Reviewed, UniProtKB/Swiss-Prot Q8IUD2 (RB6I2_HUMAN)

Names and origin

Protein names

Recommended name:
    ELKS/RAB6-interacting/CAST family member 1
      Short name=ERC protein 1
Alternative name(s):
    RAB6-interacting protein 2

Gene names

Name:	ERC1
Synonyms:	ELKS, KIAA1081, RAB6IP2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1116 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. Ref.8
Subunit structure	Part of a complex with CHUK, IKBKB and IKBKG. Interacts with CHUK, IKBKB and IKBKG. The interaction with IKBKG is independent of CHUK and IKBKB. Interacts with NFKBIA. Isoform 4 interacts with PPFIA1, and through its C-terminus with the PDZ domains of RIMS1 and RIMS2. Interacts with ERC2/CAST1. Interacts with the GTB-bound forms of RAB6A isoform 1 and isoform 2 and with RAB6B. The interaction was strongest with RAB6B, followed by RAB6A isoform 2 and weakest with RAB6A isoform 1 By similarity.
Subcellular location	Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity. Golgi apparatus membrane; Peripheral membrane protein By similarity. Note: In neurons, localized closed to presynaptic membrane. Recruited on Golgi membranes by RAB6A in a GTP-dependent manner By similarity.
Tissue specificity	Widely expressed. Isoform 2 and isoform 4 are abundantly expressed in brain. Isoform 1 and isoform 3 are predominantly expressed in testis and thyroid, and isoform 1 predominates in other tissues tested. Ref.2
Involvement in disease	A chromosomal aberration involving ERC1/RAB6IP2 may be a cause of thyroid papillary carcinoma (PACT) [MIM:188550]. Translocation t(10;12)(q11;p13) involving RET. In vitro, isoform 1, isoform 3 and isoform 5 participating in a ERC1-RET fusion protein activate tyrosine-protein kinase activity.
Sequence caution	The sequence AAH68006.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing Chromosomal rearrangement Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	I-kappaB phosphorylation Ref.8 Inferred from direct assay. Source: UniProtKB multicellular organismal development Ref.8 Non-traceable author statement. Source: UniProtKB positive regulation of NF-kappaB transcription factor activity Ref.8 Traceable author statement. Source: UniProtKB positive regulation of anti-apoptosis Ref.8 Traceable author statement. Source: UniProtKB protein transport Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Ref.8 Non-traceable author statement. Source: UniProtKB
Cellular component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell IkappaB kinase complex Ref.8 Inferred from direct assay. Source: UniProtKB presynaptic membrane Traceable author statement. Source: UniProtKB
Molecular function	leucine zipper domain binding Ref.8 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TWF2	Q6IBS0	1	EBI-1044755,EBI-722204
YWHAG	P61981	1	EBI-1044755,EBI-359832

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IUD2-1)

Also known as: ELKS epsilon;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IUD2-2)

Also known as: ELKS beta;

The sequence of this isoform differs from the canonical sequence as follows:
     440-467: Missing.
     783-783: E → ESLTS
     1009-1016: IIQPLLEL → DEEEGIWA
     1017-1116: Missing.

Isoform 3 (identifier: Q8IUD2-3)

Also known as: ELKS delta;

The sequence of this isoform differs from the canonical sequence as follows:
     440-467: Missing.

Isoform 4 (identifier: Q8IUD2-4)

Also known as: ELKS alpha;

The sequence of this isoform differs from the canonical sequence as follows:
     440-467: Missing.
     783-783: E → ESLTS
     830-873: Missing.
     1009-1016: IIQPLLEL → DEEEGIWA
     1017-1116: Missing.

