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Protein

ELKS/Rab6-interacting/CAST family member 1

Gene

ERC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport.1 Publication

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • leucine zipper domain binding Source: UniProtKB
  • PDZ domain binding Source: ParkinsonsUK-UCL
  • Rab GTPase binding Source: ParkinsonsUK-UCL

GO - Biological processi

  • I-kappaB phosphorylation Source: UniProtKB
  • multicellular organism development Source: UniProtKB
  • positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • regulation of transcription, DNA-templated Source: UniProtKB
  • retrograde transport, endosome to Golgi Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

SIGNORiQ8IUD2.

Names & Taxonomyi

Protein namesi
Recommended name:
ELKS/Rab6-interacting/CAST family member 1
Short name:
ERC-1
Alternative name(s):
Rab6-interacting protein 2
Gene namesi
Name:ERC1
Synonyms:ELKS, KIAA1081, RAB6IP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:17072. ERC1.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cytoplasm Source: UniProtKB
  • Golgi membrane Source: UniProtKB-SubCell
  • IkappaB kinase complex Source: UniProtKB
  • presynaptic active zone Source: InterPro
  • presynaptic membrane Source: UniProtKB
  • synapse Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving ERC1/RAB6IP2 is found in papillary thyroid carcinomas (PTCs). Translocation t(10;12)(q11;p13) involving RET. In vitro, isoform 1, isoform 3 and isoform 5 participating in a ERC1-RET fusion protein activate tyrosine-protein kinase activity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei719 – 7202Breakpoint for translocation to form ERC1-RET oncogene

Organism-specific databases

MalaCardsiERC1.
Orphaneti280325. Distal monosomy 12p.
146. Papillary or follicular thyroid carcinoma.
PharmGKBiPA134970875.

Polymorphism and mutation databases

BioMutaiERC1.
DMDMi51827892.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11161116ELKS/Rab6-interacting/CAST family member 1PRO_0000097176Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101N6-acetyllysineBy similarity
Modified residuei17 – 171PhosphoserineCombined sources
Modified residuei21 – 211PhosphoserineCombined sources
Modified residuei37 – 371PhosphoserineCombined sources
Modified residuei38 – 381PhosphothreonineCombined sources
Modified residuei55 – 551PhosphoserineBy similarity
Modified residuei75 – 751PhosphoserineCombined sources
Modified residuei94 – 941PhosphoserineCombined sources
Modified residuei1005 – 10051PhosphoserineBy similarity
Modified residuei1046 – 10461PhosphothreonineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8IUD2.
MaxQBiQ8IUD2.
PaxDbiQ8IUD2.
PeptideAtlasiQ8IUD2.
PRIDEiQ8IUD2.

PTM databases

iPTMnetiQ8IUD2.
PhosphoSiteiQ8IUD2.

Expressioni

Tissue specificityi

Widely expressed. Isoform 2 and isoform 4 are abundantly expressed in brain. Isoform 1 and isoform 3 are predominantly expressed in testis and thyroid, and isoform 1 predominates in other tissues tested.1 Publication

Gene expression databases

BgeeiENSG00000082805.
ExpressionAtlasiQ8IUD2. baseline and differential.
GenevisibleiQ8IUD2. HS.

Organism-specific databases

HPAiHPA019513.
HPA019523.
HPA024130.

Interactioni

Subunit structurei

Part of a complex with CHUK, IKBKB and IKBKG. Interacts with CHUK, IKBKB and IKBKG. The interaction with IKBKG is independent of CHUK and IKBKB. Interacts with NFKBIA. Isoform 4 interacts with PPFIA1, and through its C-terminus with the PDZ domains of RIMS1 and RIMS2. Interacts with ERC2/CAST1. Interacts with the GTB-bound forms of RAB6A isoform 1 and isoform 2 and with RAB6B. The interaction was strongest with RAB6B, followed by RAB6A isoform 2 and weakest with RAB6A isoform 1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
P279588EBI-9352449,EBI-3649474From a different organism.
Cacnb4Q8R0S42EBI-6920871,EBI-3647752From a different organism.

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • leucine zipper domain binding Source: UniProtKB
  • PDZ domain binding Source: ParkinsonsUK-UCL
  • Rab GTPase binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi116714. 62 interactions.
IntActiQ8IUD2. 41 interactions.
MINTiMINT-1683843.
STRINGi9606.ENSP00000354158.

Structurei

3D structure databases

ProteinModelPortaliQ8IUD2.
SMRiQ8IUD2. Positions 148-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1046 – 110863FIP-RBDPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili144 – 988845Sequence analysisAdd
BLAST
Coiled coili1060 – 110041Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 FIP-RBD domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4809. Eukaryota.
ENOG410Y4GU. LUCA.
GeneTreeiENSGT00650000093320.
HOVERGENiHBG051496.
InParanoidiQ8IUD2.
KOiK16072.
PhylomeDBiQ8IUD2.
TreeFamiTF324969.

