Reviewed, UniProtKB/Swiss-Prot Q8IUE0 (TF2LY_HUMAN)

Names and origin

Protein names

Recommended name:
    Homeobox protein TGIF2LY
Alternative name(s):
    TGFB-induced factor 2-like protein, Y-linked
    TGF(beta)induced transcription factor 2-like protein
    TGIF-like on the Y

Gene names

Name:	TGIF2LY
Synonyms:	TGIFLY

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May have a transcription role in testis. May act as a competitor/regulator of TGIF2LX.
Subcellular location	Nucleus By similarity.
Tissue specificity	Specifically expressed in adult testis.
Sequence similarities	Belongs to the TALE/TGIF homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Homeobox protein TGIF2LY		PRO_0000049332
Regions
	DNA binding	48 – 111	64	Homeobox; TALE-type

Sequences

	Sequence		Length	Mass (Da)
	Q8IUE0-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: F02975B3EA9866F4	FASTA	185	20,814
	10 20 30 40 50 60 MEAAADGPAE TQSPVEKDSP AKTQSPAQDT SIMSRNNADT GRVLALPEHK KKRKGNLPAE 70 80 90 100 110 120 SVKILRDWMY KHRFKAYPSE EEKQMLSEKT NLSLLRISNW FINARRRILP DMLQQRRNDP 130 140 150 160 170 180 IIGHKTGKDA HATHLQSTEA SVPAKSGPVV QTMYKACPCG PCQRARCQER SNQIRSRPLA RSSPE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human-specific Yp11.2/Xq21.3 homology block encodes a potentially functional testis-specific TGIF-like retroposon." Blanco-Arias P., Sargent C.A., Affara N.A. Mamm. Genome 13:463-468(2002) [PubMed: 12226713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Testis.
[2]	"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes." Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. , Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H., Wilson R.K., Rozen S., Page D.C. Nature 423:825-837(2003) [PubMed: 12815422] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ427750 Genomic DNA. Translation: CAD20751.1. AF332223 mRNA. Translation: AAK13475.1. AK292609 mRNA. Translation: BAF85298.1. BC128604 mRNA. Translation: AAI28605.1.
IPI	IPI00216726.
RefSeq	NP_631960.1.
UniGene	Hs.112148
3D structure databases
SMR	Q8IUE0. Positions 51-120.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8IUE0.
Genome annotation databases
Ensembl	ENST00000321217; ENSP00000318502; ENSG00000176679; Homo sapiens. [Genome view] ENST00000383049; ENSP00000372521; ENSG00000176679; Homo sapiens. [Genome view]
GeneID	90655.
KEGG	hsa:90655.
UCSC	uc004fqk.1. human.
Organism-specific databases
CTD	90655.
GeneCards	GC0YP003490.
H-InvDB	HIX0056669.
HGNC	HGNC:18569. TGIF2LY.
MIM	400025. gene.
PharmGKB	PA38581.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8IUE0.
OMA	LLRISNW
OrthoDB	EOG9W3W6F
Gene expression databases
CleanEx	HS_TGIF2LY.
Genevestigator	Q8IUE0.
GermOnline	ENSG00000176679. Homo sapiens.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	76905.
SOURCE	Search...

Entry information

Entry name

TF2LY_HUMAN

Accession

Primary (citable) accession number: Q8IUE0
Secondary accession number(s): A2VCU1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
Last sequence update:	March 1, 2003
Last modified:	November 24, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.