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Q8IUC6

- TCAM1_HUMAN

UniProt

Q8IUC6 - TCAM1_HUMAN

Protein

TIR domain-containing adapter molecule 1

Gene

TICAM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.3 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein kinase binding Source: UniProtKB
    3. signal transducer activity Source: UniProtKB

    GO - Biological processi

    1. apoptotic signaling pathway Source: Ensembl
    2. defense response to virus Source: UniProtKB-KW
    3. I-kappaB kinase/NF-kappaB signaling Source: Reactome
    4. inflammatory response Source: UniProtKB-KW
    5. innate immune response Source: Reactome
    6. lipopolysaccharide-mediated signaling pathway Source: Ensembl
    7. macrophage activation involved in immune response Source: Ensembl
    8. MyD88-independent toll-like receptor signaling pathway Source: Reactome
    9. positive regulation of B cell proliferation Source: Ensembl
    10. positive regulation of chemokine biosynthetic process Source: Ensembl
    11. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    12. positive regulation of interferon-beta biosynthetic process Source: Ensembl
    13. positive regulation of interleukin-6 production Source: Ensembl
    14. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
    15. positive regulation of nitric oxide biosynthetic process Source: Ensembl
    16. positive regulation of protein binding Source: Ensembl
    17. positive regulation of protein ubiquitination Source: Ensembl
    18. positive regulation of tumor necrosis factor production Source: Ensembl
    19. positive regulation of type I interferon production Source: Ensembl
    20. regulation of protein homodimerization activity Source: Ensembl
    21. response to exogenous dsRNA Source: MGI
    22. toll-like receptor 3 signaling pathway Source: Reactome
    23. toll-like receptor 4 signaling pathway Source: Reactome
    24. toll-like receptor signaling pathway Source: Reactome
    25. TRIF-dependent toll-like receptor signaling pathway Source: Reactome

    Keywords - Biological processi

    Antiviral defense, Apoptosis, Immunity, Inflammatory response, Innate immunity

    Enzyme and pathway databases

    ReactomeiREACT_118563. RIP-mediated NFkB activation via ZBP1.
    REACT_150361. TRIF-mediated programmed cell death.
    REACT_25148. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
    REACT_25351. TRAF6 mediated induction of TAK1 complex.
    REACT_25374. IKK complex recruitment mediated by RIP1.
    SignaLinkiQ8IUC6.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TIR domain-containing adapter molecule 1
    Short name:
    TICAM-1
    Alternative name(s):
    Proline-rich, vinculin and TIR domain-containing protein B
    Putative NF-kappa-B-activating protein 502H
    Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
    Short name:
    MyD88-3
    Short name:
    TIR domain-containing adapter protein inducing IFN-beta
    Gene namesi
    Name:TICAM1
    Synonyms:PRVTIRB, TRIF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:18348. TICAM1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. endosome membrane Source: Reactome
    3. ripoptosome Source: UniProtKB

    Pathology & Biotechi

    Involvement in diseasei

    Herpes simplex encephalitis 4 (HSE4) [MIM:614850]: A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome.1 Publication
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti186 – 1861S → L in HSE4. 1 Publication
    Corresponds to variant rs146550489 [ dbSNP | Ensembl ].
    VAR_069082

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi88 – 881E → A: Reduces binding to TRAF6 and activation of NFKB signaling pathway; when associated with A-252 and A-303. 1 Publication
    Mutagenesisi252 – 2521E → A: Loss of TCAM1-induced NF-kappa-B activation. Reduces interaction with TRAF6 and activation of NF-kappa-B signaling pathway; when associated with A-88 and A-303. 2 Publications
    Mutagenesisi303 – 3031E → A: Reduces binding to TRAF6 and activation of NFKB signaling pathway; when associated with A-88 and A-252. 1 Publication
    Mutagenesisi434 – 4341P → H: Abolishes interaction with TLR3. 1 Publication
    Mutagenesisi493 – 4931E → A: Loss of TCAM1-induced NF-kappa-B and IRF3 activation. 1 Publication

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi614850. phenotype.
    Orphaneti1930. Herpetic encephalitis.
    PharmGKBiPA142670812.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 712712TIR domain-containing adapter molecule 1PRO_0000317663Add
    BLAST

    Post-translational modificationi

    Phosphorylated by TBK1.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8IUC6.
    PaxDbiQ8IUC6.
    PRIDEiQ8IUC6.

    PTM databases

    PhosphoSiteiQ8IUC6.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed but with higher levels in liver.2 Publications

    Gene expression databases

    BgeeiQ8IUC6.
    CleanExiHS_TICAM1.
    GenevestigatoriQ8IUC6.

    Organism-specific databases

    HPAiHPA042460.