Isoform 5 (identifier: Q8IUD2-5)

Also known as: ELKS gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     224-523: Missing.
     783-783: E → ESLTS
     1009-1016: IIQPLLEL → DEEEGIWA
     1017-1116: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1116	1116	ELKS/RAB6-interacting/CAST family member 1		PRO_0000097176
Regions
	Coiled coil	144 – 988	845	Potential
	Coiled coil	1060 – 1100	41	Potential
Sites
	Site	719 – 720	2	Breakpoint for translocation to form ERC1-RET oncogene
Amino acid modifications
	Modified residue	17	1	Phosphoserine Ref.10 Ref.11
	Modified residue	21	1	Phosphoserine Ref.10 Ref.11
	Modified residue	191	1	Phosphoserine Ref.11
	Modified residue	252	1	Phosphoserine By similarity
	Modified residue	1046	1	Phosphothreonine Ref.11
Natural variations
	Alternative sequence	224 – 523	300	Missing in isoform 5.		VSP_011450
	Alternative sequence	440 – 467	28	Missing in isoform 2, isoform 3 and isoform 4.		VSP_011451
	Alternative sequence	783	1	E → ESLTS in isoform 2, isoform 4 and isoform 5.		VSP_011452
	Alternative sequence	830 – 873	44	Missing in isoform 4.		VSP_011453
	Alternative sequence	1009 – 1016	8	IIQPLLEL → DEEEGIWA in isoform 2, isoform 4 and isoform 5.		VSP_011454
	Alternative sequence	1017 – 1116	100	Missing in isoform 2, isoform 4 and isoform 5.		VSP_011455
	Natural variant	50	1	S → G: dbSNP rs35037408.		VAR_051304
	Natural variant	1032	1	T → A: dbSNP rs12319376.		VAR_051305
Experimental info
	Sequence conflict	828	1	L → G in BAA90975. Ref.7
	Sequence conflict	892	1	K → R in BAC03827. Ref.7
	Sequence conflict	910	1	T → I in BAC03827. Ref.7
	Sequence conflict	1021	1	S → G in BAA90975. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (ELKS epsilon) [UniParc]. Last modified March 1, 2003. Version 1. Checksum: CCB70380AA7C6E69	FASTA	1,116	128,086
	10 20 30 40 50 60 MYGSARSVGK VEPSSQSPGR SPRLPRSPRL GHRRTNSTGG SSGSSVGGGS GKTLSMENIQ 70 80 90 100 110 120 SLNAAYATSG PMYLSDHENV GSETPKSTMT LGRSGGRLPY GVRMTAMGSS PNIASSGVAS 130 140 150 160 170 180 DTIAFGEHHL PPVSMASTVP HSLRQARDNT IMDLQTQLKE VLRENDLLRK DVEVKESKLS 190 200 210 220 230 240 SSMNSIKTFW SPELKKERAL RKDEASKITI WKEQYRVVQE ENQHMQMTIQ ALQDELRIQR 250 260 270 280 290 300 DLNQLFQQDS SSRTGEPCVA ELTEENFQRL HAEHERQAKE LFLLRKTLEE MELRIETQKQ 310 320 330 340 350 360 TLNARDESIK KLLEMLQSKG LSAKATEEDH ERTRRLAEAE MHVHHLESLL EQKEKENSML 370 380 390 400 410 420 REEMHRRFEN APDSAKTKAL QTVIEMKDSK ISSMERGLRD LEEEIQMLKS NGALSTEERE 430 440 450 460 470 480 EEMKQMEVYR SHSKFMKNKV EQLKEELSSK EAQWEELKKK AAGLQAEIGQ VKQELSRKDT 490 500 510 520 530 540 ELLALQTKLE TLTNQFSDSK QHIEVLKESL TAKEQRAAIL QTEVDALRLR LEEKETMLNK 550 560 570 580 590 600 KTKQIQDMAE EKGTQAGEIH DLKDMLDVKE RKVNVLQKKI ENLQEQLRDK