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Protein

Keratin-associated protein 11-1

Gene

KRTAP11-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 11-1
Alternative name(s):
High sulfur keratin-associated protein 11.1
Gene namesi
Name:KRTAP11-1
Synonyms:KAP11.1, KRTAP11.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000182591.5.
HGNCiHGNC:18922. KRTAP11-1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182591.
PharmGKBiPA134907329.

Polymorphism and mutation databases

BioMutaiKRTAP11-1.
DMDMi32363182.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001851941 – 163Keratin-associated protein 11-1Add BLAST163

Proteomic databases

PaxDbiQ8IUC1.
PeptideAtlasiQ8IUC1.
PRIDEiQ8IUC1.

Expressioni

Tissue specificityi

Expressed in the upper matrix and in the entire hair cortex.

Gene expression databases

BgeeiENSG00000182591.
CleanExiHS_KRTAP11-1.
GenevisibleiQ8IUC1. HS.

Organism-specific databases

HPAiHPA054008.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi130626. 3 interactors.
IntActiQ8IUC1. 103 interactors.
STRINGi9606.ENSP00000330720.

Structurei

3D structure databases

ProteinModelPortaliQ8IUC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati111 – 120110
Repeati121 – 130210
Repeati131 – 140310
Repeati141 – 150410

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni111 – 1504 X 10 AA approximate repeatsAdd BLAST40

Sequence similaritiesi

Belongs to the PMG family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J23J. Eukaryota.
ENOG411180K. LUCA.
GeneTreeiENSGT00730000111463.
HOGENOMiHOG000234032.
HOVERGENiHBG096675.
InParanoidiQ8IUC1.
OMAiSTVCQPV.
OrthoDBiEOG091G0NTH.
PhylomeDBiQ8IUC1.
TreeFamiTF337331.

Family and domain databases

InterProiView protein in InterPro
IPR007659. Keratin_matx.
IPR007951. KRTAP_PMG.
PANTHERiPTHR19051. PTHR19051. 1 hit.
PfamiView protein in Pfam
PF05287. PMG. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010562. Keratin_matx. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IUC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFNCSTRNC SSRPIGGRCI VPVAQVTTTS TTDADCLGGI CLPSSFQTGS
60 70 80 90 100
WLLDHCQETC CEPTACQPTC YRRTSCVSNP CQVTCSRQTT CISNPCSTTY
110 120 130 140 150
SRPLTFVSSG CQPLGGISSV CQPVGGISTV CQPVGGVSTV CQPACGVSRT
160
YQQSCVSSCR RTC
Length:163
Mass (Da):17,085
Last modified:March 1, 2003 - v1
Checksum:iF485585FF46AD7BA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053467111C → S. Corresponds to variant dbSNP:rs9636845Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ457065 mRNA. Translation: CAD29721.1.
AP000244 Genomic DNA. No translation available.
BC130555 mRNA. Translation: AAI30556.1.
BC130557 mRNA. Translation: AAI30558.1.
CCDSiCCDS13608.1.
RefSeqiNP_787054.1. NM_175858.2.
UniGeneiHs.407654.

Genome annotation databases

EnsembliENST00000332378; ENSP00000330720; ENSG00000182591.
GeneIDi337880.
KEGGihsa:337880.
UCSCiuc002yov.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKR111_HUMAN
AccessioniPrimary (citable) accession number: Q8IUC1
Secondary accession number(s): A1L4I8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families