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Protein

Homeobox protein TGIF2LX

Gene

TGIF2LX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May have a transcription role in testis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi48 – 11164Homeobox; TALE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein TGIF2LX
Alternative name(s):
TGF-beta-induced transcription factor 2-like protein
TGFB-induced factor 2-like protein, X-linked
TGIF-like on the X
Gene namesi
Name:TGIF2LX
Synonyms:TGIFLX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:18570. TGIF2LX.

Subcellular locationi

  1. Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38582.

Polymorphism and mutation databases

BioMutaiTGIF2LX.
DMDMi44888510.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Homeobox protein TGIF2LXPRO_0000049324Add
BLAST

Proteomic databases

MaxQBiQ8IUE1.
PaxDbiQ8IUE1.
PRIDEiQ8IUE1.

Expressioni

Tissue specificityi

Specifically expressed in adult testis.

Gene expression databases

BgeeiQ8IUE1.
CleanExiHS_TGIF2LX.
GenevestigatoriQ8IUE1.

Organism-specific databases

HPAiHPA034543.

Interactioni

Protein-protein interaction databases

BioGridi124690. 1 interaction.
STRINGi9606.ENSP00000355119.

Structurei

Secondary structure

1
241
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi59 – 7113
Turni72 – 754
Helixi80 – 9011
Helixi94 – 10714
Helixi109 – 1124

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DMNNMR-A51-120[»]
ProteinModelPortaliQ8IUE1.
SMRiQ8IUE1. Positions 51-120.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IUE1.

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/TGIF homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG297708.
GeneTreeiENSGT00550000074260.
HOGENOMiHOG000232039.
HOVERGENiHBG001143.
InParanoidiQ8IUE1.
OMAiPLPKGQM.
OrthoDBiEOG7J70GJ.
PhylomeDBiQ8IUE1.
TreeFamiTF318093.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IUE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAAADGPAE TQSPVEKDSP AKTQSPAQDT SIMSRNNADT GRVLALPEHK
60 70 80 90 100
KKRKGNLPAE SVKILRDWMY KHRFKAYPSE EEKQMLSEKT NLSLLQISNW
110 120 130 140 150
FINARRRILP DMLQQRRNDP IIGHKTGKDA HATHLQSTEA SVPAKSGPSG
160 170 180 190 200
PDNVQSLPLW PLPKGQMSRE KQPDPESAPS QKLTGIAQPK KKVKVSVTSP
210 220 230 240
SSPELVSPEE HADFSSFLLL VDAAVQRAAE LELEKKQEPN P
Length:241
Mass (Da):26,675
Last modified:March 1, 2003 - v1
Checksum:iA3E393E0BAD0B3BA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti197 – 1971V → I.2 Publications
Corresponds to variant rs2290380 [ dbSNP | Ensembl ].
VAR_017867

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ427749 Genomic DNA. Translation: CAD20750.1.
AF497480 mRNA. Translation: AAM18073.1.
AL590041 Genomic DNA. Translation: CAI41575.1.
BC117398 mRNA. Translation: AAI17399.1.
BC117400 mRNA. Translation: AAI17401.1.
CCDSiCCDS14459.1.
RefSeqiNP_620410.3. NM_138960.3.
UniGeneiHs.592220.

Genome annotation databases

EnsembliENST00000283891; ENSP00000355119; ENSG00000153779.
ENST00000561129; ENSP00000453704; ENSG00000153779.
GeneIDi90316.
KEGGihsa:90316.
UCSCiuc004efe.3. human.

Polymorphism and mutation databases

BioMutaiTGIF2LX.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ427749 Genomic DNA. Translation: CAD20750.1.
AF497480 mRNA. Translation: AAM18073.1.
AL590041 Genomic DNA. Translation: CAI41575.1.
BC117398 mRNA. Translation: AAI17399.1.
BC117400 mRNA. Translation: AAI17401.1.
CCDSiCCDS14459.1.
RefSeqiNP_620410.3. NM_138960.3.
UniGeneiHs.592220.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DMNNMR-A51-120[»]
ProteinModelPortaliQ8IUE1.
SMRiQ8IUE1. Positions 51-120.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124690. 1 interaction.
STRINGi9606.ENSP00000355119.

Polymorphism and mutation databases

BioMutaiTGIF2LX.
DMDMi44888510.

Proteomic databases

MaxQBiQ8IUE1.
PaxDbiQ8IUE1.
PRIDEiQ8IUE1.

Protocols and materials databases

DNASUi90316.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283891; ENSP00000355119; ENSG00000153779.
ENST00000561129; ENSP00000453704; ENSG00000153779.
GeneIDi90316.
KEGGihsa:90316.
UCSCiuc004efe.3. human.

Organism-specific databases

CTDi90316.
GeneCardsiGC0XP089176.
H-InvDBHIX0016906.
HGNCiHGNC:18570. TGIF2LX.
HPAiHPA034543.
MIMi300411. gene.
neXtProtiNX_Q8IUE1.
PharmGKBiPA38582.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG297708.
GeneTreeiENSGT00550000074260.
HOGENOMiHOG000232039.
HOVERGENiHBG001143.
InParanoidiQ8IUE1.
OMAiPLPKGQM.
OrthoDBiEOG7J70GJ.
PhylomeDBiQ8IUE1.
TreeFamiTF318093.

Miscellaneous databases

EvolutionaryTraceiQ8IUE1.
GenomeRNAii90316.
NextBioi76648.
PROiQ8IUE1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IUE1.
CleanExiHS_TGIF2LX.
GenevestigatoriQ8IUE1.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human-specific Yp11.2/Xq21.3 homology block encodes a potentially functional testis-specific TGIF-like retroposon."
    Blanco-Arias P., Sargent C.A., Affara N.A.
    Mamm. Genome 13:463-468(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-197.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-197.
    Tissue: Testis.
  5. "The solution structure of the homeobox domain of human homeobox protein TGIF2LX."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 51-120.

Entry informationi

Entry nameiTF2LX_HUMAN
AccessioniPrimary (citable) accession number: Q8IUE1
Secondary accession number(s): Q5JRM9, Q8TD48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2003
Last modified: April 29, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.