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Protein

Homeobox protein TGIF2LY

Gene

TGIF2LY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May have a transcription role in testis. May act as a competitor/regulator of TGIF2LX.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi48 – 11164Homeobox; TALE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein TGIF2LY
Alternative name(s):
TGF-beta-induced transcription factor 2-like protein
TGFB-induced factor 2-like protein, Y-linked
TGIF-like on the Y
Gene namesi
Name:TGIF2LY
Synonyms:TGIFLY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome Y

Organism-specific databases

HGNCiHGNC:18569. TGIF2LY.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38581.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Homeobox protein TGIF2LYPRO_0000049332Add
BLAST

Proteomic databases

PaxDbiQ8IUE0.
PRIDEiQ8IUE0.

Expressioni

Tissue specificityi

Specifically expressed in adult testis.

Gene expression databases

BgeeiQ8IUE0.
CleanExiHS_TGIF2LY.
GenevestigatoriQ8IUE0.

Organism-specific databases

HPAiHPA046427.

Interactioni

Protein-protein interaction databases

BioGridi124750. 4 interactions.
IntActiQ8IUE0. 1 interaction.
MINTiMINT-7899478.
STRINGi9606.ENSP00000318502.

Structurei

3D structure databases

ProteinModelPortaliQ8IUE0.
SMRiQ8IUE0. Positions 51-120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/TGIF homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG302919.
GeneTreeiENSGT00550000074260.
HOGENOMiHOG000237310.
HOVERGENiHBG001143.
InParanoidiQ8IUE0.
OrthoDBiEOG7J70GJ.
PhylomeDBiQ8IUE0.
TreeFamiTF318093.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IUE0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEAAADGPAE TQSPVEKDSP AKTQSPAQDT SIMSRNNADT GRVLALPEHK
60 70 80 90 100
KKRKGNLPAE SVKILRDWMY KHRFKAYPSE EEKQMLSEKT NLSLLRISNW
110 120 130 140 150
FINARRRILP DMLQQRRNDP IIGHKTGKDA HATHLQSTEA SVPAKSGPVV
160 170 180
QTMYKACPCG PCQRARCQER SNQIRSRPLA RSSPE
Length:185
Mass (Da):20,814
Last modified:March 1, 2003 - v1
Checksum:iF02975B3EA9866F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ427750 Genomic DNA. Translation: CAD20751.1.
AF332223 mRNA. Translation: AAK13475.1.
AK292609 mRNA. Translation: BAF85298.1.
BC128604 mRNA. Translation: AAI28605.1.
CCDSiCCDS14775.1.
RefSeqiNP_631960.1. NM_139214.2.
UniGeneiHs.112148.

Genome annotation databases

EnsembliENST00000321217; ENSP00000318502; ENSG00000176679.
ENST00000559055; ENSP00000453750; ENSG00000176679.
ENST00000623660; ENSP00000485092; ENSG00000279055.
GeneIDi90655.
KEGGihsa:90655.
UCSCiuc004fqk.3. human.

Polymorphism databases

DMDMi44888509.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ427750 Genomic DNA. Translation: CAD20751.1.
AF332223 mRNA. Translation: AAK13475.1.
AK292609 mRNA. Translation: BAF85298.1.
BC128604 mRNA. Translation: AAI28605.1.
CCDSiCCDS14775.1.
RefSeqiNP_631960.1. NM_139214.2.
UniGeneiHs.112148.

3D structure databases

ProteinModelPortaliQ8IUE0.
SMRiQ8IUE0. Positions 51-120.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124750. 4 interactions.
IntActiQ8IUE0. 1 interaction.
MINTiMINT-7899478.
STRINGi9606.ENSP00000318502.

Polymorphism databases

DMDMi44888509.

Proteomic databases

PaxDbiQ8IUE0.
PRIDEiQ8IUE0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321217; ENSP00000318502; ENSG00000176679.
ENST00000559055; ENSP00000453750; ENSG00000176679.
ENST00000623660; ENSP00000485092; ENSG00000279055.
GeneIDi90655.
KEGGihsa:90655.
UCSCiuc004fqk.3. human.

Organism-specific databases

CTDi90655.
GeneCardsiGC0YP003447.
HGNCiHGNC:18569. TGIF2LY.
HPAiHPA046427.
MIMi400025. gene.
neXtProtiNX_Q8IUE0.
PharmGKBiPA38581.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG302919.
GeneTreeiENSGT00550000074260.
HOGENOMiHOG000237310.
HOVERGENiHBG001143.
InParanoidiQ8IUE0.
OrthoDBiEOG7J70GJ.
PhylomeDBiQ8IUE0.
TreeFamiTF318093.

Miscellaneous databases

GenomeRNAii90655.
NextBioi76905.
PROiQ8IUE0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IUE0.
CleanExiHS_TGIF2LY.
GenevestigatoriQ8IUE0.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human-specific Yp11.2/Xq21.3 homology block encodes a potentially functional testis-specific TGIF-like retroposon."
    Blanco-Arias P., Sargent C.A., Affara N.A.
    Mamm. Genome 13:463-468(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiTF2LY_HUMAN
AccessioniPrimary (citable) accession number: Q8IUE0
Secondary accession number(s): A2VCU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2003
Last modified: February 4, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.