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Q8IUC6

- TCAM1_HUMAN

UniProt

Q8IUC6 - TCAM1_HUMAN

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Protein
TIR domain-containing adapter molecule 1
Gene
TICAM1, PRVTIRB, TRIF
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.3 Publications

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. protein kinase binding Source: UniProtKB
  3. signal transducer activity Source: UniProtKB

GO - Biological processi

  1. I-kappaB kinase/NF-kappaB signaling Source: Reactome
  2. MyD88-independent toll-like receptor signaling pathway Source: Reactome
  3. TRIF-dependent toll-like receptor signaling pathway Source: Reactome
  4. apoptotic signaling pathway Source: Ensembl
  5. defense response to virus Source: UniProtKB-KW
  6. inflammatory response Source: UniProtKB-KW
  7. innate immune response Source: Reactome
  8. lipopolysaccharide-mediated signaling pathway Source: Ensembl
  9. macrophage activation involved in immune response Source: Ensembl
  10. positive regulation of B cell proliferation Source: Ensembl
  11. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  12. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  13. positive regulation of chemokine biosynthetic process Source: Ensembl
  14. positive regulation of interferon-beta biosynthetic process Source: Ensembl
  15. positive regulation of interleukin-6 production Source: Ensembl
  16. positive regulation of nitric oxide biosynthetic process Source: Ensembl
  17. positive regulation of protein binding Source: Ensembl
  18. positive regulation of protein ubiquitination Source: Ensembl
  19. positive regulation of tumor necrosis factor production Source: Ensembl
  20. positive regulation of type I interferon production Source: Ensembl
  21. regulation of protein homodimerization activity Source: Ensembl
  22. response to exogenous dsRNA Source: MGI
  23. toll-like receptor 3 signaling pathway Source: Reactome
  24. toll-like receptor 4 signaling pathway Source: Reactome
  25. toll-like receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Apoptosis, Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiREACT_118563. RIP-mediated NFkB activation via ZBP1.
REACT_150361. TRIF-mediated programmed cell death.
REACT_25148. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
REACT_25351. TRAF6 mediated induction of TAK1 complex.
REACT_25374. IKK complex recruitment mediated by RIP1.
SignaLinkiQ8IUC6.

Names & Taxonomyi

Protein namesi
Recommended name:
TIR domain-containing adapter molecule 1
Short name:
TICAM-1
Alternative name(s):
Proline-rich, vinculin and TIR domain-containing protein B
Putative NF-kappa-B-activating protein 502H
Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
Short name:
MyD88-3
Short name:
TIR domain-containing adapter protein inducing IFN-beta
Gene namesi
Name:TICAM1
Synonyms:PRVTIRB, TRIF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:18348. TICAM1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. endosome membrane Source: Reactome
  3. ripoptosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Herpes simplex encephalitis 4 (HSE4) [MIM:614850]: A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti186 – 1861S → L in HSE4. 1 Publication
Corresponds to variant rs146550489 [ dbSNP | Ensembl ].
VAR_069082

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi88 – 881E → A: Reduces binding to TRAF6 and activation of NFKB signaling pathway; when associated with A-252 and A-303. 1 Publication
Mutagenesisi252 – 2521E → A: Loss of TCAM1-induced NF-kappa-B activation. Reduces interaction with TRAF6 and activation of NF-kappa-B signaling pathway; when associated with A-88 and A-303. 2 Publications
Mutagenesisi303 – 3031E → A: Reduces binding to TRAF6 and activation of NFKB signaling pathway; when associated with A-88 and A-252. 1 Publication
Mutagenesisi434 – 4341P → H: Abolishes interaction with TLR3. 1 Publication
Mutagenesisi493 – 4931E → A: Loss of TCAM1-induced NF-kappa-B and IRF3 activation. 1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi614850. phenotype.
Orphaneti1930. Herpetic encephalitis.
PharmGKBiPA142670812.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 712712TIR domain-containing adapter molecule 1
PRO_0000317663Add
BLAST

Post-translational modificationi

Phosphorylated by TBK1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IUC6.
PaxDbiQ8IUC6.
PRIDEiQ8IUC6.

PTM databases

PhosphoSiteiQ8IUC6.

Expressioni

Tissue specificityi

Ubiquitously expressed but with higher levels in liver.2 Publications

Gene expression databases

BgeeiQ8IUC6.
CleanExiHS_TICAM1.
GenevestigatoriQ8IUC6.

Organism-specific databases

HPAiHPA042460.

