERLQLLFY QRTFVSTLQR YQEEGVPVQF
1010 1020 1030 1040 1050
DLPDPSPGTT VAVVDQNPSQ VRLPAGGGAQ DARGLFWVLD EEVHVEGSSD
1060 1070 1080 1090 1100
SVVLERLCAA FEKKGAGTEG SSALRTCEQP LQCEIFHQLG WDPVRYDLTG
1110 1120 1130 1140 1150
WLHRAKPNLS ALDAPQVLHQ SKREELRSLF QARAKLPPVC RAVAGLEGTS
1160 1170 1180 1190 1200
QQALQRSRMV RRTFASSLAA VRRKAPCSQI KLQMDALTSM IKRSRLHFIH
1210 1220 1230 1240 1250
CLVPNPVVES RSGQESPPPP QPGRDKPGAG GPLALDIPAL RVQLAGFHIL
1260 1270 1280 1290 1300
EALRLHRTGY ADHMGLTRFR RQFQVLDAPL LKKLMSTSEG IDERKAVEEL
1310 1320 1330 1340 1350
LETLDLEKKA VAVGHSQVFL KAGVISRLEK QREKLVSQSI VLFQAACKGF
1360 1370 1380 1390 1400
LSRQEFKKLK IRRLAAQCIQ KNVAVFLAVK DWPWWQLLGS LQPLLSATIG
1410 1420 1430 1440 1450
TEQLRAKEEE LTTLRRKLEK SEKLRNELRQ NTDLLESKIA DLTSDLADER
1460 1470 1480 1490 1500
FKGDVACQVL ESERAERLQA FREVQELKSK HEQVQKKLGD VNKQLEEAQQ
1510 1520 1530 1540 1550
KIQLNDLERN PTGGADEWQM RFDCAQMENE FLRKRLQQCE ERLDSELTAR
1560 1570 1580 1590 1600
KELEQKLGEL QSAYDGAKKM AHQLKRKCHH LTCDLEDTCV LLENQQSRNH
1610 1620 1630 1640 1650
ELEKKQKKFD LQLAQALGES VFEKGLREKV TQENTSVRWE LGQLQQQLKQ
1660 1670 1680 1690 1700
KEQEASQLKQ QVEMLQDHKR ELLGSPSLGE NCVAGLKERL WKLESSALEQ
1710 1720 1730 1740 1750
QKIQSQQENT IKQLEQLRQR FELEIERMKQ MHQKDREDQE EELEDVRQSC
1760 1770 1780 1790 1800
QKRLHQLEMQ LEQEYEEKQM VLHEKQDLEG LIGTLCDQIG HRDFDVEKRL
1810 1820 1830 1840 1850
RRDLRRTHAL LSDVQLLLGT MEDGKTSVSK EELEKVHSQL EQSEAKCEEA
1860 1870 1880 1890 1900
LKTQKVLTAD LESMHSELEN MTRNKSLVDE QLYRLQFEKA DLLKRIDEDQ
1910 1920 1930 1940 1950
DDLNELMQKH KDLIAQSAAD IGQIQELQLQ LEEAKKEKHK LQEQLQVAQM
1960 1970 1980 1990 2000
RIEYLEQSTV DRAIVSRQEA VICDLENKTE FQKVQIKRFE VLVIRLRDSL
2010 2020 2030 2040 2050
IKMGEELSQA ATSESQQRES SQYYQRRLEE LKADMEELVQ REAEASRRCM
2060 2070 2080 2090 2100
ELEKYVEELA AVRQTLQTDL ETSIRRIADL QAALEEVASS DSDTESVQTA
2110 2120 2130 2140 2150
VDCGSSGRKE MDNVSILSSQ PEGSLQSWLS CTLSLATDTM RTPSRQSATS
2160 2170 2180 2190 2200
SRILSPRINE EAGDTERTQS ALALSRARST NVHSKTSGDK PVSPHFVRRQ
2210 2220 2230 2240 2250
KYCHFGDGEV LAVQRKSTER LEPASSPLAS RSTNTSPLSR EKLPSPSAAL
2260 2270 2280 2290 2300
SEFVEGLRRK RAQRGQGSTL GLEDWPTLPI YQTTGASTLR RGRAGSDEGN
2310 2320 2330 2340 2350
LSLRVGAKSP LEIEGAAGGL LRSTSLKCIS SDGVGGTTLL PEKSKTQFSS
2360 2370 2380 2390 2400
CESLLESRPS MGRKLSSPTT PRDMLLSPTL RPRRRCLESS VDDAGCPDLG
2410 2420 2430 2440 2450
KEPLVFQNRQ FAHLMEEPLG SDPFSWKLPS LDYERKTKVD FDDFLPAIRK
2460 2470 2480 2490 2500
PQTPTSLAGS AKGGQDGSQR SSIHFETEEA NRSFLSGIKT ILKKSPEPKE
2510 2520 2530 2540 2550
DPAHLSDSSS SSGSIVSFKS ADSIKSRPGI PRLAGDGGER TSPERREPGT
2560
GRKDDDVASI MKKYLQK
Length:2,567
Mass (Da):285,185
Last modified:March 1, 2003 - v1
Checksum:i9ABC2F64C644F110
GO
Isoform 2 (identifier: Q8IUG5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-487: Missing.
     488-503: PAPQEEGKGGQSRDSD → MGSGAICWFNLRDVGS

