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Q8IUF8

- MINA_HUMAN

UniProt

Q8IUF8 - MINA_HUMAN

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Protein

Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA

Gene

MINA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.8 Publications

Catalytic activityi

L-histidine-[60S ribosomal protein L27a] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidine-[60S ribosomal protein L27a] + succinate + CO2.1 Publication

Cofactori

Binds 1 Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi179 – 1791Iron; catalyticCurated
Metal bindingi181 – 1811Iron; catalyticPROSITE-ProRule annotation
Metal bindingi240 – 2401Iron; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. dioxygenase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription Source: Ensembl

GO - Biological processi

  1. ribosome biogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Ribosome biogenesis, Transcription, Transcription regulation

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA (EC:1.14.11.-)
Alternative name(s):
60S ribosomal protein L27a histidine hydroxylase
Histone lysine demethylase MINA
MYC-induced nuclear antigen
Mineral dust-induced gene protein
Nucleolar protein 52
Ribosomal oxygenase MINA
Short name:
ROX
Gene namesi
Name:MINAImported
Synonyms:MDIGImported, MINA53Imported, NO52Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:19441. MINA.

Subcellular locationi

Nucleus 2 Publications. Nucleusnucleolus 2 Publications

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytosol Source: Ensembl
  3. nucleolus Source: HPA
  4. nucleus Source: HPA
  5. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi179 – 1791H → Y: Abolishes demethylase activity. 1 Publication

Organism-specific databases

PharmGKBiPA134991047.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINAPRO_0000308377Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei309 – 3091Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IUF8.
PaxDbiQ8IUF8.
PRIDEiQ8IUF8.

PTM databases

PhosphoSiteiQ8IUF8.

Expressioni

Tissue specificityi

Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines.4 Publications

Inductioni

Up-regulated in response to MYC, in alveolar macrophages from coal miners and in silica particle-treated A549 lung cancer cells.2 Publications

Gene expression databases

BgeeiQ8IUF8.
CleanExiHS_MINA.
ExpressionAtlasiQ8IUF8. baseline and differential.
GenevestigatoriQ8IUF8.

Organism-specific databases

HPAiCAB013458.
HPA007603.
HPA008080.

Interactioni

Protein-protein interaction databases

BioGridi124309. 14 interactions.
DIPiDIP-28141N.
IntActiQ8IUF8. 2 interactions.
MINTiMINT-1454329.
STRINGi9606.ENSP00000328251.

Structurei

Secondary structure

1
465
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi38 – 458
Turni46 – 483
Helixi51 – 577
Turni58 – 614
Beta strandi64 – 663
Helixi71 – 8010
Helixi85 – 906
Beta strandi94 – 963
Turni97 – 993
Beta strandi100 – 1067
Beta strandi109 – 1124
Beta strandi116 – 1194
Helixi121 – 1299
Beta strandi134 – 1385
Helixi140 – 1423
Helixi145 – 15814
Beta strandi162 – 1698
Beta strandi178 – 1803
Beta strandi182 – 19211
Beta strandi194 – 1996
Helixi214 – 2163
Beta strandi221 – 2266
Beta strandi231 – 2344
Beta strandi239 – 2435
Beta strandi246 – 2483
Beta strandi251 – 2588
Helixi264 – 27613
Helixi284 – 2874
Helixi294 – 2963
Helixi302 – 32120
Helixi329 – 3379
Beta strandi344 – 3485
Turni349 – 3513
Beta strandi363 – 3664
Helixi369 – 3713
Beta strandi372 – 3754
Beta strandi390 – 3956
Turni402 – 4054
Beta strandi417 – 4204
Helixi421 – 4233
Helixi424 – 4318
Beta strandi434 – 4374
Helixi438 – 4403
Helixi446 – 45813
Beta strandi462 – 4643

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XDVX-ray2.57A26-465[»]
4BU2X-ray2.78A26-465[»]
4BXFX-ray2.05A/B26-465[»]
ProteinModelPortaliQ8IUF8.
SMRiQ8IUF8. Positions 30-465.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IUF8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini139 – 271133JmjCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MINA53/NO66 family.Curated
Contains 1 JmjC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG83808.
GeneTreeiENSGT00390000000083.
HOVERGENiHBG055265.
InParanoidiQ8IUF8.
OMAiSTYQNNS.
OrthoDBiEOG7T1RBJ.
PhylomeDBiQ8IUF8.
TreeFamiTF318659.

