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Q8IUF1

- CBWD2_HUMAN

UniProt

Q8IUF1 - CBWD2_HUMAN

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Protein

COBW domain-containing protein 2

Gene
CBWD2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi49 – 568ATP Reviewed prediction
Nucleotide bindingi110 – 1145ATP Reviewed prediction
Nucleotide bindingi203 – 2064ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
COBW domain-containing protein 2
Alternative name(s):
Cobalamin synthase W domain-containing protein 2
Gene namesi
Name:CBWD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:17907. CBWD2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26125.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395COBW domain-containing protein 2PRO_0000316813Add
BLAST

Proteomic databases

MaxQBiQ8IUF1.
PaxDbiQ8IUF1.
PRIDEiQ8IUF1.

PTM databases

PhosphoSiteiQ8IUF1.

Expressioni

Gene expression databases

BgeeiQ8IUF1.
GenevestigatoriQ8IUF1.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
YWHAQP273481EBI-359159,EBI-359854

Protein-protein interaction databases

BioGridi127299. 6 interactions.
IntActiQ8IUF1. 2 interactions.
MINTiMINT-1136223.
STRINGi9606.ENSP00000259199.

Structurei

3D structure databases

ProteinModelPortaliQ8IUF1.
SMRiQ8IUF1. Positions 42-373.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini274 – 377104CobW C-terminalAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi31 – 344Poly-Glu

Sequence similaritiesi

Belongs to the CobW family.

Phylogenomic databases

eggNOGiCOG0523.
HOGENOMiHOG000182211.
HOVERGENiHBG056297.
InParanoidiQ8IUF1.
OMAiTICICET.
OrthoDBiEOG7HHWS8.
PhylomeDBiQ8IUF1.
TreeFamiTF332679.

Family and domain databases

Gene3Di3.30.1220.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR011629. Cbl_biosynth_CobW-like_C.
IPR003495. CobW/HypB/UreG_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02492. cobW. 1 hit.
PF07683. CobW_C. 1 hit.
[Graphical view]
SMARTiSM00833. CobW_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90002. SSF90002. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IUF1-1 [UniParc]FASTAAdd to Basket

« Hide

MLPAVGSADE EEDPAEEDCP ELVPMETTQS EEEEKSGLGA KIPVTIITGY    50
LGAGKTTLLN YILTEQHSKR VAVILNEFGE GSALEKSLAV SQGGELYEEW 100
LELRNGCLCC SVKDNGLRAI ENLMQKKGKF DYILLETTGL ADPGAVASMF 150
WVDAELGSDI YLDGIITIVD SKYGLKHLAE EKPDGLINEA TRQVALADAI 200
LINKTDLVPE EDVKKLRATI RSINGLGQIL ETQRSRVDLS NVLDLHAFDS 250
LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE 300
KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD 350
TERTNRLVLL GRNLDKDILK QLFIATVTET EKQWTTHFKE DQVCT 395
Length:395
Mass (Da):44,034
Last modified:March 1, 2003 - v1
Checksum:iD1BAA6864670939F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti242 – 2421V → I in AAI20992. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF452722 mRNA. Translation: AAN64907.1.
AY343910 mRNA. Translation: AAQ76868.1.
AK290072 mRNA. Translation: BAF82761.1.
AL078621, AC016745 Genomic DNA. Translation: CAO03555.1.
BC120991 mRNA. Translation: AAI20992.1.
BC120992 mRNA. Translation: AAI20993.1.
CCDSiCCDS2116.1.
RefSeqiNP_742000.1. NM_172003.3.
UniGeneiHs.531330.

Genome annotation databases

EnsembliENST00000259199; ENSP00000259199; ENSG00000136682.
GeneIDi150472.
KEGGihsa:150472.
UCSCiuc002tju.3. human.

Polymorphism databases

DMDMi74714301.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF452722 mRNA. Translation: AAN64907.1 .
AY343910 mRNA. Translation: AAQ76868.1 .
AK290072 mRNA. Translation: BAF82761.1 .
AL078621 , AC016745 Genomic DNA. Translation: CAO03555.1 .
BC120991 mRNA. Translation: AAI20992.1 .
BC120992 mRNA. Translation: AAI20993.1 .
CCDSi CCDS2116.1.
RefSeqi NP_742000.1. NM_172003.3.
UniGenei Hs.531330.

3D structure databases

ProteinModelPortali Q8IUF1.
SMRi Q8IUF1. Positions 42-373.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127299. 6 interactions.
IntActi Q8IUF1. 2 interactions.
MINTi MINT-1136223.
STRINGi 9606.ENSP00000259199.

PTM databases

PhosphoSitei Q8IUF1.

Polymorphism databases

DMDMi 74714301.

Proteomic databases

MaxQBi Q8IUF1.
PaxDbi Q8IUF1.
PRIDEi Q8IUF1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000259199 ; ENSP00000259199 ; ENSG00000136682 .
GeneIDi 150472.
KEGGi hsa:150472.
UCSCi uc002tju.3. human.

Organism-specific databases

CTDi 150472.
GeneCardsi GC02P114188.
H-InvDB HIX0023935.
HGNCi HGNC:17907. CBWD2.
MIMi 611079. gene.
neXtProti NX_Q8IUF1.
PharmGKBi PA26125.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0523.
HOGENOMi HOG000182211.
HOVERGENi HBG056297.
InParanoidi Q8IUF1.
OMAi TICICET.
OrthoDBi EOG7HHWS8.
PhylomeDBi Q8IUF1.
TreeFami TF332679.

Miscellaneous databases

GenomeRNAii 150472.
NextBioi 86453.
PROi Q8IUF1.
SOURCEi Search...

Gene expression databases

Bgeei Q8IUF1.
Genevestigatori Q8IUF1.

Family and domain databases

Gene3Di 3.30.1220.10. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR011629. Cbl_biosynth_CobW-like_C.
IPR003495. CobW/HypB/UreG_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF02492. cobW. 1 hit.
PF07683. CobW_C. 1 hit.
[Graphical view ]
SMARTi SM00833. CobW_C. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF90002. SSF90002. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions."
    Fan Y., Newman T., Linardopoulou E., Trask B.J.
    Genome Res. 12:1663-1672(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Diverse fates of paralogs following segmental duplication of telomeric genes."
    Wong A., Vallender E.J., Heretis K., Ilkin Y., Lahn B.T., Lese Martin C., Ledbetter D.H.
    Genomics 84:239-247(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Substantia nigra.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCBWD2_HUMAN
AccessioniPrimary (citable) accession number: Q8IUF1
Secondary accession number(s): Q0VAN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3