Reviewed, UniProtKB/Swiss-Prot Q8IUF1 (CBWD2_HUMAN)

Names and origin

Protein names

Recommended name:
    COBW domain-containing protein 2
Alternative name(s):
    Cobalamin synthetase W domain-containing protein 2

Gene names

Name:

CBWD2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Belongs to the cobW family. Contains 1 cobW C-terminal domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
YWHAQ	P27348	1	EBI-359159,EBI-359854

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 395	395	COBW domain-containing protein 2		PRO_0000316813
Regions
	Domain	274 – 377	104	CobW C-terminal
	Nucleotide binding	49 – 56	8	ATP Potential
	Nucleotide binding	110 – 114	5	ATP Potential
	Nucleotide binding	203 – 206	4	ATP Potential
	Compositional bias	31 – 34	4	Poly-Glu
Experimental info
	Sequence conflict	242	1	V → I in AAI20992. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q8IUF1-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: D1BAA6864670939F	FASTA	395	44,034
	10 20 30 40 50 60 MLPAVGSADE EEDPAEEDCP ELVPMETTQS EEEEKSGLGA KIPVTIITGY LGAGKTTLLN 70 80 90 100 110 120 YILTEQHSKR VAVILNEFGE GSALEKSLAV SQGGELYEEW LELRNGCLCC SVKDNGLRAI 130 140 150 160 170 180 ENLMQKKGKF DYILLETTGL ADPGAVASMF WVDAELGSDI YLDGIITIVD SKYGLKHLAE 190 200 210 220 230 240 EKPDGLINEA TRQVALADAI LINKTDLVPE EDVKKLRATI RSINGLGQIL ETQRSRVDLS 250 260 270 280 290 300 NVLDLHAFDS LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE 310 320 330 340 350 360 KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD TERTNRLVLL 370 380 390 GRNLDKDILK QLFIATVTET EKQWTTHFKE DQVCT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions." Fan Y., Newman T., Linardopoulou E., Trask B.J. Genome Res. 12:1663-1672(2002) [PubMed: 12421752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Diverse fates of paralogs following segmental duplication of telomeric genes." Wong A., Vallender E.J., Heretis K., Ilkin Y., Lahn B.T., Lese Martin C., Ledbetter D.H. Genomics 84:239-247(2004) [PubMed: 15233989] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Substantia nigra.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF452722 mRNA. Translation: AAN64907.1. AY343910 mRNA. Translation: AAQ76868.1. AK290072 mRNA. Translation: BAF82761.1. AL078621, AC016745 Genomic DNA. Translation: CAO03555.1. BC120991 mRNA. Translation: AAI20992.1. BC120992 mRNA. Translation: AAI20993.1.
IPI	IPI00216734.
RefSeq	NP_742000.1.
UniGene	Hs.531330
3D structure databases
HSSP	HSSP built from PDB template 1NIJ based on UniProtKB P24203.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IUF1. 3 interactions.
Proteomic databases
PRIDE	Q8IUF1.
Genome annotation databases
Ensembl	ENSG00000136682. Homo sapiens. [Contig view]
GeneID	150472.
KEGG	hsa:150472.
NMPDR	fig|9606.3.peg.18530.
UCSC	uc002tju.1. human.
Organism-specific databases
GeneCards	GC02P113912.
HGNC	HGNC:17907. CBWD2.
MIM	611079. gene.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8IUF1.
OMA	Q8IUF1. YSTEVER.
Family and domain databases
InterPro	IPR003495. Cbl_biosynth_CobW-like. IPR011629. Cbl_biosynth_CobW-like_C. [Graphical view]
Gene3D	G3DSA:3.30.1220.10. Cbl_biosynth_CobW-like_C. 1 hit.
Pfam	PF02492. cobW. 1 hit. PF07683. CobW_C. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	86453.
SOURCE	Search...

Entry information

Entry name

CBWD2_HUMAN

Accession

Primary (citable) accession number: Q8IUF1
Secondary accession number(s): Q0VAN3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	March 1, 2003
Last modified:	July 7, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)