Note: No experimental confirmation available.

Show »
Length:2,080
Mass (Da):233,671
Checksum:iF7ABF4EF5BD30755
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31I → M in CAC70712 (PubMed:12547197).Curated
Sequence conflicti828 – 8281A → T in AAI50627 (PubMed:15489334).Curated
Sequence conflicti828 – 8281A → T in AAI44598 (PubMed:15489334).Curated
Sequence conflicti1020 – 10201Q → QQ in AAL75811 (Ref. 3) Curated
Sequence conflicti1060 – 10601A → T in AAL75811 (Ref. 3) Curated
Sequence conflicti1510 – 15101N → D in AAL75811 (Ref. 3) Curated
Sequence conflicti1515 – 15151Missing in AAI50627 (PubMed:15489334).Curated
Sequence conflicti1515 – 15151Missing in AAI44598 (PubMed:15489334).Curated
Sequence conflicti2343 – 23442KS → LT (Ref. 5) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti44 – 441G → E.
Corresponds to variant rs133885 [ dbSNP | Ensembl ].
VAR_056190
Natural varianti177 – 1771P → L.
Corresponds to variant rs13058434 [ dbSNP | Ensembl ].
VAR_056191
Natural varianti234 – 2341G → V in a lung small cell carcinoma sample; somatic mutation. 1 Publication
VAR_015862
Natural varianti347 – 3471K → N in a lung small cell carcinoma sample; somatic mutation. 1 Publication
VAR_015863
Natural varianti379 – 3791R → Q in a lung small cell carcinoma sample; somatic mutation. 1 Publication
VAR_015864
Natural varianti389 – 3891W → C in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_015865
Natural varianti547 – 5471W → C.2 Publications
Corresponds to variant rs3859866 [ dbSNP | Ensembl ].
VAR_056192
Natural varianti590 – 5901T → M in a lung large cell carcinoma sample; somatic mutation. 1 Publication
VAR_015866
Natural varianti661 – 6611R → W in a lung adenocarcinoma sample; somatic mutation. 2 Publications
Corresponds to variant rs5761170 [ dbSNP | Ensembl ].
VAR_015867
Natural varianti835 – 8351A → G in a lung squamous cell carcinoma sample; somatic mutation. 1 Publication
VAR_015868
Natural varianti925 – 9251S → L.1 Publication
Corresponds to variant rs9624909 [ dbSNP | Ensembl ].
VAR_056193
Natural varianti1037 – 10371W → S.
Corresponds to variant rs17704912 [ dbSNP | Ensembl ].
VAR_056194
Natural varianti1095 – 10951R → L in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_015869
Natural varianti1119 – 11191H → Q.2 Publications
Corresponds to variant rs5761268 [ dbSNP | Ensembl ].
VAR_056195
Natural varianti1195 – 11951R → Q in a lung small cell carcinoma sample; somatic mutation. 1 Publication
VAR_015870
Natural varianti1238 – 12381P → Q in a lung large cell carcinoma sample; somatic mutation. 1 Publication
VAR_015871
Natural varianti1238 – 12381P → T in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_015872
Natural varianti1390 – 13901S → F.
Corresponds to variant rs35578357 [ dbSNP | Ensembl ].
VAR_056196
Natural varianti1399 – 13991I → V.
Corresponds to variant rs695633 [ dbSNP | Ensembl ].
VAR_056197
Natural varianti1444 – 14441S → T.
Corresponds to variant rs33928909 [ dbSNP | Ensembl ].
VAR_056198
Natural varianti1708 – 17081E → K in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_015873
Natural varianti1715 – 17151E → D in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_015874
Natural varianti1970 – 19701A → E in a lung small cell carcinoma sample; somatic mutation. 1 Publication
VAR_015875
Natural varianti2294 – 22941A → D.
Corresponds to variant rs35370367 [ dbSNP | Ensembl ].
VAR_056199
Natural varianti2295 – 22951G → C in a lung small cell carcinoma sample; somatic mutation. 1 Publication
VAR_015876
Natural varianti2347 – 23471Q → R.1 Publication
Corresponds to variant rs2236005 [ dbSNP | Ensembl ].
VAR_015877
Natural varianti2381 – 23811R → H in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_015878
Natural varianti2395 – 23951G → A.
Corresponds to variant rs6004901 [ dbSNP | Ensembl ].
VAR_056200
Natural varianti2513 – 25131G → S.
Corresponds to variant rs7284177 [ dbSNP | Ensembl ].
VAR_056201
Natural varianti2532 – 25321R → Q.
Corresponds to variant rs34875296 [ dbSNP | Ensembl ].
VAR_056202
Natural varianti2554 – 25541D → E in a lung large cell carcinoma sample; somatic mutation. 1 Publication
VAR_015879

