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Q8IUG5

- MY18B_HUMAN

UniProt

Q8IUG5 - MY18B_HUMAN

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Protein
Unconventional myosin-XVIIIb
Gene
MYO18B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi660 – 6678ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. motor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-XVIIIb
Gene namesi
Name:MYO18B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:18150. MYO18B.

Subcellular locationi

Cytoplasm. Nucleus. Cytoplasmmyofibrilsarcomere
Note: Punctate pattern in undifferentiated myoblasts. Nuclear, on primary cardiomyocytes and adult muscle. A partial sarcomeric location was found in some cardiomyocytes.

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. sarcomere Source: UniProtKB-SubCell
  3. unconventional myosin complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38300.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 25672567Unconventional myosin-XVIIIb
PRO_0000123478Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1829 – 18291Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IUG5.
PaxDbiQ8IUG5.
PRIDEiQ8IUG5.

PTM databases

PhosphoSiteiQ8IUG5.

Expressioni

Tissue specificityi

Selectively expressed in cardiac and skeletal muscles. Weakly expressed in testis, pancreas, placenta, prostate, lung and thymus.

Developmental stagei

Reaches an expression peak in the third day after induction and remains at similar level during successive myotubule maturation.

Gene expression databases

ArrayExpressiQ8IUG5.
BgeeiQ8IUG5.
CleanExiHS_MYO18B.
GenevestigatoriQ8IUG5.

Organism-specific databases

HPAiHPA000953.

Interactioni

Subunit structurei

Homodimer. May interact with F actin through the GPA motif (Gly/Pro/Ala-rich).

Protein-protein interaction databases

BioGridi124214. 2 interactions.
IntActiQ8IUG5. 3 interactions.
STRINGi9606.ENSP00000386096.

Structurei

3D structure databases

ProteinModelPortaliQ8IUG5.
SMRiQ8IUG5. Positions 505-1395.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini571 – 1333763Myosin motor
Add
BLAST
Domaini1336 – 136530IQ
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1213 – 124028GPA Reviewed prediction
Add
BLAST
Regioni1426 – 2083658Tail
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1396 – 1783388 Reviewed prediction
Add
BLAST
Coiled coili1825 – 1961137 Reviewed prediction
Add
BLAST
Coiled coili2014 – 209077 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi71 – 11444Ser-rich
Add
BLAST
Compositional biasi799 – 8046Poly-Ala
Compositional biasi1217 – 12226Poly-Pro
Compositional biasi1643 – 1769127Gln-rich
Add
BLAST
Compositional biasi2506 – 25149Poly-Ser