EKQMSSLKER 610 620 630 640 650 660 VKSLQADTTN TDTALTTLEE ALAEKERTIE RLKEQRDRDE REKQEEIDNY KKDLKDLKEK 670 680 690 700 710 720 VSLLQGDLSE KEASLLDLKE HASSLASSGL KKDSRLKTLE IALEQKKEEC LKMESQLKKA 730 740 750 760 770 780 HEAALEARAS PEMSDRIQHL EREITRYKDE SSKAQAEVDR LLEILKEVEN EKNDKDKKIA 790 800 810 820 830 840 ELERQVKDQN KKVANLKHKE QVEKKKSAQM LEEARRREDN LNDSSQQLQD SLRKKDDRIE 850 860 870 880 890 900 ELEEALRESV QITAEREMVL AQEESARTNA EKQVEELLMA MEKVKQELES MKAKLSSTQQ 910 920 930 940 950 960 SLAEKETHLT NLRAERRKHL EEVLEMKQEA LLAAISEKDA NIALLELSSS KKKTQEEVAA 970 980 990 1000 1010 1020 LKREKDRLVQ QLKQQTQNRM KLMADNYEDD HFKSSHSNQT NHKPSPDQII QPLLELDQNR 1030 1040 1050 1060 1070 1080 SKLKLYIGHL TTLCHDRDPL ILRGLTPPAS YNLDDDQAAW ENELQKMTRG QLQDELEKGE 1090 1100 1110 RDNAELQEFA NAILQQIADH CPDILEQVVN ALEESS
	Isoform 2 (ELKS beta). Checksum: 049A5831DC5F79B4	FASTA	992	113,920
	10 20 30 40 50 60 MYGSARSVGK VEPSSQSPGR SPRLPRSPRL GHRRTNSTGG SSGSSVGGGS GKTLSMENIQ 70 80 90 100 110 120 SLNAAYATSG PMYLSDHENV GSETPKSTMT LGRSGGRLPY GVRMTAMGSS PNIASSGVAS 130 140 150 160 170 180 DTIAFGEHHL PPVSMASTVP HSLRQARDNT IMDLQTQLKE VLRENDLLRK DVEVKESKLS 190 200 210 220 230 240 SSMNSIKTFW SPELKKERAL RKDEASKITI WKEQYRVVQE ENQHMQMTIQ ALQDELRIQR 250 260 270 280 290 300 DLNQLFQQDS SSRTGEPCVA ELTEENFQRL HAEHERQAKE LFLLRKTLEE MELRIETQKQ 310 320 330 340 350 360 TLNARDESIK KLLEMLQSKG LSAKATEEDH ERTRRLAEAE MHVHHLESLL EQKEKENSML 370 380 390 400 410 420 REEMHRRFEN APDSAKTKAL QTVIEMKDSK ISSMERGLRD LEEEIQMLKS NGALSTEERE 430 440 450 460 470 480 EEMKQMEVYR SHSKFMKNKI GQVKQELSRK DTELLALQTK LETLTNQFSD SKQHIEVLKE 490 500 510 520 530 540 SLTAKEQRAA ILQTEVDALR LRLEEKETML NKKTKQIQDM AEEKGTQAGE IHDLKDMLDV 550 560 570 580 590 600 KERKVNVLQK KIENLQEQLR DKEKQMSSLK ERVKSLQADT TNTDTALTTL EEALAEKERT 610 620 630 640 650 660 IERLKEQRDR DEREKQEEID NYKKDLKDLK EKVSLLQGDL SEKEASLLDL KEHASSLASS 670 680 690 700 710 720 GLKKDSRLKT LEIALEQKKE ECLKMESQLK KAHEAALEAR ASPEMSDRIQ HLEREITRYK 730 740 750 760 770 780 DESSKAQAEV DRLLEILKEV ENEKNDKDKK IAELESLTSR QVKDQNKKVA NLKHKEQVEK 790 800 810 820 830 840 KKSAQMLEEA RRREDNLNDS SQQLQDSLRK KDDRIEELEE ALRESVQITA EREMVLAQEE 850 860 870 880 890 900 SARTNAEKQV EELLMAMEKV KQELESMKAK LSSTQQSLAE KETHLTNLRA ERRKHLEEVL 910 920 930 940 950 960 EMKQEALLAA ISEKDANIAL LELSSSKKKT QEEVAALKRE KDRLVQQLKQ QTQNRMKLMA 970 980 990 DNYEDDHFKS SHSNQTNHKP SPDQDEEEGI WA
	Isoform 3 (ELKS delta). Checksum: 52AF9DDF5720A2CB	FASTA	1,088	124,904