Family and domain databases

InterProiIPR019323. ELKS/CAST.
IPR019018. Rab-bd_FIP-RBD.
[Graphical view]
PANTHERiPTHR18861. PTHR18861. 2 hits.
PfamiPF10174. Cast. 3 hits.
PF09457. RBD-FIP. 1 hit.
[Graphical view]
PROSITEiPS51511. FIP_RBD. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IUD2-1) [UniParc]FASTAAdd to basket
Also known as: ELKS epsilon

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYGSARSVGK VEPSSQSPGR SPRLPRSPRL GHRRTNSTGG SSGSSVGGGS
60 70 80 90 100
GKTLSMENIQ SLNAAYATSG PMYLSDHENV GSETPKSTMT LGRSGGRLPY
110 120 130 140 150
GVRMTAMGSS PNIASSGVAS DTIAFGEHHL PPVSMASTVP HSLRQARDNT
160 170 180 190 200
IMDLQTQLKE VLRENDLLRK DVEVKESKLS SSMNSIKTFW SPELKKERAL
210 220 230 240 250
RKDEASKITI WKEQYRVVQE ENQHMQMTIQ ALQDELRIQR DLNQLFQQDS
260 270 280 290 300
SSRTGEPCVA ELTEENFQRL HAEHERQAKE LFLLRKTLEE MELRIETQKQ
310 320 330 340 350
TLNARDESIK KLLEMLQSKG LSAKATEEDH ERTRRLAEAE MHVHHLESLL
360 370 380 390 400
EQKEKENSML REEMHRRFEN APDSAKTKAL QTVIEMKDSK ISSMERGLRD
410 420 430 440 450
LEEEIQMLKS NGALSTEERE EEMKQMEVYR SHSKFMKNKV EQLKEELSSK
460 470 480 490 500
EAQWEELKKK AAGLQAEIGQ VKQELSRKDT ELLALQTKLE TLTNQFSDSK
510 520 530 540 550
QHIEVLKESL TAKEQRAAIL QTEVDALRLR LEEKETMLNK KTKQIQDMAE
560 570 580 590 600
EKGTQAGEIH DLKDMLDVKE RKVNVLQKKI ENLQEQLRDK EKQMSSLKER
610 620 630 640 650
VKSLQADTTN TDTALTTLEE ALAEKERTIE RLKEQRDRDE REKQEEIDNY
660 670 680 690 700
KKDLKDLKEK VSLLQGDLSE KEASLLDLKE HASSLASSGL KKDSRLKTLE
710 720 730 740 750
IALEQKKEEC LKMESQLKKA HEAALEARAS PEMSDRIQHL EREITRYKDE
760 770 780 790 800
SSKAQAEVDR LLEILKEVEN EKNDKDKKIA ELERQVKDQN KKVANLKHKE
810 820 830 840 850
QVEKKKSAQM LEEARRREDN LNDSSQQLQD SLRKKDDRIE ELEEALRESV
860 870 880 890 900
QITAEREMVL AQEESARTNA EKQVEELLMA MEKVKQELES MKAKLSSTQQ
910 920 930 940 950
SLAEKETHLT NLRAERRKHL EEVLEMKQEA LLAAISEKDA NIALLELSSS
960 970 980 990 1000
KKKTQEEVAA LKREKDRLVQ QLKQQTQNRM KLMADNYEDD HFKSSHSNQT
1010 1020 1030 1040 1050
NHKPSPDQII QPLLELDQNR SKLKLYIGHL TTLCHDRDPL ILRGLTPPAS
1060 1070 1080 1090 1100
YNLDDDQAAW ENELQKMTRG QLQDELEKGE RDNAELQEFA NAILQQIADH
1110
CPDILEQVVN ALEESS
Length:1,116
Mass (Da):128,086
Last modified:March 1, 2003 - v1
Checksum:iCCB70380AA7C6E69
GO
Isoform 2 (identifier: Q8IUD2-2) [UniParc]FASTAAdd to basket
Also known as: ELKS beta

The sequence of this isoform differs from the canonical sequence as follows:
     440-467: Missing.
     783-783: E → ESLTS
     1009-1016: IIQPLLEL → DEEEGIWA
     1017-1116: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:992
Mass (Da):113,920
Checksum:i049A5831DC5F79B4
GO
Isoform 3 (identifier: Q8IUD2-3) [UniParc]FASTAAdd to basket
Also known as: ELKS delta

The sequence of this isoform differs from the canonical sequence as follows:
     440-467: Missing.

