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Protein

COBW domain-containing protein 2

Gene

CBWD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi49 – 56ATPSequence analysis8
Nucleotide bindingi110 – 114ATPSequence analysis5
Nucleotide bindingi203 – 206ATPSequence analysis4

GO - Molecular functioni

Keywordsi

LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
COBW domain-containing protein 2
Alternative name(s):
Cobalamin synthase W domain-containing protein 2
Gene namesi
Name:CBWD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000136682.14.
HGNCiHGNC:17907. CBWD2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136682.
PharmGKBiPA26125.

Polymorphism and mutation databases

BioMutaiCBWD2.
DMDMi74714301.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003168131 – 395COBW domain-containing protein 2Add BLAST395

Proteomic databases

EPDiQ8IUF1.
MaxQBiQ8IUF1.
PaxDbiQ8IUF1.
PeptideAtlasiQ8IUF1.
PRIDEiQ8IUF1.

PTM databases

iPTMnetiQ8IUF1.
PhosphoSitePlusiQ8IUF1.

Expressioni

Gene expression databases

BgeeiENSG00000136682.
ExpressionAtlasiQ8IUF1. baseline and differential.
GenevisibleiQ8IUF1. HS.

Organism-specific databases

HPAiHPA042759.
HPA042813.

Interactioni

Protein-protein interaction databases

BioGridi127299. 17 interactors.
IntActiQ8IUF1. 4 interactors.
MINTiMINT-1136223.
STRINGi9606.ENSP00000259199.

Structurei

3D structure databases

ProteinModelPortaliQ8IUF1.
SMRiQ8IUF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini274 – 377CobW C-terminalAdd BLAST104

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi31 – 34Poly-Glu4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2743. Eukaryota.
COG0523. LUCA.
GeneTreeiENSGT00640000091523.
HOGENOMiHOG000182211.
HOVERGENiHBG056297.
InParanoidiQ8IUF1.
OMAiXTIVAIT.
OrthoDBiEOG091G0JUI.
PhylomeDBiQ8IUF1.
TreeFamiTF332679.

Family and domain databases

Gene3Di3.30.1220.10. 1 hit.
InterProiView protein in InterPro
IPR011629. Cbl_biosynth_CobW-like_C.
IPR003495. CobW/HypB/UreG_dom.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF02492. cobW. 1 hit.
PF07683. CobW_C. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90002. SSF90002. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IUF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPAVGSADE EEDPAEEDCP ELVPMETTQS EEEEKSGLGA KIPVTIITGY
60 70 80 90 100
LGAGKTTLLN YILTEQHSKR VAVILNEFGE GSALEKSLAV SQGGELYEEW
110 120 130 140 150
LELRNGCLCC SVKDNGLRAI ENLMQKKGKF DYILLETTGL ADPGAVASMF
160 170 180 190 200
WVDAELGSDI YLDGIITIVD SKYGLKHLAE EKPDGLINEA TRQVALADAI
210 220 230 240 250
LINKTDLVPE EDVKKLRATI RSINGLGQIL ETQRSRVDLS NVLDLHAFDS
260 270 280 290 300
LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE
310 320 330 340 350
KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD
360 370 380 390
TERTNRLVLL GRNLDKDILK QLFIATVTET EKQWTTHFKE DQVCT
Length:395
Mass (Da):44,034
Last modified:March 1, 2003 - v1
Checksum:iD1BAA6864670939F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242V → I in AAI20992 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF452722 mRNA. Translation: AAN64907.1.
AY343910 mRNA. Translation: AAQ76868.1.
AK290072 mRNA. Translation: BAF82761.1.
AL078621, AC016745 Genomic DNA. Translation: CAO03555.1.
BC120991 mRNA. Translation: AAI20992.1.
BC120992 mRNA. Translation: AAI20993.1.
CCDSiCCDS2116.1.
RefSeqiNP_742000.1. NM_172003.3.
UniGeneiHs.531330.

Genome annotation databases

EnsembliENST00000259199; ENSP00000259199; ENSG00000136682.
GeneIDi150472.
KEGGihsa:150472.
UCSCiuc002tju.4. human.

Similar proteinsi

Entry informationi

Entry nameiCBWD2_HUMAN
AccessioniPrimary (citable) accession number: Q8IUF1
Secondary accession number(s): Q0VAN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2003
Last modified: September 27, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families