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Q8IUE0

- TF2LY_HUMAN

UniProt

Q8IUE0 - TF2LY_HUMAN

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Protein

Homeobox protein TGIF2LY

Gene

TGIF2LY

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May have a transcription role in testis. May act as a competitor/regulator of TGIF2LX.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi48 – 11164Homeobox; TALE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein TGIF2LY
Alternative name(s):
TGF-beta-induced transcription factor 2-like protein
TGFB-induced factor 2-like protein, Y-linked
TGIF-like on the Y
Gene namesi
Name:TGIF2LY
Synonyms:TGIFLY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome Y

Organism-specific databases

HGNCiHGNC:18569. TGIF2LY.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38581.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Homeobox protein TGIF2LYPRO_0000049332Add
BLAST

Proteomic databases

PaxDbiQ8IUE0.
PRIDEiQ8IUE0.

Expressioni

Tissue specificityi

Specifically expressed in adult testis.

Gene expression databases

BgeeiQ8IUE0.
CleanExiHS_TGIF2LY.
GenevestigatoriQ8IUE0.

Organism-specific databases

HPAiHPA046427.

Interactioni

Protein-protein interaction databases

BioGridi124750. 2 interactions.
IntActiQ8IUE0. 1 interaction.
MINTiMINT-7899478.
STRINGi9606.ENSP00000318502.

Structurei

3D structure databases

ProteinModelPortaliQ8IUE0.
SMRiQ8IUE0. Positions 51-120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/TGIF homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG302919.
GeneTreeiENSGT00550000074260.
HOGENOMiHOG000237310.
HOVERGENiHBG001143.
InParanoidiQ8IUE0.
OMAiRYESEAN.
OrthoDBiEOG7J70GJ.
PhylomeDBiQ8IUE0.
TreeFamiTF318093.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IUE0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEAAADGPAE TQSPVEKDSP AKTQSPAQDT SIMSRNNADT GRVLALPEHK
60 70 80 90 100
KKRKGNLPAE SVKILRDWMY KHRFKAYPSE EEKQMLSEKT NLSLLRISNW
110 120 130 140 150
FINARRRILP DMLQQRRNDP IIGHKTGKDA HATHLQSTEA SVPAKSGPVV
160 170 180
QTMYKACPCG PCQRARCQER SNQIRSRPLA RSSPE
Length:185
Mass (Da):20,814
Last modified:March 1, 2003 - v1
Checksum:iF02975B3EA9866F4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ427750 Genomic DNA. Translation: CAD20751.1.
AF332223 mRNA. Translation: AAK13475.1.
AK292609 mRNA. Translation: BAF85298.1.
BC128604 mRNA. Translation: AAI28605.1.
CCDSiCCDS14775.1.
RefSeqiNP_631960.1. NM_139214.2.
UniGeneiHs.112148.

Genome annotation databases

EnsembliENST00000321217; ENSP00000318502; ENSG00000176679.
ENST00000559055; ENSP00000453750; ENSG00000176679.
GeneIDi90655.
KEGGihsa:90655.
UCSCiuc004fqk.3. human.

Polymorphism databases

DMDMi44888509.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ427750 Genomic DNA. Translation: CAD20751.1 .
AF332223 mRNA. Translation: AAK13475.1 .
AK292609 mRNA. Translation: BAF85298.1 .
BC128604 mRNA. Translation: AAI28605.1 .
CCDSi CCDS14775.1.
RefSeqi NP_631960.1. NM_139214.2.
UniGenei Hs.112148.

3D structure databases

ProteinModelPortali Q8IUE0.
SMRi Q8IUE0. Positions 51-120.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124750. 2 interactions.
IntActi Q8IUE0. 1 interaction.
MINTi MINT-7899478.
STRINGi 9606.ENSP00000318502.

Polymorphism databases

DMDMi 44888509.

Proteomic databases

PaxDbi Q8IUE0.
PRIDEi Q8IUE0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000321217 ; ENSP00000318502 ; ENSG00000176679 .
ENST00000559055 ; ENSP00000453750 ; ENSG00000176679 .
GeneIDi 90655.
KEGGi hsa:90655.
UCSCi uc004fqk.3. human.

Organism-specific databases

CTDi 90655.
GeneCardsi GC0YP003447.
HGNCi HGNC:18569. TGIF2LY.
HPAi HPA046427.
MIMi 400025. gene.
neXtProti NX_Q8IUE0.
PharmGKBi PA38581.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG302919.
GeneTreei ENSGT00550000074260.
HOGENOMi HOG000237310.
HOVERGENi HBG001143.
InParanoidi Q8IUE0.
OMAi RYESEAN.
OrthoDBi EOG7J70GJ.
PhylomeDBi Q8IUE0.
TreeFami TF318093.

Miscellaneous databases

GenomeRNAii 90655.
NextBioi 76905.
PROi Q8IUE0.
SOURCEi Search...

Gene expression databases

Bgeei Q8IUE0.
CleanExi HS_TGIF2LY.
Genevestigatori Q8IUE0.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF05920. Homeobox_KN. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human-specific Yp11.2/Xq21.3 homology block encodes a potentially functional testis-specific TGIF-like retroposon."
    Blanco-Arias P., Sargent C.A., Affara N.A.
    Mamm. Genome 13:463-468(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiTF2LY_HUMAN
AccessioniPrimary (citable) accession number: Q8IUE0
Secondary accession number(s): A2VCU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3