Sequence similaritiesi

Contains 1 IQ domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5022.
HOVERGENiHBG052544.
KOiK10362.
OrthoDBiEOG71P29W.
PhylomeDBiQ8IUG5.
TreeFamiTF339614.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR028561. MYO18B.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR13140:SF254. PTHR13140:SF254. 1 hit.
PfamiPF00063. Myosin_head. 2 hits.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IUG5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAISSRLALW EQKIREEDKS PPPSSPPPLF SVIPGGFIKQ LVRGTEKEAK     50
EARQRKQLAV ASPEREIPEI SISQPNSKSS SGTRSGSQQI SQDDQSSSPG 100
SSDILGKESE GSRSPDPEQM TSINGEKAQE LGSSATPTKK TVPFKRGVRR 150
GDVLLMVAKL DPDSAKPEKT HPHDAPPCKT SPPATDTGKE KKGETSRTPC 200
GSQASTEILA PKAEKTRTGG LGDPGQGTVA LKKGEEGQSI VGKGLGTPKT 250
TELKEAEPQG KDRQGTRPQA QGPGEGVRPG KAEKEGAEPT NTVEKGNVSK 300
DVGSEGKHVR PQIPGRKWGG FLGRRSKWDG PQNKKDKEGV LLSKAEKTGE 350
PQTQMEKTSQ VQGELGDDLR MGEKAGELRS TTGKAGESWD KKEKMGQPQG 400
KSGNAGEARS QTEKGCEAPK EVSTMVESPA APGKGGWPGS RGQEAEEPCS 450
RAGDGAGALE TELEGPSQPA LEKDAERPRI RKENQDGPAP QEEGKGGQSR 500
DSDQAPEDRW YEAEKVWLAQ KDGFTLATVL KPDEGTADLP AGRVRLWIDA 550
DKTITEVDEE HVHRANPPEL DQVEDLASLI SVNESSVLNT LLQRYKAQLL 600
HTCTGPDLIV LQPRGPSVPS AGKVPKGRRD GLPAHIGSMA QRAYWALLNQ 650
RRDQSIVALG RSGAGKTTCC EQVLEHLVGM AGSVDGRVSV EKIRATFTVL 700
RAFGSVSMAH SRSATRFSMV MSLDFNATGR ITAAQLQTML LEKSRVARQP 750
EGESNFLVFS QMLAGLDLDL RTELNLHQMA DSSSFGMGVW SKPEDKQKAA 800
AAFAQLQGAM EMLGISESEQ RAVWRVLAAI YHLGAAGACK VGRKQFMRFE 850
WANYAAEALG CEYEELNTAT FKHHLRQIIQ QMTFGPSRWG LEDEETSSGL 900
KMTGVDCVEG MASGLYQELF AAVVSLINRS FSSHHLSMAS IMVVDSPGFQ 950
NPRHQGKDRA ATFEELCHNY AHERLQLLFY QRTFVSTLQR YQEEGVPVQF 1000
DLPDPSPGTT VAVVDQNPSQ VRLPAGGGAQ DARGLFWVLD EEVHVEGSSD 1050
SVVLERLCAA FEKKGAGTEG SSALRTCEQP LQCEIFHQLG WDPVRYDLTG 1100
WLHRAKPNLS ALDAPQVLHQ SKREELRSLF QARAKLPPVC RAVAGLEGTS 1150
QQALQRSRMV RRTFASSLAA VRRKAPCSQI KLQMDALTSM IKRSRLHFIH 1200
CLVPNPVVES RSGQESPPPP QPGRDKPGAG GPLALDIPAL RVQLAGFHIL 1250
EALRLHRTGY ADHMGLTRFR RQFQVLDAPL LKKLMSTSEG IDERKAVEEL 1300
LETLDLEKKA VAVGHSQVFL KAGVISRLEK QREKLVSQSI VLFQAACKGF 1350
LSRQEFKKLK IRRLAAQCIQ KNVAVFLAVK DWPWWQLLGS LQPLLSATIG 1400
TEQLRAKEEE LTTLRRKLEK SEKLRNELRQ NTDLLESKIA DLTSDLADER 1450
FKGDVACQVL ESERAERLQA FREVQELKSK HEQVQKKLGD VNKQLEEAQQ 1500
KIQLNDLERN PTGGADEWQM RFDCAQMENE FLRKRLQQCE ERLDSELTAR 1550
KELEQKLGEL QSAYDGAKKM AHQLKRKCHH LTCDLEDTCV LLENQQSRNH 1600
ELEKKQKKFD LQLAQALGES VFEKGLREKV TQENTSVRWE LGQLQQQLKQ 1650
KEQEASQLKQ QVEMLQDHKR ELLGSPSLGE NCVAGLKERL WKLESSALEQ 1700
QKIQSQQENT IKQLEQLRQR FELEIERMKQ MHQKDREDQE EELEDVRQSC 1750
QKRLHQLEMQ LEQEYEEKQM VLHEKQDLEG LIGTLCDQIG HRDFDVEKRL 1800
RRDLRRTHAL LSDVQLLLGT MEDGKTSVSK EELEKVHSQL EQSEAKCEEA 1850
LKTQKVLTAD LESMHSELEN MTRNKSLVDE QLYRLQFEKA DLLKRIDEDQ 1900
DDLNELMQKH KDLIAQSAAD IGQIQELQLQ LEEAKKEKHK LQEQLQVAQM 1950
RIEYLEQSTV DRAIVSRQEA VICDLENKTE FQKVQIKRFE VLVIRLRDSL 2000
IKMGEELSQA ATSESQQRES SQYYQRRLEE LKADMEELVQ REAEASRRCM 2050
ELEKYVEELA AVRQTLQTDL ETSIRRIADL QAALEEVASS DSDTESVQTA 2100
VDCGSSGRKE MDNVSILSSQ PEGSLQSWLS CTLSLATDTM RTPSRQSATS 2150
SRILSPRINE EAGDTERTQS ALALSRARST NVHSKTSGDK PVSPHFVRRQ 2200
KYCHFGDGEV LAVQRKSTER LEPASSPLAS RSTNTSPLSR EKLPSPSAAL 2250
SEFVEGLRRK RAQRGQGSTL GLEDWPTLPI YQTTGASTLR RGRAGSDEGN 2300
LSLRVGAKSP LEIEGAAGGL LRSTSLKCIS SDGVGGTTLL PEKSKTQFSS 2350
CESLLESRPS MGRKLSSPTT PRDMLLSPTL RPRRRCLESS VDDAGCPDLG 2400
KEPLVFQNRQ FAHLMEEPLG SDPFSWKLPS LDYERKTKVD FDDFLPAIRK 2450
PQTPTSLAGS AKGGQDGSQR SSIHFETEEA NRSFLSGIKT ILKKSPEPKE 2500
DPAHLSDSSS SSGSIVSFKS ADSIKSRPGI PRLAGDGGER TSPERREPGT 2550
GRKDDDVASI MKKYLQK 2567
Length:2,567
Mass (Da):285,185
Last modified:March 1, 2003 - v1
Checksum:i9ABC2F64C644F110
GO
Isoform 2 (identifier: Q8IUG5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-487: Missing.
     488-503: PAPQEEGKGGQSRDSD → MGSGAICWFNLRDVGS

