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Q8IUG5 (MY18B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Unconventional myosin-XVIIIb
Gene names
Name:MYO18B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2567 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth. Ref.1

Subunit structure

Homodimer. May interact with F actin through the GPA motif (Gly/Pro/Ala-rich).

Subcellular location

Cytoplasm. Nucleus. Cytoplasmmyofibrilsarcomere. Note: Punctate pattern in undifferentiated myoblasts. Nuclear, on primary cardiomyocytes and adult muscle. A partial sarcomeric location was found in some cardiomyocytes.

Tissue specificity

Selectively expressed in cardiac and skeletal muscles. Weakly expressed in testis, pancreas, placenta, prostate, lung and thymus.

Developmental stage

Reaches an expression peak in the third day after induction and remains at similar level during successive myotubule maturation.

Miscellaneous

Frequently deleted, mutated, and hypermethylated in lung cancers.

Sequence similarities

Contains 1 IQ domain.

Contains 1 myosin head-like domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   LigandActin-binding
ATP-binding
Nucleotide-binding
   Molecular functionMotor protein
Myosin
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

sarcomere

Inferred from electronic annotation. Source: UniProtKB-SubCell

unconventional myosin complex

Inferred from direct assay Ref.2. Source: UniProtKB

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

motor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IUG5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IUG5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-487: Missing.
     488-503: PAPQEEGKGGQSRDSD → MGSGAICWFNLRDVGS
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 25672567Unconventional myosin-XVIIIb
PRO_0000123478

Regions

Domain573 – 1321749Myosin head-like
Domain1336 – 136530IQ
Nucleotide binding660 – 6678ATP Potential
Region1213 – 124028GPA Potential
Region1426 – 2083658Tail
Coiled coil1396 – 1783388 Potential
Coiled coil1825 – 1961137 Potential
Coiled coil2014 – 209077 Potential
Compositional bias71 – 11444Ser-rich
Compositional bias799 – 8046Poly-Ala
Compositional bias1217 – 12226Poly-Pro
Compositional bias1643 – 1769127Gln-rich
Compositional bias2506 – 25149Poly-Ser