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 487487Missing in isoform 2. 1 PublicationVSP_007764Add
BLAST
Alternative sequencei488 – 50316PAPQE…SRDSD → MGSGAICWFNLRDVGS in isoform 2. 1 PublicationVSP_007765Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075376 mRNA. Translation: BAC16363.1.
AB042648 mRNA. Translation: BAB55550.2.
AJ310931 mRNA. Translation: CAC70712.2.
AJ310932 Genomic DNA. Translation: CAC70714.3.
AY077700 mRNA. Translation: AAL75811.1.
Z98949 Genomic DNA. No translation available.
AL080245 Genomic DNA. No translation available.
AL022329 Genomic DNA. No translation available.
AL079300 Genomic DNA. No translation available.
BC144597 mRNA. Translation: AAI44598.1.
BC150626 mRNA. Translation: AAI50627.1.
AJ271918 mRNA. Translation: CAC81082.1.
AL833890 mRNA. Translation: CAD38746.1.
CCDSiCCDS54507.1. [Q8IUG5-1]
RefSeqiNP_115997.5. NM_032608.5.
UniGeneiHs.417959.

Genome annotation databases

EnsembliENST00000540454; ENSP00000441301; ENSG00000133454.
GeneIDi84700.
KEGGihsa:84700.
UCSCiuc003abz.1. human. [Q8IUG5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075376 mRNA. Translation: BAC16363.1.
AB042648 mRNA. Translation: BAB55550.2.
AJ310931 mRNA. Translation: CAC70712.2.
AJ310932 Genomic DNA. Translation: CAC70714.3.
AY077700 mRNA. Translation: AAL75811.1.
Z98949 Genomic DNA. No translation available.
AL080245 Genomic DNA. No translation available.
AL022329 Genomic DNA. No translation available.
AL079300 Genomic DNA. No translation available.
BC144597 mRNA. Translation: AAI44598.1.
BC150626 mRNA. Translation: AAI50627.1.
AJ271918 mRNA. Translation: CAC81082.1.
AL833890 mRNA. Translation: CAD38746.1.
CCDSiCCDS54507.1. [Q8IUG5-1]
RefSeqiNP_115997.5. NM_032608.5.
UniGeneiHs.417959.

