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Q8IUE0

- TF2LY_HUMAN

UniProt

Q8IUE0 - TF2LY_HUMAN

Protein

Homeobox protein TGIF2LY

Gene

TGIF2LY

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    May have a transcription role in testis. May act as a competitor/regulator of TGIF2LX.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi48 – 11164Homeobox; TALE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein TGIF2LY
    Alternative name(s):
    TGF-beta-induced transcription factor 2-like protein
    TGFB-induced factor 2-like protein, Y-linked
    TGIF-like on the Y
    Gene namesi
    Name:TGIF2LY
    Synonyms:TGIFLY
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome Y

    Organism-specific databases

    HGNCiHGNC:18569. TGIF2LY.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38581.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 185185Homeobox protein TGIF2LYPRO_0000049332Add
    BLAST

    Proteomic databases

    PaxDbiQ8IUE0.
    PRIDEiQ8IUE0.

    Expressioni

    Tissue specificityi

    Specifically expressed in adult testis.

    Gene expression databases

    BgeeiQ8IUE0.
    CleanExiHS_TGIF2LY.
    GenevestigatoriQ8IUE0.

    Organism-specific databases

    HPAiHPA046427.

    Interactioni

    Protein-protein interaction databases

    BioGridi124750. 2 interactions.
    IntActiQ8IUE0. 1 interaction.
    MINTiMINT-7899478.
    STRINGi9606.ENSP00000318502.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IUE0.
    SMRiQ8IUE0. Positions 51-120.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TALE/TGIF homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG302919.
    HOGENOMiHOG000237310.
    HOVERGENiHBG001143.
    InParanoidiQ8IUE0.
    OMAiRYESEAN.
    OrthoDBiEOG7J70GJ.
    PhylomeDBiQ8IUE0.
    TreeFamiTF318093.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR001356. Homeobox_dom.
    IPR008422. Homeobox_KN_domain.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF05920. Homeobox_KN. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8IUE0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAAADGPAE TQSPVEKDSP AKTQSPAQDT SIMSRNNADT GRVLALPEHK    50
    KKRKGNLPAE SVKILRDWMY KHRFKAYPSE EEKQMLSEKT NLSLLRISNW 100
    FINARRRILP DMLQQRRNDP IIGHKTGKDA HATHLQSTEA SVPAKSGPVV 150
    QTMYKACPCG PCQRARCQER SNQIRSRPLA RSSPE 185
    Length:185
    Mass (Da):20,814
    Last modified:March 1, 2003 - v1
    Checksum:iF02975B3EA9866F4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ427750 Genomic DNA. Translation: CAD20751.1.
    AF332223 mRNA. Translation: AAK13475.1.
    AK292609 mRNA. Translation: BAF85298.1.
    BC128604 mRNA. Translation: AAI28605.1.
    CCDSiCCDS14775.1.
    RefSeqiNP_631960.1. NM_139214.2.
    UniGeneiHs.112148.

    Genome annotation databases

    EnsembliENST00000321217; ENSP00000318502; ENSG00000176679.
    ENST00000559055; ENSP00000453750; ENSG00000176679.
    GeneIDi90655.
    KEGGihsa:90655.
    UCSCiuc004fqk.3. human.

    Polymorphism databases

    DMDMi44888509.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ427750 Genomic DNA. Translation: CAD20751.1 .
    AF332223 mRNA. Translation: AAK13475.1 .
    AK292609 mRNA. Translation: BAF85298.1 .
    BC128604 mRNA. Translation: AAI28605.1 .
    CCDSi CCDS14775.1.
    RefSeqi NP_631960.1. NM_139214.2.
    UniGenei Hs.112148.

    3D structure databases

    ProteinModelPortali Q8IUE0.
    SMRi Q8IUE0. Positions 51-120.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124750. 2 interactions.
    IntActi Q8IUE0. 1 interaction.
    MINTi MINT-7899478.
    STRINGi 9606.ENSP00000318502.

    Polymorphism databases

    DMDMi 44888509.

    Proteomic databases

    PaxDbi Q8IUE0.
    PRIDEi Q8IUE0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000321217 ; ENSP00000318502 ; ENSG00000176679 .
    ENST00000559055 ; ENSP00000453750 ; ENSG00000176679 .
    GeneIDi 90655.
    KEGGi hsa:90655.
    UCSCi uc004fqk.3. human.

    Organism-specific databases

    CTDi 90655.
    GeneCardsi GC0YP003447.
    HGNCi HGNC:18569. TGIF2LY.
    HPAi HPA046427.
    MIMi 400025. gene.
    neXtProti NX_Q8IUE0.
    PharmGKBi PA38581.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG302919.
    HOGENOMi HOG000237310.
    HOVERGENi HBG001143.
    InParanoidi Q8IUE0.
    OMAi RYESEAN.
    OrthoDBi EOG7J70GJ.
    PhylomeDBi Q8IUE0.
    TreeFami TF318093.

    Miscellaneous databases

    GenomeRNAii 90655.
    NextBioi 76905.
    PROi Q8IUE0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8IUE0.
    CleanExi HS_TGIF2LY.
    Genevestigatori Q8IUE0.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR001356. Homeobox_dom.
    IPR008422. Homeobox_KN_domain.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF05920. Homeobox_KN. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human-specific Yp11.2/Xq21.3 homology block encodes a potentially functional testis-specific TGIF-like retroposon."
      Blanco-Arias P., Sargent C.A., Affara N.A.
      Mamm. Genome 13:463-468(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiTF2LY_HUMAN
    AccessioniPrimary (citable) accession number: Q8IUE0
    Secondary accession number(s): A2VCU1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome Y
      Human chromosome Y: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3