Amino acid modifications

Modified residue18291Phosphoserine Ref.10

Natural variations

Alternative sequence1 – 487487Missing in isoform 2.
VSP_007764
Alternative sequence488 – 50316PAPQE…SRDSD → MGSGAICWFNLRDVGS in isoform 2.
VSP_007765
Natural variant441G → E.
Corresponds to variant rs133885 [ dbSNP | Ensembl ].
VAR_056190
Natural variant1771P → L.
Corresponds to variant rs13058434 [ dbSNP | Ensembl ].
VAR_056191
Natural variant2341G → V in a lung small cell carcinoma sample; somatic mutation. Ref.1
VAR_015862
Natural variant3471K → N in a lung small cell carcinoma sample; somatic mutation. Ref.1
VAR_015863
Natural variant3791R → Q in a lung small cell carcinoma sample; somatic mutation. Ref.1
VAR_015864
Natural variant3891W → C in a lung adenocarcinoma sample; somatic mutation. Ref.1
VAR_015865
Natural variant5471W → C. Ref.3 Ref.6
Corresponds to variant rs3859866 [ dbSNP | Ensembl ].
VAR_056192
Natural variant5901T → M in a lung large cell carcinoma sample; somatic mutation. Ref.1
VAR_015866
Natural variant6611R → W in a lung adenocarcinoma sample; somatic mutation. Ref.1 Ref.4
Corresponds to variant rs5761170 [ dbSNP | Ensembl ].
VAR_015867
Natural variant8351A → G in a lung squamous cell carcinoma sample; somatic mutation. Ref.1
VAR_015868
Natural variant9251S → L. Ref.2
Corresponds to variant rs9624909 [ dbSNP | Ensembl ].
VAR_056193
Natural variant10371W → S.
Corresponds to variant rs17704912 [ dbSNP | Ensembl ].
VAR_056194
Natural variant10951R → L in a lung adenocarcinoma sample; somatic mutation. Ref.1
VAR_015869
Natural variant11191H → Q. Ref.3 Ref.6
Corresponds to variant rs5761268 [ dbSNP | Ensembl ].
VAR_056195
Natural variant11951R → Q in a lung small cell carcinoma sample; somatic mutation. Ref.1
VAR_015870
Natural variant12381P → Q in a lung large cell carcinoma sample; somatic mutation. Ref.1
VAR_015871
Natural variant12381P → T in a lung adenocarcinoma sample; somatic mutation. Ref.1
VAR_015872
Natural variant13901S → F.
Corresponds to variant rs35578357 [ dbSNP | Ensembl ].
VAR_056196
Natural variant13991I → V.
Corresponds to variant rs695633 [ dbSNP | Ensembl ].
VAR_056197
Natural variant14441S → T.
Corresponds to variant rs33928909 [ dbSNP | Ensembl ].
VAR_056198
Natural variant17081E → K in a lung adenocarcinoma sample; somatic mutation. Ref.1
VAR_015873
Natural variant17151E → D in a lung adenocarcinoma sample; somatic mutation. Ref.1
VAR_015874
Natural variant19701A → E in a lung small cell carcinoma sample; somatic mutation. Ref.1
VAR_015875
Natural variant22941A → D.
Corresponds to variant rs35370367 [ dbSNP | Ensembl ].
VAR_056199
Natural variant22951G → C in a lung small cell carcinoma sample; somatic mutation. Ref.1
VAR_015876
Natural variant23471Q → R. Ref.6
Corresponds to variant rs2236005 [ dbSNP | Ensembl ].
VAR_015877
Natural variant23811R → H in a lung adenocarcinoma sample; somatic mutation. Ref.1
VAR_015878
Natural variant23951G → A.
Corresponds to variant rs6004901 [ dbSNP | Ensembl ].
VAR_056200
Natural variant25131G → S.
Corresponds to variant rs7284177 [ dbSNP | Ensembl ].
VAR_056201
Natural variant25321R → Q.
Corresponds to variant rs34875296 [ dbSNP | Ensembl ].
VAR_056202
Natural variant25541D → E in a lung large cell carcinoma sample; somatic mutation. Ref.1
VAR_015879

Experimental info

Sequence conflict31I → M in CAC70712. Ref.2
Sequence conflict8281A → T in AAI50627. Ref.6
Sequence conflict8281A → T in AAI44598. Ref.6
Sequence conflict10201Q → QQ in AAL75811. Ref.3
Sequence conflict10601A → T in AAL75811. Ref.3
Sequence conflict15101N → D in AAL75811. Ref.3
Sequence conflict15151Missing in AAI50627. Ref.6
Sequence conflict15151Missing in AAI44598. Ref.6
Sequence conflict2343 – 23442KS → LT Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 9ABC2F64C644F110

FASTA2,567285,185
        10         20         30         40         50         60 
MAISSRLALW EQKIREEDKS PPPSSPPPLF SVIPGGFIKQ LVRGTEKEAK EARQRKQLAV 

        70         80         90        100        110        120 
ASPEREIPEI SISQPNSKSS SGTRSGSQQI SQDDQSSSPG SSDILGKESE GSRSPDPEQM 

       130        140        150        160        170        180 
TSINGEKAQE LGSSATPTKK TVPFKRGVRR GDVLLMVAKL DPDSAKPEKT HPHDAPPCKT 

       190        200        210        220        230        240 
SPPATDTGKE KKGETSRTPC GSQASTEILA PKAEKTRTGG LGDPGQGTVA LKKGEEGQSI 

       250        260        270        280        290        300 
VGKGLGTPKT TELKEAEPQG KDRQGTRPQA QGPGEGVRPG KAEKEGAEPT NTVEKGNVSK 

       310        320        330        340        350        360 
DVGSEGKHVR PQIPGRKWGG FLGRRSKWDG PQNKKDKEGV LLSKAEKTGE PQTQMEKTSQ 

       370        380        390        400        410        420 
VQGELGDDLR MGEKAGELRS TTGKAGESWD KKEKMGQPQG KSGNAGEARS QTEKGCEAPK 