Family and domain databases

InterProiIPR003347. JmjC_dom.
[Graphical view]
PfamiPF08007. Cupin_4. 1 hit.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 16 Publications (identifier: Q8IUF8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPKKAKPTGS GKEEGPAPCK QMKLEAAGGP SALNFDSPSS LFESLISPIK
60 70 80 90 100
TETFFKEFWE QKPLLIQRDD PALATYYGSL FKLTDLKSLC SRGMYYGRDV
110 120 130 140 150
NVCRCVNGKK KVLNKDGKAH FLQLRKDFDQ KRATIQFHQP QRFKDELWRI
160 170 180 190 200
QEKLECYFGS LVGSNVYITP AGSQGLPPHY DDVEVFILQL EGEKHWRLYH
210 220 230 240 250
PTVPLAREYS VEAEERIGRP VHEFMLKPGD LLYFPRGTIH QADTPAGLAH
260 270 280 290 300
STHVTISTYQ NNSWGDFLLD TISGLVFDTA KEDVELRTGI PRQLLLQVES
310 320 330 340 350
TTVATRRLSG FLRTLADRLE GTKELLSSDM KKDFIMHRLP PYSAGDGAEL
360 370 380 390 400
STPGGKLPRL DSVVRLQFKD HIVLTVLPDQ DQSDEAQEKM VYIYHSLKNS
410 420 430 440 450
RETHMMGNEE ETEFHGLRFP LSHLDALKQI WNSPAISVKD LKLTTDEEKE
460
SLVLSLWTEC LIQVV
Length:465
Mass (Da):52,800
Last modified:March 1, 2003 - v1
Checksum:iB59F8AE9C802FEB0
GO
Isoform 21 Publication (identifier: Q8IUF8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-280: SWGDFLLDTISGLVFDTA → DAGARMRRCDLRAIAPQK
     281-465: Missing.

Show »
Length:280
Mass (Da):31,818
Checksum:i8B69C261ABC594EB
GO
Isoform 31 Publication (identifier: Q8IUF8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-254: Missing.
     255-261: TISTYQN → MLLQVPC

Show »
Length:211
Mass (Da):23,909
Checksum:iDA5AB0F080853151
GO
Isoform 4 (identifier: Q8IUF8-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     297-297: Missing.

Show »
Length:464
Mass (Da):52,672
Checksum:i24902143244D1A79
GO

Sequence cautioni

The sequence CAH10679.1 differs from that shown. Reason: Erroneous termination at position 431. Translated as Trp.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti87 – 871K → E in BAC16359. (PubMed:12091391)Curated
Sequence conflicti107 – 1071N → S in BAC16359. (PubMed:12091391)Curated
Sequence conflicti159 – 1591G → S in BAB55024. (PubMed:14702039)Curated
Sequence conflicti221 – 2211V → A in BAC16359. (PubMed:12091391)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171A → P.
Corresponds to variant rs35391656 [ dbSNP | Ensembl ].
VAR_054079
Natural varianti201 – 2011P → L.
Corresponds to variant rs56183666 [ dbSNP | Ensembl ].
VAR_062241
Natural varianti386 – 3861A → T.4 Publications
Corresponds to variant rs2172257 [ dbSNP | Ensembl ].
VAR_036811

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 254254Missing in isoform 3. 1 PublicationVSP_052587Add
BLAST
Alternative sequencei255 – 2617TISTYQN → MLLQVPC in isoform 3. 1 PublicationVSP_052588
Alternative sequencei263 – 28018SWGDF…VFDTA → DAGARMRRCDLRAIAPQK in isoform 2. 1 PublicationVSP_052589Add
BLAST
Alternative sequencei281 – 465185Missing in isoform 2. 1 PublicationVSP_052590Add
BLAST
Alternative sequencei297 – 2971Missing in isoform 4. 2 PublicationsVSP_038373