    Interactioni

    Subunit structurei

    Homodimer Probable. Interacts (via the TIR domain) with TLR3; mediates TLR3 signaling. Interacts with AZI2, TBK1, IRF3 and IRF7. Interacts with TICAM2 in TLR4 recruitment. Interaction with PIAS4 inhibits the TICAM1-induced NF-kappa-B, IRF and IFNB1 activation. Interacts with IKBKB and IKBKE. Interaction with SARM1 blocks TICAM1-dependent transcription factor activation. Interacts with TRAF3 By similarity. Interacts with TRAF6. Interacts with TRAFD1 By similarity.By similarityCurated

    Protein-protein interaction databases

    BioGridi127114. 25 interactions.
    DIPiDIP-33490N.
    IntActiQ8IUC6. 4 interactions.
    MINTiMINT-1202912.
    STRINGi9606.ENSP00000248244.

    Structurei

    Secondary structure

    1
    712
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi8 – 169
    Helixi20 – 3011
    Helixi40 – 5011
    Helixi54 – 629
    Turni63 – 664
    Helixi68 – 769
    Beta strandi83 – 853
    Helixi93 – 10513
    Helixi111 – 12717
    Helixi133 – 14412
    Beta strandi369 – 3713
    Helixi406 – 41712
    Beta strandi431 – 4333
    Helixi444 – 4474
    Beta strandi448 – 4558
    Helixi462 – 47514
    Turni477 – 4804
    Beta strandi486 – 4905
    Beta strandi492 – 4943
    Helixi503 – 5064
    Beta strandi508 – 5103
    Beta strandi513 – 5164
    Helixi520 – 5278
    Helixi530 – 5356
    Turni536 – 5405
    Helixi541 – 5433

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2M1XNMR-A387-545[»]
    2M63NMR-A1-156[»]
    3RC4X-ray1.50B360-372[»]
    4BSXX-ray2.23A/B/C/D1-153[»]
    4C0MX-ray2.80A/B/C/D1-153[»]
    ProteinModelPortaliQ8IUC6.
    SMRiQ8IUC6. Positions 1-156, 386-545.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8IUC6.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini390 – 46071TIRAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni512 – 712201Sufficient to induce apoptosisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi84 – 918TRAF6-binding
    Motifi248 – 2558TRAF6-binding
    Motifi299 – 30911TRAF6-bindingAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi213 – 371159Pro-richAdd
    BLAST
    Compositional biasi614 – 67865Pro-richAdd
    BLAST

    Domaini

    The N-terminal region is essential for activation of the IFNB promoter activity.3 Publications

    Sequence similaritiesi

    Contains 1 TIR domain.Curated

    Phylogenomic databases

    eggNOGiNOG67739.
    HOGENOMiHOG000068973.
    HOVERGENiHBG108551.
    InParanoidiQ8IUC6.
    KOiK05842.
    OMAiEQKFYNF.
    OrthoDBiEOG7GFB4H.
    PhylomeDBiQ8IUC6.
    TreeFamiTF336953.

    Family and domain databases

    InterProiIPR025735. RHIM_dom.
    IPR017278. TICAM1.
    IPR000157. TIR_dom.
    [Graphical view]
    PfamiPF12721. RHIM. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037744. TIR_Ticam. 1 hit.
    SUPFAMiSSF52200. SSF52200. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8IUC6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MACTGPSLPS AFDILGAAGQ DKLLYLKHKL KTPRPGCQGQ DLLHAMVLLK    50
    LGQETEARIS LEALKADAVA RLVARQWAGV DSTEDPEEPP DVSWAVARLY 100
    HLLAEEKLCP ASLRDVAYQE AVRTLSSRDD HRLGELQDEA RNRCGWDIAG 150
    DPGSIRTLQS NLGCLPPSSA LPSGTRSLPR PIDGVSDWSQ GCSLRSTGSP 200
    ASLASNLEIS QSPTMPFLSL HRSPHGPSKL CDDPQASLVP EPVPGGCQEP 250
    EEMSWPPSGE IASPPELPSS PPPGLPEVAP DATSTGLPDT PAAPETSTNY 300
    PVECTEGSAG PQSLPLPILE PVKNPCSVKD QTPLQLSVED TTSPNTKPCP 350
    PTPTTPETSP PPPPPPPSST PCSAHLTPSS LFPSSLESSS EQKFYNFVIL 400
    HARADEHIAL RVREKLEALG VPDGATFCED FQVPGRGELS CLQDAIDHSA 450
    FIILLLTSNF DCRLSLHQVN QAMMSNLTRQ GSPDCVIPFL PLESSPAQLS 500
    SDTASLLSGL VRLDEHSQIF ARKVANTFKP HRLQARKAMW RKEQDTRALR 550
    EQSQHLDGER MQAAALNAAY SAYLQSYLSY QAQMEQLQVA FGSHMSFGTG 600
    APYGARMPFG GQVPLGAPPP FPTWPGCPQP PPLHAWQAGT PPPPSPQPAA 650
    FPQSLPFPQS PAFPTASPAP PQSPGLQPLI IHHAQMVQLG LNNHMWNQRG 700
    SQAPEDKTQE AE 712
    Length:712
    Mass (Da):76,422
    Last modified:March 1, 2003 - v1
    Checksum:i5D071E3BE9240D9A
    GO