       430        440        450        460        470        480 
EVSTMVESPA APGKGGWPGS RGQEAEEPCS RAGDGAGALE TELEGPSQPA LEKDAERPRI 

       490        500        510        520        530        540 
RKENQDGPAP QEEGKGGQSR DSDQAPEDRW YEAEKVWLAQ KDGFTLATVL KPDEGTADLP 

       550        560        570        580        590        600 
AGRVRLWIDA DKTITEVDEE HVHRANPPEL DQVEDLASLI SVNESSVLNT LLQRYKAQLL 

       610        620        630        640        650        660 
HTCTGPDLIV LQPRGPSVPS AGKVPKGRRD GLPAHIGSMA QRAYWALLNQ RRDQSIVALG 

       670        680        690        700        710        720 
RSGAGKTTCC EQVLEHLVGM AGSVDGRVSV EKIRATFTVL RAFGSVSMAH SRSATRFSMV 

       730        740        750        760        770        780 
MSLDFNATGR ITAAQLQTML LEKSRVARQP EGESNFLVFS QMLAGLDLDL RTELNLHQMA 

       790        800        810        820        830        840 
DSSSFGMGVW SKPEDKQKAA AAFAQLQGAM EMLGISESEQ RAVWRVLAAI YHLGAAGACK 

       850        860        870        880        890        900 
VGRKQFMRFE WANYAAEALG CEYEELNTAT FKHHLRQIIQ QMTFGPSRWG LEDEETSSGL 

       910        920        930        940        950        960 
KMTGVDCVEG MASGLYQELF AAVVSLINRS FSSHHLSMAS IMVVDSPGFQ NPRHQGKDRA 

       970        980        990       1000       1010       1020 
ATFEELCHNY AHERLQLLFY QRTFVSTLQR YQEEGVPVQF DLPDPSPGTT VAVVDQNPSQ 

      1030       1040       1050       1060       1070       1080 
VRLPAGGGAQ DARGLFWVLD EEVHVEGSSD SVVLERLCAA FEKKGAGTEG SSALRTCEQP 

      1090       1100       1110       1120       1130       1140 
LQCEIFHQLG WDPVRYDLTG WLHRAKPNLS ALDAPQVLHQ SKREELRSLF QARAKLPPVC 

      1150       1160       1170       1180       1190       1200 
RAVAGLEGTS QQALQRSRMV RRTFASSLAA VRRKAPCSQI KLQMDALTSM IKRSRLHFIH 

      1210       1220       1230       1240       1250       1260 
CLVPNPVVES RSGQESPPPP QPGRDKPGAG GPLALDIPAL RVQLAGFHIL EALRLHRTGY 

      1270       1280       1290       1300       1310       1320 
ADHMGLTRFR RQFQVLDAPL LKKLMSTSEG IDERKAVEEL LETLDLEKKA VAVGHSQVFL 

      1330       1340       1350       1360       1370       1380 
KAGVISRLEK QREKLVSQSI VLFQAACKGF LSRQEFKKLK IRRLAAQCIQ KNVAVFLAVK 

      1390       1400       1410       1420       1430       1440 
DWPWWQLLGS LQPLLSATIG TEQLRAKEEE LTTLRRKLEK SEKLRNELRQ NTDLLESKIA 

      1450       1460       1470       1480       1490       1500 
DLTSDLADER FKGDVACQVL ESERAERLQA FREVQELKSK HEQVQKKLGD VNKQLEEAQQ 

      1510       1520       1530       1540       1550       1560 
KIQLNDLERN PTGGADEWQM RFDCAQMENE FLRKRLQQCE ERLDSELTAR KELEQKLGEL 

      1570       1580       1590       1600       1610       1620 
QSAYDGAKKM AHQLKRKCHH LTCDLEDTCV LLENQQSRNH ELEKKQKKFD LQLAQALGES 

      1630       1640       1650       1660       1670       1680 
VFEKGLREKV TQENTSVRWE LGQLQQQLKQ KEQEASQLKQ QVEMLQDHKR ELLGSPSLGE 

