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Protein

Homeobox protein TGIF2LY

Gene

TGIF2LY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have a transcription role in testis. May act as a competitor/regulator of TGIF2LX.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi48 – 111Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST64

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein TGIF2LY
Alternative name(s):
TGF-beta-induced transcription factor 2-like protein
TGFB-induced factor 2-like protein, Y-linked
TGIF-like on the Y
Gene namesi
Name:TGIF2LY
Synonyms:TGIFLY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome Y

Organism-specific databases

EuPathDBiHostDB:ENSG00000176679.8
HGNCiHGNC:18569 TGIF2LY
MIMi400025 gene
neXtProtiNX_Q8IUE0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38581

Polymorphism and mutation databases

BioMutaiTGIF2LY
DMDMi44888509

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000493321 – 185Homeobox protein TGIF2LYAdd BLAST185

Proteomic databases

MaxQBiQ8IUE0
PaxDbiQ8IUE0
PeptideAtlasiQ8IUE0
PRIDEiQ8IUE0

PTM databases

iPTMnetiQ8IUE0
PhosphoSitePlusiQ8IUE0

Expressioni

Tissue specificityi

Specifically expressed in adult testis.

Gene expression databases

BgeeiENSG00000176679
CleanExiHS_TGIF2LY
GenevisibleiQ8IUE0 HS

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124750, 29 interactors
IntActiQ8IUE0, 3 interactors
MINTiQ8IUE0
STRINGi9606.ENSP00000318502

Structurei

3D structure databases

ProteinModelPortaliQ8IUE0
SMRiQ8IUE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/TGIF homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00550000074260
HOGENOMiHOG000237310
HOVERGENiHBG001143
InParanoidiQ8IUE0
KOiK19554
OrthoDBiEOG091G0HJ6
PhylomeDBiQ8IUE0
TreeFamiTF318093

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IUE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAAADGPAE TQSPVEKDSP AKTQSPAQDT SIMSRNNADT GRVLALPEHK
60 70 80 90 100
KKRKGNLPAE SVKILRDWMY KHRFKAYPSE EEKQMLSEKT NLSLLRISNW
110 120 130 140 150
FINARRRILP DMLQQRRNDP IIGHKTGKDA HATHLQSTEA SVPAKSGPVV
160 170 180
QTMYKACPCG PCQRARCQER SNQIRSRPLA RSSPE
Length:185
Mass (Da):20,814
Last modified:March 1, 2003 - v1
Checksum:iF02975B3EA9866F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ427750 Genomic DNA Translation: CAD20751.1
AF332223 mRNA Translation: AAK13475.1
AK292609 mRNA Translation: BAF85298.1
BC128604 mRNA Translation: AAI28605.1
CCDSiCCDS14775.1
RefSeqiNP_631960.1, NM_139214.2
UniGeneiHs.112148

Genome annotation databases

EnsembliENST00000321217; ENSP00000318502; ENSG00000176679
ENST00000559055; ENSP00000453750; ENSG00000176679
GeneIDi90655
KEGGihsa:90655
UCSCiuc004fqk.4 human

Similar proteinsi

Entry informationi

Entry nameiTF2LY_HUMAN
AccessioniPrimary (citable) accession number: Q8IUE0
Secondary accession number(s): A2VCU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health