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Protein

Keratin-associated protein 8-1

Gene

KRTAP8-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 8-1
Alternative name(s):
High glycine-tyrosine keratin-associated protein 8.1
Gene namesi
Name:KRTAP8-1
Synonyms:KAP8.1, KRTAP8.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:18935. KRTAP8-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134918132.

Polymorphism and mutation databases

BioMutaiKRTAP8-1.
DMDMi32363185.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6363Keratin-associated protein 8-1PRO_0000185185Add
BLAST

Proteomic databases

PaxDbiQ8IUC2.
PRIDEiQ8IUC2.

Expressioni

Tissue specificityi

Is essentially restricted to only one vertical half of the hair forming compartment and in beard hairs is absent from the central medulla.

Gene expression databases

BgeeiQ8IUC2.
CleanExiHS_KRTAP8-1.
GenevisibleiQ8IUC2. HS.

Organism-specific databases

HPAiHPA027054.

Interactioni

Subunit structurei

Interacts with hair keratins.

Binary interactionsi

WithEntry#Exp.IntActNotes
DAB1O755533EBI-10261141,EBI-7875264
DAZAP2Q150383EBI-10261141,EBI-724310
HEL-S-101V9HW273EBI-10261141,EBI-10178933
PSMA3P257883EBI-10261141,EBI-348380
RBPMSQ930623EBI-10261141,EBI-740322

Protein-protein interaction databases

BioGridi130625. 5 interactions.
IntActiQ8IUC2. 5 interactions.
STRINGi9606.ENSP00000332805.

Structurei

3D structure databases

ProteinModelPortaliQ8IUC2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni12 – 544312 X 2 AA repeats of G-[YCGS]Add
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 8 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J841. Eukaryota.
ENOG41117YH. LUCA.
GeneTreeiENSGT00530000064274.
HOGENOMiHOG000113258.
HOVERGENiHBG063242.
InParanoidiQ8IUC2.
OMAiYSVGCGF.
OrthoDBiEOG75QR76.
PhylomeDBiQ8IUC2.
TreeFamiTF338337.

Family and domain databases

InterProiIPR021743. KRTAP_type6/8/16/19/20/21.
[Graphical view]
PfamiPF11759. KRTAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IUC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCDNFPGAV FPGCYWGSYG YPLGYSVGCG YGSTYSPVGY GFGYGYNGCG
60
AFGYRRYSPF ALY
Length:63
Mass (Da):6,826
Last modified:March 1, 2003 - v1
Checksum:i4D967085A15D295F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ457064 mRNA. Translation: CAD29720.1.
AB096961 mRNA. Translation: BAE46376.1.
AP000244 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09896.1.
BC130397 mRNA. Translation: AAI30398.1.
BC133033 mRNA. Translation: AAI33034.1.
CCDSiCCDS13607.1.
RefSeqiNP_787053.1. NM_175857.3.
UniGeneiHs.407655.

Genome annotation databases

EnsembliENST00000329621; ENSP00000332805; ENSG00000183640.
GeneIDi337879.
KEGGihsa:337879.
UCSCiuc002you.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ457064 mRNA. Translation: CAD29720.1.
AB096961 mRNA. Translation: BAE46376.1.
AP000244 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09896.1.
BC130397 mRNA. Translation: AAI30398.1.
BC133033 mRNA. Translation: AAI33034.1.
CCDSiCCDS13607.1.
RefSeqiNP_787053.1. NM_175857.3.
UniGeneiHs.407655.

3D structure databases

ProteinModelPortaliQ8IUC2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130625. 5 interactions.
IntActiQ8IUC2. 5 interactions.
STRINGi9606.ENSP00000332805.

Polymorphism and mutation databases

BioMutaiKRTAP8-1.
DMDMi32363185.

Proteomic databases

PaxDbiQ8IUC2.
PRIDEiQ8IUC2.

Protocols and materials databases

DNASUi337879.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329621; ENSP00000332805; ENSG00000183640.
GeneIDi337879.
KEGGihsa:337879.
UCSCiuc002you.3. human.

Organism-specific databases

CTDi337879.
GeneCardsiKRTAP8-1.
HGNCiHGNC:18935. KRTAP8-1.
HPAiHPA027054.
neXtProtiNX_Q8IUC2.
PharmGKBiPA134918132.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J841. Eukaryota.
ENOG41117YH. LUCA.
GeneTreeiENSGT00530000064274.
HOGENOMiHOG000113258.
HOVERGENiHBG063242.
InParanoidiQ8IUC2.
OMAiYSVGCGF.
OrthoDBiEOG75QR76.
PhylomeDBiQ8IUC2.
TreeFamiTF338337.

Miscellaneous databases

GenomeRNAii337879.
NextBioi96769.
PROiQ8IUC2.

Gene expression databases

BgeeiQ8IUC2.
CleanExiHS_KRTAP8-1.
GenevisibleiQ8IUC2. HS.

Family and domain databases

InterProiIPR021743. KRTAP_type6/8/16/19/20/21.
[Graphical view]
PfamiPF11759. KRTAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1."
    Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Schweizer J.
    J. Biol. Chem. 277:48993-49002(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Scalp.
  2. "A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3."
    Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J., Shimizu N.
    Genomics 83:679-693(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hair root.
  3. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiKRA81_HUMAN
AccessioniPrimary (citable) accession number: Q8IUC2
Secondary accession number(s): Q3LI57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.