	10 20 30 40 50 60 MYGSARSVGK VEPSSQSPGR SPRLPRSPRL GHRRTNSTGG SSGSSVGGGS GKTLSMENIQ 70 80 90 100 110 120 SLNAAYATSG PMYLSDHENV GSETPKSTMT LGRSGGRLPY GVRMTAMGSS PNIASSGVAS 130 140 150 160 170 180 DTIAFGEHHL PPVSMASTVP HSLRQARDNT IMDLQTQLKE VLRENDLLRK DVEVKESKLS 190 200 210 220 230 240 SSMNSIKTFW SPELKKERAL RKDEASKITI WKEQYRVVQE ENQHMQMTIQ ALQDELRIQR 250 260 270 280 290 300 DLNQLFQQDS SSRTGEPCVA ELTEENFQRL HAEHERQAKE LFLLRKTLEE MELRIETQKQ 310 320 330 340 350 360 TLNARDESIK KLLEMLQSKG LSAKATEEDH ERTRRLAEAE MHVHHLESLL EQKEKENSML 370 380 390 400 410 420 REEMHRRFEN APDSAKTKAL QTVIEMKDSK ISSMERGLRD LEEEIQMLKS NGALSTEERE 430 440 450 460 470 480 EEMKQMEVYR SHSKFMKNKI GQVKQELSRK DTELLALQTK LETLTNQFSD SKQHIEVLKE 490 500 510 520 530 540 SLTAKEQRAA ILQTEVDALR LRLEEKETML NKKTKQIQDM AEEKGTQAGE IHDLKDMLDV 550 560 570 580 590 600 KERKVNVLQK KIENLQEQLR DKEKQMSSLK ERVKSLQADT TNTDTALTTL EEALAEKERT 610 620 630 640 650 660 IERLKEQRDR DEREKQEEID NYKKDLKDLK EKVSLLQGDL SEKEASLLDL KEHASSLASS 670 680 690 700 710 720 GLKKDSRLKT LEIALEQKKE ECLKMESQLK KAHEAALEAR ASPEMSDRIQ HLEREITRYK 730 740 750 760 770 780 DESSKAQAEV DRLLEILKEV ENEKNDKDKK IAELERQVKD QNKKVANLKH KEQVEKKKSA 790 800 810 820 830 840 QMLEEARRRE DNLNDSSQQL QDSLRKKDDR IEELEEALRE SVQITAEREM VLAQEESART 850 860 870 880 890 900 NAEKQVEELL MAMEKVKQEL ESMKAKLSST QQSLAEKETH LTNLRAERRK HLEEVLEMKQ 910 920 930 940 950 960 EALLAAISEK DANIALLELS SSKKKTQEEV AALKREKDRL VQQLKQQTQN RMKLMADNYE 970 980 990 1000 1010 1020 DDHFKSSHSN QTNHKPSPDQ IIQPLLELDQ NRSKLKLYIG HLTTLCHDRD PLILRGLTPP 1030 1040 1050 1060 1070 1080 ASYNLDDDQA AWENELQKMT RGQLQDELEK GERDNAELQE FANAILQQIA DHCPDILEQV VNALEESS
	Isoform 4 (ELKS alpha). Checksum: 344297FDFC9F7602	FASTA	948	108,793
	10 20 30 40 50 60 MYGSARSVGK VEPSSQSPGR SPRLPRSPRL GHRRTNSTGG SSGSSVGGGS GKTLSMENIQ 70 80 90 100 110 120 SLNAAYATSG PMYLSDHENV GSETPKSTMT LGRSGGRLPY GVRMTAMGSS PNIASSGVAS 130 140 150 160 170 180 DTIAFGEHHL PPVSMASTVP HSLRQARDNT IMDLQTQLKE VLRENDLLRK DVEVKESKLS 190 200 210 220 230 240 SSMNSIKTFW SPELKKERAL RKDEASKITI WKEQYRVVQE ENQHMQMTIQ ALQDELRIQR 250 260 270 280 290 300 DLNQLFQQDS SSRTGEPCVA ELTEENFQRL HAEHERQAKE LFLLRKTLEE MELRIETQKQ 310 320 330 340 350 360 TLNARDESIK KLLEMLQSKG LSAKATEEDH ERTRRLAEAE MHVHHLESLL EQKEKENSML 370 380 390 400 410 420 REEMHRRFEN APDSAKTKAL QTVIEMKDSK ISSMERGLRD LEEEIQMLKS NGALSTEERE 430 440 450 460 470 480 EEMKQMEVYR SHSKFMKNKI GQVKQELSRK DTELLALQTK LETLTNQFSD SKQHIEVLKE 490 500 510 520 530 540 SLTAKEQRAA ILQTEVDALR LRLEEKETML NKKTKQIQDM AEEKGTQAGE IHDLKDMLDV 550 560 570 580 590 600 KERKVNVLQK KIENLQEQLR DKEKQMSSLK ERVKSLQADT TNTDTALTTL EEALAEKERT 610 620 630 640 650 660 IERLKEQRDR DEREKQEEID NYKKDLKDLK EKVSLLQGDL SEKEASLLDL KEHASSLASS 670 680 690 700 710 720 GLKKDSRLKT LEIALEQKKE ECLKMESQLK KAHEAALEAR ASPEMSDRIQ HLEREITRYK 730 740 750 760 770 780 DESSKAQAEV DRLLEILKEV ENEKNDKDKK IAELESLTSR QVKDQNKKVA NLKHKEQVEK 790 800 810 820 830 840 KKSAQMLEEA RRREDNLNDS SQQLQVEELL MAMEKVKQEL ESMKAKLSST QQSLAEKETH 850 860 870 880 890 900 LTNLRAERRK HLEEVLEMKQ EALLAAISEK DANIALLELS SSKKKTQEEV AALKREKDRL 910 920 930 940 VQQLKQQTQN RMKLMADNYE DDHFKSSHSN QTNHKPSPDQ DEEEGIWA