Note: No experimental confirmation available.

Show »
Length:2,080
Mass (Da):233,671
Checksum:iF7ABF4EF5BD30755
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti44 – 441G → E.
Corresponds to variant rs133885 [ dbSNP | Ensembl ].
VAR_056190
Natural varianti177 – 1771P → L.
Corresponds to variant rs13058434 [ dbSNP | Ensembl ].
VAR_056191
Natural varianti234 – 2341G → V in a lung small cell carcinoma sample; somatic mutation. 1 Publication
VAR_015862
Natural varianti347 – 3471K → N in a lung small cell carcinoma sample; somatic mutation. 1 Publication
VAR_015863
Natural varianti379 – 3791R → Q in a lung small cell carcinoma sample; somatic mutation. 1 Publication
VAR_015864
Natural varianti389 – 3891W → C in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_015865
Natural varianti547 – 5471W → C.2 Publications
Corresponds to variant rs3859866 [ dbSNP | Ensembl ].
VAR_056192
Natural varianti590 – 5901T → M in a lung large cell carcinoma sample; somatic mutation. 1 Publication
VAR_015866
Natural varianti661 – 6611R → W in a lung adenocarcinoma sample; somatic mutation. 2 Publications
Corresponds to variant rs5761170 [ dbSNP | Ensembl ].
VAR_015867
Natural varianti835 – 8351A → G in a lung squamous cell carcinoma sample; somatic mutation. 1 Publication
VAR_015868
Natural varianti925 – 9251S → L.1 Publication
Corresponds to variant rs9624909 [ dbSNP | Ensembl ].
VAR_056193
Natural varianti1037 – 10371W → S.
Corresponds to variant rs17704912 [ dbSNP | Ensembl ].
VAR_056194
Natural varianti1095 – 10951R → L in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_015869
Natural varianti1119 – 11191H → Q.2 Publications
Corresponds to variant rs5761268 [ dbSNP | Ensembl ].
VAR_056195
Natural varianti1195 – 11951R → Q in a lung small cell carcinoma sample; somatic mutation. 1 Publication
VAR_015870
Natural varianti1238 – 12381P → Q in a lung large cell carcinoma sample; somatic mutation. 1 Publication
VAR_015871
Natural varianti1238 – 12381P → T in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_015872
Natural varianti1390 – 13901S → F.
Corresponds to variant rs35578357 [ dbSNP | Ensembl ].
VAR_056196
Natural varianti1399 – 13991I → V.
Corresponds to variant rs695633 [ dbSNP | Ensembl ].
VAR_056197
Natural varianti1444 – 14441S → T.
Corresponds to variant rs33928909 [ dbSNP | Ensembl ].
VAR_056198
Natural varianti1708 – 17081E → K in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_015873
Natural varianti1715 – 17151E → D in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_015874
Natural varianti1970 – 19701A → E in a lung small cell carcinoma sample; somatic mutation. 1 Publication
VAR_015875
Natural varianti2294 – 22941A → D.
Corresponds to variant rs35370367 [ dbSNP | Ensembl ].
VAR_056199
Natural varianti2295 – 22951G → C in a lung small cell carcinoma sample; somatic mutation. 1 Publication
VAR_015876
Natural varianti2347 – 23471Q → R.1 Publication
Corresponds to variant rs2236005 [ dbSNP | Ensembl ].
VAR_015877
Natural varianti2381 – 23811R → H in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_015878
Natural varianti2395 – 23951G → A.
Corresponds to variant rs6004901 [ dbSNP | Ensembl ].
VAR_056200
Natural varianti2513 – 25131G → S.
Corresponds to variant rs7284177 [ dbSNP | Ensembl ].
VAR_056201
Natural varianti2532 – 25321R → Q.
Corresponds to variant rs34875296 [ dbSNP | Ensembl ].
VAR_056202
Natural varianti2554 – 25541D → E in a lung large cell carcinoma sample; somatic mutation. 1 Publication
VAR_015879