3D structure databases

ProteinModelPortaliQ8IUG5.
SMRiQ8IUG5. Positions 505-1395.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124214. 2 interactions.
IntActiQ8IUG5. 3 interactions.
STRINGi9606.ENSP00000386096.

PTM databases

PhosphoSiteiQ8IUG5.

Polymorphism and mutation databases

BioMutaiMYO18B.
DMDMi32699565.

Proteomic databases

MaxQBiQ8IUG5.
PaxDbiQ8IUG5.
PRIDEiQ8IUG5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000540454; ENSP00000441301; ENSG00000133454.
GeneIDi84700.
KEGGihsa:84700.
UCSCiuc003abz.1. human. [Q8IUG5-1]

Organism-specific databases

CTDi84700.
GeneCardsiGC22P026138.
H-InvDBHIX0016319.
HGNCiHGNC:18150. MYO18B.
HPAiHPA000953.
MIMi607295. gene.
neXtProtiNX_Q8IUG5.
PharmGKBiPA38300.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5022.
HOVERGENiHBG052544.
InParanoidiQ8IUG5.
KOiK10362.
OrthoDBiEOG71P29W.
PhylomeDBiQ8IUG5.
TreeFamiTF339614.

Miscellaneous databases

GeneWikiiMYO18B.
GenomeRNAii84700.
NextBioi74784.
PROiQ8IUG5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IUG5.
CleanExiHS_MYO18B.
ExpressionAtlasiQ8IUG5. baseline.
GenevestigatoriQ8IUG5.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR028561. MYO18B.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR13140:SF254. PTHR13140:SF254. 1 hit.
PfamiPF00063. Myosin_head. 2 hits.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer."
    Nishioka M., Kohno T., Tani M., Yanaihara N., Tomizawa Y., Otsuka A., Sasaki S., Kobayashi K., Niki T., Maeshima A., Sekido Y., Minna J.D., Sone S., Yokota J.
    Proc. Natl. Acad. Sci. U.S.A. 99:12269-12274(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), VARIANTS VAL-234; ASN-347; GLN-379; CYS-389; MET-590; TRP-661; GLY-835; LEU-1095; GLN-1195; GLN-1238; THR-1238; LYS-1708; ASP-1715; GLU-1970; CYS-2295; HIS-2381 AND GLU-2554, POSSIBLE ROLE IN TUMOR SUPPRESSION.
    Tissue: Skeletal muscle.
  2. "Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation."
    Salamon M., Millino C., Raffaello A., Mongillo M., Sandri C., Bean C., Negrisolo E., Pallavicini A., Valle G., Zaccolo M., Schiaffino S., Lanfranchi G.
    J. Mol. Biol. 326:137-149(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), CHARACTERIZATION, VARIANT LEU-925.
    Tissue: Skeletal muscle.
  3. "Myosin-like gene expressed in human heart and muscle."
    Gu Y., Ji Y., Penn S.G., Hanzel D.K., Rank D.R., Chen W., Shannon M.E.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS CYS-547 AND GLN-1119.
  4. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT TRP-661.
  5. "Full-length sequencing of 100 cDNA clones from human adult skeletal muscle."
    Stanchi F., Lanfranchi G.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2343-2567.
    Tissue: Skeletal muscle.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS CYS-547; GLN-1119 AND ARG-2347.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2359-2567.
    Tissue: Testis.
  8. "Genetic alterations responsible for metastatic phenotypes of lung cancer cells."
    Yokota J., Nishioka M., Tani M., Kohno T.
    Clin. Exp. Metastasis 20:189-193(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE INVOLVEMENT IN SUPPRESSION OF CELL ANCHORAGE-INDEPENDENT GROWTH.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1829, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiMY18B_HUMAN
AccessioniPrimary (citable) accession number: Q8IUG5
Secondary accession number(s): B2RWP3
, F5GYU7, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: March 1, 2003
Last modified: April 29, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Frequently deleted, mutated, and hypermethylated in lung cancers.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.