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB083189 mRNA. Translation: BAC16537.1.
AB083190 mRNA. Translation: BAC16358.1.
AB083191 mRNA. Translation: BAC16359.1.
AB083192 mRNA. Translation: BAC16360.1.
AB083193 mRNA. Translation: BAC16361.1.
AY390536 mRNA. Translation: AAR27293.1.
AY302110 mRNA. Translation: AAP59421.1.
AY456380 mRNA. Translation: AAR21572.1.
DQ453796 mRNA. Translation: ABE28016.1.
AK027299 mRNA. Translation: BAB55024.1.
AC026100 Genomic DNA. No translation available.
AC110491 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79872.1.
CH471052 Genomic DNA. Translation: EAW79873.1.
BC014928 mRNA. Translation: AAH14928.1.
CR627479 mRNA. Translation: CAH10679.1. Different termination.
CCDSiCCDS2929.1. [Q8IUF8-4]
CCDS43114.1. [Q8IUF8-1]
RefSeqiNP_001035998.1. NM_001042533.2. [Q8IUF8-1]
NP_001248758.1. NM_001261829.1. [Q8IUF8-4]
NP_116167.3. NM_032778.5. [Q8IUF8-4]
NP_694822.2. NM_153182.3. [Q8IUF8-1]
XP_005247895.1. XM_005247838.2. [Q8IUF8-1]
UniGeneiHs.570562.
Hs.742206.

Genome annotation databases

EnsembliENST00000333396; ENSP00000328251; ENSG00000170854. [Q8IUF8-1]
ENST00000360258; ENSP00000353395; ENSG00000170854. [Q8IUF8-4]
ENST00000394198; ENSP00000377748; ENSG00000170854. [Q8IUF8-1]
ENST00000514314; ENSP00000424955; ENSG00000170854. [Q8IUF8-2]
GeneIDi84864.
KEGGihsa:84864.
UCSCiuc003drz.2. human. [Q8IUF8-1]
uc003dsa.2. human. [Q8IUF8-4]

Polymorphism databases

DMDMi74750624.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB083189 mRNA. Translation: BAC16537.1 .
AB083190 mRNA. Translation: BAC16358.1 .
AB083191 mRNA. Translation: BAC16359.1 .
AB083192 mRNA. Translation: BAC16360.1 .
AB083193 mRNA. Translation: BAC16361.1 .
AY390536 mRNA. Translation: AAR27293.1 .
AY302110 mRNA. Translation: AAP59421.1 .
AY456380 mRNA. Translation: AAR21572.1 .
DQ453796 mRNA. Translation: ABE28016.1 .
AK027299 mRNA. Translation: BAB55024.1 .
AC026100 Genomic DNA. No translation available.
AC110491 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79872.1 .
CH471052 Genomic DNA. Translation: EAW79873.1 .
BC014928 mRNA. Translation: AAH14928.1 .
CR627479 mRNA. Translation: CAH10679.1 . Different termination.
CCDSi CCDS2929.1. [Q8IUF8-4 ]
CCDS43114.1. [Q8IUF8-1 ]
RefSeqi NP_001035998.1. NM_001042533.2. [Q8IUF8-1 ]
NP_001248758.1. NM_001261829.1. [Q8IUF8-4 ]
NP_116167.3. NM_032778.5. [Q8IUF8-4 ]
NP_694822.2. NM_153182.3. [Q8IUF8-1 ]
XP_005247895.1. XM_005247838.2. [Q8IUF8-1 ]
UniGenei Hs.570562.
Hs.742206.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2XDV X-ray 2.57 A 26-465 [» ]
4BU2 X-ray 2.78 A 26-465 [» ]
4BXF X-ray 2.05 A/B 26-465 [» ]
ProteinModelPortali Q8IUF8.
SMRi Q8IUF8. Positions 30-465.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124309. 14 interactions.
DIPi DIP-28141N.
IntActi Q8IUF8. 2 interactions.
MINTi MINT-1454329.
STRINGi 9606.ENSP00000328251.

PTM databases

PhosphoSitei Q8IUF8.

Polymorphism databases

DMDMi 74750624.

Proteomic databases

MaxQBi Q8IUF8.
PaxDbi Q8IUF8.
PRIDEi Q8IUF8.

Protocols and materials databases

DNASUi 84864.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000333396 ; ENSP00000328251 ; ENSG00000170854 . [Q8IUF8-1 ]
ENST00000360258 ; ENSP00000353395 ; ENSG00000170854 . [Q8IUF8-4 ]
ENST00000394198 ; ENSP00000377748 ; ENSG00000170854 . [Q8IUF8-1 ]
ENST00000514314 ; ENSP00000424955 ; ENSG00000170854 . [Q8IUF8-2 ]
GeneIDi 84864.
KEGGi hsa:84864.
UCSCi uc003drz.2. human. [Q8IUF8-1 ]
uc003dsa.2. human. [Q8IUF8-4 ]

Organism-specific databases

CTDi 84864.
GeneCardsi GC03M097660.
HGNCi HGNC:19441. MINA.
HPAi CAB013458.
HPA007603.
HPA008080.
MIMi 612049. gene.
neXtProti NX_Q8IUF8.
PharmGKBi PA134991047.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG83808.
GeneTreei ENSGT00390000000083.
HOVERGENi HBG055265.
InParanoidi Q8IUF8.
OMAi STYQNNS.
OrthoDBi EOG7T1RBJ.
PhylomeDBi Q8IUF8.
TreeFami TF318659.