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 487487Missing in isoform 2.
VSP_007764Add
BLAST
Alternative sequencei488 – 50316PAPQE…SRDSD → MGSGAICWFNLRDVGS in isoform 2.
VSP_007765Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31I → M in CAC70712. 1 Publication
Sequence conflicti828 – 8281A → T in AAI50627. 1 Publication
Sequence conflicti828 – 8281A → T in AAI44598. 1 Publication
Sequence conflicti1020 – 10201Q → QQ in AAL75811. 1 Publication
Sequence conflicti1060 – 10601A → T in AAL75811. 1 Publication
Sequence conflicti1510 – 15101N → D in AAL75811. 1 Publication
Sequence conflicti1515 – 15151Missing in AAI50627. 1 Publication
Sequence conflicti1515 – 15151Missing in AAI44598. 1 Publication
Sequence conflicti2343 – 23442KS → LT1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB075376 mRNA. Translation: BAC16363.1.
AB042648 mRNA. Translation: BAB55550.2.
AJ310931 mRNA. Translation: CAC70712.2.
AJ310932 Genomic DNA. Translation: CAC70714.3.
AY077700 mRNA. Translation: AAL75811.1.
Z98949 Genomic DNA. No translation available.
AL080245 Genomic DNA. No translation available.
AL022329 Genomic DNA. No translation available.
AL079300 Genomic DNA. No translation available.
BC144597 mRNA. Translation: AAI44598.1.
BC150626 mRNA. Translation: AAI50627.1.
AJ271918 mRNA. Translation: CAC81082.1.
AL833890 mRNA. Translation: CAD38746.1.
CCDSiCCDS54507.1. [Q8IUG5-1]
RefSeqiNP_115997.5. NM_032608.5.
UniGeneiHs.417959.

Genome annotation databases

EnsembliENST00000540454; ENSP00000441301; ENSG00000133454.
GeneIDi84700.
KEGGihsa:84700.
UCSCiuc003abz.1. human. [Q8IUG5-1]

Polymorphism databases

DMDMi32699565.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB075376 mRNA. Translation: BAC16363.1 .
AB042648 mRNA. Translation: BAB55550.2 .
AJ310931 mRNA. Translation: CAC70712.2 .
AJ310932 Genomic DNA. Translation: CAC70714.3 .
AY077700 mRNA. Translation: AAL75811.1 .
Z98949 Genomic DNA. No translation available.
AL080245 Genomic DNA. No translation available.
AL022329 Genomic DNA. No translation available.
AL079300 Genomic DNA. No translation available.
BC144597 mRNA. Translation: AAI44598.1 .
BC150626 mRNA. Translation: AAI50627.1 .
AJ271918 mRNA. Translation: CAC81082.1 .
AL833890 mRNA. Translation: CAD38746.1 .
CCDSi CCDS54507.1. [Q8IUG5-1 ]
RefSeqi NP_115997.5. NM_032608.5.
UniGenei Hs.417959.

