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Protein

Homeobox protein TGIF2LX

Gene

TGIF2LX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May have a transcription role in testis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi48 – 111Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST64

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein TGIF2LX
Alternative name(s):
TGF-beta-induced transcription factor 2-like protein
TGFB-induced factor 2-like protein, X-linked
TGIF-like on the X
Gene namesi
Name:TGIF2LX
Synonyms:TGIFLX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:18570. TGIF2LX.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi90316.
OpenTargetsiENSG00000153779.
PharmGKBiPA38582.

Polymorphism and mutation databases

BioMutaiTGIF2LX.
DMDMi44888510.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000493241 – 241Homeobox protein TGIF2LXAdd BLAST241

Proteomic databases

EPDiQ8IUE1.
MaxQBiQ8IUE1.
PaxDbiQ8IUE1.
PeptideAtlasiQ8IUE1.
PRIDEiQ8IUE1.

PTM databases

iPTMnetiQ8IUE1.
PhosphoSitePlusiQ8IUE1.

Expressioni

Tissue specificityi

Specifically expressed in adult testis.

Gene expression databases

BgeeiENSG00000153779.
CleanExiHS_TGIF2LX.
GenevisibleiQ8IUE1. HS.

Organism-specific databases

HPAiHPA034543.

Interactioni

Protein-protein interaction databases

BioGridi124690. 1 interactor.
STRINGi9606.ENSP00000355119.

Structurei

Secondary structure

1241
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi59 – 71Combined sources13
Turni72 – 75Combined sources4
Helixi80 – 90Combined sources11
Helixi94 – 107Combined sources14
Helixi109 – 112Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DMNNMR-A51-120[»]
ProteinModelPortaliQ8IUE1.
SMRiQ8IUE1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IUE1.

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/TGIF homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773. Eukaryota.
ENOG410XPMQ. LUCA.
GeneTreeiENSGT00550000074260.
HOGENOMiHOG000232039.
HOVERGENiHBG001143.
InParanoidiQ8IUE1.
KOiK19554.
OMAiWPLPKGQ.
OrthoDBiEOG091G0HJ6.
PhylomeDBiQ8IUE1.
TreeFamiTF318093.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IUE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAAADGPAE TQSPVEKDSP AKTQSPAQDT SIMSRNNADT GRVLALPEHK
60 70 80 90 100
KKRKGNLPAE SVKILRDWMY KHRFKAYPSE EEKQMLSEKT NLSLLQISNW
110 120 130 140 150
FINARRRILP DMLQQRRNDP IIGHKTGKDA HATHLQSTEA SVPAKSGPSG
160 170 180 190 200
PDNVQSLPLW PLPKGQMSRE KQPDPESAPS QKLTGIAQPK KKVKVSVTSP
210 220 230 240
SSPELVSPEE HADFSSFLLL VDAAVQRAAE LELEKKQEPN P
Length:241
Mass (Da):26,675
Last modified:March 1, 2003 - v1
Checksum:iA3E393E0BAD0B3BA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017867197V → I.2 PublicationsCorresponds to variant rs2290380dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ427749 Genomic DNA. Translation: CAD20750.1.
AF497480 mRNA. Translation: AAM18073.1.
AL590041 Genomic DNA. Translation: CAI41575.1.
BC117398 mRNA. Translation: AAI17399.1.
BC117400 mRNA. Translation: AAI17401.1.
CCDSiCCDS14459.1.
RefSeqiNP_620410.3. NM_138960.3.
UniGeneiHs.592220.

Genome annotation databases

EnsembliENST00000283891; ENSP00000355119; ENSG00000153779.
ENST00000561129; ENSP00000453704; ENSG00000153779.
GeneIDi90316.
KEGGihsa:90316.
UCSCiuc004efe.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ427749 Genomic DNA. Translation: CAD20750.1.
AF497480 mRNA. Translation: AAM18073.1.
AL590041 Genomic DNA. Translation: CAI41575.1.
BC117398 mRNA. Translation: AAI17399.1.
BC117400 mRNA. Translation: AAI17401.1.
CCDSiCCDS14459.1.
RefSeqiNP_620410.3. NM_138960.3.
UniGeneiHs.592220.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DMNNMR-A51-120[»]
ProteinModelPortaliQ8IUE1.
SMRiQ8IUE1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124690. 1 interactor.
STRINGi9606.ENSP00000355119.

PTM databases

iPTMnetiQ8IUE1.
PhosphoSitePlusiQ8IUE1.

Polymorphism and mutation databases

BioMutaiTGIF2LX.
DMDMi44888510.

Proteomic databases

EPDiQ8IUE1.
MaxQBiQ8IUE1.
PaxDbiQ8IUE1.
PeptideAtlasiQ8IUE1.
PRIDEiQ8IUE1.

Protocols and materials databases

DNASUi90316.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283891; ENSP00000355119; ENSG00000153779.
ENST00000561129; ENSP00000453704; ENSG00000153779.
GeneIDi90316.
KEGGihsa:90316.
UCSCiuc004efe.4. human.

Organism-specific databases

CTDi90316.
DisGeNETi90316.
GeneCardsiTGIF2LX.
H-InvDBHIX0016906.
HGNCiHGNC:18570. TGIF2LX.
HPAiHPA034543.
MIMi300411. gene.
neXtProtiNX_Q8IUE1.
OpenTargetsiENSG00000153779.
PharmGKBiPA38582.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0773. Eukaryota.
ENOG410XPMQ. LUCA.
GeneTreeiENSGT00550000074260.
HOGENOMiHOG000232039.
HOVERGENiHBG001143.
InParanoidiQ8IUE1.
KOiK19554.
OMAiWPLPKGQ.
OrthoDBiEOG091G0HJ6.
PhylomeDBiQ8IUE1.
TreeFamiTF318093.

Miscellaneous databases

EvolutionaryTraceiQ8IUE1.
GenomeRNAii90316.
PROiQ8IUE1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153779.
CleanExiHS_TGIF2LX.
GenevisibleiQ8IUE1. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTF2LX_HUMAN
AccessioniPrimary (citable) accession number: Q8IUE1
Secondary accession number(s): Q5JRM9, Q8TD48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.