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Protein

COBW domain-containing protein 2

Gene

CBWD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi49 – 568ATPSequence Analysis
Nucleotide bindingi110 – 1145ATPSequence Analysis
Nucleotide bindingi203 – 2064ATPSequence Analysis

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
COBW domain-containing protein 2
Alternative name(s):
Cobalamin synthase W domain-containing protein 2
Gene namesi
Name:CBWD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:17907. CBWD2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26125.

Polymorphism and mutation databases

BioMutaiCBWD2.
DMDMi74714301.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395COBW domain-containing protein 2PRO_0000316813Add
BLAST

Proteomic databases

MaxQBiQ8IUF1.
PaxDbiQ8IUF1.
PRIDEiQ8IUF1.

PTM databases

PhosphoSiteiQ8IUF1.

Expressioni

Gene expression databases

BgeeiQ8IUF1.
ExpressionAtlasiQ8IUF1. baseline.
GenevisibleiQ8IUF1. HS.

Organism-specific databases

HPAiHPA042759.
HPA042813.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
YWHAQP273481EBI-359159,EBI-359854

Protein-protein interaction databases

BioGridi127299. 13 interactions.
IntActiQ8IUF1. 2 interactions.
MINTiMINT-1136223.
STRINGi9606.ENSP00000259199.

Structurei

3D structure databases

ProteinModelPortaliQ8IUF1.
SMRiQ8IUF1. Positions 42-373.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini274 – 377104CobW C-terminalAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi31 – 344Poly-Glu

Sequence similaritiesi

Belongs to the CobW family.Curated
Contains 1 cobW C-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG0523.
GeneTreeiENSGT00640000091523.
HOGENOMiHOG000182211.
HOVERGENiHBG056297.
InParanoidiQ8IUF1.
OMAiLWEENPH.
OrthoDBiEOG7HHWS8.
PhylomeDBiQ8IUF1.
TreeFamiTF332679.

Family and domain databases

Gene3Di3.30.1220.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR011629. Cbl_biosynth_CobW-like_C.
IPR003495. CobW/HypB/UreG_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02492. cobW. 1 hit.
PF07683. CobW_C. 1 hit.
[Graphical view]
SMARTiSM00833. CobW_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90002. SSF90002. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IUF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPAVGSADE EEDPAEEDCP ELVPMETTQS EEEEKSGLGA KIPVTIITGY
60 70 80 90 100
LGAGKTTLLN YILTEQHSKR VAVILNEFGE GSALEKSLAV SQGGELYEEW
110 120 130 140 150
LELRNGCLCC SVKDNGLRAI ENLMQKKGKF DYILLETTGL ADPGAVASMF
160 170 180 190 200
WVDAELGSDI YLDGIITIVD SKYGLKHLAE EKPDGLINEA TRQVALADAI
210 220 230 240 250
LINKTDLVPE EDVKKLRATI RSINGLGQIL ETQRSRVDLS NVLDLHAFDS
260 270 280 290 300
LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE
310 320 330 340 350
KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD
360 370 380 390
TERTNRLVLL GRNLDKDILK QLFIATVTET EKQWTTHFKE DQVCT
Length:395
Mass (Da):44,034
Last modified:March 1, 2003 - v1
Checksum:iD1BAA6864670939F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti242 – 2421V → I in AAI20992 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF452722 mRNA. Translation: AAN64907.1.
AY343910 mRNA. Translation: AAQ76868.1.
AK290072 mRNA. Translation: BAF82761.1.
AL078621, AC016745 Genomic DNA. Translation: CAO03555.1.
BC120991 mRNA. Translation: AAI20992.1.
BC120992 mRNA. Translation: AAI20993.1.
CCDSiCCDS2116.1.
RefSeqiNP_742000.1. NM_172003.3.
UniGeneiHs.531330.

Genome annotation databases

EnsembliENST00000259199; ENSP00000259199; ENSG00000136682.
GeneIDi150472.
KEGGihsa:150472.
UCSCiuc002tju.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF452722 mRNA. Translation: AAN64907.1.
AY343910 mRNA. Translation: AAQ76868.1.
AK290072 mRNA. Translation: BAF82761.1.
AL078621, AC016745 Genomic DNA. Translation: CAO03555.1.
BC120991 mRNA. Translation: AAI20992.1.
BC120992 mRNA. Translation: AAI20993.1.
CCDSiCCDS2116.1.
RefSeqiNP_742000.1. NM_172003.3.
UniGeneiHs.531330.

3D structure databases

ProteinModelPortaliQ8IUF1.
SMRiQ8IUF1. Positions 42-373.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127299. 13 interactions.
IntActiQ8IUF1. 2 interactions.
MINTiMINT-1136223.
STRINGi9606.ENSP00000259199.

PTM databases

PhosphoSiteiQ8IUF1.

Polymorphism and mutation databases

BioMutaiCBWD2.
DMDMi74714301.

Proteomic databases

MaxQBiQ8IUF1.
PaxDbiQ8IUF1.
PRIDEiQ8IUF1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259199; ENSP00000259199; ENSG00000136682.
GeneIDi150472.
KEGGihsa:150472.
UCSCiuc002tju.3. human.

Organism-specific databases

CTDi150472.
GeneCardsiGC02P114196.
H-InvDBHIX0023935.
HGNCiHGNC:17907. CBWD2.
HPAiHPA042759.
HPA042813.
MIMi611079. gene.
neXtProtiNX_Q8IUF1.
PharmGKBiPA26125.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0523.
GeneTreeiENSGT00640000091523.
HOGENOMiHOG000182211.
HOVERGENiHBG056297.
InParanoidiQ8IUF1.
OMAiLWEENPH.
OrthoDBiEOG7HHWS8.
PhylomeDBiQ8IUF1.
TreeFamiTF332679.

Miscellaneous databases

ChiTaRSiCBWD2. human.
GenomeRNAii150472.
NextBioi86453.
PROiQ8IUF1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IUF1.
ExpressionAtlasiQ8IUF1. baseline.
GenevisibleiQ8IUF1. HS.

Family and domain databases

Gene3Di3.30.1220.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR011629. Cbl_biosynth_CobW-like_C.
IPR003495. CobW/HypB/UreG_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02492. cobW. 1 hit.
PF07683. CobW_C. 1 hit.
[Graphical view]
SMARTiSM00833. CobW_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90002. SSF90002. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions."
    Fan Y., Newman T., Linardopoulou E., Trask B.J.
    Genome Res. 12:1663-1672(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Diverse fates of paralogs following segmental duplication of telomeric genes."
    Wong A., Vallender E.J., Heretis K., Ilkin Y., Lahn B.T., Lese Martin C., Ledbetter D.H.
    Genomics 84:239-247(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Substantia nigra.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCBWD2_HUMAN
AccessioniPrimary (citable) accession number: Q8IUF1
Secondary accession number(s): Q0VAN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2003
Last modified: July 22, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.