Interactioni

Subunit structurei

Homodimer Inferred. Interacts (via the TIR domain) with TLR3; mediates TLR3 signaling. Interacts with AZI2, TBK1, IRF3 and IRF7. Interacts with TICAM2 in TLR4 recruitment. Interaction with PIAS4 inhibits the TICAM1-induced NF-kappa-B, IRF and IFNB1 activation. Interacts with IKBKB and IKBKE. Interaction with SARM1 blocks TICAM1-dependent transcription factor activation. Interacts with TRAF3 By similarity. Interacts with TRAF6. Interacts with TRAFD1 By similarity.9 Publications

Protein-protein interaction databases

BioGridi127114. 25 interactions.
DIPiDIP-33490N.
IntActiQ8IUC6. 4 interactions.
MINTiMINT-1202912.
STRINGi9606.ENSP00000248244.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi8 – 169
Helixi20 – 3011
Helixi40 – 5011
Helixi54 – 629
Turni63 – 664
Helixi68 – 769
Beta strandi83 – 853
Helixi93 – 10513
Helixi111 – 12717
Helixi133 – 14412
Beta strandi369 – 3713
Helixi406 – 41712
Beta strandi431 – 4333
Helixi444 – 4474
Beta strandi448 – 4558
Helixi462 – 47514
Turni477 – 4804
Beta strandi486 – 4905
Beta strandi492 – 4943
Helixi503 – 5064
Beta strandi508 – 5103
Beta strandi513 – 5164
Helixi520 – 5278
Helixi530 – 5356
Turni536 – 5405
Helixi541 – 5433

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2M1XNMR-A387-545[»]
2M63NMR-A1-156[»]
3RC4X-ray1.50B360-372[»]
4BSXX-ray2.23A/B/C/D1-153[»]
4C0MX-ray2.80A/B/C/D1-153[»]
ProteinModelPortaliQ8IUC6.
SMRiQ8IUC6. Positions 1-156, 386-545.

Miscellaneous databases

EvolutionaryTraceiQ8IUC6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini390 – 46071TIR
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni512 – 712201Sufficient to induce apoptosis
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi84 – 918TRAF6-binding
Motifi248 – 2558TRAF6-binding
Motifi299 – 30911TRAF6-binding
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi213 – 371159Pro-rich
Add
BLAST
Compositional biasi614 – 67865Pro-rich
Add
BLAST

Domaini

The N-terminal region is essential for activation of the IFNB promoter activity.3 Publications

Sequence similaritiesi

Contains 1 TIR domain.

Phylogenomic databases

eggNOGiNOG67739.
HOGENOMiHOG000068973.
HOVERGENiHBG108551.
InParanoidiQ8IUC6.
KOiK05842.
OMAiEQKFYNF.
OrthoDBiEOG7GFB4H.
PhylomeDBiQ8IUC6.
TreeFamiTF336953.

Family and domain databases

InterProiIPR025735. RHIM_dom.
IPR017278. TICAM1.
IPR000157. TIR_dom.
[Graphical view]
PfamiPF12721. RHIM. 1 hit.
[Graphical view]
PIRSFiPIRSF037744. TIR_Ticam. 1 hit.
SUPFAMiSSF52200. SSF52200. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IUC6-1 [UniParc]FASTAAdd to Basket

« Hide

MACTGPSLPS AFDILGAAGQ DKLLYLKHKL KTPRPGCQGQ DLLHAMVLLK    50
LGQETEARIS LEALKADAVA RLVARQWAGV DSTEDPEEPP DVSWAVARLY 100
HLLAEEKLCP ASLRDVAYQE AVRTLSSRDD HRLGELQDEA RNRCGWDIAG 150
DPGSIRTLQS NLGCLPPSSA LPSGTRSLPR PIDGVSDWSQ GCSLRSTGSP 200
ASLASNLEIS QSPTMPFLSL HRSPHGPSKL CDDPQASLVP EPVPGGCQEP 250
EEMSWPPSGE IASPPELPSS PPPGLPEVAP DATSTGLPDT PAAPETSTNY 300
PVECTEGSAG PQSLPLPILE PVKNPCSVKD QTPLQLSVED TTSPNTKPCP 350
PTPTTPETSP PPPPPPPSST PCSAHLTPSS LFPSSLESSS EQKFYNFVIL 400
HARADEHIAL RVREKLEALG VPDGATFCED FQVPGRGELS CLQDAIDHSA 450
FIILLLTSNF DCRLSLHQVN QAMMSNLTRQ GSPDCVIPFL PLESSPAQLS 500
SDTASLLSGL VRLDEHSQIF ARKVANTFKP HRLQARKAMW RKEQDTRALR 550
EQSQHLDGER MQAAALNAAY SAYLQSYLSY QAQMEQLQVA FGSHMSFGTG 600
APYGARMPFG GQVPLGAPPP FPTWPGCPQP PPLHAWQAGT PPPPSPQPAA 650
FPQSLPFPQS PAFPTASPAP PQSPGLQPLI IHHAQMVQLG LNNHMWNQRG 700
SQAPEDKTQE AE 712
Length:712
Mass (Da):76,422
Last modified:March 1, 2003 - v1
Checksum:i5D071E3BE9240D9A
GO

