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Protein

Keratin-associated protein 19-1

Gene

KRTAP19-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 19-1
Alternative name(s):
High tyrosine-glycine keratin-associated protein 19.1
Gene namesi
Name:KRTAP19-1
Synonyms:KAP19.1, KRTAP19.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:18936. KRTAP19-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134956142.

Polymorphism and mutation databases

BioMutaiKRTAP19-1.
DMDMi88984327.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9090Keratin-associated protein 19-1PRO_0000185221Add
BLAST

Proteomic databases

PaxDbiQ8IUB9.
PRIDEiQ8IUB9.

Expressioni

Tissue specificityi

Detected in the upper portion of the hair cortex.

Gene expression databases

BgeeiQ8IUB9.
CleanExiHS_KRTAP19-1.
GenevisibleiQ8IUB9. HS.

Interactioni

Subunit structurei

Interacts with hair keratins.

Protein-protein interaction databases

STRINGi9606.ENSP00000375108.

Structurei

3D structure databases

ProteinModelPortaliQ8IUB9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni5 – 848026 X 2 AA repeats of G-[YCGS]Add
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 19 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

OMAiCFRPRCY.

Family and domain databases

InterProiIPR021743. KRTAP_type6/8/16/19/20/21.
[Graphical view]
PfamiPF11759. KRTAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IUB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHYGSYYGG LGYSCGGFGG LGYGYGCGCG SFCRRGSGCG YGGYGYGSGF
60 70 80 90
GSYGYGSGFG GYGYGSGFGG YGYGCCRPSY NGGYGFSGFY
Length:90
Mass (Da):9,008
Last modified:February 21, 2006 - v2
Checksum:iC442DB474ACA47A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096943 mRNA. Translation: BAE46358.1.
AP000567 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09898.1.
BC126284 mRNA. Translation: AAI26285.1.
BC126286 mRNA. Translation: AAI26287.1.
AJ457067 mRNA. Translation: CAD29723.1.
CCDSiCCDS13594.1.
RefSeqiNP_853638.1. NM_181607.1.
UniGeneiHs.61552.

Genome annotation databases

EnsembliENST00000390689; ENSP00000375108; ENSG00000184351.
GeneIDi337882.
KEGGihsa:337882.
UCSCiuc011acx.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096943 mRNA. Translation: BAE46358.1.
AP000567 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09898.1.
BC126284 mRNA. Translation: AAI26285.1.
BC126286 mRNA. Translation: AAI26287.1.
AJ457067 mRNA. Translation: CAD29723.1.
CCDSiCCDS13594.1.
RefSeqiNP_853638.1. NM_181607.1.
UniGeneiHs.61552.

3D structure databases

ProteinModelPortaliQ8IUB9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000375108.

Polymorphism and mutation databases

BioMutaiKRTAP19-1.
DMDMi88984327.

Proteomic databases

PaxDbiQ8IUB9.
PRIDEiQ8IUB9.

Protocols and materials databases

DNASUi337882.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000390689; ENSP00000375108; ENSG00000184351.
GeneIDi337882.
KEGGihsa:337882.
UCSCiuc011acx.3. human.

Organism-specific databases

CTDi337882.
GeneCardsiKRTAP19-1.
H-InvDBHIX0040896.
HGNCiHGNC:18936. KRTAP19-1.
neXtProtiNX_Q8IUB9.
PharmGKBiPA134956142.
GenAtlasiSearch...

Phylogenomic databases

OMAiCFRPRCY.

Miscellaneous databases

GenomeRNAii337882.
PROiQ8IUB9.

Gene expression databases

BgeeiQ8IUB9.
CleanExiHS_KRTAP19-1.
GenevisibleiQ8IUB9. HS.

Family and domain databases

InterProiIPR021743. KRTAP_type6/8/16/19/20/21.
[Graphical view]
PfamiPF11759. KRTAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of complete keratin-associated protein (KAP) gene cluster spanning 800 kb region on human chromosome 21q22.11."
    Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hair root.
  2. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1."
    Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Schweizer J.
    J. Biol. Chem. 277:48993-49002(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-90.
    Tissue: Scalp.

Entry informationi

Entry nameiKR191_HUMAN
AccessioniPrimary (citable) accession number: Q8IUB9
Secondary accession number(s): A4QN27, Q3LI75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: February 21, 2006
Last modified: June 8, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.