Reviewed,
UniProtKB/Swiss-Prot Q8IUE0 (TF2LY_HUMAN)
Last modified
November 24, 2009.
Version 58.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Homeobox protein TGIF2LY Alternative name(s): TGFB-induced factor 2-like protein, Y-linked TGF(beta)induced transcription factor 2-like protein TGIF-like on the Y | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 185 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | May have a transcription role in testis. May act as a competitor/regulator of TGIF2LX. |
| Subcellular location | Nucleus By similarity. |
| Tissue specificity | Specifically expressed in adult testis. |
| Sequence similarities | Belongs to the TALE/TGIF homeobox family. Contains 1 homeobox DNA-binding domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Domain | Homeobox |
| Ligand | DNA-binding |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| AJ427750 Genomic DNA. Translation: CAD20751.1. AF332223 mRNA. Translation: AAK13475.1. AK292609 mRNA. Translation: BAF85298.1. BC128604 mRNA. Translation: AAI28605.1. | |
| IPI | IPI00216726. |
| RefSeq | NP_631960.1. |
| UniGene | Hs.112148 |
3D structure databases | |
| SMR | Q8IUE0. Positions 51-120. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q8IUE0. |
Genome annotation databases | |
| Ensembl | ENST00000321217; ENSP00000318502; ENSG00000176679; Homo sapiens. [Genome view] ENST00000383049; ENSP00000372521; ENSG00000176679; Homo sapiens. [Genome view] |
| GeneID | 90655. |
| KEGG | hsa:90655. |
| UCSC | uc004fqk.1. human. |
Organism-specific databases | |
| CTD | 90655. |
| GeneCards | GC0YP003490. |
| H-InvDB | HIX0056669. |
| HGNC | HGNC:18569. TGIF2LY. |
| MIM | 400025. gene. |
| PharmGKB | PA38581. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q8IUE0. |
| OMA | LLRISNW |
| OrthoDB | EOG9W3W6F |
Gene expression databases | |
| CleanEx | HS_TGIF2LY. |
| Genevestigator | Q8IUE0. |
| GermOnline | ENSG00000176679. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001356. Homeobox. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view] |
| Gene3D | G3DSA:1.10.10.60. Homeodomain-rel. 1 hit. |
| Pfam | PF00046. Homeobox. 1 hit. [Graphical view] |
| SMART | SM00389. HOX. 1 hit. [Graphical view] |
| PROSITE | PS50071. HOMEOBOX_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 76905. |
| SOURCE | Search... |
Entry information
| Entry name | TF2LY_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8IUE0 Secondary accession number(s): A2VCU1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome Y Human chromosome Y: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