3D structure databases

ProteinModelPortali Q8IUG5.
SMRi Q8IUG5. Positions 505-1395.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124214. 2 interactions.
IntActi Q8IUG5. 3 interactions.
STRINGi 9606.ENSP00000386096.

PTM databases

PhosphoSitei Q8IUG5.

Polymorphism databases

DMDMi 32699565.

Proteomic databases

MaxQBi Q8IUG5.
PaxDbi Q8IUG5.
PRIDEi Q8IUG5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000540454 ; ENSP00000441301 ; ENSG00000133454 .
GeneIDi 84700.
KEGGi hsa:84700.
UCSCi uc003abz.1. human. [Q8IUG5-1 ]

Organism-specific databases

CTDi 84700.
GeneCardsi GC22P026138.
H-InvDB HIX0016319.
HGNCi HGNC:18150. MYO18B.
HPAi HPA000953.
MIMi 607295. gene.
neXtProti NX_Q8IUG5.
PharmGKBi PA38300.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5022.
HOVERGENi HBG052544.
KOi K10362.
OrthoDBi EOG71P29W.
PhylomeDBi Q8IUG5.
TreeFami TF339614.

Miscellaneous databases

GeneWikii MYO18B.
GenomeRNAii 84700.
NextBioi 74784.
PROi Q8IUG5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8IUG5.
Bgeei Q8IUG5.
CleanExi HS_MYO18B.
Genevestigatori Q8IUG5.

Family and domain databases

Gene3Di 4.10.270.10. 1 hit.
InterProi IPR000048. IQ_motif_EF-hand-BS.
IPR028561. MYO18B.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR13140:SF254. PTHR13140:SF254. 1 hit.
Pfami PF00063. Myosin_head. 2 hits.
[Graphical view ]
PRINTSi PR00193. MYOSINHEAVY.
SMARTi SM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer."
    Nishioka M., Kohno T., Tani M., Yanaihara N., Tomizawa Y., Otsuka A., Sasaki S., Kobayashi K., Niki T., Maeshima A., Sekido Y., Minna J.D., Sone S., Yokota J.
    Proc. Natl. Acad. Sci. U.S.A. 99:12269-12274(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), VARIANTS VAL-234; ASN-347; GLN-379; CYS-389; MET-590; TRP-661; GLY-835; LEU-1095; GLN-1195; GLN-1238; THR-1238; LYS-1708; ASP-1715; GLU-1970; CYS-2295; HIS-2381 AND GLU-2554, POSSIBLE ROLE IN TUMOR SUPPRESSION.
    Tissue: Skeletal muscle.
  2. "Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation."
    Salamon M., Millino C., Raffaello A., Mongillo M., Sandri C., Bean C., Negrisolo E., Pallavicini A., Valle G., Zaccolo M., Schiaffino S., Lanfranchi G.
    J. Mol. Biol. 326:137-149(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), CHARACTERIZATION, VARIANT LEU-925.
    Tissue: Skeletal muscle.
  3. "Myosin-like gene expressed in human heart and muscle."
    Gu Y., Ji Y., Penn S.G., Hanzel D.K., Rank D.R., Chen W., Shannon M.E.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS CYS-547 AND GLN-1119.
  4. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT TRP-661.
  5. "Full-length sequencing of 100 cDNA clones from human adult skeletal muscle."
    Stanchi F., Lanfranchi G.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2343-2567.
    Tissue: Skeletal muscle.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS CYS-547; GLN-1119 AND ARG-2347.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2359-2567.
    Tissue: Testis.
  8. "Genetic alterations responsible for metastatic phenotypes of lung cancer cells."
    Yokota J., Nishioka M., Tani M., Kohno T.
    Clin. Exp. Metastasis 20:189-193(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE INVOLVEMENT IN SUPPRESSION OF CELL ANCHORAGE-INDEPENDENT GROWTH.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1829, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiMY18B_HUMAN
AccessioniPrimary (citable) accession number: Q8IUG5
Secondary accession number(s): B2RWP3
, F5GYU7, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Frequently deleted, mutated, and hypermethylated in lung cancers.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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