	Isoform 5 (ELKS gamma). Checksum: 1CD24193AFA919A5	FASTA	720	81,967
	10 20 30 40 50 60 MYGSARSVGK VEPSSQSPGR SPRLPRSPRL GHRRTNSTGG SSGSSVGGGS GKTLSMENIQ 70 80 90 100 110 120 SLNAAYATSG PMYLSDHENV GSETPKSTMT LGRSGGRLPY GVRMTAMGSS PNIASSGVAS 130 140 150 160 170 180 DTIAFGEHHL PPVSMASTVP HSLRQARDNT IMDLQTQLKE VLRENDLLRK DVEVKESKLS 190 200 210 220 230 240 SSMNSIKTFW SPELKKERAL RKDEASKITI WKEQYRVVQE ENQVDALRLR LEEKETMLNK 250 260 270 280 290 300 KTKQIQDMAE EKGTQAGEIH DLKDMLDVKE RKVNVLQKKI ENLQEQLRDK EKQMSSLKER 310 320 330 340 350 360 VKSLQADTTN TDTALTTLEE ALAEKERTIE RLKEQRDRDE REKQEEIDNY KKDLKDLKEK 370 380 390 400 410 420 VSLLQGDLSE KEASLLDLKE HASSLASSGL KKDSRLKTLE IALEQKKEEC LKMESQLKKA 430 440 450 460 470 480 HEAALEARAS PEMSDRIQHL EREITRYKDE SSKAQAEVDR LLEILKEVEN EKNDKDKKIA 490 500 510 520 530 540 ELESLTSRQV KDQNKKVANL KHKEQVEKKK SAQMLEEARR REDNLNDSSQ QLQDSLRKKD 550 560 570 580 590 600 DRIEELEEAL RESVQITAER EMVLAQEESA RTNAEKQVEE LLMAMEKVKQ ELESMKAKLS 610 620 630 640 650 660 STQQSLAEKE THLTNLRAER RKHLEEVLEM KQEALLAAIS EKDANIALLE LSSSKKKTQE 670 680 690 700 710 720 EVAALKREKD RLVQQLKQQT QNRMKLMADN YEDDHFKSSH SNQTNHKPSP DQDEEEGIWA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Fusion of a novel gene, ELKS, to RET due to translocation t(10;12)(q11;p13) in a papillary thyroid carcinoma." Nakata T., Kitamura Y., Shimizu K., Tanaka S., Fujimori M., Yokoyama S., Ito K., Emi M. Genes Chromosomes Cancer 25:97-103(1999) [PubMed: 10337992] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), CHROMOSOMAL TRANSLOCATION WITH RET.
[2]	"Differential expression of multiple isoforms of the ELKS mRNAs involved in a papillary thyroid carcinoma." Nakata T., Yokota T., Emi M., Minami S. Genes Chromosomes Cancer 35:30-37(2002) [PubMed: 12203787] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 5), TISSUE SPECIFICITY.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-652 (ISOFORM 3). Tissue: Eye.
[4]	"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:197-205(1999) [PubMed: 10470851] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1061 (ISOFORM 2). Tissue: Brain.
[5]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[6]	Lubec G., Chen W.-Q., Sun Y. Submitted (DEC-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 254-269, MASS SPECTROMETRY. Tissue: Fetal brain cortex.
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 733-1116 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 828-1116 (ISOFORMS 1/3). Tissue: Colon.
