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Protein

Homeobox protein TGIF2LY

Gene

TGIF2LY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May have a transcription role in testis. May act as a competitor/regulator of TGIF2LX.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi48 – 111Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST64

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein TGIF2LY
Alternative name(s):
TGF-beta-induced transcription factor 2-like protein
TGFB-induced factor 2-like protein, Y-linked
TGIF-like on the Y
Gene namesi
Name:TGIF2LY
Synonyms:TGIFLY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome Y

Organism-specific databases

HGNCiHGNC:18569. TGIF2LY.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38581.

Polymorphism and mutation databases

BioMutaiTGIF2LY.
DMDMi44888509.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000493321 – 185Homeobox protein TGIF2LYAdd BLAST185

Proteomic databases

EPDiQ8IUE0.
MaxQBiQ8IUE0.
PaxDbiQ8IUE0.
PeptideAtlasiQ8IUE0.
PRIDEiQ8IUE0.

PTM databases

iPTMnetiQ8IUE0.
PhosphoSitePlusiQ8IUE0.

Expressioni

Tissue specificityi

Specifically expressed in adult testis.

Gene expression databases

BgeeiENSG00000176679.
CleanExiHS_TGIF2LY.
GenevisibleiQ8IUE0. HS.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124750. 27 interactors.
IntActiQ8IUE0. 3 interactors.
MINTiMINT-7899478.
STRINGi9606.ENSP00000318502.

Structurei

3D structure databases

ProteinModelPortaliQ8IUE0.
SMRiQ8IUE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/TGIF homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773. Eukaryota.
ENOG410XPMQ. LUCA.
GeneTreeiENSGT00550000074260.
HOGENOMiHOG000237310.
HOVERGENiHBG001143.
InParanoidiQ8IUE0.
KOiK19554.
OrthoDBiEOG091G0HJ6.
PhylomeDBiQ8IUE0.
TreeFamiTF318093.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
PfamiView protein in Pfam
PF05920. Homeobox_KN. 1 hit.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IUE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAAADGPAE TQSPVEKDSP AKTQSPAQDT SIMSRNNADT GRVLALPEHK
60 70 80 90 100
KKRKGNLPAE SVKILRDWMY KHRFKAYPSE EEKQMLSEKT NLSLLRISNW
110 120 130 140 150
FINARRRILP DMLQQRRNDP IIGHKTGKDA HATHLQSTEA SVPAKSGPVV
160 170 180
QTMYKACPCG PCQRARCQER SNQIRSRPLA RSSPE
Length:185
Mass (Da):20,814
Last modified:March 1, 2003 - v1
Checksum:iF02975B3EA9866F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ427750 Genomic DNA. Translation: CAD20751.1.
AF332223 mRNA. Translation: AAK13475.1.
AK292609 mRNA. Translation: BAF85298.1.
BC128604 mRNA. Translation: AAI28605.1.
CCDSiCCDS14775.1.
RefSeqiNP_631960.1. NM_139214.2.
UniGeneiHs.112148.

Genome annotation databases

EnsembliENST00000321217; ENSP00000318502; ENSG00000176679.
ENST00000559055; ENSP00000453750; ENSG00000176679.
GeneIDi90655.
KEGGihsa:90655.
UCSCiuc004fqk.4. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTF2LY_HUMAN
AccessioniPrimary (citable) accession number: Q8IUE0
Secondary accession number(s): A2VCU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2003
Last modified: May 10, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families