      1690       1700       1710       1720       1730       1740 
NCVAGLKERL WKLESSALEQ QKIQSQQENT IKQLEQLRQR FELEIERMKQ MHQKDREDQE 

      1750       1760       1770       1780       1790       1800 
EELEDVRQSC QKRLHQLEMQ LEQEYEEKQM VLHEKQDLEG LIGTLCDQIG HRDFDVEKRL 

      1810       1820       1830       1840       1850       1860 
RRDLRRTHAL LSDVQLLLGT MEDGKTSVSK EELEKVHSQL EQSEAKCEEA LKTQKVLTAD 

      1870       1880       1890       1900       1910       1920 
LESMHSELEN MTRNKSLVDE QLYRLQFEKA DLLKRIDEDQ DDLNELMQKH KDLIAQSAAD 

      1930       1940       1950       1960       1970       1980 
IGQIQELQLQ LEEAKKEKHK LQEQLQVAQM RIEYLEQSTV DRAIVSRQEA VICDLENKTE 

      1990       2000       2010       2020       2030       2040 
FQKVQIKRFE VLVIRLRDSL IKMGEELSQA ATSESQQRES SQYYQRRLEE LKADMEELVQ 

      2050       2060       2070       2080       2090       2100 
REAEASRRCM ELEKYVEELA AVRQTLQTDL ETSIRRIADL QAALEEVASS DSDTESVQTA 

      2110       2120       2130       2140       2150       2160 
VDCGSSGRKE MDNVSILSSQ PEGSLQSWLS CTLSLATDTM RTPSRQSATS SRILSPRINE 

      2170       2180       2190       2200       2210       2220 
EAGDTERTQS ALALSRARST NVHSKTSGDK PVSPHFVRRQ KYCHFGDGEV LAVQRKSTER 

      2230       2240       2250       2260       2270       2280 
LEPASSPLAS RSTNTSPLSR EKLPSPSAAL SEFVEGLRRK RAQRGQGSTL GLEDWPTLPI 

      2290       2300       2310       2320       2330       2340 
YQTTGASTLR RGRAGSDEGN LSLRVGAKSP LEIEGAAGGL LRSTSLKCIS SDGVGGTTLL 

      2350       2360       2370       2380       2390       2400 
PEKSKTQFSS CESLLESRPS MGRKLSSPTT PRDMLLSPTL RPRRRCLESS VDDAGCPDLG 

      2410       2420       2430       2440       2450       2460 
KEPLVFQNRQ FAHLMEEPLG SDPFSWKLPS LDYERKTKVD FDDFLPAIRK PQTPTSLAGS 

      2470       2480       2490       2500       2510       2520 
AKGGQDGSQR SSIHFETEEA NRSFLSGIKT ILKKSPEPKE DPAHLSDSSS SSGSIVSFKS 

      2530       2540       2550       2560 
ADSIKSRPGI PRLAGDGGER TSPERREPGT GRKDDDVASI MKKYLQK 

« Hide

Isoform 2 [UniParc].

Checksum: F7ABF4EF5BD30755
Show »