Miscellaneous databases

EvolutionaryTracei Q8IUF8.
GeneWikii MINA.
MYC-induced_nuclear_antigen.
GenomeRNAii 84864.
NextBioi 75123.
PROi Q8IUF8.
SOURCEi Search...

Gene expression databases

Bgeei Q8IUF8.
CleanExi HS_MINA.
ExpressionAtlasi Q8IUF8. baseline and differential.
Genevestigatori Q8IUF8.

Family and domain databases

InterProi IPR003347. JmjC_dom.
[Graphical view ]
Pfami PF08007. Cupin_4. 1 hit.
[Graphical view ]
SMARTi SM00558. JmjC. 1 hit.
[Graphical view ]
PROSITEi PS51184. JMJC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel myc target gene, mina53, that is involved in cell proliferation."
    Tsuneoka M., Koda Y., Soejima M., Teye K., Kimura H.
    J. Biol. Chem. 277:35450-35459(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 4), FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
    Tissue: ErythroleukemiaImported.
  2. "NO66, a highly conserved dual location protein in the nucleolus and in a special type of synchronously replicating chromatin."
    Eilbracht J., Reichenzeller M., Hergt M., Schnoelzer M., Heid H., Stoehr M., Franke W.W., Schmidt-Zachmann M.S.
    Mol. Biol. Cell 15:1816-1832(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-386.
  3. "The human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer."
    Zhang Y., Lu Y., Yuan B.-Z., Castranova V., Shi X., Stauffer J.L., Demers L.M., Chen F.
    Oncogene 24:4873-4882(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), FUNCTION, TISSUE SPECIFICITY, INDUCTION.
    Tissue: Alveolar macrophageImported and Lung cancerImported.
  4. "MDIG gene, a potential biomarker for human lung cancer."
    Chang Q., Castranova V., Chen F.
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: LungImported.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT THR-386.
    Tissue: EmbryoImported.
  6. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-386.
    Tissue: SkinImported.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 47-465 (ISOFORM 1), VARIANT THR-386.
    Tissue: Melanoma.
  10. "Increased expression of a Myc target gene Mina53 in human colon cancer."
    Teye K., Tsuneoka M., Arima N., Koda Y., Nakamura Y., Ueta Y., Shirouzu K., Kimura H.
    Am. J. Pathol. 164:205-216(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  11. "Mina53 as a potential prognostic factor for esophageal squamous cell carcinoma."
    Tsuneoka M., Fujita H., Arima N., Teye K., Okamura T., Inutsuka H., Koda Y., Shirouzu K., Kimura H.
    Clin. Cancer Res. 10:7347-7356(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  12. "Protein NO52 -- a constitutive nucleolar component sharing high sequence homologies to protein NO66."
    Eilbracht J., Kneissel S., Hofmann A., Schmidt-Zachmann M.S.
    Eur. J. Cell Biol. 84:279-294(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  13. "Immunohistochemical expression of Mina53 and Ki67 proteins in human primary gingival squamous cell carcinoma."
    Kuratomi K., Yano H., Tsuneoka M., Sakamoto K., Kusukawa J., Kojiro M.
    Kurume Med. J. 53:71-78(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  14. "Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3."
    Lu Y., Chang Q., Zhang Y., Beezhold K., Rojanasakul Y., Zhao H., Castranova V., Shi X., Chen F.
    Cell Cycle 8:2101-2109(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS HISTONE DEMETHYLASE, TISSUE SPECIFICITY, MUTAGENESIS OF HIS-179.
  15. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-309, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. Cited for: FUNCTION AS RPL27A HYDROXYLASE, CATALYTIC ACTIVITY.

Entry informationi

Entry nameiMINA_HUMAN
AccessioniPrimary (citable) accession number: Q8IUF8
Secondary accession number(s): D3DN35
, Q6AHW4, Q6SKS0, Q8IU69, Q8IUF6, Q8IUF7, Q96C17, Q96KB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3