    Sequence cautioni

    The sequence AAO85488.1 differs from that shown. Reason: Frameshift at positions 141, 148 and 161.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti147 – 1471D → T in AAO85488. 1 PublicationCurated
    Sequence conflicti150 – 1501G → W in AAO85488. 1 PublicationCurated
    Sequence conflicti162 – 1621L → S in AAO85488. 1 PublicationCurated
    Sequence conflicti633 – 65927Missing in AAO85488. 1 PublicationCuratedAdd
    BLAST
    Sequence conflicti660 – 6601S → P in AAO85488. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti46 – 461M → I in a breast cancer sample; somatic mutation. 1 Publication
    VAR_038789
    Natural varianti75 – 751R → C.
    Corresponds to variant rs11466719 [ dbSNP | Ensembl ].
    VAR_051416
    Natural varianti186 – 1861S → L in HSE4. 1 Publication
    Corresponds to variant rs146550489 [ dbSNP | Ensembl ].
    VAR_069082
    Natural varianti275 – 2751L → V.
    Corresponds to variant rs11466721 [ dbSNP | Ensembl ].
    VAR_051417
    Natural varianti666 – 6661A → T.
    Corresponds to variant rs11466724 [ dbSNP | Ensembl ].
    VAR_051418

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB093555 mRNA. Translation: BAC44839.1.
    AB086380 mRNA. Translation: BAC55579.1.
    AB446484 mRNA. Translation: BAG55261.1.
    AB097023 mRNA. Translation: BAC77376.1.
    BC009860 mRNA. Translation: AAH09860.2.
    BC136556 mRNA. Translation: AAI36557.1.
    BC136557 mRNA. Translation: AAI36558.1.
    AF492646 mRNA. Translation: AAO85488.1. Frameshift.
    AF070530 mRNA. Translation: AAC28630.1.
    CCDSiCCDS12136.1.
    RefSeqiNP_891549.1. NM_182919.3.
    UniGeneiHs.29344.

    Genome annotation databases

    EnsembliENST00000248244; ENSP00000248244; ENSG00000127666.
    GeneIDi148022.
    KEGGihsa:148022.
    UCSCiuc002mbi.4. human.

    Polymorphism databases

    DMDMi74727957.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB093555 mRNA. Translation: BAC44839.1 .
    AB086380 mRNA. Translation: BAC55579.1 .
    AB446484 mRNA. Translation: BAG55261.1 .
    AB097023 mRNA. Translation: BAC77376.1 .
    BC009860 mRNA. Translation: AAH09860.2 .
    BC136556 mRNA. Translation: AAI36557.1 .
    BC136557 mRNA. Translation: AAI36558.1 .
    AF492646 mRNA. Translation: AAO85488.1 . Frameshift.
    AF070530 mRNA. Translation: AAC28630.1 .
    CCDSi CCDS12136.1.
    RefSeqi NP_891549.1. NM_182919.3.
    UniGenei Hs.29344.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2M1X NMR - A 387-545 [» ]
    2M63 NMR - A 1-156 [» ]
    3RC4 X-ray 1.50 B 360-372 [» ]
    4BSX X-ray 2.23 A/B/C/D 1-153 [» ]
    4C0M X-ray 2.80 A/B/C/D 1-153 [» ]
    ProteinModelPortali Q8IUC6.
    SMRi Q8IUC6. Positions 1-156, 386-545.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127114. 25 interactions.
    DIPi DIP-33490N.
    IntActi Q8IUC6. 4 interactions.
    MINTi MINT-1202912.
    STRINGi 9606.ENSP00000248244.

    PTM databases

    PhosphoSitei Q8IUC6.

    Polymorphism databases

    DMDMi 74727957.

    Proteomic databases

    MaxQBi Q8IUC6.
    PaxDbi Q8IUC6.
    PRIDEi Q8IUC6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000248244 ; ENSP00000248244 ; ENSG00000127666 .
    GeneIDi 148022.
    KEGGi hsa:148022.
    UCSCi uc002mbi.4. human.