Sequence cautioni

The sequence AAO85488.1 differs from that shown. Reason: Frameshift at positions 141, 148 and 161.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461M → I in a breast cancer sample; somatic mutation. 1 Publication
VAR_038789
Natural varianti75 – 751R → C.
Corresponds to variant rs11466719 [ dbSNP | Ensembl ].
VAR_051416
Natural varianti186 – 1861S → L in HSE4. 1 Publication
Corresponds to variant rs146550489 [ dbSNP | Ensembl ].
VAR_069082
Natural varianti275 – 2751L → V.
Corresponds to variant rs11466721 [ dbSNP | Ensembl ].
VAR_051417
Natural varianti666 – 6661A → T.
Corresponds to variant rs11466724 [ dbSNP | Ensembl ].
VAR_051418

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti147 – 1471D → T in AAO85488. 1 Publication
Sequence conflicti150 – 1501G → W in AAO85488. 1 Publication
Sequence conflicti162 – 1621L → S in AAO85488. 1 Publication
Sequence conflicti633 – 65927Missing in AAO85488. 1 Publication
Add
BLAST
Sequence conflicti660 – 6601S → P in AAO85488. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB093555 mRNA. Translation: BAC44839.1.
AB086380 mRNA. Translation: BAC55579.1.
AB446484 mRNA. Translation: BAG55261.1.
AB097023 mRNA. Translation: BAC77376.1.
BC009860 mRNA. Translation: AAH09860.2.
BC136556 mRNA. Translation: AAI36557.1.
BC136557 mRNA. Translation: AAI36558.1.
AF492646 mRNA. Translation: AAO85488.1. Frameshift.
AF070530 mRNA. Translation: AAC28630.1.
CCDSiCCDS12136.1.
RefSeqiNP_891549.1. NM_182919.3.
UniGeneiHs.29344.

Genome annotation databases

EnsembliENST00000248244; ENSP00000248244; ENSG00000127666.
GeneIDi148022.
KEGGihsa:148022.
UCSCiuc002mbi.4. human.

Polymorphism databases

DMDMi74727957.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB093555 mRNA. Translation: BAC44839.1 .
AB086380 mRNA. Translation: BAC55579.1 .
AB446484 mRNA. Translation: BAG55261.1 .
AB097023 mRNA. Translation: BAC77376.1 .
BC009860 mRNA. Translation: AAH09860.2 .
BC136556 mRNA. Translation: AAI36557.1 .
BC136557 mRNA. Translation: AAI36558.1 .
AF492646 mRNA. Translation: AAO85488.1 . Frameshift.
AF070530 mRNA. Translation: AAC28630.1 .
CCDSi CCDS12136.1.
RefSeqi NP_891549.1. NM_182919.3.
UniGenei Hs.29344.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2M1X NMR - A 387-545 [» ]
2M63 NMR - A 1-156 [» ]
3RC4 X-ray 1.50 B 360-372 [» ]
4BSX X-ray 2.23 A/B/C/D 1-153 [» ]
4C0M X-ray 2.80 A/B/C/D 1-153 [» ]
ProteinModelPortali Q8IUC6.
SMRi Q8IUC6. Positions 1-156, 386-545.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127114. 25 interactions.
DIPi DIP-33490N.
IntActi Q8IUC6. 4 interactions.
MINTi MINT-1202912.
STRINGi 9606.ENSP00000248244.

PTM databases

PhosphoSitei Q8IUC6.

Polymorphism databases

DMDMi 74727957.

Proteomic databases

MaxQBi Q8IUC6.
PaxDbi Q8IUC6.
PRIDEi Q8IUC6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000248244 ; ENSP00000248244 ; ENSG00000127666 .
GeneIDi 148022.
KEGGi hsa:148022.
UCSCi uc002mbi.4. human.