[8]	"Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit." Ducut Sigala J.L., Bottero V., Young D.B., Shevchenko A., Mercurio F., Verma I.M. Science 304:1963-1967(2004) [PubMed: 15218148] [Abstract] Cited for: FUNCTION, INTERACTION WITH CHUK; IKBKB; IKBKG AND NFKBIA.
[9]	"Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins." Ko J., Na M., Kim S., Lee J.R., Kim E. J. Biol. Chem. 278:42377-42385(2003) [PubMed: 12923177] [Abstract] Cited for: INTERACTION WITH PPFIA1.
[10]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17 AND SER-21, MASS SPECTROMETRY. Tissue: Epithelium.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17; SER-21; SER-191 AND THR-1046, MASS SPECTROMETRY.
[12]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB015617 mRNA. Translation: BAA88763.1. AB053469 mRNA. Translation: BAC54108.1. AB053468 mRNA. Translation: BAC54107.1. AB053470 mRNA. Translation: BAC54109.1. AB053471 mRNA. Translation: BAC54110.1. BC068006 mRNA. Translation: AAH68006.1. Sequence problems. BC150248 mRNA. Translation: AAI50249.1. AB029004 mRNA. Translation: BAA83033.2. Different initiation. AK000148 mRNA. Translation: BAA90975.1. Different initiation. AK092201 mRNA. Translation: BAC03827.1.
IPI	IPI00171230. IPI00181684. IPI00216719. IPI00216720. IPI00374976.
RefSeq	NP_055879.1. NP_829881.1. NP_829882.1. NP_829883.1. NP_829884.1.
UniGene	Hs.658200
3D structure databases
HSSP	HSSP built from PDB template 1FOS based on UniProtKB P01100.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IUD2. 2 interactions.
PTM databases
PhosphoSite	Q8IUD2.
Proteomic databases
PRIDE	Q8IUD2.
Genome annotation databases
Ensembl	ENSG00000082805. Homo sapiens. [Contig view]
GeneID	23085.
KEGG	hsa:23085.
Organism-specific databases
GeneCards	GC12P000972.
H-InvDB	HIX0010314.
HGNC	HGNC:17072. ERC1.
MIM	188550. phenotype. 607127. gene.
Orphanet	146. Thyroid carcinoma, papillary or follicular.
PharmGKB	PA29242.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8IUD2.
OMA	Q8IUD2. MKDSKIS.
Enzyme and pathway databases
Pathway_Interaction_DB	nfkappabcanonicalpathway. Canonical NF-kappaB pathway. il1pathway. IL1-mediated signaling events.
Gene expression databases
ArrayExpress	Q8IUD2.
Bgee	Q8IUD2.
GermOnline	ENSG00000082805. Homo sapiens.
Family and domain databases
InterPro	IPR019323. CAZ_cplx_RIM-bd_prot. IPR019018. Rab11-bd_FIP_dom_C. [Graphical view]
Pfam	PF10174. Cast. 1 hit. PF09457. RBD-FIP. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	44213.
SOURCE	Search...

Entry information

Entry name

RB6I2_HUMAN

Accession

Primary (citable) accession number: Q8IUD2
Secondary accession number(s): A7E295 , Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	March 1, 2003
Last modified:	June 16, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)