    Organism-specific databases

    CTDi 148022.
    GeneCardsi GC19M004815.
    HGNCi HGNC:18348. TICAM1.
    HPAi HPA042460.
    MIMi 607601. gene.
    614850. phenotype.
    neXtProti NX_Q8IUC6.
    Orphaneti 1930. Herpetic encephalitis.
    PharmGKBi PA142670812.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG67739.
    HOGENOMi HOG000068973.
    HOVERGENi HBG108551.
    InParanoidi Q8IUC6.
    KOi K05842.
    OMAi EQKFYNF.
    OrthoDBi EOG7GFB4H.
    PhylomeDBi Q8IUC6.
    TreeFami TF336953.

    Enzyme and pathway databases

    Reactomei REACT_118563. RIP-mediated NFkB activation via ZBP1.
    REACT_150361. TRIF-mediated programmed cell death.
    REACT_25148. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
    REACT_25351. TRAF6 mediated induction of TAK1 complex.
    REACT_25374. IKK complex recruitment mediated by RIP1.
    SignaLinki Q8IUC6.

    Miscellaneous databases

    EvolutionaryTracei Q8IUC6.
    GenomeRNAii 148022.
    NextBioi 85815.
    PROi Q8IUC6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8IUC6.
    CleanExi HS_TICAM1.
    Genevestigatori Q8IUC6.

    Family and domain databases

    InterProi IPR025735. RHIM_dom.
    IPR017278. TICAM1.
    IPR000157. TIR_dom.
    [Graphical view ]
    Pfami PF12721. RHIM. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037744. TIR_Ticam. 1 hit.
    SUPFAMi SSF52200. SSF52200. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling."
      Yamamoto M., Sato S., Mori K., Hoshino K., Takeuchi O., Takeda K., Akira S.
      J. Immunol. 169:6668-6672(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DOMAIN, INTERACTION WITH IRF3; TLR2 AND TLR3.
    2. "TICAM-1, an adapter molecule that participates in Toll-like receptor 3 mediated interferon-beta induction."
      Oshiumi H., Matsumoto M., Funami K., Akazawa T., Seya T.
      Nat. Immunol. 4:161-167(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TLR3, SUBUNIT, TISSUE SPECIFICITY, DOMAIN, MUTAGENESIS OF PRO-434.
      Tissue: Lung.
    3. "Natural selection in the TLR-related genes in the course of primate evolution."
      Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., Kimura A.
      Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
      Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
      Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary and Testis.
    6. "PRVTIRB is a differentially expressed gene."
      Begum N.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 137-712.
    7. Yu W., Gibbs R.A.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 297-712.
      Tissue: Brain.
    8. "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling."
      Bin L.-H., Xu L.-G., Shu H.-B.
      J. Biol. Chem. 278:24526-24532(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TICAM2.
    9. "Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling."
      Sato S., Sugiyama M., Yamamoto M., Watanabe Y., Kawai T., Takeda K., Akira S.
      J. Immunol. 171:4304-4310(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TRAF6 AND TBK1, PHOSPHORYLATION BY TBK1, MOTIF, MUTAGENESIS OF GLU-88; GLU-252 AND GLU-303.
    10. "PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis."
      Zhang J., Xu L.G., Han K.J., Wei X., Shu H.B.
      FEBS Lett. 570:97-101(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PIAS4.
    11. "Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways."
      Han K.J., Su X., Xu L.-G., Bin L.H., Zhang J., Shu H.-B.
      J. Biol. Chem. 279:15652-15661(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH IKBKB; IKBKE; IRF3; IRF7; TBK1 AND TRAF6, DOMAIN.
    12. "Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta."
      Jiang Z., Mak T.W., Sen G., Li X.
      Proc. Natl. Acad. Sci. U.S.A. 101:3533-3538(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TRAF6, MUTAGENESIS OF GLU-252 AND GLU-493.
    13. "NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation."
      Sasai M., Oshiumi H., Matsumoto M., Inoue N., Fujita F., Nakanishi M., Seya T.
      J. Immunol. 174:27-30(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AZI2.
    14. "The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling."
      Carty M., Goodbody R., Schroeder M., Stack J., Moynagh P.N., Bowie A.G.
      Nat. Immunol. 7:1074-1081(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SARM1.
    15. "The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling."
      O'Neill L.A., Bowie A.G.
      Nat. Rev. Immunol. 7:353-364(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-46.
    18. Cited for: VARIANT HSE4 LEU-186.

    Entry informationi

    Entry nameiTCAM1_HUMAN
    AccessioniPrimary (citable) accession number: Q8IUC6
    Secondary accession number(s): B3Y691
    , O75532, Q86XP8, Q96GA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3