Organism-specific databases

CTDi 148022.
GeneCardsi GC19M004815.
HGNCi HGNC:18348. TICAM1.
HPAi HPA042460.
MIMi 607601. gene.
614850. phenotype.
neXtProti NX_Q8IUC6.
Orphaneti 1930. Herpetic encephalitis.
PharmGKBi PA142670812.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG67739.
HOGENOMi HOG000068973.
HOVERGENi HBG108551.
InParanoidi Q8IUC6.
KOi K05842.
OMAi EQKFYNF.
OrthoDBi EOG7GFB4H.
PhylomeDBi Q8IUC6.
TreeFami TF336953.

Enzyme and pathway databases

Reactomei REACT_118563. RIP-mediated NFkB activation via ZBP1.
REACT_150361. TRIF-mediated programmed cell death.
REACT_25148. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
REACT_25351. TRAF6 mediated induction of TAK1 complex.
REACT_25374. IKK complex recruitment mediated by RIP1.
SignaLinki Q8IUC6.

Miscellaneous databases

EvolutionaryTracei Q8IUC6.
GenomeRNAii 148022.
NextBioi 85815.
PROi Q8IUC6.
SOURCEi Search...

Gene expression databases

Bgeei Q8IUC6.
CleanExi HS_TICAM1.
Genevestigatori Q8IUC6.

Family and domain databases

InterProi IPR025735. RHIM_dom.
IPR017278. TICAM1.
IPR000157. TIR_dom.
[Graphical view ]
Pfami PF12721. RHIM. 1 hit.
[Graphical view ]
PIRSFi PIRSF037744. TIR_Ticam. 1 hit.
SUPFAMi SSF52200. SSF52200. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling."
    Yamamoto M., Sato S., Mori K., Hoshino K., Takeuchi O., Takeda K., Akira S.
    J. Immunol. 169:6668-6672(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DOMAIN, INTERACTION WITH IRF3; TLR2 AND TLR3.
  2. "TICAM-1, an adapter molecule that participates in Toll-like receptor 3 mediated interferon-beta induction."
    Oshiumi H., Matsumoto M., Funami K., Akazawa T., Seya T.
    Nat. Immunol. 4:161-167(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TLR3, SUBUNIT, TISSUE SPECIFICITY, DOMAIN, MUTAGENESIS OF PRO-434.
    Tissue: Lung.
  3. "Natural selection in the TLR-related genes in the course of primate evolution."
    Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., Kimura A.
    Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
    Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
    Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary and Testis.
  6. "PRVTIRB is a differentially expressed gene."
    Begum N.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 137-712.
  7. Yu W., Gibbs R.A.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 297-712.
    Tissue: Brain.
  8. "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling."
    Bin L.-H., Xu L.-G., Shu H.-B.
    J. Biol. Chem. 278:24526-24532(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TICAM2.
  9. "Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling."
    Sato S., Sugiyama M., Yamamoto M., Watanabe Y., Kawai T., Takeda K., Akira S.
    J. Immunol. 171:4304-4310(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRAF6 AND TBK1, PHOSPHORYLATION BY TBK1, MOTIF, MUTAGENESIS OF GLU-88; GLU-252 AND GLU-303.
  10. "PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis."
    Zhang J., Xu L.G., Han K.J., Wei X., Shu H.B.
    FEBS Lett. 570:97-101(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PIAS4.
  11. "Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways."
    Han K.J., Su X., Xu L.-G., Bin L.H., Zhang J., Shu H.-B.
    J. Biol. Chem. 279:15652-15661(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH IKBKB; IKBKE; IRF3; IRF7; TBK1 AND TRAF6, DOMAIN.
  12. "Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta."
    Jiang Z., Mak T.W., Sen G., Li X.
    Proc. Natl. Acad. Sci. U.S.A. 101:3533-3538(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRAF6, MUTAGENESIS OF GLU-252 AND GLU-493.
  13. "NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation."
    Sasai M., Oshiumi H., Matsumoto M., Inoue N., Fujita F., Nakanishi M., Seya T.
    J. Immunol. 174:27-30(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AZI2.
  14. "The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling."
    Carty M., Goodbody R., Schroeder M., Stack J., Moynagh P.N., Bowie A.G.
    Nat. Immunol. 7:1074-1081(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SARM1.
  15. "The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling."
    O'Neill L.A., Bowie A.G.
    Nat. Rev. Immunol. 7:353-364(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-46.
  18. Cited for: VARIANT HSE4 LEU-186.

Entry informationi

Entry nameiTCAM1_HUMAN
AccessioniPrimary (citable) accession number: Q8IUC6
Secondary accession number(s): B3Y691
, O75532, Q86XP8, Q96GA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi