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Protein

Keratin-associated protein 13-1

Gene

KRTAP13-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 13-1
Alternative name(s):
High sulfur keratin-associated protein 13.1
Gene namesi
Name:KRTAP13-1
Synonyms:KAP13.1, KRTAP13.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000198390.4.
HGNCiHGNC:18924. KRTAP13-1.
MIMi608718. gene.
neXtProtiNX_Q8IUC0.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198390.
PharmGKBiPA134987916.

Polymorphism and mutation databases

BioMutaiKRTAP13-1.
DMDMi33112378.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001852001 – 172Keratin-associated protein 13-1Add BLAST172

Proteomic databases

PaxDbiQ8IUC0.
PeptideAtlasiQ8IUC0.
PRIDEiQ8IUC0.

PTM databases

iPTMnetiQ8IUC0.
PhosphoSitePlusiQ8IUC0.

Expressioni

Tissue specificityi

Weak expression seen in the late matrix and entire cortex area of the hair follicle.1 Publication

Gene expression databases

BgeeiENSG00000198390.
CleanExiHS_KRTAP13-1.
GenevisibleiQ8IUC0. HS.

Interactioni

Subunit structurei

Interacts with hair keratins.

Protein-protein interaction databases

BioGridi126601. 9 interactors.
IntActiQ8IUC0. 1 interactor.
STRINGi9606.ENSP00000347635.

Structurei

3D structure databases

ProteinModelPortaliQ8IUC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati46 – 55110
Repeati56 – 65210
Repeati66 – 75310
Repeati76 – 85410
Repeati92 – 101510

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni46 – 1015 X 10 AA approximate repeatsAdd BLAST56

Sequence similaritiesi

Belongs to the PMG family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J2YJ. Eukaryota.
ENOG41119RP. LUCA.
GeneTreeiENSGT00390000012339.
HOGENOMiHOG000234032.
HOVERGENiHBG052275.
InParanoidiQ8IUC0.
OMAiASRTCQS.
OrthoDBiEOG091G0PYN.
PhylomeDBiQ8IUC0.
TreeFamiTF337331.

Family and domain databases

InterProiView protein in InterPro
IPR007951. KRTAP_PMG.
PANTHERiPTHR19051. PTHR19051. 1 hit.
PfamiView protein in Pfam
PF05287. PMG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IUC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYNCCSGNF SSRSCGGYLH YPASSCGFSY PSNQVYSTDL CSPSTCQLGS
60 70 80 90 100
SLYRGCQQTC WEPTSCQTSY VESSPCQTSC YRPRTSLLCS PCQTTYSGSL
110 120 130 140 150
GFGSSSCRSL GYGSRSCYSV GCGSSGFRSL GYGGCGFPSL GYGVGFCRPT
160 170
YLASRSCQSS CYRPTCGSGF YY
Length:172
Mass (Da):18,320
Last modified:July 19, 2003 - v2
Checksum:i1699D1A35AB378AE
GO

Sequence cautioni

The sequence AAI13537 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI13539 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ457066 mRNA. Translation: CAD29722.1.
AB096939 mRNA. Translation: BAE46354.1.
AP001708 Genomic DNA. No translation available.
BC113536 mRNA. Translation: AAI13537.1. Different initiation.
BC113538 mRNA. Translation: AAI13539.1. Different initiation.
CCDSiCCDS13590.2.
RefSeqiNP_853630.2. NM_181599.2.
UniGeneiHs.407653.

Genome annotation databases

EnsembliENST00000355459; ENSP00000347635; ENSG00000198390.
GeneIDi140258.
KEGGihsa:140258.
UCSCiuc002yoa.4. human.

Similar proteinsi

Entry informationi

Entry nameiKR131_HUMAN
AccessioniPrimary (citable) accession number: Q8IUC0
Secondary accession number(s): Q14D20, Q3LI79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: July 19, 2003
Last modified: September 27, 2017
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence of 1-41 of PubMed:12359730 has not been submitted.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families