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Protein

Keratin-associated protein 7-1

Gene

KRTAP7-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 7-1
Alternative name(s):
High tyrosine-glycine keratin-associated protein 7.1
Gene namesi
Name:KRTAP7-1
Synonyms:KAP7.1, KRTAP7.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:18934. KRTAP7-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134993282.

Polymorphism and mutation databases

BioMutaiKRTAP7-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8787Keratin-associated protein 7-1PRO_0000185182Add
BLAST

Proteomic databases

PeptideAtlasiQ8IUC3.
PRIDEiQ8IUC3.

PTM databases

PhosphoSiteiQ8IUC3.

Expressioni

Tissue specificityi

Expressed in the upper portion of the hair cortex.

Gene expression databases

CleanExiHS_KRTAP7-1.
GenevisibleiQ8IUC3. HS.

Interactioni

Subunit structurei

Interacts with hair keratins.

Structurei

3D structure databases

ProteinModelPortaliQ8IUC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni43 – 844211 X 2 AA repeats of G-[YCGS]Add
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 7 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00390000015202.
HOVERGENiHBG052289.
InParanoidiQ8IUC3.
OMAiNCVVPLG.
OrthoDBiEOG091G0YGR.
PhylomeDBiQ8IUC3.

Family and domain databases

InterProiIPR020184. KRTAP7.
[Graphical view]
PfamiPF15034. KRTAP7. 1 hit.
[Graphical view]
ProDomiPD061258. Keratin-associated_7. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q8IUC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRYFCCGSY FPGYPIYGTN FHGTFRATPL NCVVPLGSPL NYGCGCNGYS
60 70 80
SLGYSFGGSN INNLGGCYGG SFYRPWGSGS GFGYSTY
Length:87
Mass (Da):9,288
Last modified:July 19, 2003 - v2
Checksum:iD08DB80A2D0DC033
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ457063 mRNA. Translation: CAD29719.1.
AB096962 mRNA. Translation: BAE46377.1.
AP001709 Genomic DNA. No translation available.
CCDSiCCDS74780.1.
RefSeqiNP_853637.2. NM_181606.2.
UniGeneiHs.407656.

Genome annotation databases

EnsembliENST00000621162; ENSP00000479656; ENSG00000274749.
GeneIDi337878.
KEGGihsa:337878.
UCSCiuc032pxy.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ457063 mRNA. Translation: CAD29719.1.
AB096962 mRNA. Translation: BAE46377.1.
AP001709 Genomic DNA. No translation available.
CCDSiCCDS74780.1.
RefSeqiNP_853637.2. NM_181606.2.
UniGeneiHs.407656.

3D structure databases

ProteinModelPortaliQ8IUC3.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8IUC3.

Polymorphism and mutation databases

BioMutaiKRTAP7-1.

Proteomic databases

PeptideAtlasiQ8IUC3.
PRIDEiQ8IUC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000621162; ENSP00000479656; ENSG00000274749.
GeneIDi337878.
KEGGihsa:337878.
UCSCiuc032pxy.2. human.

Organism-specific databases

CTDi337878.
GeneCardsiKRTAP7-1.
HGNCiHGNC:18934. KRTAP7-1.
neXtProtiNX_Q8IUC3.
PharmGKBiPA134993282.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000015202.
HOVERGENiHBG052289.
InParanoidiQ8IUC3.
OMAiNCVVPLG.
OrthoDBiEOG091G0YGR.
PhylomeDBiQ8IUC3.

Miscellaneous databases

GenomeRNAii337878.
PROiQ8IUC3.

Gene expression databases

CleanExiHS_KRTAP7-1.
GenevisibleiQ8IUC3. HS.

Family and domain databases

InterProiIPR020184. KRTAP7.
[Graphical view]
PfamiPF15034. KRTAP7. 1 hit.
[Graphical view]
ProDomiPD061258. Keratin-associated_7. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiKRA71_HUMAN
AccessioniPrimary (citable) accession number: Q8IUC3
Secondary accession number(s): Q3LI56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: July 19, 2003
Last modified: September 7, 2016
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence of 1-36 of PubMed:12359730 has not been submitted.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.