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Q8IUF1

- CBWD2_HUMAN

UniProt

Q8IUF1 - CBWD2_HUMAN

Protein

COBW domain-containing protein 2

Gene

CBWD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi49 – 568ATPSequence Analysis
    Nucleotide bindingi110 – 1145ATPSequence Analysis
    Nucleotide bindingi203 – 2064ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    COBW domain-containing protein 2
    Alternative name(s):
    Cobalamin synthase W domain-containing protein 2
    Gene namesi
    Name:CBWD2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:17907. CBWD2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26125.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 395395COBW domain-containing protein 2PRO_0000316813Add
    BLAST

    Proteomic databases

    MaxQBiQ8IUF1.
    PaxDbiQ8IUF1.
    PRIDEiQ8IUF1.

    PTM databases

    PhosphoSiteiQ8IUF1.

    Expressioni

    Gene expression databases

    BgeeiQ8IUF1.
    GenevestigatoriQ8IUF1.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    YWHAQP273481EBI-359159,EBI-359854

    Protein-protein interaction databases

    BioGridi127299. 6 interactions.
    IntActiQ8IUF1. 2 interactions.
    MINTiMINT-1136223.
    STRINGi9606.ENSP00000259199.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IUF1.
    SMRiQ8IUF1. Positions 42-373.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini274 – 377104CobW C-terminalAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi31 – 344Poly-Glu

    Sequence similaritiesi

    Belongs to the CobW family.Curated
    Contains 1 cobW C-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG0523.
    HOGENOMiHOG000182211.
    HOVERGENiHBG056297.
    InParanoidiQ8IUF1.
    OMAiTICICET.
    OrthoDBiEOG7HHWS8.
    PhylomeDBiQ8IUF1.
    TreeFamiTF332679.

    Family and domain databases

    Gene3Di3.30.1220.10. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR011629. Cbl_biosynth_CobW-like_C.
    IPR003495. CobW/HypB/UreG_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF02492. cobW. 1 hit.
    PF07683. CobW_C. 1 hit.
    [Graphical view]
    SMARTiSM00833. CobW_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF90002. SSF90002. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8IUF1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPAVGSADE EEDPAEEDCP ELVPMETTQS EEEEKSGLGA KIPVTIITGY    50
    LGAGKTTLLN YILTEQHSKR VAVILNEFGE GSALEKSLAV SQGGELYEEW 100
    LELRNGCLCC SVKDNGLRAI ENLMQKKGKF DYILLETTGL ADPGAVASMF 150
    WVDAELGSDI YLDGIITIVD SKYGLKHLAE EKPDGLINEA TRQVALADAI 200
    LINKTDLVPE EDVKKLRATI RSINGLGQIL ETQRSRVDLS NVLDLHAFDS 250
    LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE 300
    KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD 350
    TERTNRLVLL GRNLDKDILK QLFIATVTET EKQWTTHFKE DQVCT 395
    Length:395
    Mass (Da):44,034
    Last modified:March 1, 2003 - v1
    Checksum:iD1BAA6864670939F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti242 – 2421V → I in AAI20992. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF452722 mRNA. Translation: AAN64907.1.
    AY343910 mRNA. Translation: AAQ76868.1.
    AK290072 mRNA. Translation: BAF82761.1.
    AL078621, AC016745 Genomic DNA. Translation: CAO03555.1.
    BC120991 mRNA. Translation: AAI20992.1.
    BC120992 mRNA. Translation: AAI20993.1.
    CCDSiCCDS2116.1.
    RefSeqiNP_742000.1. NM_172003.3.
    UniGeneiHs.531330.

    Genome annotation databases

    EnsembliENST00000259199; ENSP00000259199; ENSG00000136682.
    GeneIDi150472.
    KEGGihsa:150472.
    UCSCiuc002tju.3. human.

    Polymorphism databases

    DMDMi74714301.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF452722 mRNA. Translation: AAN64907.1 .
    AY343910 mRNA. Translation: AAQ76868.1 .
    AK290072 mRNA. Translation: BAF82761.1 .
    AL078621 , AC016745 Genomic DNA. Translation: CAO03555.1 .
    BC120991 mRNA. Translation: AAI20992.1 .
    BC120992 mRNA. Translation: AAI20993.1 .
    CCDSi CCDS2116.1.
    RefSeqi NP_742000.1. NM_172003.3.
    UniGenei Hs.531330.

    3D structure databases

    ProteinModelPortali Q8IUF1.
    SMRi Q8IUF1. Positions 42-373.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127299. 6 interactions.
    IntActi Q8IUF1. 2 interactions.
    MINTi MINT-1136223.
    STRINGi 9606.ENSP00000259199.

    PTM databases

    PhosphoSitei Q8IUF1.

    Polymorphism databases

    DMDMi 74714301.

    Proteomic databases

    MaxQBi Q8IUF1.
    PaxDbi Q8IUF1.
    PRIDEi Q8IUF1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000259199 ; ENSP00000259199 ; ENSG00000136682 .
    GeneIDi 150472.
    KEGGi hsa:150472.
    UCSCi uc002tju.3. human.

    Organism-specific databases

    CTDi 150472.
    GeneCardsi GC02P114188.
    H-InvDB HIX0023935.
    HGNCi HGNC:17907. CBWD2.
    MIMi 611079. gene.
    neXtProti NX_Q8IUF1.
    PharmGKBi PA26125.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0523.
    HOGENOMi HOG000182211.
    HOVERGENi HBG056297.
    InParanoidi Q8IUF1.
    OMAi TICICET.
    OrthoDBi EOG7HHWS8.
    PhylomeDBi Q8IUF1.
    TreeFami TF332679.

    Miscellaneous databases

    GenomeRNAii 150472.
    NextBioi 86453.
    PROi Q8IUF1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8IUF1.
    Genevestigatori Q8IUF1.

    Family and domain databases

    Gene3Di 3.30.1220.10. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR011629. Cbl_biosynth_CobW-like_C.
    IPR003495. CobW/HypB/UreG_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF02492. cobW. 1 hit.
    PF07683. CobW_C. 1 hit.
    [Graphical view ]
    SMARTi SM00833. CobW_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF90002. SSF90002. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions."
      Fan Y., Newman T., Linardopoulou E., Trask B.J.
      Genome Res. 12:1663-1672(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Diverse fates of paralogs following segmental duplication of telomeric genes."
      Wong A., Vallender E.J., Heretis K., Ilkin Y., Lahn B.T., Lese Martin C., Ledbetter D.H.
      Genomics 84:239-247(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Substantia nigra.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiCBWD2_HUMAN
    AccessioniPrimary (citable) accession number: Q8IUF1
    Secondary accession number(s): Q0VAN3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3