Show »
Length:1,088
Mass (Da):124,904
Checksum:i52AF9DDF5720A2CB
GO
Isoform 4 (identifier: Q8IUD2-4) [UniParc]FASTAAdd to basket
Also known as: ELKS alpha

The sequence of this isoform differs from the canonical sequence as follows:
     440-467: Missing.
     783-783: E → ESLTS
     830-873: Missing.
     1009-1016: IIQPLLEL → DEEEGIWA
     1017-1116: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:948
Mass (Da):108,793
Checksum:i344297FDFC9F7602
GO
Isoform 5 (identifier: Q8IUD2-5) [UniParc]FASTAAdd to basket
Also known as: ELKS gamma

The sequence of this isoform differs from the canonical sequence as follows:
     224-523: Missing.
     783-783: E → ESLTS
     1009-1016: IIQPLLEL → DEEEGIWA
     1017-1116: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:720
Mass (Da):81,967
Checksum:i1CD24193AFA919A5
GO

Sequence cautioni

The sequence AAH68006 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA83033 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA90975 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti828 – 8281L → G in BAA90975 (PubMed:14702039).Curated
Sequence conflicti892 – 8921K → R in BAC03827 (PubMed:14702039).Curated
Sequence conflicti910 – 9101T → I in BAC03827 (PubMed:14702039).Curated
Sequence conflicti1021 – 10211S → G in BAA90975 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501S → G.
Corresponds to variant rs35037408 [ dbSNP | Ensembl ].
VAR_051304
Natural varianti1032 – 10321T → A.
Corresponds to variant rs12319376 [ dbSNP | Ensembl ].
VAR_051305

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei224 – 523300Missing in isoform 5. 1 PublicationVSP_011450Add
BLAST
Alternative sequencei440 – 46728Missing in isoform 2, isoform 3 and isoform 4. 5 PublicationsVSP_011451Add
BLAST
Alternative sequencei783 – 7831E → ESLTS in isoform 2, isoform 4 and isoform 5. 5 PublicationsVSP_011452
Alternative sequencei830 – 87344Missing in isoform 4. 1 PublicationVSP_011453Add
BLAST
Alternative sequencei1009 – 10168IIQPLLEL → DEEEGIWA in isoform 2, isoform 4 and isoform 5. 5 PublicationsVSP_011454
Alternative sequencei1017 – 1116100Missing in isoform 2, isoform 4 and isoform 5. 5 PublicationsVSP_011455Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015617 mRNA. Translation: BAA88763.1.
AB053469 mRNA. Translation: BAC54108.1.
AB053468 mRNA. Translation: BAC54107.1.
AB053470 mRNA. Translation: BAC54109.1.
AB053471 mRNA. Translation: BAC54110.1.
CH471116 Genomic DNA. Translation: EAW88932.1.
CH471116 Genomic DNA. Translation: EAW88934.1.
CH471116 Genomic DNA. Translation: EAW88936.1.
CH471116 Genomic DNA. Translation: EAW88938.1.
BC068006 mRNA. Translation: AAH68006.1. Sequence problems.
BC132782 mRNA. Translation: AAI32783.1.
BC132784 mRNA. Translation: AAI32785.1.
BC150248 mRNA. Translation: AAI50249.1.
AB029004 mRNA. Translation: BAA83033.2. Different initiation.
AK000148 mRNA. Translation: BAA90975.1. Different initiation.
AK092201 mRNA. Translation: BAC03827.1.
CCDSiCCDS53732.1. [Q8IUD2-3]
CCDS8508.1. [Q8IUD2-1]
RefSeqiNP_829883.1. NM_178039.3. [Q8IUD2-3]
NP_829884.1. NM_178040.3. [Q8IUD2-1]
XP_011519243.1. XM_011520941.2. [Q8IUD2-1]
UniGeneiHs.601216.

Genome annotation databases

EnsembliENST00000347735; ENSP00000340054; ENSG00000082805. [Q8IUD2-4]
ENST00000360905; ENSP00000354158; ENSG00000082805. [Q8IUD2-1]
ENST00000397203; ENSP00000380386; ENSG00000082805. [Q8IUD2-3]
ENST00000440394; ENSP00000410064; ENSG00000082805. [Q8IUD2-2]
ENST00000543086; ENSP00000438546; ENSG00000082805. [Q8IUD2-3]
ENST00000545948; ENSP00000442976; ENSG00000082805. [Q8IUD2-5]
ENST00000589028; ENSP00000468263; ENSG00000082805. [Q8IUD2-1]
ENST00000611180; ENSP00000479523; ENSG00000082805. [Q8IUD2-5]
GeneIDi23085.
KEGGihsa:23085.
UCSCiuc001qjb.3. human. [Q8IUD2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015617 mRNA. Translation: BAA88763.1.
AB053469 mRNA. Translation: BAC54108.1.
AB053468 mRNA. Translation: BAC54107.1.
AB053470 mRNA. Translation: BAC54109.1.
AB053471 mRNA. Translation: BAC54110.1.
CH471116 Genomic DNA. Translation: EAW88932.1.
CH471116 Genomic DNA. Translation: EAW88934.1.
CH471116 Genomic DNA. Translation: EAW88936.1.
CH471116 Genomic DNA. Translation: EAW88938.1.
BC068006 mRNA. Translation: AAH68006.1. Sequence problems.
BC132782 mRNA. Translation: AAI32783.1.
BC132784 mRNA. Translation: AAI32785.1.
BC150248 mRNA. Translation: AAI50249.1.
AB029004 mRNA. Translation: BAA83033.2. Different initiation.
AK000148 mRNA. Translation: BAA90975.1. Different initiation.
AK092201 mRNA. Translation: BAC03827.1.
CCDSiCCDS53732.1. [Q8IUD2-3]
CCDS8508.1. [Q8IUD2-1]
RefSeqiNP_829883.1. NM_178039.3. [Q8IUD2-3]
NP_829884.1. NM_178040.3. [Q8IUD2-1]
XP_011519243.1. XM_011520941.2. [Q8IUD2-1]
UniGeneiHs.601216.

3D structure databases

ProteinModelPortaliQ8IUD2.
SMRiQ8IUD2. Positions 148-180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116714. 62 interactions.
IntActiQ8IUD2. 41 interactions.
MINTiMINT-1683843.
STRINGi9606.ENSP00000354158.

PTM databases

iPTMnetiQ8IUD2.
PhosphoSiteiQ8IUD2.

Polymorphism and mutation databases

BioMutaiERC1.
DMDMi51827892.

Proteomic databases

EPDiQ8IUD2.
MaxQBiQ8IUD2.
PaxDbiQ8IUD2.
PeptideAtlasiQ8IUD2.
PRIDEiQ8IUD2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000347735; ENSP00000340054; ENSG00000082805. [Q8IUD2-4]
ENST00000360905; ENSP00000354158; ENSG00000082805. [Q8IUD2-1]
ENST00000397203; ENSP00000380386; ENSG00000082805. [Q8IUD2-3]
ENST00000440394; ENSP00000410064; ENSG00000082805. [Q8IUD2-2]
ENST00000543086; ENSP00000438546; ENSG00000082805. [Q8IUD2-3]
ENST00000545948; ENSP00000442976; ENSG00000082805. [Q8IUD2-5]
ENST00000589028; ENSP00000468263; ENSG00000082805. [Q8IUD2-1]
ENST00000611180; ENSP00000479523; ENSG00000082805. [Q8IUD2-5]
GeneIDi23085.
KEGGihsa:23085.
UCSCiuc001qjb.3. human. [Q8IUD2-1]

Organism-specific databases

CTDi23085.
GeneCardsiERC1.
HGNCiHGNC:17072. ERC1.
HPAiHPA019513.
HPA019523.
HPA024130.
MalaCardsiERC1.
MIMi607127. gene.
neXtProtiNX_Q8IUD2.
Orphaneti280325. Distal monosomy 12p.
146. Papillary or follicular thyroid carcinoma.
PharmGKBiPA134970875.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4809. Eukaryota.
ENOG410Y4GU. LUCA.
GeneTreeiENSGT00650000093320.
HOVERGENiHBG051496.
InParanoidiQ8IUD2.
KOiK16072.
PhylomeDBiQ8IUD2.
TreeFamiTF324969.

Enzyme and pathway databases

SIGNORiQ8IUD2.

Miscellaneous databases

ChiTaRSiERC1. human.
GeneWikiiERC1.
GenomeRNAii23085.
PROiQ8IUD2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000082805.
ExpressionAtlasiQ8IUD2. baseline and differential.
GenevisibleiQ8IUD2. HS.

Family and domain databases

InterProiIPR019323. ELKS/CAST.
IPR019018. Rab-bd_FIP-RBD.
[Graphical view]
PANTHERiPTHR18861. PTHR18861. 2 hits.
PfamiPF10174. Cast. 3 hits.
PF09457. RBD-FIP. 1 hit.
[Graphical view]
PROSITEiPS51511. FIP_RBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRB6I2_HUMAN
AccessioniPrimary (citable) accession number: Q8IUD2
Secondary accession number(s): A2RU77
, A7E295, D3DUP7, D3DUP8, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.