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Protein

Keratin-associated protein 11-1

Gene

KRTAP11-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 11-1
Alternative name(s):
High sulfur keratin-associated protein 11.1
Gene namesi
Name:KRTAP11-1
Synonyms:KAP11.1, KRTAP11.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:18922. KRTAP11-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134907329.

Polymorphism and mutation databases

BioMutaiKRTAP11-1.
DMDMi32363182.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163Keratin-associated protein 11-1PRO_0000185194Add
BLAST

Proteomic databases

PaxDbiQ8IUC1.
PeptideAtlasiQ8IUC1.
PRIDEiQ8IUC1.

Expressioni

Tissue specificityi

Expressed in the upper matrix and in the entire hair cortex.

Gene expression databases

BgeeiQ8IUC1.
CleanExiHS_KRTAP11-1.
GenevisibleiQ8IUC1. HS.

Interactioni

Protein-protein interaction databases

BioGridi130626. 3 interactions.
IntActiQ8IUC1. 2 interactions.
STRINGi9606.ENSP00000330720.

Structurei

3D structure databases

ProteinModelPortaliQ8IUC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati111 – 120101
Repeati121 – 130102
Repeati131 – 140103
Repeati141 – 150104

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni111 – 150404 X 10 AA approximate repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the PMG family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J23J. Eukaryota.
ENOG411180K. LUCA.
GeneTreeiENSGT00730000111463.
HOGENOMiHOG000234032.
HOVERGENiHBG096675.
InParanoidiQ8IUC1.
OMAiSTVCQPV.
OrthoDBiEOG7MKW78.
PhylomeDBiQ8IUC1.
TreeFamiTF337331.

Family and domain databases

InterProiIPR007659. Keratin_matx.
IPR007951. KRTAP_PMG.
[Graphical view]
PANTHERiPTHR19051. PTHR19051. 1 hit.
PfamiPF05287. PMG. 1 hit.
[Graphical view]
ProDomiPD010562. Keratin_matx. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q8IUC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFNCSTRNC SSRPIGGRCI VPVAQVTTTS TTDADCLGGI CLPSSFQTGS
60 70 80 90 100
WLLDHCQETC CEPTACQPTC YRRTSCVSNP CQVTCSRQTT CISNPCSTTY
110 120 130 140 150
SRPLTFVSSG CQPLGGISSV CQPVGGISTV CQPVGGVSTV CQPACGVSRT
160
YQQSCVSSCR RTC
Length:163
Mass (Da):17,085
Last modified:March 1, 2003 - v1
Checksum:iF485585FF46AD7BA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti111 – 1111C → S.
Corresponds to variant rs9636845 [ dbSNP | Ensembl ].
VAR_053467

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ457065 mRNA. Translation: CAD29721.1.
AP000244 Genomic DNA. No translation available.
BC130555 mRNA. Translation: AAI30556.1.
BC130557 mRNA. Translation: AAI30558.1.
CCDSiCCDS13608.1.
RefSeqiNP_787054.1. NM_175858.2.
UniGeneiHs.407654.

Genome annotation databases

EnsembliENST00000332378; ENSP00000330720; ENSG00000182591.
GeneIDi337880.
KEGGihsa:337880.
UCSCiuc002yov.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ457065 mRNA. Translation: CAD29721.1.
AP000244 Genomic DNA. No translation available.
BC130555 mRNA. Translation: AAI30556.1.
BC130557 mRNA. Translation: AAI30558.1.
CCDSiCCDS13608.1.
RefSeqiNP_787054.1. NM_175858.2.
UniGeneiHs.407654.

3D structure databases

ProteinModelPortaliQ8IUC1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130626. 3 interactions.
IntActiQ8IUC1. 2 interactions.
STRINGi9606.ENSP00000330720.

Polymorphism and mutation databases

BioMutaiKRTAP11-1.
DMDMi32363182.

Proteomic databases

PaxDbiQ8IUC1.
PeptideAtlasiQ8IUC1.
PRIDEiQ8IUC1.

Protocols and materials databases

DNASUi337880.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332378; ENSP00000330720; ENSG00000182591.
GeneIDi337880.
KEGGihsa:337880.
UCSCiuc002yov.4. human.

Organism-specific databases

CTDi337880.
GeneCardsiKRTAP11-1.
HGNCiHGNC:18922. KRTAP11-1.
MIMi600064. gene.
neXtProtiNX_Q8IUC1.
PharmGKBiPA134907329.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J23J. Eukaryota.
ENOG411180K. LUCA.
GeneTreeiENSGT00730000111463.
HOGENOMiHOG000234032.
HOVERGENiHBG096675.
InParanoidiQ8IUC1.
OMAiSTVCQPV.
OrthoDBiEOG7MKW78.
PhylomeDBiQ8IUC1.
TreeFamiTF337331.

Miscellaneous databases

GenomeRNAii337880.
PROiQ8IUC1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IUC1.
CleanExiHS_KRTAP11-1.
GenevisibleiQ8IUC1. HS.

Family and domain databases

InterProiIPR007659. Keratin_matx.
IPR007951. KRTAP_PMG.
[Graphical view]
PANTHERiPTHR19051. PTHR19051. 1 hit.
PfamiPF05287. PMG. 1 hit.
[Graphical view]
ProDomiPD010562. Keratin_matx. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1."
    Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Schweizer J.
    J. Biol. Chem. 277:48993-49002(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Scalp.
  2. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiKR111_HUMAN
AccessioniPrimary (citable) accession number: Q8IUC1
Secondary accession number(s): A1L4I8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.