FASTA2,080233,671

References

« Hide 'large scale' references
[1]"MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer."
Nishioka M., Kohno T., Tani M., Yanaihara N., Tomizawa Y., Otsuka A., Sasaki S., Kobayashi K., Niki T., Maeshima A., Sekido Y., Minna J.D., Sone S., Yokota J.
Proc. Natl. Acad. Sci. U.S.A. 99:12269-12274(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), VARIANTS VAL-234; ASN-347; GLN-379; CYS-389; MET-590; TRP-661; GLY-835; LEU-1095; GLN-1195; GLN-1238; THR-1238; LYS-1708; ASP-1715; GLU-1970; CYS-2295; HIS-2381 AND GLU-2554, POSSIBLE ROLE IN TUMOR SUPPRESSION.
Tissue: Skeletal muscle.
[2]"Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation."
Salamon M., Millino C., Raffaello A., Mongillo M., Sandri C., Bean C., Negrisolo E., Pallavicini A., Valle G., Zaccolo M., Schiaffino S., Lanfranchi G.
J. Mol. Biol. 326:137-149(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), CHARACTERIZATION, VARIANT LEU-925.
Tissue: Skeletal muscle.
[3]"Myosin-like gene expressed in human heart and muscle."
Gu Y., Ji Y., Penn S.G., Hanzel D.K., Rank D.R., Chen W., Shannon M.E.
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS CYS-547 AND GLN-1119.
[4]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT TRP-661.
[5]"Full-length sequencing of 100 cDNA clones from human adult skeletal muscle."
Stanchi F., Lanfranchi G.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2343-2567.
Tissue: Skeletal muscle.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS CYS-547; GLN-1119 AND ARG-2347.
[7]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2359-2567.
Tissue: Testis.
[8]"Genetic alterations responsible for metastatic phenotypes of lung cancer cells."
Yokota J., Nishioka M., Tani M., Kohno T.
Clin. Exp. Metastasis 20:189-193(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: POSSIBLE INVOLVEMENT IN SUPPRESSION OF CELL ANCHORAGE-INDEPENDENT GROWTH.
[9]"Phosphoproteome of resting human platelets."
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A.
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Platelet.
[10]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1829, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB075376 mRNA. Translation: BAC16363.1.
AB042648 mRNA. Translation: BAB55550.2.
AJ310931 mRNA. Translation: CAC70712.2.
AJ310932 Genomic DNA. Translation: CAC70714.3.
AY077700 mRNA. Translation: AAL75811.1.
Z98949 Genomic DNA. No translation available.
AL080245 Genomic DNA. No translation available.
AL022329 Genomic DNA. No translation available.
AL079300 Genomic DNA. No translation available.
BC144597 mRNA. Translation: AAI44598.1.
BC150626 mRNA. Translation: AAI50627.1.
AJ271918 mRNA. Translation: CAC81082.1.
AL833890 mRNA. Translation: CAD38746.1.
RefSeqNP_115997.5. NM_032608.5.
UniGeneHs.417959.

3D structure databases

ProteinModelPortalQ8IUG5.
SMRQ8IUG5. Positions 512-1395.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124214. 2 interactions.
IntActQ8IUG5. 3 interactions.
STRING9606.ENSP00000386096.

PTM databases

PhosphoSiteQ8IUG5.

Polymorphism databases

DMDM32699565.

Proteomic databases

PaxDbQ8IUG5.
PRIDEQ8IUG5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000540454; ENSP00000441301; ENSG00000133454.
GeneID84700.
KEGGhsa:84700.
UCSCuc003abz.1. human. [Q8IUG5-1]

Organism-specific databases

CTD84700.
GeneCardsGC22P026138.
H-InvDBHIX0016319.
HGNCHGNC:18150. MYO18B.
HPAHPA000953.
MIM607295. gene.
neXtProtNX_Q8IUG5.
PharmGKBPA38300.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5022.
HOVERGENHBG052544.
KOK10362.
OrthoDBEOG71P29W.
PhylomeDBQ8IUG5.
TreeFamTF339614.

Gene expression databases

ArrayExpressQ8IUG5.
BgeeQ8IUG5.
CleanExHS_MYO18B.
GenevestigatorQ8IUG5.

Family and domain databases

Gene3D4.10.270.10. 1 hit.
InterProIPR000048. IQ_motif_EF-hand-BS.
IPR028561. MYO18A/B.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR13140:SF14. PTHR13140:SF14. 1 hit.
PfamPF00063. Myosin_head. 2 hits.
[Graphical view]
PRINTSPR00193. MYOSINHEAVY.
SMARTSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS50096. IQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMYO18B.
GenomeRNAi84700.
NextBio74784.
PROQ8IUG5.
SOURCESearch...

Entry information

Entry nameMY18B_HUMAN
AccessionPrimary (citable) accession number: Q8IUG5
Secondary accession number(s): B2RWP3 expand/collapse secondary AC list , F5GYU7, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM