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Q8IUE1

- TF2LX_HUMAN

UniProt

Q8IUE1 - TF2LX_HUMAN

Protein

Homeobox protein TGIF2LX

Gene

TGIF2LX

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    May have a transcription role in testis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi48 – 11164Homeobox; TALE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein TGIF2LX
    Alternative name(s):
    TGF-beta-induced transcription factor 2-like protein
    TGFB-induced factor 2-like protein, X-linked
    TGIF-like on the X
    Gene namesi
    Name:TGIF2LX
    Synonyms:TGIFLX
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:18570. TGIF2LX.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38582.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 241241Homeobox protein TGIF2LXPRO_0000049324Add
    BLAST

    Proteomic databases

    MaxQBiQ8IUE1.
    PaxDbiQ8IUE1.
    PRIDEiQ8IUE1.

    Expressioni

    Tissue specificityi

    Specifically expressed in adult testis.

    Gene expression databases

    BgeeiQ8IUE1.
    CleanExiHS_TGIF2LX.
    GenevestigatoriQ8IUE1.

    Organism-specific databases

    HPAiHPA034543.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000355119.

    Structurei

    Secondary structure

    1
    241
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi59 – 7113
    Turni72 – 754
    Helixi80 – 9011
    Helixi94 – 10714
    Helixi109 – 1124

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DMNNMR-A51-120[»]
    ProteinModelPortaliQ8IUE1.
    SMRiQ8IUE1. Positions 51-120.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8IUE1.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TALE/TGIF homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG297708.
    HOGENOMiHOG000232039.
    HOVERGENiHBG001143.
    InParanoidiQ8IUE1.
    OMAiEEYADFS.
    OrthoDBiEOG7J70GJ.
    PhylomeDBiQ8IUE1.
    TreeFamiTF318093.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR001356. Homeobox_dom.
    IPR008422. Homeobox_KN_domain.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF05920. Homeobox_KN. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8IUE1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAAADGPAE TQSPVEKDSP AKTQSPAQDT SIMSRNNADT GRVLALPEHK    50
    KKRKGNLPAE SVKILRDWMY KHRFKAYPSE EEKQMLSEKT NLSLLQISNW 100
    FINARRRILP DMLQQRRNDP IIGHKTGKDA HATHLQSTEA SVPAKSGPSG 150
    PDNVQSLPLW PLPKGQMSRE KQPDPESAPS QKLTGIAQPK KKVKVSVTSP 200
    SSPELVSPEE HADFSSFLLL VDAAVQRAAE LELEKKQEPN P 241
    Length:241
    Mass (Da):26,675
    Last modified:March 1, 2003 - v1
    Checksum:iA3E393E0BAD0B3BA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti197 – 1971V → I.2 Publications
    Corresponds to variant rs2290380 [ dbSNP | Ensembl ].
    VAR_017867

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ427749 Genomic DNA. Translation: CAD20750.1.
    AF497480 mRNA. Translation: AAM18073.1.
    AL590041 Genomic DNA. Translation: CAI41575.1.
    BC117398 mRNA. Translation: AAI17399.1.
    BC117400 mRNA. Translation: AAI17401.1.
    CCDSiCCDS14459.1.
    RefSeqiNP_620410.3. NM_138960.3.
    UniGeneiHs.592220.

    Genome annotation databases

    EnsembliENST00000283891; ENSP00000355119; ENSG00000153779.
    ENST00000561129; ENSP00000453704; ENSG00000153779.
    GeneIDi90316.
    KEGGihsa:90316.
    UCSCiuc004efe.3. human.

    Polymorphism databases

    DMDMi44888510.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ427749 Genomic DNA. Translation: CAD20750.1 .
    AF497480 mRNA. Translation: AAM18073.1 .
    AL590041 Genomic DNA. Translation: CAI41575.1 .
    BC117398 mRNA. Translation: AAI17399.1 .
    BC117400 mRNA. Translation: AAI17401.1 .
    CCDSi CCDS14459.1.
    RefSeqi NP_620410.3. NM_138960.3.
    UniGenei Hs.592220.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DMN NMR - A 51-120 [» ]
    ProteinModelPortali Q8IUE1.
    SMRi Q8IUE1. Positions 51-120.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000355119.

    Polymorphism databases

    DMDMi 44888510.

    Proteomic databases

    MaxQBi Q8IUE1.
    PaxDbi Q8IUE1.
    PRIDEi Q8IUE1.

    Protocols and materials databases

    DNASUi 90316.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000283891 ; ENSP00000355119 ; ENSG00000153779 .
    ENST00000561129 ; ENSP00000453704 ; ENSG00000153779 .
    GeneIDi 90316.
    KEGGi hsa:90316.
    UCSCi uc004efe.3. human.

    Organism-specific databases

    CTDi 90316.
    GeneCardsi GC0XP089176.
    H-InvDB HIX0016906.
    HGNCi HGNC:18570. TGIF2LX.
    HPAi HPA034543.
    MIMi 300411. gene.
    neXtProti NX_Q8IUE1.
    PharmGKBi PA38582.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG297708.
    HOGENOMi HOG000232039.
    HOVERGENi HBG001143.
    InParanoidi Q8IUE1.
    OMAi EEYADFS.
    OrthoDBi EOG7J70GJ.
    PhylomeDBi Q8IUE1.
    TreeFami TF318093.

    Miscellaneous databases

    EvolutionaryTracei Q8IUE1.
    GenomeRNAii 90316.
    NextBioi 76648.
    PROi Q8IUE1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8IUE1.
    CleanExi HS_TGIF2LX.
    Genevestigatori Q8IUE1.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR001356. Homeobox_dom.
    IPR008422. Homeobox_KN_domain.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF05920. Homeobox_KN. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human-specific Yp11.2/Xq21.3 homology block encodes a potentially functional testis-specific TGIF-like retroposon."
      Blanco-Arias P., Sargent C.A., Affara N.A.
      Mamm. Genome 13:463-468(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-197.
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-197.
      Tissue: Testis.
    5. "The solution structure of the homeobox domain of human homeobox protein TGIF2LX."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 51-120.

    Entry informationi

    Entry nameiTF2LX_HUMAN
    AccessioniPrimary (citable) accession number: Q8IUE1
    Secondary accession number(s): Q5JRM9, Q8TD48
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3